Tramadol is a synthetic, centrally acting opioid analgesic. This drug is a μ-opioid agonist that ... more Tramadol is a synthetic, centrally acting opioid analgesic. This drug is a μ-opioid agonist that also inhibits the reuptake of noradrenaline and serotonin. The present study was carried out to investigate the effects of this drug on blood profile, hepatic enzymes activities and blood urea nitrogen (BUN) in sheep. For this purpose, ten healthy non-pregnant Lory ewes were used. Before the experiment, three blood samples were taken from the jugular vein as a control; ewes were then randomly divided into two groups. The test group was given tramadol IV (5 mg/kg) for five consecutive days; group 2, the sham group, was given normal saline IV (5 mg/kg) for the same time period. The results of present study showed that short-term injection of tramadol causes significant change in red blood cell count and packed cell volume value. However, level of serum activities of hepatic enzymes and BUN remained unaltered. In conclusion, these results suggest that although short-term use of tramadol may have no toxic effects on the liver and kidney, its effects on the blood profile should be kept in mind.
The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal ... more The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal growth plate in submuscular transplantation (ectopic osteoinduction) as a new xenogenic biomaterial in rat model. Demineralized bovine foetal growth plate was ectopically implanted in 18 male Sprague-Dawley rats. In 18 of the animals under aseptic conditions two submuscular pouches were created between external and internal oblique abdominal muscles in the two flanks: the right was left empty (sham) and the left was filled with 20mg of demineralized bovine foetal growth plate powder. Radiographs were taken in 2, 4 and 6 weeks after the surgery, then six animals were pharmacologically euthanized after 2, 4 and 6 weeks for histopathological evaluation. Results showed: (1) osteoinductivity of xenogenic demineralized bovine foetal growth plate powder, and (2) earlier mineralization of ectopically implanted demineralized bovine foetal growth plate in the submuscular implanted area. Our results show that submuscular implantation of xenogenic demineralized bovine foetal growth plate has osteoinductive properties in a rat model.
Tramadol is a synthetic, centrally acting opioid analgesic. This drug is a μ-opioid agonist that ... more Tramadol is a synthetic, centrally acting opioid analgesic. This drug is a μ-opioid agonist that also inhibits the reuptake of noradrenaline and serotonin. The present study was carried out to investigate the effects of this drug on blood profile, hepatic enzymes activities and blood urea nitrogen (BUN) in sheep. For this purpose, ten healthy non-pregnant Lory ewes were used. Before the experiment, three blood samples were taken from the jugular vein as a control; ewes were then randomly divided into two groups. The test group was given tramadol IV (5 mg/kg) for five consecutive days; group 2, the sham group, was given normal saline IV (5 mg/kg) for the same time period. The results of present study showed that short-term injection of tramadol causes significant change in red blood cell count and packed cell volume value. However, level of serum activities of hepatic enzymes and BUN remained unaltered. In conclusion, these results suggest that although short-term use of tramadol may have no toxic effects on the liver and kidney, its effects on the blood profile should be kept in mind.
The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal ... more The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal growth plate in submuscular transplantation (ectopic osteoinduction) as a new xenogenic biomaterial in rat model. Demineralized bovine foetal growth plate was ectopically implanted in 18 male Sprague-Dawley rats. In 18 of the animals under aseptic conditions two submuscular pouches were created between external and internal oblique abdominal muscles in the two flanks: the right was left empty (sham) and the left was filled with 20mg of demineralized bovine foetal growth plate powder. Radiographs were taken in 2, 4 and 6 weeks after the surgery, then six animals were pharmacologically euthanized after 2, 4 and 6 weeks for histopathological evaluation. Results showed: (1) osteoinductivity of xenogenic demineralized bovine foetal growth plate powder, and (2) earlier mineralization of ectopically implanted demineralized bovine foetal growth plate in the submuscular implanted area. Our results show that submuscular implantation of xenogenic demineralized bovine foetal growth plate has osteoinductive properties in a rat model.
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