Acute Decompensated Heart Failure (ADHF) (DBCOND0054941)

Identifiers

Synonyms
Decompensated cardiac failure / Decompensated Heart Failure / ADHF / Acute Decompensated Heart Failure / Decompensated cardiac failure (disorder) / Heart failure / Heart failure (disorder) / Failure heart / Heart failure (NOS) / Heart failures / Cardiac failure / Heart: [weak] or [failure NOS] / Heart failure NOS (disorder) / Heart failure NOS / (Congestive cardiac failure) or (dropsy) or (cardiac insufficiency) or (right heart failure) or (right ventricular failure) / Heart failure, unspecified / Cardiac failure NOS / Cardiac failure (NOS) / Cardiac insufficiency / Insufficiency cardiac / Cardiac function failure / Cardiac function failed / Heart insufficiency / Acute cardiac insufficiency / Cardiac failure acute / Acute heart failure (disorder) / Acute heart failure

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Levosimendan
A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
Milrinone
A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.
Nesiritide
A recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04905160
Care Coordination to Assess Improvement in Outcomes in Hospital ReadmissionsNo drug interventionspreventionNot Availablerecruiting
NCT02003040
Role of the Mespere Venus 1000 in Predicting Heart Failure Hospital ReadmissionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01700023
3-dimensional Sensor Technology to Quantify Leg-edemaNo drug interventionsNot AvailableNot Availableunknown_status
NCT01419132
Troponin I Release After High Diuretic Dosestreatment4completed
NCT01316432
PK/PD Study of Subcutaneous Cenderitide Infusion in CHF PatientsNot Available1completed
NCT05677100
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart FailureNo drug interventionstreatmentNot Availablerecruiting
NCT06169540
Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)No drug interventionsNot AvailableNot Availablerecruiting
NCT03998410
Evaluation of the Diagnostic Value of the TPD System in Determining ADHF Causing Acute DyspneaNo drug interventionsdiagnosticNot Availableterminated
NCT03951467
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical RecommendationsNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT06272734
Reprieve System Pilot StudyNo drug interventionstreatmentNot Availablerecruiting
NCT04158674
Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLStreatment3terminated
NCT05876078
DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response to DiureticsNo drug interventionstreatmentNot Availablerecruiting
NCT06243029
A Study to Assess Multidomain Endpoints of an ECG PatchNo drug interventionsNot AvailableNot Availablerecruiting
NCT06586008
The Association Between Visual Echocardiographic Scoring System and Clinical Outcomes in Patient With Acute Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT05291884
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility StudyNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT02620384
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center Pilot Study.treatment3terminated
NCT03488979
Effect of Providing Education and Patient's Inferior Vena Cava Ultrasound Images on Adherence to a Heart Failure RegimenNo drug interventionsNot AvailableNot Availablecompleted
NCT00894387
Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failuretreatment3completed
NCT03146754
A Study to Evaluate Lung Ultrasound as a Method to Measure Changes in Extravascular Lung Water Induced by Positional Changes (LUPE)No drug interventionsbasic_scienceNot Availablecompleted
NCT05240651
Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT01570153
Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) TrialNo drug interventionsNot AvailableNot Availablecompleted
NCT01457053
Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus DiureticsdiagnosticNot Availableterminated
NCT06453577
Pharmacokinetics of Bisoprolol and SGLT2i in Acutely Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT03897647
Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial PressuresNo drug interventionsdiagnosticNot Availablewithdrawn
NCT05298098
Impact of Hypertonic Saline Solution on Acute Decompensated Heart FailuretreatmentNot Availablerecruiting
NCT06475105
Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomestreatment4recruiting
NCT04855097
Evaluation of Blood Volume Analysis- Guided Management of Decompensated Heart FailureNo drug interventionstreatmentNot Availablecompleted
NCT01138683
Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus UltrafiltrationNo drug interventionstreatment3completed
NCT02721511
A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimentreatment1 / 2withdrawn
NCT01060293
Dopamine in Acute Decompensated Heart Failure IItreatment4terminated
NCT03262571
Usefulness of Lung Ultrasound in Ambulatory Management of Patients With Chronic Heart FailureNo drug interventionstreatment3terminated
NCT02440971
Adaptive Servo Ventilation (ASV) in Heart FailureNo drug interventionsNot AvailableNot Availablesuspended
NCT00904488
Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failuretreatment4terminated
NCT01924507
Bedside Sleep MedicineNo drug interventionstreatmentNot Availableunknown_status
NCT04877652
DR REGISTRY: Prospective Observational Study of ADHF Patients With Insufficient Response to DiureticsNo drug interventionsNot AvailableNot Availablecompleted
NCT05807152
Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid OverloadNo drug interventionstreatmentNot Availablerecruiting
NCT06414759
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overloadtreatment4recruiting
NCT05759806
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHFNo drug interventionstreatmentNot Availablerecruiting
NCT01837849
A Comparison of Recombinant Human Brain Natriuretic Peptide and DobutamineNo drug interventionsNot AvailableNot Availablecompleted
NCT05100836
SURPASS Impella 5.5 StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04834336
Inspiratory Muscle Training in Acute Decompensated Heart FailureNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04814134
Cardionomic STOP-ADHF StudyNo drug interventionstreatmentNot Availablecompleted
NCT00843986
Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF)treatment3terminated
NCT05206422
DORAYA-HF Early Feasibility StudyNo drug interventionstreatmentNot Availablerecruiting
NCT06298825
S-ADHF:Sarcopenia in Patients With ADHFNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06354426
Short-term Mortality Prediction by the SOFA Score in Acute Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT03863626
Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA TrialNo drug interventionstreatmentNot Availableunknown_status
NCT03695120
RAAS Optimization for Acute CHF PatientsNo drug interventionstreatmentNot Availablecompleted
NCT02248831
Evaluation of Cardiopulmonary Diseases by UltrasoundNo drug interventionsdiagnosticNot Availablecompleted
NCT04752462
Motivational Enhancement - Acute Decompensated Heart Failure and OSANo drug interventionsotherNot Availablerecruiting
NCT06278792
Readily Available Urinary Sodium Analysis in Patients With Acute Decompensated Heart FailureNo drug interventionstreatmentNot Availablecompleted
NCT01574144
REducing 30-day ADMIssions in posT-discharge Subjects (READMIT)No drug interventionsNot AvailableNot Availablecompleted
NCT01347567
Heart Failure (HF) Outpatient Monitoring Evaluation (HOME) StudyNo drug interventionsotherNot Availablecompleted
NCT01966601
A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failuretreatment2completed
NCT06003972
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failuretreatment2completed
NCT04471610
Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart FailureNo drug interventionsotherNot Availablecompleted
NCT02289508
Role of USCOM in Adult Patients With Heart FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT05313438
The STIM-ADHF StudyNo drug interventionstreatmentNot Availablecompleted
NCT05776043
Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failuretreatment3recruiting
NCT01389843
Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF)No drug interventionsNot AvailableNot Availablecompleted
NCT03924102
Cardiac Perfusion and Metabolism With [11C] Acetate PET/CT is Associated With Hematopoietic System Activation in Acute Decompensated Heart Failure: An Imaging Sub-studyNo drug interventionsdiagnostic1withdrawn
NCT03836079
SVC Occlusion in Subjects With Acute Decompensated Heart FailureNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT06161987
EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHFNo drug interventionstreatmentNot Availablerecruiting
NCT05346653
The Hemodynamic Effects of SGLT2i in Acute Decompensated Heart FailureNo drug interventionstreatment4terminated
NCT00693745
Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HFNo drug interventionsNot AvailableNot Availablecompleted
NCT04049045
Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failuretreatment2completed
NCT06081205
Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01863511
Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failuretreatment4completed
NCT04318093
Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart FailureNo drug interventionstreatment2completed
NCT03505788
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)treatment4completed
NCT00839007
Study to Assess the Safety and Efficacy of CD-NP in the Treatment of Patients With Acute Decompensated Heart Failuretreatment2completed
NCT06401109
Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European RegistryNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06459115
Adherence to Medication in Patients With Acute Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT01140399
REWORD-HF REverse WOrsening Renal Function in Decompensated Heart Failuretreatment4terminated
NCT06161649
Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart FailureNo drug interventionshealth_services_researchNot Availablerecruiting
NCT01291836
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05840536
Combination Diuretic Therapy for Acute Decompensated Heart Failuretreatment4withdrawn
NCT03388918
Future Patient - Telerehabilitation of Heart Failure PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04241718
A Feasibility Study on Ultrafiltration and Blood Volume MeasurementsNo drug interventionsdiagnosticNot Availableterminated
NCT04436718
Does Ultrasound Assessment for Extravascular Lung Water and IVC Measurement Affect Outcomes in Inpatient Heart Failure Management?No drug interventionstreatmentNot Availableunknown_status
NCT01960218
Gas Exchange for Predicting Hospital Heart Failure ReadmissionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04390919
Prognostic Factors of Patients With ADHFNo drug interventionsNot AvailableNot Availablecompleted
NCT01661634
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failuretreatment3completed
NCT05633758
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failuretreatment2withdrawn
NCT03246035
Reducing Readmission for Frail Elderly Patients With Decompensated Heart FailureNo drug interventionssupportive_careNot Availablecompleted
NCT02823626
High-dose Aldosterone Antagonist for Acute Decompensated Heart FailureNot AvailableNot Availablecompleted
NCT05327374
Use of ΔIVC for Early Diagnosis of AHF in AECOPDNo drug interventionsNot AvailableNot Availablecompleted
NCT01953874
Cardiovascular Improvements With MV ASV Therapy in Heart FailureNo drug interventionssupportive_careNot Availableterminated
NCT04391231
HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trialtreatment4not_yet_recruiting
NCT06535529
Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patientstreatment3recruiting
NCT01971944
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT06362668
EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU)treatmentNot Availablerecruiting
NCT02617446
The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failuretreatment2completed
NCT00699712
Study to Assess Hemodynamic Effects, Safety and Tolerability of Chimeric Natriuretic Peptide (CD-NP) in Patients With Stabilized Acute Heart Failure (AHF)treatment2completed
NCT05174312
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)No drug interventionstreatmentNot Availablerecruiting
NCT06556810
IC14 for Treatment of Acute Decompensated Heart Failuretreatment1 / 2not_yet_recruiting
NCT02898181
Low Level Tragus Stimulation in Acute Decompensated Heart FailureNo drug interventionstreatmentNot Availablerecruiting
NCT03555123
Evaluate the Efficacy and Safety of Short-term Administration of SIMDAXtreatment3unknown_status
NCT06174623
Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic ResistanceNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00842023
Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapytreatment4completed
NCT00762008
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT02196038
A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01885403
Acute Congestive Heart FailureNo drug interventionsbasic_scienceNot Availableunknown_status
NCT01474200
Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic TreatmenttreatmentNot Availableterminated