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Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer's associated proteins
release_wjuedqnhb5ghnbxrildvewg3z4
by
John Yates, Ashraf M. Mohieldin, Surya M. Nauli, Amal Alachkar
Published
in Communicative & Integrative Biology by Informa UK Limited.
2021 Volume 14, Issue 1, p264-269
Abstract
Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.
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