CLEC5A

CLEC5A
Identificadores
Símbolo	CLEC5A
Símbolos alt.	CLECSF5, MDL-1, MDL1
Entrez	23601
RefSeq	NP_001288096
UniProt	Q9NY25
Outros datos
Locus	Cr. 7 7q34(141.93 – 141.95 Mb)

O CLEC5A (do inglés C-type lectin domain family 5 member A, ou membro A da familia do dominio de lectina tipo C 5), tamén chamado CLECFSF5 (do inglés C-type lectin superfamily member 5, ou membro 5 da superfamilia de lectina tipoC) e MDL1 (do inglés myeloid DAP12-associating lectin 1, ou lectina 1 asociada a DAP12 mieloide) é unha lectina tipo C que en humanos está codificada polo xene CLEC5A, situado no cromosoma 7.^[1]^[2] Parece ser un membro dunha importante vía de activación da liñaxe mieloide. É unha proteína necesaria para o desenvolvemento da enfermidade do dengue.^[3]

Notas

↑ "Entrez Gene: C-type lectin domain family 5".
↑ Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. PMC 22289. PMID 10449773. doi:10.1073/pnas.96.17.9792.
↑ Chen ST, Lin YL, Huang MT, et al. (2008). "CLEC5A is critical for dengue-virus-induced lethal disease.". Nature 453 (7195): 672–6. PMID 18496526. doi:10.1038/nature07013.

Véxase tamén

Ligazóns externas

UCSC gene info CLEC5A

Bibliografía

Joyce-Shaikh B; et al. (2010). "Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.". J Exp Med 207 (3): 579–89. PMC 2839155. PMID 20212065. doi:10.1084/jem.20090516.
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. PMID 20237496. doi:10.1038/gene.2010.1.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. PMC 2882961. PMID 12690205. doi:10.1126/science.1083423.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. PMID 12945048. doi:10.1002/prot.10440.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765. doi:10.1016/S0959-440X(99)00009-3.
Watson AA, O'Callaghan CA (2010). "Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 29–31. PMC 2805530. PMID 20057064. doi:10.1107/S1744309109047915.

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[entrez-1] "Entrez Gene: C-type lectin domain family 5".

[pmid10449773-2] Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. PMC 22289. PMID 10449773. doi:10.1073/pnas.96.17.9792.

[3] Chen ST, Lin YL, Huang MT, et al. (2008). "CLEC5A is critical for dengue-virus-induced lethal disease.". Nature 453 (7195): 672–6. PMID 18496526. doi:10.1038/nature07013.

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