Papers by Tatjana Skaric-Juric
Personality and Individual Differences, 2007
Paediatria Croatica, 2008
Molecular and experimental biology in medicine, Apr 4, 2019
Immunoglobulin G (IgG) is the most abundant serum antibody and is a key determinant of the humora... more Immunoglobulin G (IgG) is the most abundant serum antibody and is a key determinant of the humoral immune response. Its structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. IgG N-glycome patterns change with the age of individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is affected by a combination of genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of whole IgG, analysed in 5 different populations totalling 10,482 IgG glycomes, and of IgG’s fragment crystallisable region (Fc), analysed in 2,530 samples from 27 populations sampled across the world. We observed that country of residence associates with many N-glycan features and is a strong predictor of monogalactosylation variability. IgG galactosylation...
Pharmacogenomics, 2017
To determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) popul... more To determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) population originating from India and to examine it in the worldwide perspective. Seven SNP loci (rs12721655, rs2279343, rs28399499, rs34097093, rs3745274, rs7260329 and rs8192709) were genotyped in 439 subjects using Kompetitive Allele Specific PCR (KASP) method. The Croatian Roma took an outlying position in CYP2B6 variation from the worldwide perspective mainly due to their exceptionally high minor allele frequency (MAF) for rs8192709 (12.8%), and lower for rs2279343 (21.1%) compared with south Asian populations. This study provides the first data of several CYP2B6 polymorphisms in Roma population and indicates the need for systematic investigation of the most important pharmacogenes' variants in this large, transnationally isolated population worldwide.
Collegium antropologicum, 2008
Researches into health inequalities consistently show disadvantages in health status, morbidity a... more Researches into health inequalities consistently show disadvantages in health status, morbidity and mortality for various ethnic minority groups. Current knowledge about prevention of cardiovascular diseases (CVD) mainly derives from studies carried out in populations of European origin while the evidences involving Roma population are scarce. Roma, an ethnic minority of northern Indian origin, live in many countries throughout the world and are well known for preserved traditions and resistance to assimilation. They are most often marginalized economically, spatially, politically and in terms of culture. In order to assess the health status and health-related lifestyle attributes, a multidisciplinary anthropological and epidemiological community-based study was carried out including a total of 423 members of the Bayash Roma minority population living in two regions of Croatia (144 men and 279 women, aged 18-84 yrs). Hypertension (HT) was found in 24.8% Bayash Roma (21.5% men and 26...
Collegium antropologicum, 2006
This study examines anthropometrically assessed nutritional status of the Bayash, the Roma popula... more This study examines anthropometrically assessed nutritional status of the Bayash, the Roma population from the eastern Croatian region of Baranya, and compares it to the non-Roma general population of eastern Croatia. The analysis of nutritional status and diets is a segment of multidisciplinary anthropological and epidemiological survey of the Roma minority population in Croatia began in 2005. The Bayash are an ethnic group that arrived to Croatia from Romania most likely in the 19th century and speaks a distinct archaic dialect of the Romanian language. The Roma population of Baranya approximates 1,000 according to the 2001 census. The Bayash sample comprised 227 adults aged 18-65yrs. The women fall below the Croatian 10th percentile for stature and men track about the 10th percentile. Both sexes approximate the 25th percentile for body weight. Despite their diminutive size, the Bayash appear to have adequate nutritional status until the age of 35yrs after which their average BMI ...
Collegium antropologicum, 1997
The analysis of family data of 18 metacarpal morphometric dimensions (bone length -L, total diaph... more The analysis of family data of 18 metacarpal morphometric dimensions (bone length -L, total diaphysis width-T and medullary canal width-M of the second, third and fourth metacarpals of both hands) has been performed on 956 randomly sampled adult examinees (age 18 to 85), inhabitants of the islands of Brac and Hvar and the Peljesac peninsula, Croatia. Interclass (for parent-offspring family pairs) and intraclass (for siblings) correlation coefficients have been calculated as well as heritability coefficient (h2) and coefficient quantifying effects of common sibling environment (c2) have been estimated. Heritability estimates (h2) for the medullary canal width dimensions (54%-71%) showed to be at least as high, and c2 (2%-14%) values showed to be at least as low as those obtained for bone length dimensions (h2 = 51%-65%; c2 = 5%-16%) suggesting a strong influence of genetic factors in medullary canal width formation. For both traits the highest heritability and the lowest environmenta...
American journal of hypertension, 2006
A case-control association study was conducted to investigate a possible involvement of polymorph... more A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension. One hundred nineteen hypertensive and 125 normotensive participants aged 18 to 40 years were selected from a broader sample representative of the general population of Croatia. The selection criteria for hypertensive cases were systolic blood pressure (BP) higher than 140 mm Hg or diastolic BP higher than 90 mm Hg and a history of hypertension according to patient interview. Among the polymorphisms investigated, only those located on the ACE gene were associated with hypertension. For ACE I/D, the odds ratio for hypertension of DD versus II homozygote individuals was 2.50 (95% confidence interval [CI] 1.19-5.25) and for ACE T-3892C, the odds ratio of CC versus TT individuals was 2.32 (95% CI 1.05-5.10). Both polymorphisms of the ACE gene ...
American Journal of Hypertension, 2009
A B S T R A C T This study examines anthropometrically assessed nutritional status of the Bayash,... more A B S T R A C T This study examines anthropometrically assessed nutritional status of the Bayash, the Roma population from the eastern Croatian region of Baranya, and compares it to the non-Roma general population of eastern Croatia. The analysis of nutritional status and diets is a segment of multidisciplinary anthropological and epidemiological survey of the Roma minority population in Croatia began in 2005. The Bayash are an ethnic group that arrived to Croatia from Ro-mania most likely in the 19th century and speaks a distinct archaic dialect of the Romanian language. The Roma population of Baranya approximates 1,000 according to the 2001 census. The Bayash sample comprised 227 adults aged 18–65 yrs. The women fall below the Croatian 10th percentile for stature and men track about the 10th percentile. Both sexes approximate the 25th percentile for body weight. Despite their diminutive size, the Bayash appear to have adequate nutritional status until the age of 35 yrs after which their average BMI exceeds the value of 25 kg/m 2 and falls in the overweight category. However, 8% of Bayash are underweight (BMI<18.5) in contrast to 1% of the majority population in the region. Underweight rates are especially high in women (11%) compared to men (4%). The prevalence of overweight (BMI 25.0 to 29.9) of 30% is considerably lower than in the majority population (42%) while the prevalence of obesity (BMI>or=30.0) of 23% is approximately equal. Overall unsatisfactory nutritional status of the Bayash merits attention. It appears to be the product of unhealthy dietary habits and their socioeconomic deprivation that resulted from their poor education and extremely high unemployment.
Human Biology, 2004
We examined dermatoglyphic prints of children in 11 Hungarian and 5 Gypsy population samples (col... more We examined dermatoglyphic prints of children in 11 Hungarian and 5 Gypsy population samples (collected from 1,998 children). We compared Hungarian and Gypsy populations based on 22 finger and 24 palmar traits. In univariate comparisons the two ethnic groups differed significantly in half of the studied variables (9 finger and 14 palmar traits). We used several types of multivariate analyses of the studied traits to separate the population samples. Homogeneity analysis and discriminant analysis proved to be the most appropriate method to distinguish the populations, whereas a principal components analysis was less adequate. Multivariate analyses were conducted separately for both finger and palmar traits. Although the differences between the populations were more pronounced for palmar traits, in our study Hungarian and Gypsy populations showed the best separation when finger and palmar traits were combined for analysis, except in the principal components analysis. As expected, the Hungarian and Gypsy populations separated definitely in most statistical analyses; the main reason for this is the different origins of the two ethnic groups. The existence of the difference also shows that admixture between Hungarians and Gypsies has been small despite their living beside one another for several centuries.
Collegium antropologicum, 2011
Dermatoglyphic prints were collected from 800 inhabitants of Dukagjin valley in Kosovo. The sampl... more Dermatoglyphic prints were collected from 800 inhabitants of Dukagjin valley in Kosovo. The sample consisted of two ethnically different sub-populations who refer themselves as Albanians (N = 400) and Turks (N = 400). Qualitative analysis of prints concerned the frequency of the patterns on fingers (arch, ulnar and radial loop, whorl, accidental whorl) and on palms (Thenar and I, II, III, and IV interdigital area and the hypothenar, main line index, and the axial "t" triradius position). As was expected due to previous study of quantitative dermatoglyphic traits, in the same population the Alba-nians and Turks showed to be significantly different in most explored qualitative dermatoglyphic variables. Found differences indicated that the reproductive isolation between the Albanian and Turkish population in Kosovo is substantial, despite the fact that those two ethnic sub-populations live in the close vicinity through several centuries.
Collegium Antropologicum, Jul 1, 2008
Collegium antropologicum, 2008
In a cross-sectional study of growth, 5,260 healthy children of both sexes from Zagreb (Croatia) ... more In a cross-sectional study of growth, 5,260 healthy children of both sexes from Zagreb (Croatia) aged 2 to 18 years were measured. Six transversal body dimensions were studied: biacromial, transverse chest, antero-posterior chest, biiliocristal, bicondylar humerus and bicondylar femur diamters. A significant increase in body diameters has been observed until the age of 14 to 15 in girls and until the age of 16 in boys, showing that girls have a 1 to 2 years shorter period of growth. Compared to boys of the same age, they achieved larger amounts of final transversal bone size throughout the whole growth period. The most pronounced example was the knee diameter that in girls attained 95% of adult size as early as the age of 10. In both genders, the adult size is achieved earlier in widths of the extremities than in those of the trunk. The studied transversal body segments showed different growth dynamics, which is gender-specific. While sexual dimorphism in pelvic and shoulder diamete...
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Papers by Tatjana Skaric-Juric