Sialidase-4

NEU4
Identifiers
Aliases	NEU4, neuraminidase 4
External IDs	OMIM: 608527; MGI: 2661364; HomoloGene: 15433; GeneCards: NEU4; OMA:NEU4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,817,413 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,956,056 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right lobe of liver; ; substantia nigra; ; duodenum; ; temporal lobe; ; amygdala; ; hippocampus proper; ; hypothalamus; ; putamen; ; anterior cingulate cortex;
	Top expressed in
	striatum of neuraxis; ; primary visual cortex; ; Cortex of frontal lobe; ; hypothalamus; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; hippocampus proper; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	exo-alpha-(2->6)-sialidase activity; exo-alpha-(2->8)-sialidase activity; hydrolase activity, acting on glycosyl bonds; protein binding; exo-alpha-(2->3)-sialidase activity; hydrolase activity; exo-alpha-sialidase activity;
Cellular component	organelle inner membrane; membrane; lysosomal lumen; lysosome; cytoplasm; intracellular membrane-bounded organelle;
Biological process	glycosphingolipid metabolic process; lipid metabolism; lipid catabolic process; glycoprotein catabolic process; oligosaccharide catabolic process; metabolism; ganglioside catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	129807
	241159
	ENSG00000204099; ENSG00000277926
	ENSMUSG00000034000
	Q8WWR8
	Q8BZL1
	NM_080741; NM_001167599; NM_001167600; NM_001167601; NM_001167602
	NM_173772; NM_001310769
NP_001161071; NP_001161072; NP_001161073; NP_001161074; NP_542779;
	NP_001161071.1; NP_001161072.1; NP_001161073.1; NP_001161074.1
	NP_001297698; NP_776133
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.^[5]

Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[5]

Interactions

Sialidase-4 has been shown to interact with phospholipid scramblase 1.^[6]

References

^ ^a ^b ^c ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034000 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NEU4 sialidase 4".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase". Gene. 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family". Genomics. 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103. S2CID 27379898.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034000 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NEU4 sialidase 4".

[pmid16189514-6] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

Function

Interactions

References

Further reading