Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that... more Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that of delta and PP cells of the islets for transplantation, have forced the scientific community to look for alternative sources through xenotransplantation and nanomedicine. The Edmonton protocol of islet transplantation has shown proof of principle of long term survival of islets in type I diabetic patients, leading to insulin prick free life. Copious volume of literature exists on the use of mammalian islets, especially of porcine origin for diabetes reversal in humans with follow-up studies upto 10 yrs. There is an obvious lack of pre-clinical results and data in the pig-to-primate model. The difficulty is in reproducing regularly the successful porcine islet isolation. Although some of the parameters have been taken, making xenotransplantation an attractive and viable alternative therapy. However, scarcity of islets is the main hurdle in the success of islet transplantation programs. ...
Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that... more Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that of delta and PP cells of the islets for transplantation, have forced the scientific community to look for alternative sources through xenotransplantation and nanomedicine. The Edmonton protocol of islet transplantation has shown proof of principle of long term survival of islets in type I diabetic patients, leading to insulin prick free life. Copious volume of literature exists on the use of mammalian islets, especially of porcine origin for diabetes reversal in humans with follow-up studies upto 10 yrs. There is an obvious lack of pre-clinical results and data in the pig-to-primate model. The difficulty is in reproducing regularly the successful porcine islet isolation. Although some of the parameters have been taken, making xenotransplantation an attractive and viable alternative therapy. However, scarcity of islets is the main hurdle in the success of islet transplantation programs. Since the islet cell receptor and the insulin molecule have remained conserved throughout the evolution of vertebrates, we reviewed islet studies from other vertebrates especially, jawless fish, cartilaginous as well as bony fishes and chick islets. The similarities of chick B islets with human islets in terms of Streptozotocin insensitivity and retention of glucose responsiveness by new born chick islets tempted us to hypothesize the use of fish and chick islets as alternative sources for transplantation to reverse experimental diabetes. Since ontogeny recapitulates phylogeny, the islets recovered from lower vertebrates are likely to be less immunogenic and may open possibility of using them without immunosuppression. Complementing xenotransplantation, nanotechnology offers an excellent module for addressing the diabetes problem from detection and treatment points of view. This review attempts to throw some light on both these approaches for an effective management and cure of diabetes.
We study the correction of the energy spectrum of a gravitational quantum well due to the combine... more We study the correction of the energy spectrum of a gravitational quantum well due to the combined effect of the braneworld model with infinite extra dimensions and generalized uncertainty principle. The correction terms arise from a natural deformation of a semiclassical theory of quantum gravity governed by the Schrödinger-Newton equation based on a minimal length framework. The two fold correction in the energy yields new values of the spectrum, which are closer to the values obtained in the GRANIT experiment. This raises the possibility that the combined theory of the semiclassical quantum gravity and the generalized uncertainty principle may provide an intermediate theory between the semiclassical and the full theory of quantum gravity. We also prepare a schematic experimental setup which may guide to the understanding of the phenomena in the laboratory.
Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that... more Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that of delta and PP cells of the islets for transplantation, have forced the scientific community to look for alternative sources through xenotransplantation and nanomedicine. The Edmonton protocol of islet transplantation has shown proof of principle of long term survival of islets in type I diabetic patients, leading to insulin prick free life. Copious volume of literature exists on the use of mammalian islets, especially of porcine origin for diabetes reversal in humans with follow-up studies upto 10 yrs. There is an obvious lack of pre-clinical results and data in the pig-to-primate model. The difficulty is in reproducing regularly the successful porcine islet isolation. Although some of the parameters have been taken, making xenotransplantation an attractive and viable alternative therapy. However, scarcity of islets is the main hurdle in the success of islet transplantation programs. ...
Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that... more Increasing incidence of diabetes and shortage of specific beta cells, hormonal switches like that of delta and PP cells of the islets for transplantation, have forced the scientific community to look for alternative sources through xenotransplantation and nanomedicine. The Edmonton protocol of islet transplantation has shown proof of principle of long term survival of islets in type I diabetic patients, leading to insulin prick free life. Copious volume of literature exists on the use of mammalian islets, especially of porcine origin for diabetes reversal in humans with follow-up studies upto 10 yrs. There is an obvious lack of pre-clinical results and data in the pig-to-primate model. The difficulty is in reproducing regularly the successful porcine islet isolation. Although some of the parameters have been taken, making xenotransplantation an attractive and viable alternative therapy. However, scarcity of islets is the main hurdle in the success of islet transplantation programs. Since the islet cell receptor and the insulin molecule have remained conserved throughout the evolution of vertebrates, we reviewed islet studies from other vertebrates especially, jawless fish, cartilaginous as well as bony fishes and chick islets. The similarities of chick B islets with human islets in terms of Streptozotocin insensitivity and retention of glucose responsiveness by new born chick islets tempted us to hypothesize the use of fish and chick islets as alternative sources for transplantation to reverse experimental diabetes. Since ontogeny recapitulates phylogeny, the islets recovered from lower vertebrates are likely to be less immunogenic and may open possibility of using them without immunosuppression. Complementing xenotransplantation, nanotechnology offers an excellent module for addressing the diabetes problem from detection and treatment points of view. This review attempts to throw some light on both these approaches for an effective management and cure of diabetes.
We study the correction of the energy spectrum of a gravitational quantum well due to the combine... more We study the correction of the energy spectrum of a gravitational quantum well due to the combined effect of the braneworld model with infinite extra dimensions and generalized uncertainty principle. The correction terms arise from a natural deformation of a semiclassical theory of quantum gravity governed by the Schrödinger-Newton equation based on a minimal length framework. The two fold correction in the energy yields new values of the spectrum, which are closer to the values obtained in the GRANIT experiment. This raises the possibility that the combined theory of the semiclassical quantum gravity and the generalized uncertainty principle may provide an intermediate theory between the semiclassical and the full theory of quantum gravity. We also prepare a schematic experimental setup which may guide to the understanding of the phenomena in the laboratory.
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Papers by Anha Bhat