Olfactomedin-like 3

OLFML3
Identifiers
Aliases	OLFML3, HNOEL-iso, OLF44, olfactomedin like 3
External IDs	OMIM: 610088; MGI: 1914877; HomoloGene: 10613; GeneCards: OLFML3; OMA:OLFML3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	114,035,572 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	103,645,317 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; left uterine tube; ; body of uterus; ; right ovary; ; placenta; ; Achilles tendon; ; left ovary; ; canal of the cervix; ; smooth muscle tissue; ; myometrium;
	Top expressed in
	genital tubercle; ; lip; ; Meckel's cartilage; ; right kidney; ; mandibular molars; ; Smooth muscle tissue of renal pelvis; ; tail of embryo; ; gastrula; ; lens; ; muscle of thigh;
	More reference expression data
	More reference expression data
Orthologs
	56944
	99543
	ENSG00000116774
	ENSMUSG00000027848
	Q9NRN5
	Q8BK62
	NM_020190; NM_001286352; NM_001286353
	NM_133859
	NP_001273281; NP_001273282; NP_064575; NP_064575.1
	NP_598620
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactomedin-like protein 3 is a protein that in humans is encoded by the OLFML3 gene.^[5] It has been shown to act as a proangiongenic factor in the tumor microenvironment, being released by endothelial cells and pericytes.^[6]

This gene has also been associated with pectinate ligament dysplasia and glaucoma in Border Collies.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116774 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027848 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OLFML3 olfactomedin-like 3".
^ Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Lee BP, Meguenani M, Chaabane C, et al. (December 2012). "Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.
^ Oliver JA, Wright H, Massidda PA, Burmeister LM, Mellersh CS (January 2020). "A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom". Veterinary Ophthalmology. 23 (1): 25–36. doi:10.1111/vop.12680. PMID 31141290. S2CID 169036374.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zeng LC, Liu F, Zhang X, Zhu ZD, Wang ZQ, Han ZG, Ma WJ (July 2004). "hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis". FEBS Letters. 571 (1–3): 74–80. doi:10.1016/j.febslet.2004.06.059. PMID 15280020. S2CID 22306106.
Fautsch MP, Vrabel AM, Johnson DH (June 2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Experimental Eye Research. 82 (6): 1046–1052. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116774 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027848 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OLFML3 olfactomedin-like 3".

[6] Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Lee BP, Meguenani M, Chaabane C, et al. (December 2012). "Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.

[7] Oliver JA, Wright H, Massidda PA, Burmeister LM, Mellersh CS (January 2020). "A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom". Veterinary Ophthalmology. 23 (1): 25–36. doi:10.1111/vop.12680. PMID 31141290. S2CID 169036374.

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References

Further reading