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LAIR2

From Wikipedia, the free encyclopedia

LAIR2
Identifiers
AliasesLAIR2, CD306, leukocyte associated immunoglobulin like receptor 2
External IDsOMIM: 602993; HomoloGene: 88663; GeneCards: LAIR2; OMA:LAIR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002288
NM_021270

n/a

RefSeq (protein)

NP_002279
NP_067154

n/a

Location (UCSC)Chr 19: 54.5 – 54.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.[3][4]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.[4]

References

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  1. ^ a b c ENSG00000275819, ENSG00000277335, ENSG00000274084 GRCh38: Ensembl release 89: ENSG00000167618, ENSG00000275819, ENSG00000277335, ENSG00000274084Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. hdl:2066/26173. PMID 9285412.
  4. ^ a b "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2".

Further reading

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