Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat... more Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy. Two patients who were treated with the drug throughout pregnancy are presented and the literature is reviewed. Although the 2 current pregnancies ended successfully, 3 neonatal deaths in 15 pregnancies (20%) have been reported. These data suggest that patients taking clofazimine during pregnancy be managed at a perinatal center where adequate neonatal care can be given.
Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat... more Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy. Two patients who were treated with the drug throughout pregnancy are presented and the literature is reviewed. Although the 2 current pregnancies ended successfully, 3 neonatal deaths in 15 pregnancies (20%) have been reported. These data suggest that patients taking clofazimine during pregnancy be managed at a perinatal center where adequate neonatal care can be given.
A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp a... more A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp and face, including her eyelids and behind her ears. The eruption began at the end of August. It flared after she used a calming moisturizer containing feverfew (Tanacetum parthenium). A second patient, a 25-year-old woman, presented complaining of a 1-month history of an eruption around the eyes that started after she began using a moisturizer containing feverfew. Both patients were patch-tested with the North American Contact Dermatitis Group series, cosmetic and plant series, and their own skin care products. Patient 1 had a + reaction to sesquiterpene lactone mix, a + reaction to Compositae mix, a + reaction to parthenolide, a + reaction to Tanacetum vulgare, and a + reaction to the calming moisturizer. Patient 2 had + reactions to sesquiterpene lactone, Compositae mix, and the same calming moisturizer. It is thought that both of these eruptions are a result of contact dermatitis from...
A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp a... more A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp and face, including her eyelids and behind her ears. The eruption began at the end of August. It flared after she used a calming moisturizer containing feverfew (Tanacetum parthenium). A second patient, a 25-year-old woman, presented complaining of a 1-month history of an eruption around the eyes that started after she began using a moisturizer containing feverfew. Both patients were patch-tested with the North American Contact Dermatitis Group series, cosmetic and plant series, and their own skin care products. Patient 1 had a + reaction to sesquiterpene lactone mix, a + reaction to Compositae mix, a + reaction to parthenolide, a + reaction to Tanacetum vulgare, and a + reaction to the calming moisturizer. Patient 2 had + reactions to sesquiterpene lactone, Compositae mix, and the same calming moisturizer. It is thought that both of these eruptions are a result of contact dermatitis from the Compositae plant family.
Erythema ab igne is caused by chronic heat exposure and presents with reticulated pigmentation. A... more Erythema ab igne is caused by chronic heat exposure and presents with reticulated pigmentation. Although various causes of erythema ab igne have been reported, in the United States, its incidence has been declining due to the advent of central heating. When seen, it is usually in the setting of local applications of a heated source, such as a hot water bottle, to treat muscular or arthritic pains. We report a novel cause of erythema ab igne occurring in a patient with chronic arthritic pains. This patient applied popcorn kernels, heated in a microwave, to his right wrist and knee for 30 minutes at a time for over four months.
... MD; Marshall N. Cyrlin, MD; Lawrence M. Solomon, MD Vitiligo is an acquired localized or gene... more ... MD; Marshall N. Cyrlin, MD; Lawrence M. Solomon, MD Vitiligo is an acquired localized or generalized total loss of pigment secondary to loss of melanocytes. Its cause is unknown. In 1947, El Mofty1 introduced the use of methoxsalen for the treatment of vitiligo. Parrish et al2 ...
(1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulce... more (1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulcers in 2 North American study centers vs European study findings and the North American Contact Dermatitis Group (NACDG) database and (2) to delineate a standard battery of allergens for patch testing in North American patients that is representative of the newer dressings and wound care products. Fifty-four patients, with or without dermatitis, were prospectively entered in the study. The patients were patch tested to the NACDG standard series and a comprehensive supplemental series of 52 allergens. Wound healing clinics at Boston University Roger Williams Medical Center and University of Ottawa. Sixty-three percent (n = 34) of patients had 1 or multiple positive patch test results, and 37% (n = 20) had no positive patch test result. The most common allergens were Myroxylon pereirae (balsam of Peru) (30% [16/54]), bacitracin (24% [13/54]), fragrance mix (20% [11/54]), wood tar mix (20% [11/54]), propylene glycol (14% [7/52]), neomycin sulfate (13% [7/54]), benzalkonium chloride (13% [7/54]), carba mix (11% [6/54]), nickel sulfate (11% [6/54]), and control gel hydrocolloid (11% [6/54]). Comparable to European study findings, there is a high incidence of positive patch test results in patients with past or present leg ulcerations. The incidences of the most common allergens in our patient population were higher than those seen in the NACDG, except for nickel. Using a modified leg ulcer series along with the standard NACDG series is important in evaluating patients with leg ulcers.
Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat... more Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy. Two patients who were treated with the drug throughout pregnancy are presented and the literature is reviewed. Although the 2 current pregnancies ended successfully, 3 neonatal deaths in 15 pregnancies (20%) have been reported. These data suggest that patients taking clofazimine during pregnancy be managed at a perinatal center where adequate neonatal care can be given.
Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat... more Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy. Two patients who were treated with the drug throughout pregnancy are presented and the literature is reviewed. Although the 2 current pregnancies ended successfully, 3 neonatal deaths in 15 pregnancies (20%) have been reported. These data suggest that patients taking clofazimine during pregnancy be managed at a perinatal center where adequate neonatal care can be given.
A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp a... more A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp and face, including her eyelids and behind her ears. The eruption began at the end of August. It flared after she used a calming moisturizer containing feverfew (Tanacetum parthenium). A second patient, a 25-year-old woman, presented complaining of a 1-month history of an eruption around the eyes that started after she began using a moisturizer containing feverfew. Both patients were patch-tested with the North American Contact Dermatitis Group series, cosmetic and plant series, and their own skin care products. Patient 1 had a + reaction to sesquiterpene lactone mix, a + reaction to Compositae mix, a + reaction to parthenolide, a + reaction to Tanacetum vulgare, and a + reaction to the calming moisturizer. Patient 2 had + reactions to sesquiterpene lactone, Compositae mix, and the same calming moisturizer. It is thought that both of these eruptions are a result of contact dermatitis from...
A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp a... more A 45-year-old woman presented in October 2005 with a history of an eruption involving her scalp and face, including her eyelids and behind her ears. The eruption began at the end of August. It flared after she used a calming moisturizer containing feverfew (Tanacetum parthenium). A second patient, a 25-year-old woman, presented complaining of a 1-month history of an eruption around the eyes that started after she began using a moisturizer containing feverfew. Both patients were patch-tested with the North American Contact Dermatitis Group series, cosmetic and plant series, and their own skin care products. Patient 1 had a + reaction to sesquiterpene lactone mix, a + reaction to Compositae mix, a + reaction to parthenolide, a + reaction to Tanacetum vulgare, and a + reaction to the calming moisturizer. Patient 2 had + reactions to sesquiterpene lactone, Compositae mix, and the same calming moisturizer. It is thought that both of these eruptions are a result of contact dermatitis from the Compositae plant family.
Erythema ab igne is caused by chronic heat exposure and presents with reticulated pigmentation. A... more Erythema ab igne is caused by chronic heat exposure and presents with reticulated pigmentation. Although various causes of erythema ab igne have been reported, in the United States, its incidence has been declining due to the advent of central heating. When seen, it is usually in the setting of local applications of a heated source, such as a hot water bottle, to treat muscular or arthritic pains. We report a novel cause of erythema ab igne occurring in a patient with chronic arthritic pains. This patient applied popcorn kernels, heated in a microwave, to his right wrist and knee for 30 minutes at a time for over four months.
... MD; Marshall N. Cyrlin, MD; Lawrence M. Solomon, MD Vitiligo is an acquired localized or gene... more ... MD; Marshall N. Cyrlin, MD; Lawrence M. Solomon, MD Vitiligo is an acquired localized or generalized total loss of pigment secondary to loss of melanocytes. Its cause is unknown. In 1947, El Mofty1 introduced the use of methoxsalen for the treatment of vitiligo. Parrish et al2 ...
(1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulce... more (1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulcers in 2 North American study centers vs European study findings and the North American Contact Dermatitis Group (NACDG) database and (2) to delineate a standard battery of allergens for patch testing in North American patients that is representative of the newer dressings and wound care products. Fifty-four patients, with or without dermatitis, were prospectively entered in the study. The patients were patch tested to the NACDG standard series and a comprehensive supplemental series of 52 allergens. Wound healing clinics at Boston University Roger Williams Medical Center and University of Ottawa. Sixty-three percent (n = 34) of patients had 1 or multiple positive patch test results, and 37% (n = 20) had no positive patch test result. The most common allergens were Myroxylon pereirae (balsam of Peru) (30% [16/54]), bacitracin (24% [13/54]), fragrance mix (20% [11/54]), wood tar mix (20% [11/54]), propylene glycol (14% [7/52]), neomycin sulfate (13% [7/54]), benzalkonium chloride (13% [7/54]), carba mix (11% [6/54]), nickel sulfate (11% [6/54]), and control gel hydrocolloid (11% [6/54]). Comparable to European study findings, there is a high incidence of positive patch test results in patients with past or present leg ulcerations. The incidences of the most common allergens in our patient population were higher than those seen in the NACDG, except for nickel. Using a modified leg ulcer series along with the standard NACDG series is important in evaluating patients with leg ulcers.
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