The novel niosomal system aimed to deliver the active drug entity to the target site. The objecti... more The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigotes treated with various concentrations of itraconazole niosome was significantly lower than that of itraconazole alone (IC₅₀=0.24 μg/ml vs. IC₅₀=0.43 μg/ml, P<0.01). In contrast, the mean multiplication rate of amastigotes inside the macrophages and also the mean number of amastigotes in each macrophage treated with itraconazole niosome (34.9 and 3.0) were significantly lower (P<0.01) than those treated with itraconazole alone (62.0 and 3.8) or tartar emetic (63.9 and 4.2), respectively. These findings indicated that niosomes could be developed as a novel drug delivery for itraconazole in the in vitro model. Further studies are required to evaluate the effect of itraconazole niosome on volunteer human subjects.
زمينه و هدف: اهميت بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل در حدي است که حتي كشورهاي پيش... more زمينه و هدف: اهميت بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل در حدي است که حتي كشورهاي پيشرفته جهان نيز از آن بي نياز نيستند. اين تحقيق با هدف بررسي ديدگاه دانش آموختگان بورسيه خارج از کشور در مورد مفهوم موفقيت تحصيلي و مصاديق آن و عوامل موثر بر موفقيت تحصيلي انجام شد. روش كار: در اين مطالعه کيفي، 11 نفر از اعضاي هيات علمي دانشگاه علوم پزشکي کرمان که دانش آموخته دانشگاه هاي خارج از کشور بودند، شرکت کردند. طي يک مصاحبه باز در خصوص معيارهاي سنجش موفقيت تحصيلي و همچنين عوامل موثر بر آن از افراد مذکور نظرخواهي ...
Methods: Using registered documents as one of the best information sources, 366 students awarded ... more Methods: Using registered documents as one of the best information sources, 366 students awarded scholarship between1997-2003 were enrolled into the study. Student's personal information at the time of going abroad, scholarship granted university, local university and students' major and duration of study were considered as useful information and excluded carefully from electronic and paper documents under the cooperation of the scholarship office of Ministry of Health and Medical Education. Results: Most of the students were ...
زمينه و هدف: توجه به تاثير بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل اهميت فراوان دارد، به... more زمينه و هدف: توجه به تاثير بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل اهميت فراوان دارد، به شکلي که حتي کشورهاي پيشرفته جهان نيز از اين امر مهم بي نياز نيستند، اين در حالي است که هنوز در کشورهاي در حال توسعه توجه کافي و مديريت مناسبي براي بهره مندي از مزاياي بورسيه دانشجويان به خارج از کشور وجود ندارد. با توجه به ضرورت بيان شده، بايست در خصوص اعزام دانشجو به خارج دقت و حساسيت بيشتري در سيستم برنامه ريزي کشور وجود داشته باشد. روش کار: تعداد 366 دانشجو در فاصله زماني بين 1376 تا 1382 که از کشور خارج شده بودند، وارد ...
Aim: Four medicinal plants of Trigonella foenum-graecum, Zhumeria majdae, Achillea wilhelsii and ... more Aim: Four medicinal plants of Trigonella foenum-graecum, Zhumeria majdae, Achillea wilhelsii and Viola tricolor are traditionally used in Iran as analgesic and for treatment of inflammatory disorders. At the present atudy, the antinociceptive and anti-inflammatory effects of these plants have been studied. Methods: The antinociceptive and anti-inflammatory activity of methanol extracts of tested plants were evaluated using hot-plate and carrageenan-induced edema methods respectively. The plant extracts were studied ...
In this article, we embarked on production of mouse monoclonal antibodies against aflatoxin B1 wh... more In this article, we embarked on production of mouse monoclonal antibodies against aflatoxin B1 which is the most commonly occurring fungal toxin in food and feed products. After immunization and fusion with myloma cells, two stable clones (A218 and B319) were selected. Isotyping showed that these monoclonal antibodies (mAbs) were IgG2b with kappa light chains. The affinity of A218 and B319 clons were 5×1011 M−1 and 6×109 M−1, respectively. Competitive indirect ELISA results indicated these mAbs had complete (100%) cross-reaction with four major types of aflatoxins: B1, B2, G1, and G2. These mAbs could be used for immunoassay measurement of aflatoxins with high affinity and low detection limits.
The novel niosomal system aimed to deliver the active drug entity to the target site. The objecti... more The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigotes treated with various concentrations of itraconazole niosome was significantly lower than that of itraconazole alone (IC₅₀=0.24 μg/ml vs. IC₅₀=0.43 μg/ml, P<0.01). In contrast, the mean multiplication rate of amastigotes inside the macrophages and also the mean number of amastigotes in each macrophage treated with itraconazole niosome (34.9 and 3.0) were significantly lower (P<0.01) than those treated with itraconazole alone (62.0 and 3.8) or tartar emetic (63.9 and 4.2), respectively. These findings indicated that niosomes could be developed as a novel drug delivery for itraconazole in the in vitro model. Further studies are required to evaluate the effect of itraconazole niosome on volunteer human subjects.
زمينه و هدف: اهميت بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل در حدي است که حتي كشورهاي پيش... more زمينه و هدف: اهميت بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل در حدي است که حتي كشورهاي پيشرفته جهان نيز از آن بي نياز نيستند. اين تحقيق با هدف بررسي ديدگاه دانش آموختگان بورسيه خارج از کشور در مورد مفهوم موفقيت تحصيلي و مصاديق آن و عوامل موثر بر موفقيت تحصيلي انجام شد. روش كار: در اين مطالعه کيفي، 11 نفر از اعضاي هيات علمي دانشگاه علوم پزشکي کرمان که دانش آموخته دانشگاه هاي خارج از کشور بودند، شرکت کردند. طي يک مصاحبه باز در خصوص معيارهاي سنجش موفقيت تحصيلي و همچنين عوامل موثر بر آن از افراد مذکور نظرخواهي ...
Methods: Using registered documents as one of the best information sources, 366 students awarded ... more Methods: Using registered documents as one of the best information sources, 366 students awarded scholarship between1997-2003 were enrolled into the study. Student's personal information at the time of going abroad, scholarship granted university, local university and students' major and duration of study were considered as useful information and excluded carefully from electronic and paper documents under the cooperation of the scholarship office of Ministry of Health and Medical Education. Results: Most of the students were ...
زمينه و هدف: توجه به تاثير بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل اهميت فراوان دارد، به... more زمينه و هدف: توجه به تاثير بسيار زياد اعزام دانشجو به خارج براي ادامه تحصيل اهميت فراوان دارد، به شکلي که حتي کشورهاي پيشرفته جهان نيز از اين امر مهم بي نياز نيستند، اين در حالي است که هنوز در کشورهاي در حال توسعه توجه کافي و مديريت مناسبي براي بهره مندي از مزاياي بورسيه دانشجويان به خارج از کشور وجود ندارد. با توجه به ضرورت بيان شده، بايست در خصوص اعزام دانشجو به خارج دقت و حساسيت بيشتري در سيستم برنامه ريزي کشور وجود داشته باشد. روش کار: تعداد 366 دانشجو در فاصله زماني بين 1376 تا 1382 که از کشور خارج شده بودند، وارد ...
Aim: Four medicinal plants of Trigonella foenum-graecum, Zhumeria majdae, Achillea wilhelsii and ... more Aim: Four medicinal plants of Trigonella foenum-graecum, Zhumeria majdae, Achillea wilhelsii and Viola tricolor are traditionally used in Iran as analgesic and for treatment of inflammatory disorders. At the present atudy, the antinociceptive and anti-inflammatory effects of these plants have been studied. Methods: The antinociceptive and anti-inflammatory activity of methanol extracts of tested plants were evaluated using hot-plate and carrageenan-induced edema methods respectively. The plant extracts were studied ...
In this article, we embarked on production of mouse monoclonal antibodies against aflatoxin B1 wh... more In this article, we embarked on production of mouse monoclonal antibodies against aflatoxin B1 which is the most commonly occurring fungal toxin in food and feed products. After immunization and fusion with myloma cells, two stable clones (A218 and B319) were selected. Isotyping showed that these monoclonal antibodies (mAbs) were IgG2b with kappa light chains. The affinity of A218 and B319 clons were 5×1011 M−1 and 6×109 M−1, respectively. Competitive indirect ELISA results indicated these mAbs had complete (100%) cross-reaction with four major types of aflatoxins: B1, B2, G1, and G2. These mAbs could be used for immunoassay measurement of aflatoxins with high affinity and low detection limits.
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