Background: Mature cystic teratomas of the ovary are the most common germ cell neoplasms. Teratom... more Background: Mature cystic teratomas of the ovary are the most common germ cell neoplasms. Teratomas consist of a number of histologic types of tissues, all of which contain mature or immature tissues. Typically mature tissues have ectodermal (skin, brain), mesodermal (fat, muscle), and endodermal (mucinous or respiratory epithelium) origins. In monodermal teratomas, one of these tissue types predominates (eg, thyroid
Uterine lipoleiomyoma is a rare and specific type of leiomyoma with a considerable amount of adip... more Uterine lipoleiomyoma is a rare and specific type of leiomyoma with a considerable amount of adipocytes. The aim of the study was to investigate the clinical, pathological and immunohistochemical features of lipoleiomyoma of the uterine corpus, and review its histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions in order to obtain a detailed profile of this somewhat uncommon lesion. Descriptive study. This study is a retrospective analysis of 70 consecutive women with 76 lipoleiomyomas, who underwent surgery mainly for uterine leiomyoma and gynecological carcinomas between January 2000 and April 2013. Clinical and pathological information was obtained from medical records. Immunohistochemistry was applied in selected cases. Parametric methods were used to compare clinical and pathologic features. The patients ranged in age from 34 to 77 years (mean 55.49 years). Lipoleiomyomas ranged from 0.5 to 55 cm in diameter (mean 5.50 cm). Typical macroscopic...
We present CT findings in a unique case of horseshoe maxillary sinus harboring a cholesteatoma. C... more We present CT findings in a unique case of horseshoe maxillary sinus harboring a cholesteatoma. CT showed interconnected maxillary sinuses with an isthmus anteriorly at the level of hard palate forming a horseshoe-shaped sinus. An expansile soft tissue density mass was seen occupying both maxillary sinuses and the bridging cavity between them. To our knowledge, this is the first report
Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, occur... more Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, occurring predominantly in the second and third decades of life. In this article, our aim is to present clinicopathologic features of STT, and to review the recent literature with regard to differentiati ng STT from other ovarian stromal tumors. We describe STT in a 17-year-old girl
AIM: To evaluate the relationship between gallbladder (GB) motor function and H pylori infection ... more AIM: To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach. METHODS: All cases (86) underwent the 14C urea breath test (UBT). 14 C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14
Primary neuroendocrine carcinoma of the breast is an extremely rare tumor. We present our experie... more Primary neuroendocrine carcinoma of the breast is an extremely rare tumor. We present our experience of primary neuroendocrine carcinoma of the breast in a 76-year-old woman. Surgical biopsies from breast and axillary lymphadenopathy showed a neuroendocrine carcinoma. Immunohistochemical staining of tumor cells with GCDFP15, NSE and chromogranin were positive. Computed tomography scans of the chest and abdomen showed no lesion for metastasis or another primary origin. Adjuvant hormone therapy was given, since the tumor was immunohistochemically receptor positive.
To analyze fine needle aspiration cytology (FNAC) material from 20 cases of histologically verifi... more To analyze fine needle aspiration cytology (FNAC) material from 20 cases of histologically verified medullary carcinoma (MC) of the breast and correlate the cytomorphologic features with histologic appearance to improve the diagnostic sensitivity and specificity of FNAC. We reviewed the cytologic features of 20 cases of MC of the breast in the archives of Ege University Hospital between 1994 and 2006. Twenty patients with an aspirate and confirmed diagnosis of MC were identified. Patient age was 30-74 years (mean, 48). The initial cytologic diagnoses were positive for cancer in 17 cases, atypical/suspicious for cancer in 2 cases and negative for cancer in 1 case. The cytologic picture was characterized by cellular smears composed of highly atypical epithelial tumor cells in loosely cohesive sheets and lying singly, admixed with polymorphous lymphocytes, plasma cells and neutrophils. Tumor cells had predominantly abundant finely granular, eosinophilic cytoplasm and moderate to marked...
A case of mature cystic teratoma that contained florid vascular proliferation is reported. The ov... more A case of mature cystic teratoma that contained florid vascular proliferation is reported. The ovarian tumor occurred in a 9-year-old girl; symptoms consisted of vomiting, abdominal pain and a palpable mass. The microscopic findings were mostly typical of a mature cystic teratoma, but also abundant vascular proliferation mimicking hemangioma in association with mature neural tissue was observed. There was a disorganized arrangement of medium- and large-sized spaces lined by cuboidal endothelial cells. Immunohistochemical staining for vascular proliferation showed immunoreactivity for CD31 and smooth muscle actin. Florid vascular proliferation may be seen in association with neural tissue of ovarian teratomas and should not be misdiagnosed as immature teratoma or a vascular neoplasm.
World journal of gastroenterology : WJG, Jan 21, 2007
To investigate the apoptotic process of cells within the intestinal metaplasia areas co-localizin... more To investigate the apoptotic process of cells within the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal ...
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2006
It has been reported that cases of Helicobacter pylori (H. pylori) gastritis, those with epitheli... more It has been reported that cases of Helicobacter pylori (H. pylori) gastritis, those with epithelial hyperproliferation, have potential for malignant transformation. This study was planned to determine the effects of H. pylori on gastritis and the gastric epithelial cell proliferation. In this study, we re-evaluated biopsy samples obtained from 331 cases of chronic gastritis according to Sydney criteria, retrospectively. We examined the gastric epithelial cell proliferation with proliferating cell nuclear antigen in the proliferating zone, in the whole mucosa of intestinal metaplasia and in areas of regenerative atypia, separately. The relationship between H. pylori colonization density and chronic active gastritis was statistically significant. We did not see any relationship between the presence and density of H. pylori in gastric mucosa via proliferating cell nuclear antigen indices. In the presence of lymphoid follicles, we noted a significant expression of proliferating cell nuc...
To evaluate specific diagnostic fine needle aspiration cytologic (FNAC) features of phyllodes tum... more To evaluate specific diagnostic fine needle aspiration cytologic (FNAC) features of phyllodes tumor (PT), particularly in the differentiation from fibroadenoma (FA). Twenty-eight FNAC of PT were reviewed for smear cellularity, epithelial and stromal fragments, their size and atypia, epithelial/stromal area ratio, background single stromal cells (oval or columnar), multinucleated giant cells, and squamous and apocrine cells. Twenty-one FNAC of fibroadenoma were also assessed for comparison. PT was significantly larger than FA. Epithelial fragments were found in all cases, with atypia present in PT. Stromal fragments were present in half the cases; there was no difference in stromal size, but the epithelial/stromal area ratio was significantly lower in PT than FA. Single columnar stromal cells with recognizable cytoplasm and multinucleated stromal giant cells were seen in some PT but not in FA. Cytologic diagnosis of PT remains difficult, with significant overlap with FA. The presence...
ABSTRACT Objectifs La chirurgie aortique abdominale peut causer des lésions d'ischémie/re... more ABSTRACT Objectifs La chirurgie aortique abdominale peut causer des lésions d'ischémie/reperfusion (I/R) non seulement au niveau des membres inférieurs mais aussi des organes à distance tels que les reins. L'exclusion du volume de sang veineux de la veine cave inférieure (phlébotomie) ou/et le mannitol sont employés comme traitement des lésions d'I/R du rein chez l'homme, malgré le fait que l'efficacité des traitements est encore discutée. Le but de cette étude était d'évaluer les effets de la phlébotomie ou/et du mannitol sur des reins de rat de lésions rénales aiguës (LRA) dans un modèle d'I/R-induite des membres inférieurs. Matériel et méthodes Trente rats mâles albinos Wistar ont été employés et divisés en cinq groupes : (I) groupe opéré d'une façon simulée, laparotomie sans lésions d'I/R (groupe [S], n = 6) ; (II) groupe d'I/R, clampage aortique sous rénal pour induire une I/R des membres inférieurs, 3 heures d'ischémie suivies de 2 heures de reperfusion (groupe [I/R], n = 6) ; (III) groupe I/R + phlébotomie, identique au groupe [I/R] excepté 1 mL d'aspiration de sang de la veine cave inférieure juste après l'ischémie (groupe [P], n = 6) ; (IV) groupe I/R + mannitol, ces rats étaient soumis à I/R et recevaient une injection d'un bolus de mannitol (groupe [M], n = 6) ; et (V) groupe I/R + phlébotomie + mannitol (groupe [P + M], n = 6), les mêmes procédures étant faites que dans les groupes précédents. À la fin de la reperfusion de deux heures, tous les rats étaient sacrifiés. Les deux reins étaient prélevés pour analyse biochimique (activités myéloperoxydase [MPO] et superoxyde dismutase [SOD], et taux réduits de malondialdéhyde [MDA] et de glutathion) et pour examen histopathologique (nécrose tubulaire et inflammation aiguë du rein [scores ARI]). Résultats L'I/R aortique augmentait de manière significative le taux de l'activité MDA (reflétant la peroxydation des lipides), SOD (antioxydant endogène enzymatique), et MPO (reflétant l'infiltration neutrophile) (p < 0,05). Les traitements par phlébotomie ou/et mannitol diminuait de manière significative le niveau de l'activité MDA, SOD, et MPO et augmentait le taux de glutathion (antioxydant non-enzymatique des tissus rénaux) (p < 0,05). L'évaluation histologique des scores LRA montrait que l'I/R aortique (la valeur de p pour le groupe [S] contre le groupe [I/R] était 0,012), tandis que les traitements par phlébotomie ou/et de mannitol diminuait de manière significative la nécrose tubulaire et l'infiltration inflammatoire (les valeurs de p pour le groupe [I/R] contre les groupes [P], [M], et [P + M] étaient 0,043, 0,043, et 0,003, respectivement). Conclusion Cette expérience a clairement montré que les ARI induites par l'I/R des membres inférieurs étaient atténuées significativement par les traitements par phlébotomie ou/et mannitol. La phlébotomie et le mannitol sont un traitement plus efficace que la phlébotomie ou le mannitol seuls pour empêcher les ARI induites par l'I/R des membres inférieurs chez le rat. D'autres études cliniques sont requises pour clarifier si les traitements par phlébotomie ou/et mannitol sont salutaires pour réduire les ARI pendant la chirurgie aortique abdominale.
Background: Mature cystic teratomas of the ovary are the most common germ cell neoplasms. Teratom... more Background: Mature cystic teratomas of the ovary are the most common germ cell neoplasms. Teratomas consist of a number of histologic types of tissues, all of which contain mature or immature tissues. Typically mature tissues have ectodermal (skin, brain), mesodermal (fat, muscle), and endodermal (mucinous or respiratory epithelium) origins. In monodermal teratomas, one of these tissue types predominates (eg, thyroid
Uterine lipoleiomyoma is a rare and specific type of leiomyoma with a considerable amount of adip... more Uterine lipoleiomyoma is a rare and specific type of leiomyoma with a considerable amount of adipocytes. The aim of the study was to investigate the clinical, pathological and immunohistochemical features of lipoleiomyoma of the uterine corpus, and review its histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions in order to obtain a detailed profile of this somewhat uncommon lesion. Descriptive study. This study is a retrospective analysis of 70 consecutive women with 76 lipoleiomyomas, who underwent surgery mainly for uterine leiomyoma and gynecological carcinomas between January 2000 and April 2013. Clinical and pathological information was obtained from medical records. Immunohistochemistry was applied in selected cases. Parametric methods were used to compare clinical and pathologic features. The patients ranged in age from 34 to 77 years (mean 55.49 years). Lipoleiomyomas ranged from 0.5 to 55 cm in diameter (mean 5.50 cm). Typical macroscopic...
We present CT findings in a unique case of horseshoe maxillary sinus harboring a cholesteatoma. C... more We present CT findings in a unique case of horseshoe maxillary sinus harboring a cholesteatoma. CT showed interconnected maxillary sinuses with an isthmus anteriorly at the level of hard palate forming a horseshoe-shaped sinus. An expansile soft tissue density mass was seen occupying both maxillary sinuses and the bridging cavity between them. To our knowledge, this is the first report
Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, occur... more Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, occurring predominantly in the second and third decades of life. In this article, our aim is to present clinicopathologic features of STT, and to review the recent literature with regard to differentiati ng STT from other ovarian stromal tumors. We describe STT in a 17-year-old girl
AIM: To evaluate the relationship between gallbladder (GB) motor function and H pylori infection ... more AIM: To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach. METHODS: All cases (86) underwent the 14C urea breath test (UBT). 14 C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14
Primary neuroendocrine carcinoma of the breast is an extremely rare tumor. We present our experie... more Primary neuroendocrine carcinoma of the breast is an extremely rare tumor. We present our experience of primary neuroendocrine carcinoma of the breast in a 76-year-old woman. Surgical biopsies from breast and axillary lymphadenopathy showed a neuroendocrine carcinoma. Immunohistochemical staining of tumor cells with GCDFP15, NSE and chromogranin were positive. Computed tomography scans of the chest and abdomen showed no lesion for metastasis or another primary origin. Adjuvant hormone therapy was given, since the tumor was immunohistochemically receptor positive.
To analyze fine needle aspiration cytology (FNAC) material from 20 cases of histologically verifi... more To analyze fine needle aspiration cytology (FNAC) material from 20 cases of histologically verified medullary carcinoma (MC) of the breast and correlate the cytomorphologic features with histologic appearance to improve the diagnostic sensitivity and specificity of FNAC. We reviewed the cytologic features of 20 cases of MC of the breast in the archives of Ege University Hospital between 1994 and 2006. Twenty patients with an aspirate and confirmed diagnosis of MC were identified. Patient age was 30-74 years (mean, 48). The initial cytologic diagnoses were positive for cancer in 17 cases, atypical/suspicious for cancer in 2 cases and negative for cancer in 1 case. The cytologic picture was characterized by cellular smears composed of highly atypical epithelial tumor cells in loosely cohesive sheets and lying singly, admixed with polymorphous lymphocytes, plasma cells and neutrophils. Tumor cells had predominantly abundant finely granular, eosinophilic cytoplasm and moderate to marked...
A case of mature cystic teratoma that contained florid vascular proliferation is reported. The ov... more A case of mature cystic teratoma that contained florid vascular proliferation is reported. The ovarian tumor occurred in a 9-year-old girl; symptoms consisted of vomiting, abdominal pain and a palpable mass. The microscopic findings were mostly typical of a mature cystic teratoma, but also abundant vascular proliferation mimicking hemangioma in association with mature neural tissue was observed. There was a disorganized arrangement of medium- and large-sized spaces lined by cuboidal endothelial cells. Immunohistochemical staining for vascular proliferation showed immunoreactivity for CD31 and smooth muscle actin. Florid vascular proliferation may be seen in association with neural tissue of ovarian teratomas and should not be misdiagnosed as immature teratoma or a vascular neoplasm.
World journal of gastroenterology : WJG, Jan 21, 2007
To investigate the apoptotic process of cells within the intestinal metaplasia areas co-localizin... more To investigate the apoptotic process of cells within the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal ...
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2006
It has been reported that cases of Helicobacter pylori (H. pylori) gastritis, those with epitheli... more It has been reported that cases of Helicobacter pylori (H. pylori) gastritis, those with epithelial hyperproliferation, have potential for malignant transformation. This study was planned to determine the effects of H. pylori on gastritis and the gastric epithelial cell proliferation. In this study, we re-evaluated biopsy samples obtained from 331 cases of chronic gastritis according to Sydney criteria, retrospectively. We examined the gastric epithelial cell proliferation with proliferating cell nuclear antigen in the proliferating zone, in the whole mucosa of intestinal metaplasia and in areas of regenerative atypia, separately. The relationship between H. pylori colonization density and chronic active gastritis was statistically significant. We did not see any relationship between the presence and density of H. pylori in gastric mucosa via proliferating cell nuclear antigen indices. In the presence of lymphoid follicles, we noted a significant expression of proliferating cell nuc...
To evaluate specific diagnostic fine needle aspiration cytologic (FNAC) features of phyllodes tum... more To evaluate specific diagnostic fine needle aspiration cytologic (FNAC) features of phyllodes tumor (PT), particularly in the differentiation from fibroadenoma (FA). Twenty-eight FNAC of PT were reviewed for smear cellularity, epithelial and stromal fragments, their size and atypia, epithelial/stromal area ratio, background single stromal cells (oval or columnar), multinucleated giant cells, and squamous and apocrine cells. Twenty-one FNAC of fibroadenoma were also assessed for comparison. PT was significantly larger than FA. Epithelial fragments were found in all cases, with atypia present in PT. Stromal fragments were present in half the cases; there was no difference in stromal size, but the epithelial/stromal area ratio was significantly lower in PT than FA. Single columnar stromal cells with recognizable cytoplasm and multinucleated stromal giant cells were seen in some PT but not in FA. Cytologic diagnosis of PT remains difficult, with significant overlap with FA. The presence...
ABSTRACT Objectifs La chirurgie aortique abdominale peut causer des lésions d'ischémie/re... more ABSTRACT Objectifs La chirurgie aortique abdominale peut causer des lésions d'ischémie/reperfusion (I/R) non seulement au niveau des membres inférieurs mais aussi des organes à distance tels que les reins. L'exclusion du volume de sang veineux de la veine cave inférieure (phlébotomie) ou/et le mannitol sont employés comme traitement des lésions d'I/R du rein chez l'homme, malgré le fait que l'efficacité des traitements est encore discutée. Le but de cette étude était d'évaluer les effets de la phlébotomie ou/et du mannitol sur des reins de rat de lésions rénales aiguës (LRA) dans un modèle d'I/R-induite des membres inférieurs. Matériel et méthodes Trente rats mâles albinos Wistar ont été employés et divisés en cinq groupes : (I) groupe opéré d'une façon simulée, laparotomie sans lésions d'I/R (groupe [S], n = 6) ; (II) groupe d'I/R, clampage aortique sous rénal pour induire une I/R des membres inférieurs, 3 heures d'ischémie suivies de 2 heures de reperfusion (groupe [I/R], n = 6) ; (III) groupe I/R + phlébotomie, identique au groupe [I/R] excepté 1 mL d'aspiration de sang de la veine cave inférieure juste après l'ischémie (groupe [P], n = 6) ; (IV) groupe I/R + mannitol, ces rats étaient soumis à I/R et recevaient une injection d'un bolus de mannitol (groupe [M], n = 6) ; et (V) groupe I/R + phlébotomie + mannitol (groupe [P + M], n = 6), les mêmes procédures étant faites que dans les groupes précédents. À la fin de la reperfusion de deux heures, tous les rats étaient sacrifiés. Les deux reins étaient prélevés pour analyse biochimique (activités myéloperoxydase [MPO] et superoxyde dismutase [SOD], et taux réduits de malondialdéhyde [MDA] et de glutathion) et pour examen histopathologique (nécrose tubulaire et inflammation aiguë du rein [scores ARI]). Résultats L'I/R aortique augmentait de manière significative le taux de l'activité MDA (reflétant la peroxydation des lipides), SOD (antioxydant endogène enzymatique), et MPO (reflétant l'infiltration neutrophile) (p < 0,05). Les traitements par phlébotomie ou/et mannitol diminuait de manière significative le niveau de l'activité MDA, SOD, et MPO et augmentait le taux de glutathion (antioxydant non-enzymatique des tissus rénaux) (p < 0,05). L'évaluation histologique des scores LRA montrait que l'I/R aortique (la valeur de p pour le groupe [S] contre le groupe [I/R] était 0,012), tandis que les traitements par phlébotomie ou/et de mannitol diminuait de manière significative la nécrose tubulaire et l'infiltration inflammatoire (les valeurs de p pour le groupe [I/R] contre les groupes [P], [M], et [P + M] étaient 0,043, 0,043, et 0,003, respectivement). Conclusion Cette expérience a clairement montré que les ARI induites par l'I/R des membres inférieurs étaient atténuées significativement par les traitements par phlébotomie ou/et mannitol. La phlébotomie et le mannitol sont un traitement plus efficace que la phlébotomie ou le mannitol seuls pour empêcher les ARI induites par l'I/R des membres inférieurs chez le rat. D'autres études cliniques sont requises pour clarifier si les traitements par phlébotomie ou/et mannitol sont salutaires pour réduire les ARI pendant la chirurgie aortique abdominale.
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