IntroductionThe incidence of preeclampsia (PE) is about 2–8%, making it one of the leading causes of perinatal morbidity and maternal mortality in the world. Early prophylactic low dose administration (150 mg) of acetylsalicylic acid is... more
IntroductionThe incidence of preeclampsia (PE) is about 2–8%, making it one of the leading causes of perinatal morbidity and maternal mortality in the world. Early prophylactic low dose administration (150 mg) of acetylsalicylic acid is associated with a significant reduction in the incidence of early-onset PE, intrauterine growth restriction (IUGR), and neonatal mean stay in the intensive care unit (ICU). Universal implementation of a first-trimester screening system including angiogenic and antiangiogenic markers [the Placental Growth Factor (PlGF) and/or soluble fms-like Tyrosine Kinase-1 (sFlt-1)] has shown a prediction rate of 90% for early-onset PE but entails a high financial cost. The aim of this study is to determine the predictive and preventive capacity of a universal PE first-trimester two-step sequential screening model, determining the PlGF only in patients previously classified as intermediate risk by means of a multivariate model based on resources already used in th...
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Esta tesis es el resumen de tres trabajos realizados siguiendo una misma linea de trabajo en relacion al papel de los factores angigogenicos en el neurodesarrollo de los fetos con cardiopatia congenita (CC). Estudio 1: Complicaciones... more
Esta tesis es el resumen de tres trabajos realizados siguiendo una misma linea de trabajo en relacion al papel de los factores angigogenicos en el neurodesarrollo de los fetos con cardiopatia congenita (CC). Estudio 1: Complicaciones derivadas de la insuficiencia placentaria en gestantes portadoras de fetos con CC. Introduccion: Estudios recientes reportaron un desequilibrio angiogenico en la circulacion materna y fetal en las gestaciones con CC sugiriendo una placentacion alterada. Objetivos: Evaluar si las gestantes con fetos con CC tiene una mayor incidencia de complicaciones derivadas de la insuficiencia placentaria. Metodos: Se compararon los resultados perinatales de gestantes con CC y una poblacion de bajo riesgo. Resultados: Se incluyeron 279 gestaciones con fetos con CC. Se observo una incidencia significativamente mayor de preeclampsia en el grupo con CC (5,7% frente a 1,2% p <0,0001). El 9,7% de los fetos con CC tenian un peso al nacer menor del p3. SAe observo una may...
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To analyze potential differences in the expression of antiangiogenic and angiogenic factors and of genes associated with chronic hypoxia in cerebral tissue from euploid fetuses with congenital heart disease (CHD) and control fetuses.... more
To analyze potential differences in the expression of antiangiogenic and angiogenic factors and of genes associated with chronic hypoxia in cerebral tissue from euploid fetuses with congenital heart disease (CHD) and control fetuses. Cerebral tissue was obtained from 15 fetuses with CHD and 12 control fetuses undergoing termination of pregnancy. Expression profiles of the antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1), the angiogenic vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF), and genes associated with chronic hypoxia were determined by real-time PCR in tissue from the frontal cortex and from basal ganglia-hypothalamus. sFlt-1 expression was 48% higher in the frontal cortex (p=0.0431) and 72% higher in the basal ganglia-hypothalamus (p=0.0369) of CHD fetuses than controls. VEGF-A expression was 60% higher in the basal ganglia-hypothalamus (p=0.0432) of CHD fetuses. The expression of hypoxia-inducible factor-2α (HIF-2α) in the basal g...