Four families of hyperbranched amphiphilic block copolymers of styrene (Sty, less polar monomer) ... more Four families of hyperbranched amphiphilic block copolymers of styrene (Sty, less polar monomer) and 2-vinylpyridine (2VPy, one of the two more polar monomers) or 4-vinylpyridine (4VPy, the other polar monomer) were prepared via self-condensing vinyl reversible addition-fragmentation chain transfer polymerization (SCVP-RAFT). Two families contained 4VPy as the more polar monomer, one of which possessing a Sty-b-4VPy architecture, and the other possessing the reverse block architecture. The other two families bore 2VPy as the more polar monomer and had either a 2VPy-b-Sty or a Sty-b-2VPy architecture. Characterization of the hyperbranched block copolymers in terms of their molecular weights and compositions indicated better control when the VPy monomers were polymerized first. Control over the molecular weights of the hyperbranched copolymers was also confirmed with the aminolysis of the dithioester moiety at the branching points to produce linear polymers with number-average molecul...
This chapter presents the synthesis, characterisation and degradation of amphiphilic polymer co-n... more This chapter presents the synthesis, characterisation and degradation of amphiphilic polymer co-networks (APCNs) based on dimethacrylate-end-linked linear amphiphilic ABA triblock copolymers prepared using labile bifunctional initiators. Three co-network families are described, each synthesised using a different ‘living’/controlled polymerisation technique, group transfer polymerisation, atom transfer radical polymerisation and reversible addition-fragmentation chain transfer polymerisation and employing the appropriate labile bifunctional initiator. The kinetics of degradation, the nature of the degradation products and the evolution of the swelling degrees are reported. A small-angle neutron scattering study is also presented, revealing two (changing) correlation peaks: one due to the scattering centres within the degrading APCNs, and the other due to the scattering by the polymeric degradation products which are amphiphilic star block copolymers.
Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chai... more Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chains through either a weak (degradable bond) or a dynamic covalent bond. These systems are known as pro-drugs in the inactive form when passing into the blood circulation system. When the prodrug reaches the target organ, tissue or cell, the drug is activated by cleavage of the bond between the drug and polymer, under certain conditions existing in the target organ. The advantages of polymer-drug conjugates compared to other controlled-release carriers and conventional pharmaceutical formulations are the increased drug loading capacity, prolonged in vivo circulation time, enhanced intercellular uptake, better-controlled release, improved therapeutic efficacy, and enhanced permeability and retention effect. The aim of the present review is the investigation of polymer-drug conjugates bearing anti-cancer drugs. The polymer, through its side chains, is linked to the anti-cancer drugs via dyna...
Degradable hyperbranched polymers were synthesized via self-condensing atom transfer radical copo... more Degradable hyperbranched polymers were synthesized via self-condensing atom transfer radical copolymerization of methyl methacrylate (MMA) with a novel inimer bearing a thermolyzable acylal group. This inimer was 1-(2-bromoisobutyryloxyl) ethyl methacrylate ...
... Weber, and others concerning possible changes in the gravitational constant, possible effects... more ... Weber, and others concerning possible changes in the gravitational constant, possible effects of gravity waves on the earth and moon, use of a laser illuminating a corner reflector on the moon, neutrino detectors ... Herman F. Mark, Norman G. Gaylord, and Norbert M. Bikales, Eds. ...
Four families of hyperbranched amphiphilic block copolymers of styrene (Sty, less polar monomer) ... more Four families of hyperbranched amphiphilic block copolymers of styrene (Sty, less polar monomer) and 2-vinylpyridine (2VPy, one of the two more polar monomers) or 4-vinylpyridine (4VPy, the other polar monomer) were prepared via self-condensing vinyl reversible addition-fragmentation chain transfer polymerization (SCVP-RAFT). Two families contained 4VPy as the more polar monomer, one of which possessing a Sty-b-4VPy architecture, and the other possessing the reverse block architecture. The other two families bore 2VPy as the more polar monomer and had either a 2VPy-b-Sty or a Sty-b-2VPy architecture. Characterization of the hyperbranched block copolymers in terms of their molecular weights and compositions indicated better control when the VPy monomers were polymerized first. Control over the molecular weights of the hyperbranched copolymers was also confirmed with the aminolysis of the dithioester moiety at the branching points to produce linear polymers with number-average molecul...
This chapter presents the synthesis, characterisation and degradation of amphiphilic polymer co-n... more This chapter presents the synthesis, characterisation and degradation of amphiphilic polymer co-networks (APCNs) based on dimethacrylate-end-linked linear amphiphilic ABA triblock copolymers prepared using labile bifunctional initiators. Three co-network families are described, each synthesised using a different ‘living’/controlled polymerisation technique, group transfer polymerisation, atom transfer radical polymerisation and reversible addition-fragmentation chain transfer polymerisation and employing the appropriate labile bifunctional initiator. The kinetics of degradation, the nature of the degradation products and the evolution of the swelling degrees are reported. A small-angle neutron scattering study is also presented, revealing two (changing) correlation peaks: one due to the scattering centres within the degrading APCNs, and the other due to the scattering by the polymeric degradation products which are amphiphilic star block copolymers.
Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chai... more Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chains through either a weak (degradable bond) or a dynamic covalent bond. These systems are known as pro-drugs in the inactive form when passing into the blood circulation system. When the prodrug reaches the target organ, tissue or cell, the drug is activated by cleavage of the bond between the drug and polymer, under certain conditions existing in the target organ. The advantages of polymer-drug conjugates compared to other controlled-release carriers and conventional pharmaceutical formulations are the increased drug loading capacity, prolonged in vivo circulation time, enhanced intercellular uptake, better-controlled release, improved therapeutic efficacy, and enhanced permeability and retention effect. The aim of the present review is the investigation of polymer-drug conjugates bearing anti-cancer drugs. The polymer, through its side chains, is linked to the anti-cancer drugs via dyna...
Degradable hyperbranched polymers were synthesized via self-condensing atom transfer radical copo... more Degradable hyperbranched polymers were synthesized via self-condensing atom transfer radical copolymerization of methyl methacrylate (MMA) with a novel inimer bearing a thermolyzable acylal group. This inimer was 1-(2-bromoisobutyryloxyl) ethyl methacrylate ...
... Weber, and others concerning possible changes in the gravitational constant, possible effects... more ... Weber, and others concerning possible changes in the gravitational constant, possible effects of gravity waves on the earth and moon, use of a laser illuminating a corner reflector on the moon, neutrino detectors ... Herman F. Mark, Norman G. Gaylord, and Norbert M. Bikales, Eds. ...
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Papers by Maria Rikkou-Kalourkoti