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Protein-coding gene in the species Homo sapiens
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene .[ 5] [ 6] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000177239 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036646 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (Aug 1999). "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis" . J Biol Chem . 274 (30): 21375–86. doi :10.1074/jbc.274.30.21375 PMID 10409699 . ^ Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis" . Glycobiology . 9 (10): 1073–8. doi :10.1093/glycob/9.10.1073 PMID 10521544 . ^ "Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1" .
Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie . 83 (8): 783–90. doi :10.1016/S0300-9084(01)01314-1 . hdl :1874/5091 PMID 11530211 . S2CID 13576808 . Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology . 187 (1): 377–82. doi :10.1016/0042-6822(92)90331-I . PMID 1736542 . Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1" . AIDS Res. Hum. Retroviruses . 6 (3): 371–80. doi :10.1089/aid.1990.6.371 . PMID 2187500 . Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins" . Jpn. J. Med. Sci. Biol . 43 (3): 75–87. doi :10.7883/yoken1952.43.75 PMID 2283726 . Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells" . J. Biol. Chem . 265 (18): 10373–82. doi :10.1016/S0021-9258(18)86956-3 PMID 2355006 . Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex" . J. Biol. Chem . 265 (5): 2640–9. doi :10.1016/S0021-9258(19)39849-7 PMID 2406237 . Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1" . Proc. Natl. Acad. Sci. U.S.A . 86 (9): 3384–8. Bibcode :1989PNAS...86.3384P . doi :10.1073/pnas.86.9.3384 PMC 287137 PMID 2541446 . Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport" . J. Virol . 63 (6): 2452–6. doi :10.1128/jvi.63.6.2452-2456.1989 . PMC 250699 PMID 2542563 . Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr . 2 (2): 163–9. PMID 2649653 . Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses . 3 (3): 265–82. doi :10.1089/aid.1987.3.265 . PMID 2829950 . Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun . 141 (1): 33–8. doi :10.1016/S0006-291X(86)80330-8 . PMID 3099781 . Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1" . Proc. Natl. Acad. Sci. U.S.A . 85 (23): 9248–52. Bibcode :1988PNAS...85.9248M . doi :10.1073/pnas.85.23.9248 PMC 282716 PMID 3264072 . Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain" . J. Virol . 67 (1): 150–60. doi :10.1128/jvi.67.1.150-160.1993 . PMC 237347 PMID 8093218 . Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry . 32 (41): 11087–99. doi :10.1021/bi00092a019 . PMID 8218172 . Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response" . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol . 12 (3): 213–20. doi :10.1097/00042560-199607000-00001 PMID 8673525 . Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface" . J. Virol . 70 (11): 7462–70. doi :10.1128/jvi.70.11.7462-7470.1996 . PMC 190813 PMID 8892864 . Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation" . FEBS Lett . 406 (1–2): 191–5. doi :10.1016/S0014-5793(97)00273-1 PMID 9109416 . S2CID 17660 . Tremblay LO, Campbell Dyke N, Herscovics A (1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation" . Glycobiology . 8 (6): 585–95. doi :10.1093/glycob/8.6.585 PMID 9592125 .
PDB gallery
1fmi : CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE
1fo2 : CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN
1fo3 : CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE
1x9d : Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue
