Anthelmintics

Name
Anthelmintics
Accession Number
DBCAT000944
Description

Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.

ATC Classification
Drugs
DrugDrug Description
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
PiperazineA medication used to treat roundworm and pinworm.
MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
LevamisoleLevamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections.
PraziquantelAn anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
NiclosamideAn anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.
PyrviniumAn anthelmintic agent used for the treatment of pinworm infestations.
FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
PyrantelAn anthelmintic used to treat helminth infections.
FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
TriclabendazoleAn anthelmintic drug used to treat fascioliasis.
DichlorophenDichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from...
NiridazoleNot Annotated
OxantelAn antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections.
OxibendazoleInvestigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.
HexylresorcinolAn ingredient used to relieve irritation, pain, and prevent infection.
CambendazoleNot Annotated
ClorsulonNot Annotated
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
FebantelNot Annotated
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
OxfendazoleOxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.
BunamidineBunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations.
DithiazanineDithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was...
Hygromycin BHygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
Milbemycin oximeNot Annotated
OltiprazOltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease.
CarbendazimCarbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.
Albendazole oxideNot Annotated
StibophenStibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms.
BepheniumNot Annotated
CiclobendazoleNot Annotated
DesaspidinNot Annotated
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
BenzimidazoleNot Available
HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
PlumbaginPlumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.
PsoralenNot Annotated
SantoninSantonin is a anthelmintic drug that was previously approved in the US to treat certain parasitic infections.
Drugs & Drug Targets
DrugTargetType
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleATP-dependent translocase ABCB1transporter
PiperazineGamma-aminobutyric acid receptor subunit beta-3target
PiperazineCytochrome P450 2D6enzyme
MebendazoleTubulin alpha-1A chaintarget
MebendazoleTubulin beta-4B chaintarget
MebendazoleCytochrome P450 1A1enzyme
MebendazoleCytochrome P450 3A Subfamilyenzyme
DiethylcarbamazinePolyunsaturated fatty acid 5-lipoxygenasetarget
DiethylcarbamazineProstaglandin G/H synthase 1target
DiethylcarbamazineCholinesteraseenzyme
ThiabendazoleFumarate reductase flavoprotein subunittarget
ThiabendazoleCytochrome P450 1A2enzyme
ThiabendazoleCytochrome P450 1A1enzyme
LevamisoleNeuronal acetylcholine receptor subunit alpha-3target
LevamisoleAlkaline phosphatase, germ cell typetarget
LevamisoleAcetylcholine receptor subunit alpha-type unc-38target
LevamisoleAcetylcholine receptor subunit alpha-type unc-63target
LevamisoleAcetylcholine receptor subunit beta-type lev-1target
LevamisoleAcetylcholine receptor subunit beta-type unc-29target
LevamisoleAlkaline phosphatase, tissue-nonspecific isozymetarget
PraziquantelSchistosome calcium ion (Ca2+) channelstarget
PraziquantelCytochrome P450 3A4enzyme
PraziquantelCytochrome P450 1A2enzyme
PraziquantelCytochrome P450 2C19enzyme
PraziquantelCytochrome P450 3A5enzyme
PraziquantelAlbumincarrier
PraziquantelHematopoietic prostaglandin D synthasetarget
OxamniquineDNAtarget
OxamniquineCytochrome P450 2D6enzyme
BithionolEstrogen receptortarget
BithionolEstrogen receptor betatarget
BithionolInduced myeloid leukemia cell differentiation protein Mcl-1target
NiclosamideDNAtarget
NiclosamideCytochrome P450 2C9enzyme
NiclosamideCytochrome P450 1A2enzyme
PyrantelG-protein coupled receptor 35target
PyrantelCytochrome P450 4A11enzyme
PyrantelMuscarinic acetylcholine receptor M1target
TriclabendazoleCytochrome P450 1A2enzyme
TriclabendazoleCytochrome P450 2C9enzyme
TriclabendazoleExcretory Secretory (ES) proteinstarget
TriclabendazoleCytochrome P450 3A4enzyme
TriclabendazoleCytochrome P450 1A1enzyme
TriclabendazoleCytochrome P450 1B1enzyme
TriclabendazoleCytochrome P450 2C19enzyme
TriclabendazoleCytochrome P450 2D6enzyme
TriclabendazoleCytochrome P450 2A6enzyme
TriclabendazoleCytochrome P450 2C8enzyme
TriclabendazoleCytochrome P450 2B6enzyme
TriclabendazoleCruzipaintarget
OxibendazoleTubulin beta-4B chaintarget
HexylresorcinolDNA topoisomerase 1target
HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2target
HexylresorcinolTyrosinasetarget
DichlorvosAlbumincarrier
DichlorvosSerotransferrintarget
DichlorvosCholinesterasetarget
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
OltiprazProtein-glutamine gamma-glutamyltransferase 2target
CarbendazimAromataseenzyme
CarbendazimAryl hydrocarbon receptortarget
IvermectinATP-dependent translocase ABCB1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinATP-binding cassette sub-family C member 2transporter
IvermectinBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
IvermectinCytochrome P450 2D6enzyme
IvermectinCytochrome P450 2E1enzyme
LucanthoneDNA topoisomerase 2-alphatarget
LucanthoneDNA repair nuclease/redox regulator APEX1target
LucanthoneDNAtarget
LucanthoneDNA topoisomerase 1target
LucanthoneDNA topoisomerase 2-betatarget
BenzimidazoleNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
BenzimidazoleDual specificity tyrosine-phosphorylation-regulated kinase 1Atarget
HycanthoneATP-dependent translocase ABCB1target
HycanthoneATP-dependent translocase ABCB1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1A9enzyme
ArtesunateBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ArtesunateATP-dependent translocase ABCB1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateOrganic anion transporter 3transporter
ArtesunateAlbumincarrier
PlumbaginDihydroorotate dehydrogenase (quinone), mitochondrialtarget
PsoralenAmine oxidase [flavin-containing] Btarget
PsoralenAmine oxidase [flavin-containing] Atarget