CCR5

CCR5
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifikatzaileak
Aliasak	CCR5 (HUGO), CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5
Kanpoko IDak	OMIM: 601373 MGI: 107182 HomoloGene: 37325 GeneCards: CCR5 OMA: CCR5 - orthologs
Genetikoki lotutako gaixotasunak
	type 1 diabetes mellitus 22 , human immunodeficiency virus infectious disease
Drogaren xedea
	aplaviroc , cenicriviroc , maraviroc , vicriviroc , aplaviroc hydrochloride , AZD5672
Genearen kokapena (gizakia)
	Kromosoma: 3 (gizakia)
Amaiera	46.376.206 bp
Genearen kokapena (sagua)
	Kromosoma: 9 (sagua)
Amaiera	123.947.736 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	epithelium of nasopharynx ; ; parietal pleura ; ; visceral pleura ; ; palpebral conjunctiva ; ; granulozito; ; germinal epithelium ; ; mucosa of urinary bladder ; ; Heste sobre; ; superficial temporal artery ; ; jejunal mucosa ;
	Adierazpen ohikoena
	lumbar subsegment of spinal cord ; ; morula ; ; lumbar spinal ganglion ; ; odol; ; enbrioi; ; gongoil linfatiko; ; mesenteric lymph nodes ; ; Guruin submaxilar; ; blastocyst ; ; enbrioi;
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	G proteina errezeptore akoplatuaren aktibitatea ; coreceptor activity ; chemokine (C-C motif) ligand 5 binding ; virus receptor activity ; seinaleen transdukzio aktibitatea ; proteina lotura ; chemokine receptor activity ; C-C chemokine receptor activity ; actin binding ; phosphatidylinositol phospholipase C activity ; C-C chemokine binding ; chemokine binding ;
Zelularen osagaia	zitoplasma ; zelula-mintzaren osagai integrala ; endosoma ; mintza ; zelula mintz ; plasma-mintzaren osagai integrala ; external side of plasma membrane ; cell surface ;
Prozesu biologikoa	G proteina errezeptore akoplatuaren komunikazio bidea ; signaling ; response to cholesterol ; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ; positive regulation of cytosolic calcium ion concentration ; cell-cell signaling ; dendritic cell chemotaxis ; MAPK cascade ; kimiotaxia ; cellular defense response ; cell surface receptor signaling pathway ; erantzun immune ; inflammatory response ; cellular response to lipopolysaccharide ; kaltzio ioi garraioa ; calcium-mediated signaling ; seinale transdukzio ; fusion of virus membrane with host plasma membrane ; chemokine-mediated signaling pathway ; viral process ; defense response ; negative regulation of macrophage apoptotic process ; cytokine-mediated signaling pathway ; cell chemotaxis ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	1234
	12774
	ENSG00000160791
	ENSMUSG00000079227
	P51681
	P51682
	NM_001100168; NM_000579; NM_001394783
	NM_009917
	NP_000570; NP_001093638
	NP_034047
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

5 motako C-C kimiokina hartzailea, CCR5 deitua, CD4 T linfozitoen eta beste zelula immunogai batzuen gainazaleko hartzailea da. R5 motako GIB birusek kohartzaile gisa erabiltzen dute zelula ostalaria infektatzeko, ezinbestez CD4 hartzailea lotzeaz gain.^[7]. Mintzeko proteina integralen kimiokina beten hartzaile-familiaren kidea da.^[8]

Erreferentziak

↑ Genetikoki lotutako gaixotasunak CCR5ikusi/editatu erreferentziak Wikidatan. .
↑ Fisikoki elkarreragiten duten drogak CCR5ikusi/editatu erreferentziak Wikidatan. .
↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160791 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079227 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Euskalterm: [Hiesa Hiztegia] [2016]
↑ Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. (1996ko martxoa). «Molecular cloning and functional expression of a new human CC-chemokine receptor gene» Biochemistry 35 (11): 3362–7. doi:10.1021/bi952950g. PMID 8639485..

Kanpo estekak

Datuak: Q418404

[1] Genetikoki lotutako gaixotasunak CCR5ikusi/editatu erreferentziak Wikidatan. .

[2] Fisikoki elkarreragiten duten drogak CCR5ikusi/editatu erreferentziak Wikidatan. .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000160791 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000079227 – Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[7] Euskalterm: [Hiesa Hiztegia] [2016]

[pmid8639485-8] Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. (1996ko martxoa). «Molecular cloning and functional expression of a new human CC-chemokine receptor gene» Biochemistry 35 (11): 3362–7. doi:10.1021/bi952950g. PMID 8639485..

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