IEEE Transactions on Systems, Man, and Cybernetics, 2007
Three-dimensional sound's effectiveness in virtual reality (VR) environments has been widely stud... more Three-dimensional sound's effectiveness in virtual reality (VR) environments has been widely studied. However, due to the big differences between VR and augmented reality (AR) systems in registration, calibration, perceptual difference of immersiveness, navigation, and localization, it is important to develop new approaches to seamlessly register virtual 3-D sound in AR environments and conduct studies on 3-D sound's effectiveness in AR context. In this paper, we design two experimental AR environments to study the effectiveness of 3-D sound both quantitatively and qualitatively. Two different tracking methods are applied to retrieve the 3-D position of virtual sound sources in each experiment. We examine the impacts of 3-D sound on improving depth perception and shortening task completion time. We also investigate its impacts on immersive and realistic perception, different spatial objects identification, and subjective feeling of "human presence and collaboration". Our studies show that applying 3-D sound is an effective way to complement visual AR environments. It helps depth perception and task performance, and facilitates collaborations between users. Moreover, it enables a more realistic environment and more immersive feeling of being inside the AR environment by both visual and auditory means. In order to make full use of the intensity cues provided by 3-D sound, a process to scale the intensity difference of 3-D sound at different depths is designed to cater small AR environments. The user study results show that the scaled 3-D sound significantly increases the accuracy of depth judgments and shortens the searching task completion time. This method provides a necessary foundation for implementing 3-D sound in small AR environments. Our user study results also show that this process does not degrade the intuitiveness and realism of an augmented audio reality environment
Lovotics is a novel field of research that strives to achieve a close relationship between humans... more Lovotics is a novel field of research that strives to achieve a close relationship between humans and robots by utilizing fundamental concepts from psychology, biology, neuroscience, and robotics to develop a model that effectively imitates human affection process to create an emotionally engaging robotic system with high level of intimacy. We have designed and developed a robotics system that is an active participant in a bi-directional non verbal communication process with humans, and uses audio and touch channels along with internal state parameters in order to establish long standing bonds with individuals. The novel Affective Intelligence system of Lovotics includes an Artificial Endocrine System and an Intimacy Module. These two modules work in tandem to develop intimate interactions between the robot and humans.
Elevated Programmed Death-1 (PD-1) expression can inhibit T cell activity and is a potential barr... more Elevated Programmed Death-1 (PD-1) expression can inhibit T cell activity and is a potential barrier to achieving persisting and optimal immunity via therapeutic vaccination. Using a direct lymph node-targeted vaccination procedure that enabled uncoupling of synthetic peptide (signal 1, TCR-mediated) and adjuvant (signal 2, non-TCR-mediated), we evaluated the impact of varied doses of Toll-like receptor (TLR)-9 ligand CpG oligodeoxynucleotide (ODN) adjuvant on epitope-specific CD8(+) T cell-associated PD-1 expression. Peptide vaccination without adjuvant yielded CD8(+) T cells with significantly elevated PD-1 expression. This conferred impaired function ex vivo, but was reversible by antibody-mediated PD-1 blockade. By comparison, peptide vaccination with escalating doses of CpG ODN adjuvant yielded higher magnitudes of CD8(+) T cells with progressively lower PD-1 expression and greater ex vivo function. CpG ODN adjuvant in context of titrated peptide doses for vaccination yielded the lowest overall PD-1 expression levels, demonstrating that fine-tuning both TCR-independent (adjuvant dose) and -dependent (antigen dose) stimuli can synergize to co-regulate PD-1 expression on epitope-specific CD8(+) T cells. These data hint at strategies to elicit PD-1(low) CD8(+) T cells using TLR-9 ligand adjuvants, and also shed light on the PD-1-regulated homeostasis of CD8(+) T cells.
Despite the increasing sophistication of augmented reality (AR) tracking technology, tracking in ... more Despite the increasing sophistication of augmented reality (AR) tracking technology, tracking in unprepared environments still remains an enormous challenge according to a recent survey. Most current systems are based on a calculation of the optical flow between the current and previous frames to adjust the label position. Here we present two alternative algorithms based on geometrical image constraints. The first is based on epipolar geometry and provides a general description of the constraints on image flow between two static scenes. The second is based on the calculation of a homography relationship between the current frame and a stored representation of the scene. A homography can exactly describe the image motion when the scene is planar, or when the camera movement is a pure rotation, and provides a good approximation when these conditions are nearly met. We assess all three styles of algorithms with a number of criteria including robustness, speed and accuracy. We demonstrate two real-time AR systems here, which are based on the estimation of homography. One is an outdoor geographical labelling/overlaying system, and the other is an AR Pacman game application.
Page 1. ABSTRACTS Abstracts for the 20th Annual Scientific Meeting of the International Society f... more Page 1. ABSTRACTS Abstracts for the 20th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (Primary Authors are Italicized) ANGIOGENESIS Preclinical Study of mAb-siRNA Combination ...
IEEE Transactions on Systems, Man, and Cybernetics, 2007
Three-dimensional sound's effectiveness in virtual reality (VR) environments has been widely stud... more Three-dimensional sound's effectiveness in virtual reality (VR) environments has been widely studied. However, due to the big differences between VR and augmented reality (AR) systems in registration, calibration, perceptual difference of immersiveness, navigation, and localization, it is important to develop new approaches to seamlessly register virtual 3-D sound in AR environments and conduct studies on 3-D sound's effectiveness in AR context. In this paper, we design two experimental AR environments to study the effectiveness of 3-D sound both quantitatively and qualitatively. Two different tracking methods are applied to retrieve the 3-D position of virtual sound sources in each experiment. We examine the impacts of 3-D sound on improving depth perception and shortening task completion time. We also investigate its impacts on immersive and realistic perception, different spatial objects identification, and subjective feeling of "human presence and collaboration". Our studies show that applying 3-D sound is an effective way to complement visual AR environments. It helps depth perception and task performance, and facilitates collaborations between users. Moreover, it enables a more realistic environment and more immersive feeling of being inside the AR environment by both visual and auditory means. In order to make full use of the intensity cues provided by 3-D sound, a process to scale the intensity difference of 3-D sound at different depths is designed to cater small AR environments. The user study results show that the scaled 3-D sound significantly increases the accuracy of depth judgments and shortens the searching task completion time. This method provides a necessary foundation for implementing 3-D sound in small AR environments. Our user study results also show that this process does not degrade the intuitiveness and realism of an augmented audio reality environment
Lovotics is a novel field of research that strives to achieve a close relationship between humans... more Lovotics is a novel field of research that strives to achieve a close relationship between humans and robots by utilizing fundamental concepts from psychology, biology, neuroscience, and robotics to develop a model that effectively imitates human affection process to create an emotionally engaging robotic system with high level of intimacy. We have designed and developed a robotics system that is an active participant in a bi-directional non verbal communication process with humans, and uses audio and touch channels along with internal state parameters in order to establish long standing bonds with individuals. The novel Affective Intelligence system of Lovotics includes an Artificial Endocrine System and an Intimacy Module. These two modules work in tandem to develop intimate interactions between the robot and humans.
Elevated Programmed Death-1 (PD-1) expression can inhibit T cell activity and is a potential barr... more Elevated Programmed Death-1 (PD-1) expression can inhibit T cell activity and is a potential barrier to achieving persisting and optimal immunity via therapeutic vaccination. Using a direct lymph node-targeted vaccination procedure that enabled uncoupling of synthetic peptide (signal 1, TCR-mediated) and adjuvant (signal 2, non-TCR-mediated), we evaluated the impact of varied doses of Toll-like receptor (TLR)-9 ligand CpG oligodeoxynucleotide (ODN) adjuvant on epitope-specific CD8(+) T cell-associated PD-1 expression. Peptide vaccination without adjuvant yielded CD8(+) T cells with significantly elevated PD-1 expression. This conferred impaired function ex vivo, but was reversible by antibody-mediated PD-1 blockade. By comparison, peptide vaccination with escalating doses of CpG ODN adjuvant yielded higher magnitudes of CD8(+) T cells with progressively lower PD-1 expression and greater ex vivo function. CpG ODN adjuvant in context of titrated peptide doses for vaccination yielded the lowest overall PD-1 expression levels, demonstrating that fine-tuning both TCR-independent (adjuvant dose) and -dependent (antigen dose) stimuli can synergize to co-regulate PD-1 expression on epitope-specific CD8(+) T cells. These data hint at strategies to elicit PD-1(low) CD8(+) T cells using TLR-9 ligand adjuvants, and also shed light on the PD-1-regulated homeostasis of CD8(+) T cells.
Despite the increasing sophistication of augmented reality (AR) tracking technology, tracking in ... more Despite the increasing sophistication of augmented reality (AR) tracking technology, tracking in unprepared environments still remains an enormous challenge according to a recent survey. Most current systems are based on a calculation of the optical flow between the current and previous frames to adjust the label position. Here we present two alternative algorithms based on geometrical image constraints. The first is based on epipolar geometry and provides a general description of the constraints on image flow between two static scenes. The second is based on the calculation of a homography relationship between the current frame and a stored representation of the scene. A homography can exactly describe the image motion when the scene is planar, or when the camera movement is a pure rotation, and provides a good approximation when these conditions are nearly met. We assess all three styles of algorithms with a number of criteria including robustness, speed and accuracy. We demonstrate two real-time AR systems here, which are based on the estimation of homography. One is an outdoor geographical labelling/overlaying system, and the other is an AR Pacman game application.
Page 1. ABSTRACTS Abstracts for the 20th Annual Scientific Meeting of the International Society f... more Page 1. ABSTRACTS Abstracts for the 20th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (Primary Authors are Italicized) ANGIOGENESIS Preclinical Study of mAb-siRNA Combination ...
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