The role of environmental pesticide exposures, such as pyrethroids, and their relationship to spe... more The role of environmental pesticide exposures, such as pyrethroids, and their relationship to sperm abnormalities are not well understood. This study investigated whether environmental exposure to pyrethroids was associated with altered frequency of sperm sex chromosome disomy in adult men. A sample of 75 subjects recruited through a Massachusetts infertility clinic provided urine and semen samples. Individual exposures were measured as urinary concentrations of three pyrethroid metabolites ((3-phenoxybenzoic acid (3PBA), cis- and trans- 3-(2,2-Dichlorovinyl)-1-methylcyclopropane-1,2-dicarboxylic acid (CDCCA and TDCCA)). Multiprobe fluorescence in situ hybridization for chromosomes X, Y, and 18 was used to determine XX, YY, XY, 1818, and total sex chromosome disomy in sperm nuclei. Poisson regression analysis was used to examine the association between aneuploidy rates and pyrethroid metabolites while adjusting for covariates. Between 25-56% of the sample were above the limit of det...
BACKGROUND: Knowledge is limited of how estrogen and progesterone variability in fertile women ar... more BACKGROUND: Knowledge is limited of how estrogen and progesterone variability in fertile women are associated with achieving pregnancy. METHODS: From 1996 to 1998, we enrolled 347 textile workers without hormone treat- ment in Anhui, China, who provided daily urine and data upon stopping contraception for up to 1 year until clinical pregnancy. Urinary hCG was assayed to detect conception and
Background: Despite high rates of disabling injuries, the meatpacking industry remains difficult ... more Background: Despite high rates of disabling injuries, the meatpacking industry remains difficult to study. We assessed the non-fatal injury incidence and factors associated with injuries in one pork processing facility in the Midwest. Methods: There were a total of 1914 workers in one plant. Data on all injuries reported over a 25-week period in 2012 were analyzed. We used Cochran-Armitage trend test to examine the injuries by shift, day of the week and the entire study period. Multiple logistic regression was used to estimate significant factors associated with injuries. Results: The cumulative incidence of injuries was 16% (n=300), and 11 (4%) were OSHA recordable. Majority of injured workers were male (62%), Hispanic (42%), English-speaking (49%), and worked in the processing department (74%). Reported injuries were musculoskeletal pain (31%), contusion (22%), laceration (20%), and other. A decreasing trend was observed in musculoskeletal (p=0.002) and laceration (p=0.02) injurie...
Several studies have indicated that slip-resistant shoes may have a positive effect on reducing t... more Several studies have indicated that slip-resistant shoes may have a positive effect on reducing the risk of slips and falls, a leading cause of injury at work. Few studies, however, have examined how duration of shoe usage affects their slip-resistance properties. This study examined the association between the duration of slip-resistant shoes usage and the self-reported rate of slipping in limited-service restaurant workers. A total of 475 workers from 36 limited-service restaurants in the USA were recruited to participate in a 12-week prospective study of workplace slipping. Of the 475 participants, 83 reported changing to a new pair of shoes at least once during the 12-week follow-up. The results show that slip-resistant shoes worn for less than six months were moderately more effective than those worn for more than six months. Changing to a new pair of shoes among those wearing slip-resistant shoes at baseline was associated with a 55% reduction in the rate of slipping (RR = 0.45, 95% CI = 0.23-0.89). Further research is needed to develop criteria for the replacement of slip-resistant shoes.
Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer product... more Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer products, has been negatively associated with sperm quality. This study aimed to estimate the association between BPA and 35 measures of semen quality among reproductive aged men recruited from 16 counties in Michigan and Texas, 2005-2009. Of 501 enrolled males, 418 (83.4%) provided a urine sample and at least one semen sample. Linear and logistic regression models assessed the association between urinary BPA levels and individual semen quality endpoints. Generalized estimating equations were used to account for repeated measures of semen quality and adjusted models accounted for 11 a priori covariates. Geometric mean total urinary BPA concentration among participants was 0.55ng/mL (95% CI 0.49-0.63). A negative relation between BPA and DNA fragmentation was the sole significant finding in adjusted linear regression (β=-0.0544, p=0.035) and suggestive of less sperm DNA damage.
This was a community-based cross-sectional study that is part of an ongoing study of genetics and... more This was a community-based cross-sectional study that is part of an ongoing study of genetics and osteoporosis. To estimate the 1-year self-reported prevalence of low back pain (LBP); and to assess the association between physical exposures (occupation, physical stress, and vibration) and LBP in a rural Chinese population. This study also explored how these associations change when individuals with LBP report additional pains in other parts of the body. Little is known about the prevalence and determinants of LBP in rural developing populations, even though approximately half of the world's population, mostly from the developing world, is engaged in agriculture, a known strenuous activity. Families with at least three participating siblings residing in the surrounding rural region of Anqing city, Anhui Province, China, were invited to participate in the study through public announcements and direct invitations by village physicians. A questionnaire including demographics, physical exposures, and musculoskeletal pain was administered to 13,965 men and women (age, 25-64 years). Generalized estimating equations were used to estimate LBP prevalence and examine associations between LBP and physical exposures. The 1-year prevalence of LBP was 64%. Twenty-five percent reported no pain at any body site. Women had higher prevalence of LBP than men across all age groups. Being a farmer, reporting moderate or heavy physical stress, and having had former or current exposures to vibration were positively associated with LBP (P < 0.05). Physical exposures were also associated with cases of LBP combined with other musculoskeletal pains, and generally, the more pains individuals reported, the more likely it was that they were farmers and were exposed to vibration. A high prevalence of LBP and LBP with additional musculoskeletal pain existed in this rural Chinese sample. We found evidence of a link between physical exposures and LBP, and LBP with additional musculoskeletal pain. Further understanding of the characteristics and risk factors of LBP in rural developing areas is needed.
Scandinavian Journal of Work, Environment & Health, 2011
Ladder falls comprise 16% of all US workplace fall-related fatalities, and ladder use may be part... more Ladder falls comprise 16% of all US workplace fall-related fatalities, and ladder use may be particularly hazardous among older workers. This follow-back study of injured workers from a nationally representative sample of US emergency departments (ED) focused on factors related to ladder falls in three domains of the work environment: work equipment, work practices, and worker-related factors. Risk factors for fractures, the most frequent and severe outcome, were also evaluated. Workers injured from a ladder fall, treated in one of the 65 participating ED in the occupational National Electronic Injury Surveillance System (NEISS) were asked to participate. The questionnaire included worker demographics, injury, ladder and work equipment and environment characteristics, work tasks, and activities. Multivariate logistic regression models estimated odds ratios and 95% confidence intervals of a work-related fracture. Three-hundred and six workers experiencing an injury from an--on average--7.5-foot-fall from a step, extension, or straight ladder were interviewed primarily from construction, installation, maintenance, and repair professions. Injuries were most frequently to the arm, elbow or shoulder; head, neck, or face with diagnoses were primarily fracture, strain, sprain, contusion or abrasion. Workers were most frequently standing or sitting on the ladder while installing, hanging an item, or performing a repair when they fell. Ladder movement was the mechanism in 40% of falls. Environmental conditions played a role in <10% of cases. There was a significant association between fracture risk and fall height while working on the ladder that was also influenced by older work age. This study advances knowledge of falls from ladders to support those who specify means and methods, select equipment, and plan, supervise, or manage the performance of employees working at heights.
Scandinavian Journal of Work, Environment & Health, 2012
The aim of this study was to quantify potential transient risk factors for occupational acute han... more The aim of this study was to quantify potential transient risk factors for occupational acute hand injury among hospitalized workers in the People's Republic of China (PRC). Participants were recruited from 11 medical facilities in 3 cities of the PRC. A face-to-face interview was used to collect information on the occurrence of 8 potential risk factors within a 90-minute time period before an acute traumatic hand injury and during a control period within the month before the injury. The reliability of reporting transient risk factors was assessed, and a case-crossover design was used to estimate the injury incidence risk ratio (IRR) of each risk factor. In total,703 hospitalized workers completed the interview (527 male, 176 female), with a mean age of 31.8 [standard deviation (SD) 10.3] years. The median time interval between injury and interview was four days. Thirty percent of participants had a crush injury and 25.7% had an amputation. Using malfunctioning machinery/tools/material, performing a task with a different method, working overtime, and wearing gloves were found to have good reliability in test-retest examination [intra-class correlation coefficient (ICC)>0.9]. The IRR of a hand injury were markedly increased while using malfunctioning machinery/tools/material [110.4, 95% confidence interval (95% CI) 97.4-125.2], performing a task with a different method than usual (84.3, 95% CI 67.7-105.1), or being distracted (69.6, 95% CI 57.9-83.7). Gender and size of company were associated with differences in glove usage. The results suggest the importance of transient, potentially modifiable factors in the etiology of occupational acute hand injury in the PRC. Regular maintenance of machinery/tools, work practice controls, and avoiding distractions should be priorities for reducing the risk of occupational acute hand injuries.
Journal of Occupational and Environmental Hygiene, 2010
The leading cause of injuries among restaurant workers is same-level falls, a significant proport... more The leading cause of injuries among restaurant workers is same-level falls, a significant proportion of which result from slipping. This study examines the experience of limited-service restaurant workers with slipping, their use of slip-resistant shoes, and their floor-cleaning practices. A total of 475 workers from 36 limited-service restaurants in six U.S. states participated in a 12-week prospective cohort study on slipping in the workplace. At baseline, participants completed a survey that gathered information about their demographics, perceptions of floor slipperiness, use of slip-resistant shoes, floor cleaning practices, and number of slips experienced in the previous 4 weeks. During the subsequent 12 weeks, participants reported their slip experience weekly. Restaurant managers reported kitchen floor cleaning protocols and shoe policies. The overall rate of slipping during the 12 weeks of the prospective study was 0.44 slips per 40 work hours. The mean of the individual rate of slipping varied among the restaurants from 0.02 to 2.49 slips per 40 work hours, a rate ratio of more than 100 among the restaurants with the highest and the lowest rate of slipping. Such a large variation, which is unlikely due to chance alone (p < 0.05), suggests that some restaurants are better able to control slipping than others. The highest numbers of slips were reported in the sink and fryer areas, which were also identified by restaurant workers as being the most slippery. Liquid and grease were reported as floor contaminants in over 70% of the slips. In restaurants where slip-resistant shoes were provided by the employer, 91% of participants wore them; whereas if they were neither provided nor encouraged, only 53.5% wore them (p < 0.01). Use of enzyme-based floor cleaners was widespread (25/36). In these restaurants, however, 62% of the participants who were responsible for cleaning floors reported using hot/warm water, thus violating the manufacturer's cold water floor cleaning protocol. These findings suggest that focused prevention efforts based on practices from restaurants with low rates of slipping could decrease slipping hazards.
Slips and falls are a leading cause of injury at work. Several studies have indicated that slip-r... more Slips and falls are a leading cause of injury at work. Several studies have indicated that slip-resistant shoes can reduce the risk of occupational slips and falls. Few studies, however, have examined the determinants of slip-resistant shoe use. This study examined the individual and workplace factors associated with slip-resistant shoe use. 475 workers from 36 limited-service restaurants in the USA participated in a study of workplace slipping. Demographic and job characteristic information about each participant was collected. Restaurant managers provided information on whether slip-resistant shoes were provided and paid for by the employer and whether any guidance was given regarding slip-resistant shoe use when they were not provided. Kitchen floor coefficient of friction was measured. Slip-resistant status of the shoes was determined by noting the presence of a 'slip-resistant' marking on the sole. Poisson regression with robust SE was used to calculate prevalence ratios. 320 participants wore slip-resistant shoes (67%). In the multivariate analysis, the prevalence of slip-resistant shoe use was lowest in 15-19-year age group. Women were more likely to wear slip-resistant shoes (prevalence ratio 1.18, 95% CI 1.07 to 1.31). The prevalence of slip-resistant shoe use was lower when no guidance regarding slip-resistant shoes was given as compared to when they were provided by the employer (prevalence ratio 0.66, 95% CI 0.55 to 0.79). Education level, job tenure and the mean coefficient of friction had no significant effects on the use of slip-resistant shoes. Provision of slip-resistant shoes was the strongest predictor of their use. Given their effectiveness and low cost, employers should consider providing slip-resistant shoes at work.
The role of environmental pesticide exposures, such as pyrethroids, and their relationship to spe... more The role of environmental pesticide exposures, such as pyrethroids, and their relationship to sperm abnormalities are not well understood. This study investigated whether environmental exposure to pyrethroids was associated with altered frequency of sperm sex chromosome disomy in adult men. A sample of 75 subjects recruited through a Massachusetts infertility clinic provided urine and semen samples. Individual exposures were measured as urinary concentrations of three pyrethroid metabolites ((3-phenoxybenzoic acid (3PBA), cis- and trans- 3-(2,2-Dichlorovinyl)-1-methylcyclopropane-1,2-dicarboxylic acid (CDCCA and TDCCA)). Multiprobe fluorescence in situ hybridization for chromosomes X, Y, and 18 was used to determine XX, YY, XY, 1818, and total sex chromosome disomy in sperm nuclei. Poisson regression analysis was used to examine the association between aneuploidy rates and pyrethroid metabolites while adjusting for covariates. Between 25-56% of the sample were above the limit of det...
BACKGROUND: Knowledge is limited of how estrogen and progesterone variability in fertile women ar... more BACKGROUND: Knowledge is limited of how estrogen and progesterone variability in fertile women are associated with achieving pregnancy. METHODS: From 1996 to 1998, we enrolled 347 textile workers without hormone treat- ment in Anhui, China, who provided daily urine and data upon stopping contraception for up to 1 year until clinical pregnancy. Urinary hCG was assayed to detect conception and
Background: Despite high rates of disabling injuries, the meatpacking industry remains difficult ... more Background: Despite high rates of disabling injuries, the meatpacking industry remains difficult to study. We assessed the non-fatal injury incidence and factors associated with injuries in one pork processing facility in the Midwest. Methods: There were a total of 1914 workers in one plant. Data on all injuries reported over a 25-week period in 2012 were analyzed. We used Cochran-Armitage trend test to examine the injuries by shift, day of the week and the entire study period. Multiple logistic regression was used to estimate significant factors associated with injuries. Results: The cumulative incidence of injuries was 16% (n=300), and 11 (4%) were OSHA recordable. Majority of injured workers were male (62%), Hispanic (42%), English-speaking (49%), and worked in the processing department (74%). Reported injuries were musculoskeletal pain (31%), contusion (22%), laceration (20%), and other. A decreasing trend was observed in musculoskeletal (p=0.002) and laceration (p=0.02) injurie...
Several studies have indicated that slip-resistant shoes may have a positive effect on reducing t... more Several studies have indicated that slip-resistant shoes may have a positive effect on reducing the risk of slips and falls, a leading cause of injury at work. Few studies, however, have examined how duration of shoe usage affects their slip-resistance properties. This study examined the association between the duration of slip-resistant shoes usage and the self-reported rate of slipping in limited-service restaurant workers. A total of 475 workers from 36 limited-service restaurants in the USA were recruited to participate in a 12-week prospective study of workplace slipping. Of the 475 participants, 83 reported changing to a new pair of shoes at least once during the 12-week follow-up. The results show that slip-resistant shoes worn for less than six months were moderately more effective than those worn for more than six months. Changing to a new pair of shoes among those wearing slip-resistant shoes at baseline was associated with a 55% reduction in the rate of slipping (RR = 0.45, 95% CI = 0.23-0.89). Further research is needed to develop criteria for the replacement of slip-resistant shoes.
Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer product... more Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer products, has been negatively associated with sperm quality. This study aimed to estimate the association between BPA and 35 measures of semen quality among reproductive aged men recruited from 16 counties in Michigan and Texas, 2005-2009. Of 501 enrolled males, 418 (83.4%) provided a urine sample and at least one semen sample. Linear and logistic regression models assessed the association between urinary BPA levels and individual semen quality endpoints. Generalized estimating equations were used to account for repeated measures of semen quality and adjusted models accounted for 11 a priori covariates. Geometric mean total urinary BPA concentration among participants was 0.55ng/mL (95% CI 0.49-0.63). A negative relation between BPA and DNA fragmentation was the sole significant finding in adjusted linear regression (β=-0.0544, p=0.035) and suggestive of less sperm DNA damage.
This was a community-based cross-sectional study that is part of an ongoing study of genetics and... more This was a community-based cross-sectional study that is part of an ongoing study of genetics and osteoporosis. To estimate the 1-year self-reported prevalence of low back pain (LBP); and to assess the association between physical exposures (occupation, physical stress, and vibration) and LBP in a rural Chinese population. This study also explored how these associations change when individuals with LBP report additional pains in other parts of the body. Little is known about the prevalence and determinants of LBP in rural developing populations, even though approximately half of the world's population, mostly from the developing world, is engaged in agriculture, a known strenuous activity. Families with at least three participating siblings residing in the surrounding rural region of Anqing city, Anhui Province, China, were invited to participate in the study through public announcements and direct invitations by village physicians. A questionnaire including demographics, physical exposures, and musculoskeletal pain was administered to 13,965 men and women (age, 25-64 years). Generalized estimating equations were used to estimate LBP prevalence and examine associations between LBP and physical exposures. The 1-year prevalence of LBP was 64%. Twenty-five percent reported no pain at any body site. Women had higher prevalence of LBP than men across all age groups. Being a farmer, reporting moderate or heavy physical stress, and having had former or current exposures to vibration were positively associated with LBP (P < 0.05). Physical exposures were also associated with cases of LBP combined with other musculoskeletal pains, and generally, the more pains individuals reported, the more likely it was that they were farmers and were exposed to vibration. A high prevalence of LBP and LBP with additional musculoskeletal pain existed in this rural Chinese sample. We found evidence of a link between physical exposures and LBP, and LBP with additional musculoskeletal pain. Further understanding of the characteristics and risk factors of LBP in rural developing areas is needed.
Scandinavian Journal of Work, Environment & Health, 2011
Ladder falls comprise 16% of all US workplace fall-related fatalities, and ladder use may be part... more Ladder falls comprise 16% of all US workplace fall-related fatalities, and ladder use may be particularly hazardous among older workers. This follow-back study of injured workers from a nationally representative sample of US emergency departments (ED) focused on factors related to ladder falls in three domains of the work environment: work equipment, work practices, and worker-related factors. Risk factors for fractures, the most frequent and severe outcome, were also evaluated. Workers injured from a ladder fall, treated in one of the 65 participating ED in the occupational National Electronic Injury Surveillance System (NEISS) were asked to participate. The questionnaire included worker demographics, injury, ladder and work equipment and environment characteristics, work tasks, and activities. Multivariate logistic regression models estimated odds ratios and 95% confidence intervals of a work-related fracture. Three-hundred and six workers experiencing an injury from an--on average--7.5-foot-fall from a step, extension, or straight ladder were interviewed primarily from construction, installation, maintenance, and repair professions. Injuries were most frequently to the arm, elbow or shoulder; head, neck, or face with diagnoses were primarily fracture, strain, sprain, contusion or abrasion. Workers were most frequently standing or sitting on the ladder while installing, hanging an item, or performing a repair when they fell. Ladder movement was the mechanism in 40% of falls. Environmental conditions played a role in <10% of cases. There was a significant association between fracture risk and fall height while working on the ladder that was also influenced by older work age. This study advances knowledge of falls from ladders to support those who specify means and methods, select equipment, and plan, supervise, or manage the performance of employees working at heights.
Scandinavian Journal of Work, Environment & Health, 2012
The aim of this study was to quantify potential transient risk factors for occupational acute han... more The aim of this study was to quantify potential transient risk factors for occupational acute hand injury among hospitalized workers in the People's Republic of China (PRC). Participants were recruited from 11 medical facilities in 3 cities of the PRC. A face-to-face interview was used to collect information on the occurrence of 8 potential risk factors within a 90-minute time period before an acute traumatic hand injury and during a control period within the month before the injury. The reliability of reporting transient risk factors was assessed, and a case-crossover design was used to estimate the injury incidence risk ratio (IRR) of each risk factor. In total,703 hospitalized workers completed the interview (527 male, 176 female), with a mean age of 31.8 [standard deviation (SD) 10.3] years. The median time interval between injury and interview was four days. Thirty percent of participants had a crush injury and 25.7% had an amputation. Using malfunctioning machinery/tools/material, performing a task with a different method, working overtime, and wearing gloves were found to have good reliability in test-retest examination [intra-class correlation coefficient (ICC)>0.9]. The IRR of a hand injury were markedly increased while using malfunctioning machinery/tools/material [110.4, 95% confidence interval (95% CI) 97.4-125.2], performing a task with a different method than usual (84.3, 95% CI 67.7-105.1), or being distracted (69.6, 95% CI 57.9-83.7). Gender and size of company were associated with differences in glove usage. The results suggest the importance of transient, potentially modifiable factors in the etiology of occupational acute hand injury in the PRC. Regular maintenance of machinery/tools, work practice controls, and avoiding distractions should be priorities for reducing the risk of occupational acute hand injuries.
Journal of Occupational and Environmental Hygiene, 2010
The leading cause of injuries among restaurant workers is same-level falls, a significant proport... more The leading cause of injuries among restaurant workers is same-level falls, a significant proportion of which result from slipping. This study examines the experience of limited-service restaurant workers with slipping, their use of slip-resistant shoes, and their floor-cleaning practices. A total of 475 workers from 36 limited-service restaurants in six U.S. states participated in a 12-week prospective cohort study on slipping in the workplace. At baseline, participants completed a survey that gathered information about their demographics, perceptions of floor slipperiness, use of slip-resistant shoes, floor cleaning practices, and number of slips experienced in the previous 4 weeks. During the subsequent 12 weeks, participants reported their slip experience weekly. Restaurant managers reported kitchen floor cleaning protocols and shoe policies. The overall rate of slipping during the 12 weeks of the prospective study was 0.44 slips per 40 work hours. The mean of the individual rate of slipping varied among the restaurants from 0.02 to 2.49 slips per 40 work hours, a rate ratio of more than 100 among the restaurants with the highest and the lowest rate of slipping. Such a large variation, which is unlikely due to chance alone (p < 0.05), suggests that some restaurants are better able to control slipping than others. The highest numbers of slips were reported in the sink and fryer areas, which were also identified by restaurant workers as being the most slippery. Liquid and grease were reported as floor contaminants in over 70% of the slips. In restaurants where slip-resistant shoes were provided by the employer, 91% of participants wore them; whereas if they were neither provided nor encouraged, only 53.5% wore them (p < 0.01). Use of enzyme-based floor cleaners was widespread (25/36). In these restaurants, however, 62% of the participants who were responsible for cleaning floors reported using hot/warm water, thus violating the manufacturer's cold water floor cleaning protocol. These findings suggest that focused prevention efforts based on practices from restaurants with low rates of slipping could decrease slipping hazards.
Slips and falls are a leading cause of injury at work. Several studies have indicated that slip-r... more Slips and falls are a leading cause of injury at work. Several studies have indicated that slip-resistant shoes can reduce the risk of occupational slips and falls. Few studies, however, have examined the determinants of slip-resistant shoe use. This study examined the individual and workplace factors associated with slip-resistant shoe use. 475 workers from 36 limited-service restaurants in the USA participated in a study of workplace slipping. Demographic and job characteristic information about each participant was collected. Restaurant managers provided information on whether slip-resistant shoes were provided and paid for by the employer and whether any guidance was given regarding slip-resistant shoe use when they were not provided. Kitchen floor coefficient of friction was measured. Slip-resistant status of the shoes was determined by noting the presence of a 'slip-resistant' marking on the sole. Poisson regression with robust SE was used to calculate prevalence ratios. 320 participants wore slip-resistant shoes (67%). In the multivariate analysis, the prevalence of slip-resistant shoe use was lowest in 15-19-year age group. Women were more likely to wear slip-resistant shoes (prevalence ratio 1.18, 95% CI 1.07 to 1.31). The prevalence of slip-resistant shoe use was lower when no guidance regarding slip-resistant shoes was given as compared to when they were provided by the employer (prevalence ratio 0.66, 95% CI 0.55 to 0.79). Education level, job tenure and the mean coefficient of friction had no significant effects on the use of slip-resistant shoes. Provision of slip-resistant shoes was the strongest predictor of their use. Given their effectiveness and low cost, employers should consider providing slip-resistant shoes at work.
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