Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2018
To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab... more To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab therapy for diabetic macular edema (DME). Retrospective cohort study. Patients receiving ranibizumab injections for centre-involving DME in a National Health Service setting. The Moorfields OpenEyes database was used to study eyes with DME treated with ranibizumab from October 2013 to November 2015 at the Moorfields City Road, Ealing, Northwick Park, and St George's Hospital sites. Only eyes receiving a minimum of 3 injections and completing 12 months of follow-up were included. If both eyes received treatment, the first eye treated was analyzed. When both eyes received initial treatment simultaneously, random number tables were used to select the eye for analysis. HbA1c was tested at the initiation of ranibizumab treatment. Multivariate regression analysis was used to identify relationships between HbA1c and the outcome measures. The primary outcome was change in visual acuity (VA)...
ABSTRACT Optic nerve injury is a consequence of numerous ophthalmic conditions including glaucoma... more ABSTRACT Optic nerve injury is a consequence of numerous ophthalmic conditions including glaucoma, a leading cause of global blindness. In adult humans, the optic nerve displays limited regenerative capacity, typical of neurons of the CNS. In efforts to address this issue, a number of recent advances have been made in the identification of potential therapeutic targets that directly inhibit or stimulate optic nerve regeneration, with more work implicating several other factors. These factors can be categorized as being intracellular or extracellular with respect to the neuron, or inflammatory cell-derived. In addition to these therapeutic strategies, it is important to guide the regrowing axons to their correct destination. Recent work has identified several developmental guidance factors important in regeneration, and potential therapeutic targets for the future. This review discusses newly identified and existing regeneration factors and evaluates current cellular- and nanotechnology-based therapies that aim to aid and guide optic nerve regeneration to achieve functional recovery.
Please login or register to print this page. ... University Hospital Coventry, Clifford Bridge Ro... more Please login or register to print this page. ... University Hospital Coventry, Clifford Bridge Road, Coventry, CV2 2DX. ... Glenfield Hospital, University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP. ... Ventricular fibrillation (VF) is induced at the time of ...
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2018
To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab... more To investigate the effect of serum glycosylated hemoglobin (HbA1c) on the outcomes of ranibizumab therapy for diabetic macular edema (DME). Retrospective cohort study. Patients receiving ranibizumab injections for centre-involving DME in a National Health Service setting. The Moorfields OpenEyes database was used to study eyes with DME treated with ranibizumab from October 2013 to November 2015 at the Moorfields City Road, Ealing, Northwick Park, and St George's Hospital sites. Only eyes receiving a minimum of 3 injections and completing 12 months of follow-up were included. If both eyes received treatment, the first eye treated was analyzed. When both eyes received initial treatment simultaneously, random number tables were used to select the eye for analysis. HbA1c was tested at the initiation of ranibizumab treatment. Multivariate regression analysis was used to identify relationships between HbA1c and the outcome measures. The primary outcome was change in visual acuity (VA)...
ABSTRACT Optic nerve injury is a consequence of numerous ophthalmic conditions including glaucoma... more ABSTRACT Optic nerve injury is a consequence of numerous ophthalmic conditions including glaucoma, a leading cause of global blindness. In adult humans, the optic nerve displays limited regenerative capacity, typical of neurons of the CNS. In efforts to address this issue, a number of recent advances have been made in the identification of potential therapeutic targets that directly inhibit or stimulate optic nerve regeneration, with more work implicating several other factors. These factors can be categorized as being intracellular or extracellular with respect to the neuron, or inflammatory cell-derived. In addition to these therapeutic strategies, it is important to guide the regrowing axons to their correct destination. Recent work has identified several developmental guidance factors important in regeneration, and potential therapeutic targets for the future. This review discusses newly identified and existing regeneration factors and evaluates current cellular- and nanotechnology-based therapies that aim to aid and guide optic nerve regeneration to achieve functional recovery.
Please login or register to print this page. ... University Hospital Coventry, Clifford Bridge Ro... more Please login or register to print this page. ... University Hospital Coventry, Clifford Bridge Road, Coventry, CV2 2DX. ... Glenfield Hospital, University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP. ... Ventricular fibrillation (VF) is induced at the time of ...
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