Acetone and methanol extracts of the fruits of Pistacia terebinthus L. subsp. terebinthus L. were... more Acetone and methanol extracts of the fruits of Pistacia terebinthus L. subsp. terebinthus L. were studied for their antioxidant activity by investigating their total phenolic and flavonoid contents, β-carotene bleaching potential, DPPH radical scavenging effect, scavenging ...
Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to ... more Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to isolation of two new diterpenes, 7-hydroxy-12-methoxy-20-nor-abieta-1,5(10),7,9,12-pentaen-6,14-dione and abieta-8,12-dien-11,14-dione (12-deoxy-royleanone), together with oleanolic acid, ursolic acid, ferruginol, inuroyoleanol and cryptanol. Their structures were determined spectroscopically, which included HREIMS and 2D NMR spectroscopic analysis. The new abietane derivatives showed appreciable in vitro antileishmanial activity against intracellular amastigote forms
Prangos platychlaena has been used in traditional medicine in eastern Turkey. It stops bleeding a... more Prangos platychlaena has been used in traditional medicine in eastern Turkey. It stops bleeding and heals the scars when applied externally. When the isolated coumarins were tested against bacterial strains, only a slight activity was obtained.
... Short Report. Terpenoids from Salvia palaestina. Ayhan Ulubelen, Mahmut Miski, Candan Johanss... more ... Short Report. Terpenoids from Salvia palaestina. Ayhan Ulubelen, Mahmut Miski, Candan Johansson, Esther Lee a , Tom J. Mabry a and Stephen A. Matlin b. ... 44 (1981), p. 119. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (3). HJ Nicholas J. Am. Pharm. ...
ABSTRACT A new hetisine-type diterpene alkaloid, venudelphine [1], was isolated from the pH 12 fr... more ABSTRACT A new hetisine-type diterpene alkaloid, venudelphine [1], was isolated from the pH 12 fraction of Delphinium venulosum (Ranunculaceae) in addition to previously isolated alkaloids. The structure of venudelphine was established by spectral data.
Http Dx Doi Org 10 1080 10575630108041297, Oct 4, 2006
From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxy... more From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 microg/ml) against S. aureus and (MIC 18 microg/ml) against S. epidermidis as well as against B. subtilis (MIC 9 microg/ml).
... 7,4'-dirnethyl ether gave a purple color on tlc plates over uv m-ith and wit... more ... 7,4'-dirnethyl ether gave a purple color on tlc plates over uv m-ith and without ammonia: furthermore, spraying with SA reagent also did not change this color. These color tests indicated that the B-ring did not contain any free hrdroxyl groups. The uv spectrum nith NaOlIe gave a ...
The three new triterpenes (1-3) and five known triterpenes and a sterol were isolated from the ac... more The three new triterpenes (1-3) and five known triterpenes and a sterol were isolated from the acetone extract of a Turkish collection of Salvia kronenburgii. The structures of the new triterpenes were established as 1beta,2alpha-dihydroxy-3beta-acetoxy-11-oxours-12-ene (1), 2alpha,20beta-dihydroxy-3beta-acetoxyurs-9(11),12-diene (2), and 1beta,2alpha-dihydroxy-3beta-acetoxyurs-9(11),12-diene (3) on the basis of spectral analyses, including 1D and 2D NMR and mass spectroscopy. It is probable that compounds 2 and 3 are artifacts from dehydration of the corresponding allylic alcohols. 1beta,2alpha,3beta,11alpha-Tetrahydroxyurs-12-ene (5), the most abundant compound in the extract, was found to be highly cytotoxic to renal, non-small cell lung, and breast cancer cell lines.
Acetone and methanol extracts of the fruits of Pistacia terebinthus L. subsp. terebinthus L. were... more Acetone and methanol extracts of the fruits of Pistacia terebinthus L. subsp. terebinthus L. were studied for their antioxidant activity by investigating their total phenolic and flavonoid contents, β-carotene bleaching potential, DPPH radical scavenging effect, scavenging ...
Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to ... more Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to isolation of two new diterpenes, 7-hydroxy-12-methoxy-20-nor-abieta-1,5(10),7,9,12-pentaen-6,14-dione and abieta-8,12-dien-11,14-dione (12-deoxy-royleanone), together with oleanolic acid, ursolic acid, ferruginol, inuroyoleanol and cryptanol. Their structures were determined spectroscopically, which included HREIMS and 2D NMR spectroscopic analysis. The new abietane derivatives showed appreciable in vitro antileishmanial activity against intracellular amastigote forms
Prangos platychlaena has been used in traditional medicine in eastern Turkey. It stops bleeding a... more Prangos platychlaena has been used in traditional medicine in eastern Turkey. It stops bleeding and heals the scars when applied externally. When the isolated coumarins were tested against bacterial strains, only a slight activity was obtained.
... Short Report. Terpenoids from Salvia palaestina. Ayhan Ulubelen, Mahmut Miski, Candan Johanss... more ... Short Report. Terpenoids from Salvia palaestina. Ayhan Ulubelen, Mahmut Miski, Candan Johansson, Esther Lee a , Tom J. Mabry a and Stephen A. Matlin b. ... 44 (1981), p. 119. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (3). HJ Nicholas J. Am. Pharm. ...
ABSTRACT A new hetisine-type diterpene alkaloid, venudelphine [1], was isolated from the pH 12 fr... more ABSTRACT A new hetisine-type diterpene alkaloid, venudelphine [1], was isolated from the pH 12 fraction of Delphinium venulosum (Ranunculaceae) in addition to previously isolated alkaloids. The structure of venudelphine was established by spectral data.
Http Dx Doi Org 10 1080 10575630108041297, Oct 4, 2006
From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxy... more From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 microg/ml) against S. aureus and (MIC 18 microg/ml) against S. epidermidis as well as against B. subtilis (MIC 9 microg/ml).
... 7,4'-dirnethyl ether gave a purple color on tlc plates over uv m-ith and wit... more ... 7,4'-dirnethyl ether gave a purple color on tlc plates over uv m-ith and without ammonia: furthermore, spraying with SA reagent also did not change this color. These color tests indicated that the B-ring did not contain any free hrdroxyl groups. The uv spectrum nith NaOlIe gave a ...
The three new triterpenes (1-3) and five known triterpenes and a sterol were isolated from the ac... more The three new triterpenes (1-3) and five known triterpenes and a sterol were isolated from the acetone extract of a Turkish collection of Salvia kronenburgii. The structures of the new triterpenes were established as 1beta,2alpha-dihydroxy-3beta-acetoxy-11-oxours-12-ene (1), 2alpha,20beta-dihydroxy-3beta-acetoxyurs-9(11),12-diene (2), and 1beta,2alpha-dihydroxy-3beta-acetoxyurs-9(11),12-diene (3) on the basis of spectral analyses, including 1D and 2D NMR and mass spectroscopy. It is probable that compounds 2 and 3 are artifacts from dehydration of the corresponding allylic alcohols. 1beta,2alpha,3beta,11alpha-Tetrahydroxyurs-12-ene (5), the most abundant compound in the extract, was found to be highly cytotoxic to renal, non-small cell lung, and breast cancer cell lines.
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