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Chemical compound
FGIN-143
2-[2-(4-chlorophenyl)-5-chloro-1H-indol-3-yl]-N,N-dihexylacetamide
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 28 H 36 Cl 2 N 2 O Molar mass 487.51 g·mol−1 3D model (JSmol )
c3cc(Cl)ccc3-c2[nH]c1ccc(Cl)cc1c2CC(=O)N(CCCCCC)CCCCCC
InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
Key:XTZUPNNVXIMWAR-UHFFFAOYSA-N
(verify)
FGIN-1-43 is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor , also known as the mitochondrial 18 kDa translocator protein or TSPO. It is thought to produce anxiolytic effects by stimulating steroidogenesis of neuroactive steroids such as allopregnanolone , and is several times more potent than the related drug FGIN-127 .[1] [2] [3] [4]
References [ edit ]
^ Romeo E, Auta J, Kozikowski AP, Ma D, Papadopoulos V, Puia G, et al. (September 1992). "2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)". The Journal of Pharmacology and Experimental Therapeutics . 262 (3): 971–8. PMID 1326631 .
^ Kozikowski AP, Ma D, Brewer J, Sun S, Costa E, Romeo E, Guidotti A (October 1993). "Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands". Journal of Medicinal Chemistry . 36 (20): 2908–20. doi :10.1021/jm00072a010 . PMID 8411007 .
^ Costa E, Auta J, Guidotti A, Korneyev A, Romeo E (June 1994). "The pharmacology of neurosteroidogenesis" . The Journal of Steroid Biochemistry and Molecular Biology . 49 (4–6): 385–9. doi :10.1016/0960-0760(94)90284-4 . PMID 8043504 . S2CID 33492066 .
^ Guillon J, Boulouard M, Lelong V, Dallemagne P, Rault S, Jarry C (November 2001). "Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43" . The Journal of Pharmacy and Pharmacology . 53 (11): 1561–8. doi :10.1211/0022357011777945 . PMID 11732760 . S2CID 11838769 .
1-Methylpsilocin
2,alpha-DMT
2-Me-DET
2-Methyl-5-HT
2,N,N-TMT
4,5-DHP-DMT
4,5-MDO-DMT
4,5-MDO-DiPT
4-AcO-DALT
4-AcO-DET
4-AcO-DMT
4-AcO-DiPT
4-AcO-EPT
4-AcO-NMT
4-AcO-MALT
4-AcO-MET
4-AcO-DPT
4-AcO-MiPT
4-F-5-MeO-DMT
4-HO-5-MeO-DMT
4-HO-DALT
4-HO-DBT
4-HO-DET
4-HO-DiPT
4-HO-DPT
4-HO-DSBT
4-HO-EPT
4-HO-MALT
4-HO-MET
4-HO-McPT
4-HO-McPeT
4-HO-MiPT
4-HO-MPMI
4-HO-MPT
4-HO-MsBT
4-HO-NMT
4-HO-PiPT
4-HO-pyr-T
4-HO-αMT
4-Me-αET
4-Me-αMT
4-MeO-DiPT
4-MeO-DMT
4-MeO-MiPT
4-PrO-DMT
5,6-MeO-MiPT
5,6-MDO-DiPT
5,6-MDO-DMT
5,6-MDO-MiPT
5,7-Dihydroxytryptamine
5-BT
5-Bromo-DMT
5-CT
5-Chloro-αMT
5-Chloro-DMT
5-Ethoxy-αMT
5-Ethoxy-DMT
5-Ethyl-DMT
5-Fluoro-AET
5-Fluoro-αMT
5-Fluoro-DET
5-Fluoro-DMT
5-Fluoro-EPT
5-Fluoro-MET
5-HO-αMT
5-HO-DiPT
5-HTP
5-iPrO-AMT
5-MeS-DMT
5-Methoxytryptamine
5-MeO-7,N,N-TMT
5-Methyl-αET
5-MeO-2-TMT
5-MeO-αET
5-MeO-αMT
5-MeO-DALT
5-MeO-DBT
5-MeO-DET
5-MeO-DiPT
5-MeO-DMT
5-MeO-DPT
5-MeO-EiPT
5-MeO-EPT
5-MeO-MALT
5-MeO-MET
5-MeO-MiPT
5-MeO-MPMI
5-MeO-NMT
5-MeO-pyr-T
5-MeO-NBpBrT
5-Methyl-DMT
5-(Nonyloxy)tryptamine
6-Fluoro-αMT
6-Fluoro-DMT
6-Hydroxymelatonin
6-MeO-THH
7-Chloro-AMT
7-Methyl-α-ethyltryptamine
7-Methyl-DMT
Acetryptine
Aeruginascin
αET
Alpha,N-DMT
α,N,N-Trimethyltryptamine
Alpha,N,O-TMS
AL-37350A
αMT
Baeocystin
BNC-210
Bufotenidine
Bufotenin (5-HO-DMT)
BW-723C86
Convolutindole A
CP-132,484
DALT
DBT
Desformylflustrabromine
DET
DiPT
DPT
E-6801
E-6837
Ethocybin
EiPT
EMDT
EPT
FGIN-127
FGIN-143
Harmaline
HIOC
Ibogaine
Idalopirdine
Indorenate
Iprocin
Lespedamine
Luzindole
MET
Methylbutyltryptamine
MiPT
MPT
Miprocin
Melatonin
MPMI
MS-245
NAS
N-Ethyltryptamine
N-Feruloylserotonin
NMT
DMT
Norbaeocystin
Normelatonin
N-t-Butyltryptamine
O-4310
Oxypertine
Plakohypaphorine
PiPT
Psilocin (4-HO-DMT)
Psilocybin (4-PO-DMT)
Pyr-T
Rizatriptan
RU-28306
Serotonin
ST-1936
Sumatriptan
Tryptamine
Tryptophan
Yohimbine
Yuremamine
Zolmitriptan