Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelina... more Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyelinated lesions of MS and an increase in circulating platelets has been described in experimental autoimmune encephalomyelitis (EAE) mice, an animal model for MS. However, the contribution of platelets to remyelination remains unexplored. Here we show platelet aggregation in proximity to OPCs in areas of experimental demyelination. Partial depletion of circulating platelets impaired OPC differentiation and remyelination, without altering blood-brain barrier stability and neuroinflammation. Transient exposure to platelets enhanced OPC differentiationin vitro, whereas sustained exposure suppressed this effect. In a mouse model of thrombocytosis (CALRHET), there was a sustained increase in platelet aggregation together with a reduction of newly-generate...
A coplanar waveguide- (CPW-) fed compact wideband defected structure shaped microstrip antenna is... more A coplanar waveguide- (CPW-) fed compact wideband defected structure shaped microstrip antenna is proposed for wireless applications. Defected structure is produced by cutting theUshape antenna in the form of two-sided T shape. The proposed antenna consists of two-sidedTshape strip as compared to usual monopole patch antenna for minimizing the height of the antenna. The large space around the radiator is fully utilized as the ground is on the same plane as of radiator. Microstrip line feed is used to excite the proposed antenna placed on an FR4 substrate (dielectric constantεr=4.4). The antenna is practically fabricated and simulated. Simulated results of the proposed antenna have been obtained by using Ansoft High-Frequency Structure Simulator (HFSS) software. These results are compared with measured results by using network analyzer. Measured result shows good agreement with the simulated results. It is observed that the proposed antenna shows a wideband from 2.96 GHz to 7.95 GHz ...
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelina... more Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyelinated lesions of MS and an increase in circulating platelets has been described in experimental autoimmune encephalomyelitis (EAE) mice, an animal model for MS. However, the contribution of platelets to remyelination remains unexplored. Here we show platelet aggregation in proximity to OPCs in areas of experimental demyelination. Partial depletion of circulating platelets impaired OPC differentiation and remyelination, without altering blood-brain barrier stability and neuroinflammation. Transient exposure to platelets enhanced OPC differentiationin vitro, whereas sustained exposure suppressed this effect. In a mouse model of thrombocytosis (CALRHET), there was a sustained increase in platelet aggregation together with a reduction of newly-generate...
A coplanar waveguide- (CPW-) fed compact wideband defected structure shaped microstrip antenna is... more A coplanar waveguide- (CPW-) fed compact wideband defected structure shaped microstrip antenna is proposed for wireless applications. Defected structure is produced by cutting theUshape antenna in the form of two-sided T shape. The proposed antenna consists of two-sidedTshape strip as compared to usual monopole patch antenna for minimizing the height of the antenna. The large space around the radiator is fully utilized as the ground is on the same plane as of radiator. Microstrip line feed is used to excite the proposed antenna placed on an FR4 substrate (dielectric constantεr=4.4). The antenna is practically fabricated and simulated. Simulated results of the proposed antenna have been obtained by using Ansoft High-Frequency Structure Simulator (HFSS) software. These results are compared with measured results by using network analyzer. Measured result shows good agreement with the simulated results. It is observed that the proposed antenna shows a wideband from 2.96 GHz to 7.95 GHz ...
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Papers by Amar Sharma CUET