Spirapril
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| Trade names | Renormax |
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| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Bioavailability | 50% |
| Metabolism | converted to spiraprilat |
| Elimination half-life | 30 to 35 hours |
| Excretion | Hepatic and renal |
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| Formula | C22H30N2O5S2 |
| Molar mass | 466.61 g·mol−1 |
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Spirapril, sold under the brand name Renormax among others, is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.[citation needed]
It was patented in 1980 and approved for medical use in 1995.[1]
Chemistry
[edit]Like many ACE inhibitors, this prodrug is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes, which may allow for greater use in patients with renal impairment.[2] However, data on its effect upon the renal function are conflicting.[3]
References
[edit]- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 978-3-527-60749-5.
- ^ Shohat J, Wittenberg C, Erman A, Rosenfeld J, Boner G (February 1999). "Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension". Scandinavian Journal of Urology and Nephrology. 33 (1): 57–62. doi:10.1080/003655999750016294. PMID 10100366.
- ^ Noble S, Sorkin EM (May 1995). "Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension". Drugs. 49 (5): 750–766. doi:10.2165/00003495-199549050-00008. PMID 7601014. S2CID 195691037.
External links
[edit]
Media related to Spirapril at Wikimedia Commons
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