Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating... more Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating acne vulgaris. Study Design: Quasi-experimental study. Place and Duration of the Study: Dermatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2018. Methodology: One hundred and fifty-four patients of both genders who had moderate acne vulgaris for more than four weeks were divided into two Groups. In both Groups, patients applied one-fourth fingertip unit of Tazarotene 0.1% cream in the evening once daily and Clindamycin 1% gel over the affected area in the morning once daily for 12 weeks. The Global Acne Grading System Score (GAGS score) was used for severity and efficacy assessment. Results: The majority of the patients belonged to 13-25 years of age, i.e., 61(79.2%) and 54(70.1%) in Group-A (Tazarotene 0.1% cream) and Group-B (Clindamycin 1% gel), respectively. The efficacy of topical Tazarotene cream (0.1%) was better than topical Clindamycin 1...
Background and objective: Low back pain is common in the elderly due to adaptive changes to stres... more Background and objective: Low back pain is common in the elderly due to adaptive changes to stress and osteoporosis of the lumbar spine. Skeletal geometry varies in different population groups. Objective of this study was to record reference values of morphometric data of lumbar spine in normal adult male and female subjects of Punjab. Study design: Cross-sectional population study Material and methods: Anterior and central height and concavity index for each vertebra were measured and calculated from radiographs. Anterior and posterior height and anteroposterior diameter were measured for each disc and wedge index was calculated. Results: All parameters were significantly larger in the males as compared to the females. Significant difference was found in the anterior height of the intervertebral discs at L1-2 to L4-5 while it was insignificant at L5-S1. Posterior height of discs was significantly larger in the male group at L1-2 to L3-4. Wedge index (WI) for discs was relatively la...
Journal of Pharmaceutical Research International, 2021
Objective: Cancer chemoprevention with phytochemicals such as “lutein” derived from the vegetable... more Objective: Cancer chemoprevention with phytochemicals such as “lutein” derived from the vegetable okra could prove beneficial. Therefore, the objective of this study was to perform a meta-analysis of “lutein” against the breast cancer cell lines (MCF-7) and to establish the possible development of lutein based nutraceuticals. Methodology: A literature survey was performed using online data bases such as PubMed, Google scholar, and EMBASE, from 2000 to 2020 by using keywords such as “Lutein”, “Anticancer activity”, “Breast cancer cell lines”, and “MCF-7”. Studies reported lutein anticancer potentials against MCF-7 were included in the study. Results: Out of 28 studies, 7 research articles fulfilled the inclusion criteria. Meta-analysis data indicated that, a lutein concentration at ≥1 µM was able to reduce the MCF-7 cell viability of 59.837 with a 95% confidence interval (CI): 48.331 to 71.343. Additionally, a forest plot of the cumulative studies also indicated that impact of lutein...
Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities ar... more Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities around the world due to its potent bioactivity. Therefore, the present study investigates the metabolite profiling of the ethanolic crude extract of E. sativa leaves using high resolution-liquid chromatography-mass spectrometry (HR-LC/MS), including antibacterial, antioxidant and anticancer potential against human colorectal carcinoma cell lines. In addition, computer-aided analysis was performed for determining the pharmacokinetic properties and toxicity prediction of the identified compounds. Our results show that E. sativa contains several bioactive compounds, such as vitamins, fatty acids, alkaloids, flavonoids, terpenoids and phenols. Furthermore, the antibacterial assay of E. sativa extract showed inhibitory effects of the tested pathogenic bacterial strains. Moreover, the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) were found to be IC50 ...
Background: A high prevalence rate of neonatal and adult tetanus in Pakistan reflects the failure... more Background: A high prevalence rate of neonatal and adult tetanus in Pakistan reflects the failure of health care systems to provide adequate immunization. Health care workers (HCWs) of emergency departments (ED) are generally at the frontline to deal with patients of road traffic accidents, trauma and burns. However, it has been observed that these patients receive incomplete preventive measures to combat tetanus. Objective: To assess the knowledge of tetanus immunization among healthcare workers (HCW) of the emergency department (ED) at a tertiary care hospital. Methods: A cross sectional study was conducted on 104 HCWs of ED of Ziauddin University. A structured questionnaire was filled by HCWs during April and May 2014. Data were analyzed on SPSS 20.0. Categorical variables were presented as frequency and percentage, while continuous variables were presented as mean. P value of <0.05 was considered significant. Results: Total 104 HCWs from ED participated in the study. Only 11....
Diabetes mellitus is a global threat affecting millions of people of different age groups. In rec... more Diabetes mellitus is a global threat affecting millions of people of different age groups. In recent years, the development of naturally derived anti-diabetic agents has gained popularity. Okra is a common vegetable containing important bioactive components such as abscisic acid (ABA). ABA, a phytohormone, has been shown to elicit potent anti-diabetic effects in mouse models. Keeping its anti-diabetic potential in mind, in silico study was performed to explore its role in inhibiting proteins relevant to diabetes mellitus- 11β-hydroxysteroid dehydrogenase (11β-HSD1), aldose reductase, glucokinase, glutamine-fructose-6-phosphate amidotransferase (GFAT), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and Sirtuin family of NAD(+)-dependent protein deacetylases 6 (SIRT6). A comparative study of the ABA-protein docked complex with already known inhibitors of these proteins relevant to diabetes was compared to explore the inhibitory potential. Calculation of molecular bindi...
Tribology - Materials, Surfaces & Interfaces, 2021
ABSTRACT With the advancement in the field of nanotechnology, various researchers have reported a... more ABSTRACT With the advancement in the field of nanotechnology, various researchers have reported an improvement in the friction and wear behaviour of different lubricating oils by the addition of different nano additives. However, the stability of these nano additives remains a challenge. In this paper, the dispersion stability of various nano additives in lubricating oils has been studied in detail. The paper aims to summarize various dispersion stability theories and several methods reported in the literature to improve dispersion stability. Apart from this, a special focus has been laid to highlight the various surfactants used to improve the dispersion stability, particularly the tribological properties. The literature suggests that although a number of studies have been carried out to study the effect of surfactant addition on dispersion stability, however, future developments could be focused to improve the dispersion stability of the existing mono and hybrid nano fluids and their underlying mechanisms. Abbreviations: SWCNH, single-walled carbon nano-horns; PAO, poly alpha olefin; MoS2, molybdenum di sulphide; H, Hamaker constant, MWCNTs, multi-walled carbon nanotubes; GNF, graphene nanoflakes; DLVO, Derjaguin and Landau Verway and Overbeek; DLS, dynamic light scattering; HLB, hydrophobic lyophilic balance; FERTEM, freeze etching replication transmission electron microscope; SDS, sodium dodecyl sulphate; PTFE, polytetrafluoroethylene; FTIR, Fourier-transform infrared spectroscopy; TBAAc, tetra butyl ammonium acetate; THF, tetrahydrofurane; UV–Vis, ultraviolet visible light; SEM, scanning electron microscope; TEM, transmission electron microscope GRAPHICAL ABSTRACT
A rapid increase in world population is leading to the rise in global demand of food and agricult... more A rapid increase in world population is leading to the rise in global demand of food and agriculture (agri) products. Nanotechnology and its applications have emerged as one of the most pioneering and promising technology for transforming conventional food and agri industries, with the aim of sustainable farming, improving the food security, quality and safety which could revolutionize the food and agri industries. Current developments in nanotechnology have led to the new paths progressively and bringing the radical changes the way food is perceived throughout the farming, transportation, processing, packaging, storage, monitoring and consumption. This review brings the current updates on novel nanomaterials in food and agri industries. Emphasis is given on the importance of nanotechnological applications, offering complete food solutions from farm to fork; including nutraceutical and functional foods, improving bioavailability, efficiency, nutritional status, nano-additives, food texture, color, taste and packaging. Agricultural sector also witnessed several nano-based products, such as nano-fertilizer, nano-pesticide, nano growth promoters and many more for the development of sustainable farming and crop improvement. Despite of numerous advantages of nanotechnology, there are still toxicity challenges, safety concerns, which needs to be addressed and demands transformations in regulatory policies. Rapid development is projected to transform several foods and agri sectors, with rapid increase in market stake and investment. Government agencies, private research centers as well as academicians are also coming together to explore the benefits of nanotechnology to improve food scarcity in the coming years.
Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes o... more Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this revi...
Inhibitory potential of ilimaquinone (marine sponge metabolite) against nine essential SARS-CoV-2... more Inhibitory potential of ilimaquinone (marine sponge metabolite) against nine essential SARS-CoV-2 target proteins, employing a molecular interaction and dynamics simulation approach.
In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticance... more In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticancer activity and detailed phytochemical analysis of Selaginellarepanda (S. repanda) ethanolic crude extract for the very first time using different in vitro approaches. Furthermore, computer-aided prediction of pharmacokinetic properties and safety profile of the identified phytoconstituents were also employed in order to provide some useful insights for drug discovery. S. repanda, which is a rich source of potent natural bioactive compounds, showed promising antibacterial activity against the tested pathogenic bacteria (S. aureus, P. aeruginosa, E. coli and S. flexneri). The crude extract displayed favorable antioxidant activity against both 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 231.6 μg/mL) and H2O2 (IC50 = 288.3 μg/mL) molecules. S. repanda also showed favorable and effective anticancer activity against all three malignant cancer cells in a dose/time dependent manner. Higher acti...
SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroyi... more SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 recep...
Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in de... more Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in defense mechanisms and other important cellular activities. Primarily, this study aims to screen the unexplored mucus extract of Puntius sophore (P. sophore) for its antagonistic potential against common pathogens, which are commonly implicated in foodborne and healthcare associated infections, with effects on their adhesion and biofilm formation. Profiling of the skin mucus was carried out by High Resolution-Liquid Chromatography Mass Spectrometry (HR-LCMS), followed by antibacterial activity and assessment of antibiofilm potency and efficacy on the development, formation, and texture of biofilms. Furthermore, bacterial cell damage, viability within the biofilm, checkerboard test, and cytotoxicity were also evaluated. As a result, P. sophore mucus extract was found to be effective against all tested strains. It also impedes the architecture of biofilm matrix by affecting the viability and...
Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating... more Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating acne vulgaris. Study Design: Quasi-experimental study. Place and Duration of the Study: Dermatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2018. Methodology: One hundred and fifty-four patients of both genders who had moderate acne vulgaris for more than four weeks were divided into two Groups. In both Groups, patients applied one-fourth fingertip unit of Tazarotene 0.1% cream in the evening once daily and Clindamycin 1% gel over the affected area in the morning once daily for 12 weeks. The Global Acne Grading System Score (GAGS score) was used for severity and efficacy assessment. Results: The majority of the patients belonged to 13-25 years of age, i.e., 61(79.2%) and 54(70.1%) in Group-A (Tazarotene 0.1% cream) and Group-B (Clindamycin 1% gel), respectively. The efficacy of topical Tazarotene cream (0.1%) was better than topical Clindamycin 1...
Background and objective: Low back pain is common in the elderly due to adaptive changes to stres... more Background and objective: Low back pain is common in the elderly due to adaptive changes to stress and osteoporosis of the lumbar spine. Skeletal geometry varies in different population groups. Objective of this study was to record reference values of morphometric data of lumbar spine in normal adult male and female subjects of Punjab. Study design: Cross-sectional population study Material and methods: Anterior and central height and concavity index for each vertebra were measured and calculated from radiographs. Anterior and posterior height and anteroposterior diameter were measured for each disc and wedge index was calculated. Results: All parameters were significantly larger in the males as compared to the females. Significant difference was found in the anterior height of the intervertebral discs at L1-2 to L4-5 while it was insignificant at L5-S1. Posterior height of discs was significantly larger in the male group at L1-2 to L3-4. Wedge index (WI) for discs was relatively la...
Journal of Pharmaceutical Research International, 2021
Objective: Cancer chemoprevention with phytochemicals such as “lutein” derived from the vegetable... more Objective: Cancer chemoprevention with phytochemicals such as “lutein” derived from the vegetable okra could prove beneficial. Therefore, the objective of this study was to perform a meta-analysis of “lutein” against the breast cancer cell lines (MCF-7) and to establish the possible development of lutein based nutraceuticals. Methodology: A literature survey was performed using online data bases such as PubMed, Google scholar, and EMBASE, from 2000 to 2020 by using keywords such as “Lutein”, “Anticancer activity”, “Breast cancer cell lines”, and “MCF-7”. Studies reported lutein anticancer potentials against MCF-7 were included in the study. Results: Out of 28 studies, 7 research articles fulfilled the inclusion criteria. Meta-analysis data indicated that, a lutein concentration at ≥1 µM was able to reduce the MCF-7 cell viability of 59.837 with a 95% confidence interval (CI): 48.331 to 71.343. Additionally, a forest plot of the cumulative studies also indicated that impact of lutein...
Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities ar... more Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities around the world due to its potent bioactivity. Therefore, the present study investigates the metabolite profiling of the ethanolic crude extract of E. sativa leaves using high resolution-liquid chromatography-mass spectrometry (HR-LC/MS), including antibacterial, antioxidant and anticancer potential against human colorectal carcinoma cell lines. In addition, computer-aided analysis was performed for determining the pharmacokinetic properties and toxicity prediction of the identified compounds. Our results show that E. sativa contains several bioactive compounds, such as vitamins, fatty acids, alkaloids, flavonoids, terpenoids and phenols. Furthermore, the antibacterial assay of E. sativa extract showed inhibitory effects of the tested pathogenic bacterial strains. Moreover, the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) were found to be IC50 ...
Background: A high prevalence rate of neonatal and adult tetanus in Pakistan reflects the failure... more Background: A high prevalence rate of neonatal and adult tetanus in Pakistan reflects the failure of health care systems to provide adequate immunization. Health care workers (HCWs) of emergency departments (ED) are generally at the frontline to deal with patients of road traffic accidents, trauma and burns. However, it has been observed that these patients receive incomplete preventive measures to combat tetanus. Objective: To assess the knowledge of tetanus immunization among healthcare workers (HCW) of the emergency department (ED) at a tertiary care hospital. Methods: A cross sectional study was conducted on 104 HCWs of ED of Ziauddin University. A structured questionnaire was filled by HCWs during April and May 2014. Data were analyzed on SPSS 20.0. Categorical variables were presented as frequency and percentage, while continuous variables were presented as mean. P value of <0.05 was considered significant. Results: Total 104 HCWs from ED participated in the study. Only 11....
Diabetes mellitus is a global threat affecting millions of people of different age groups. In rec... more Diabetes mellitus is a global threat affecting millions of people of different age groups. In recent years, the development of naturally derived anti-diabetic agents has gained popularity. Okra is a common vegetable containing important bioactive components such as abscisic acid (ABA). ABA, a phytohormone, has been shown to elicit potent anti-diabetic effects in mouse models. Keeping its anti-diabetic potential in mind, in silico study was performed to explore its role in inhibiting proteins relevant to diabetes mellitus- 11β-hydroxysteroid dehydrogenase (11β-HSD1), aldose reductase, glucokinase, glutamine-fructose-6-phosphate amidotransferase (GFAT), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and Sirtuin family of NAD(+)-dependent protein deacetylases 6 (SIRT6). A comparative study of the ABA-protein docked complex with already known inhibitors of these proteins relevant to diabetes was compared to explore the inhibitory potential. Calculation of molecular bindi...
Tribology - Materials, Surfaces & Interfaces, 2021
ABSTRACT With the advancement in the field of nanotechnology, various researchers have reported a... more ABSTRACT With the advancement in the field of nanotechnology, various researchers have reported an improvement in the friction and wear behaviour of different lubricating oils by the addition of different nano additives. However, the stability of these nano additives remains a challenge. In this paper, the dispersion stability of various nano additives in lubricating oils has been studied in detail. The paper aims to summarize various dispersion stability theories and several methods reported in the literature to improve dispersion stability. Apart from this, a special focus has been laid to highlight the various surfactants used to improve the dispersion stability, particularly the tribological properties. The literature suggests that although a number of studies have been carried out to study the effect of surfactant addition on dispersion stability, however, future developments could be focused to improve the dispersion stability of the existing mono and hybrid nano fluids and their underlying mechanisms. Abbreviations: SWCNH, single-walled carbon nano-horns; PAO, poly alpha olefin; MoS2, molybdenum di sulphide; H, Hamaker constant, MWCNTs, multi-walled carbon nanotubes; GNF, graphene nanoflakes; DLVO, Derjaguin and Landau Verway and Overbeek; DLS, dynamic light scattering; HLB, hydrophobic lyophilic balance; FERTEM, freeze etching replication transmission electron microscope; SDS, sodium dodecyl sulphate; PTFE, polytetrafluoroethylene; FTIR, Fourier-transform infrared spectroscopy; TBAAc, tetra butyl ammonium acetate; THF, tetrahydrofurane; UV–Vis, ultraviolet visible light; SEM, scanning electron microscope; TEM, transmission electron microscope GRAPHICAL ABSTRACT
A rapid increase in world population is leading to the rise in global demand of food and agricult... more A rapid increase in world population is leading to the rise in global demand of food and agriculture (agri) products. Nanotechnology and its applications have emerged as one of the most pioneering and promising technology for transforming conventional food and agri industries, with the aim of sustainable farming, improving the food security, quality and safety which could revolutionize the food and agri industries. Current developments in nanotechnology have led to the new paths progressively and bringing the radical changes the way food is perceived throughout the farming, transportation, processing, packaging, storage, monitoring and consumption. This review brings the current updates on novel nanomaterials in food and agri industries. Emphasis is given on the importance of nanotechnological applications, offering complete food solutions from farm to fork; including nutraceutical and functional foods, improving bioavailability, efficiency, nutritional status, nano-additives, food texture, color, taste and packaging. Agricultural sector also witnessed several nano-based products, such as nano-fertilizer, nano-pesticide, nano growth promoters and many more for the development of sustainable farming and crop improvement. Despite of numerous advantages of nanotechnology, there are still toxicity challenges, safety concerns, which needs to be addressed and demands transformations in regulatory policies. Rapid development is projected to transform several foods and agri sectors, with rapid increase in market stake and investment. Government agencies, private research centers as well as academicians are also coming together to explore the benefits of nanotechnology to improve food scarcity in the coming years.
Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes o... more Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this revi...
Inhibitory potential of ilimaquinone (marine sponge metabolite) against nine essential SARS-CoV-2... more Inhibitory potential of ilimaquinone (marine sponge metabolite) against nine essential SARS-CoV-2 target proteins, employing a molecular interaction and dynamics simulation approach.
In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticance... more In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticancer activity and detailed phytochemical analysis of Selaginellarepanda (S. repanda) ethanolic crude extract for the very first time using different in vitro approaches. Furthermore, computer-aided prediction of pharmacokinetic properties and safety profile of the identified phytoconstituents were also employed in order to provide some useful insights for drug discovery. S. repanda, which is a rich source of potent natural bioactive compounds, showed promising antibacterial activity against the tested pathogenic bacteria (S. aureus, P. aeruginosa, E. coli and S. flexneri). The crude extract displayed favorable antioxidant activity against both 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 231.6 μg/mL) and H2O2 (IC50 = 288.3 μg/mL) molecules. S. repanda also showed favorable and effective anticancer activity against all three malignant cancer cells in a dose/time dependent manner. Higher acti...
SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroyi... more SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 recep...
Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in de... more Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in defense mechanisms and other important cellular activities. Primarily, this study aims to screen the unexplored mucus extract of Puntius sophore (P. sophore) for its antagonistic potential against common pathogens, which are commonly implicated in foodborne and healthcare associated infections, with effects on their adhesion and biofilm formation. Profiling of the skin mucus was carried out by High Resolution-Liquid Chromatography Mass Spectrometry (HR-LCMS), followed by antibacterial activity and assessment of antibiofilm potency and efficacy on the development, formation, and texture of biofilms. Furthermore, bacterial cell damage, viability within the biofilm, checkerboard test, and cytotoxicity were also evaluated. As a result, P. sophore mucus extract was found to be effective against all tested strains. It also impedes the architecture of biofilm matrix by affecting the viability and...
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Papers by Amir Ashraf