Ana Cristina Recife

RECIFE, A.C. Retrograded starch as tablet excipient for controlled drug delivery: preparation and characterization. 2013. (Master’s Degree). School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil, 2013. Hydrophilic matrices represent important solid systems for controlled drug delivery intended to oral administration of drugs, because of the relative ease of processing, possibility of incorporating large amounts of drug, and obtaining reproducible release profiles. Resistant starch type 3 (AR3) and pectin (P) are polymers resistant to the action of digestive enzymes and are selectively degraded by colonic microbiota, making them potential candidates for drug delivery systems. In this work, retrograded starch (AR3) was prepared by starch retrogradation by two different methods: Method 1 (M1) cooling for 8 days at 4° C and Method 2 (M2) storage for 16 days in alternating temperature cycles (4° C and 30° C, 2 days at each temperature). The physico-chemical properties of the retro...