Gene transfer to the salivary glands holds the potential for the therapy of salivary gland disord... more Gene transfer to the salivary glands holds the potential for the therapy of salivary gland disorders and for delivery of therapeutic proteins to the mouth and upper gastrointestinal tract. Administration of the recombinant adenovirus vectors Ad.RSV beta gal [coding for the intracellular protein beta-galactosidase (beta-Gal)] and Ad alpha 1AT [coding for human alpha 1-antitrypsin (alpha 1-AT), a secreted protein] to salivary gland cell lines in vitro demonstrated exogenous gene expression. Retrograde ductal injection of the Ad.RSV beta gal vector to rat salivary glands in vivo resulted in beta-Gal expression in acinar and ductal cells. Exposure of submandibular glands in vivo to Ad alpha 1AT resulted in expression of alpha 1-AT mRNA transcripts, de novo synthesis of alpha 1-AT, and secretion in the saliva. To evaluate the feasibility of adenovirus-mediated gene transfer to human glands, human minor salivary glands were infected ex vivo with Ad.RSV beta gal, and implanted into severe combined immunodeficient mice. Evaluation of the human tissue demonstrated beta-Gal activity. These observations demonstrate that adenovirus vectors are capable of direct delivery of genes to the salivary glands, suggesting a variety of possible gene therapy applications.
The International journal of oral & maxillofacial implants
The objective of this study was to assess the accuracy of the model-based NobelGuide method in tr... more The objective of this study was to assess the accuracy of the model-based NobelGuide method in transferring preoperative planning and estimation of bone volume to the surgical situation. Thirteen implant replicas were placed in bounded edentulous spaces in nine human cadavers. Highly restrictive guides were fabricated using preoperative bone mapping data. A stone cast was modified to represent the bone contours at the implant site. Postoperative impressions were taken for comparison with the planning cast that had been used to generate the guides. Mucoperiosteal flaps were raised over each implant site, and the areas were inspected for fenestrations, thread exposures, or dehiscences. A coordinate measuring device was used to obtain positional and angular information from each implant placed in the planned and postsurgical casts. These were compared and analyzed for clinical and statistical significance. The median value for linear accuracy in three dimensions for the model-based NobelGuide was 0.48 mm and the median angular deviation was 2.88 degrees. The greatest measured errors were still within clinically acceptable limits. The bone mapping was of sufficient diagnostic value for implant placement in sites with sufficient bone volume (greater than 5 mm buccolingually). In sites with insufficient bone volume, dehiscences were seen, but the accuracy was independent of bone volume. The use of the model-based NobelGuide encourages adherence to the restorative-driven approach. The accuracy of the method is within acceptable limits for guided surgery described in the literature, and the use of the bone mapping is satisfactory in cases with adequate bone volume. The technique can also be used in sites with insufficient bone volume, but a mucoperiosteal flap procedure is recommended. Int J Oral Maxillofac Implants 2010;25:999-1006.
toxigenic Clostridium difficile is responsible for a spectrum of disease severity ranging from mi... more toxigenic Clostridium difficile is responsible for a spectrum of disease severity ranging from mild diarrhoea to fulminant colitis. This study attempts to determine the proportion of patients in each category of severity and evaluate the risk factors for a more prolonged and complicated course. prospective cohort study. university teaching hospital. all patients with symptomatic C. difficile infection during 4 months of an outbreak (January-April 1995); n=73; median age 74 years (range 17-91). incidence of C. difficile-associated disease (CDAD); severity of disease; percentage of patients in each category of severity; risk factors for severe disease/prolonged symptoms (univariate and multivariable analyses). the incidence of CDAD was 0.93%. Of the cases identified, 18 (24.7%) had mild, self-limiting disease; 26 (35.6%) had moderately severe disease; 23 (31.5%) had prolonged symptoms and six (8.2%) had a complicated course. Although CDAD was more common in older patients (P < 0.00...
The International journal of oral & maxillofacial implants
To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in pat... more To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in patients treated with implant-supported overdentures and complete implant fixed prostheses. From a database of patients who had undergone implant treatment over a 6-year period, a study population of 62 patients was identified; every patient had at least four implants placed in one edentulous arch and was restored with either an overdenture or a fixed prosthesis. Patients were examined and a self-administered, structured multiple-response questionnaire, including the Oral Health Impact Profile-14 measurement tool and a patient satisfaction survey, was used to evaluate patient-centered treatment outcomes. Generally, patient satisfaction was very high in both the implant overdenture and fixed prosthesis groups, although the subjects in the overdenture group, who had mostly maxillary prostheses, reported significantly lower overall satisfaction and lower satisfaction with chewing capacity and ...
Objectives: To determine if the severity of the oral condition in edentulous patients was a predi... more Objectives: To determine if the severity of the oral condition in edentulous patients was a predictor of oral health related quality of life, denture satisfaction and nutritional status. Second, whether response to treatment was related to the severity of the edentulous state. Methods: 46 edentulous patients, seeking new dentures, were recruited (14 men and 32 women), aged 49-91 years (mean 71±10). Patients were classified according to the degree that their oral condition was compromised using an objective measure, the Prosthodontic Diagnostic Index (PDI). Group 1 consisted of patients in PDI class I&II (less compromised, n=20) ;Group 2 were patients in PDI class III&IV (more compromised, n=26). Subjects completed the OHIP-Edent, Denture Satisfaction Questionnaire (DSQ) and Mini-Nutritional Analysis Short Form (MNA-SF). 22 patients were re-tested following complete denture treatment. Results: There were no significant differences in OHIP-Edent, total denture satisfaction and nutriti...
During extensive prosthodontic treatment, the use of an accurately adjusted articulator is recomm... more During extensive prosthodontic treatment, the use of an accurately adjusted articulator is recommended to simulate mandibular movements. This clinical study was undertaken to assess any possible effect of the underlying skeletal pattern on programming articulator settings. Subjects (n = 73, mean age: 22.8 ± 6.8 years) were recruited from a dental school and two regional specialist orthodontic units. Subjects were allocated into groups based on their underlying sagittal (I, II, or III) and vertical (reduced, average, or increased) skeletal patterns by three orthodontists and three prosthodontists who examined their profile photographs. Electronic pantographic recordings were made of each subject using the Cadiax Compact system to record the sagittal condylar inclination (SCI), progressive mandibular lateral translation (PMLT), and immediate mandibular lateral translation (IMLT). Agreement between assessors for sagittal skeletal pattern classification was excellent (97% for total or g...
Little has been reported about the demographics of implant placement in the Irish population and ... more Little has been reported about the demographics of implant placement in the Irish population and the complications that occur. This is important in terms of service planning and providing patient information. The purpose of this study was to construct a database of patients who had implants placed in the Dublin Dental School et Hospital from 2000 to 2006. Also, we wanted to compare the complications that occurred in patients who had overdentures to those with a fixed prosthesis. Hospital records were searched for all patients who had implants placed over a seven-year period and we recorded demographic information, as well as details of the implant site, implant type and restoration. Patients who had four or more implants placed for an implant-supported overdenture or fixed prosthesis were invited to attend for a clinical examination. A total of 1,111 implants were placed in 452 patients over the study period--half of the implants supported single crowns, while the other half support...
The International journal of oral & maxillofacial implants
Radiographs are commonly used to assess the fit of implant components, but there is no clear agre... more Radiographs are commonly used to assess the fit of implant components, but there is no clear agreement on the amount of misfit that can be detected by this method. This study investigated the effect of gap size and the relative angle at which a radiograph was taken on the detection of component misfit. Different types of implant connections (internal or external) and radiographic modalities (film or digital) were assessed. Twelve internal-connection and 12 external-connection implant analogs with impression copings were assembled, with radiolucent washers interposed, to produce vertical misfits of 0, 12.7, 25, 38, 51, 63, 76, 88, 102, 114, 127, and 190 μm. A custom-made positioning apparatus was used to obtain radiographs of the components at angulations between 0 and 35 degrees. The images were randomized, and three experienced examiners assessed whether a gap was visible at the interface. Their responses were compared to the actual status of the samples, and a probability model wa...
Technology and health care : official journal of the European Society for Engineering and Medicine, 2010
Technology and Health Care 18 (2010) 233243 233 DOI 10.3233/THC-2010-0586 IOS Press Biomaterials... more Technology and Health Care 18 (2010) 233243 233 DOI 10.3233/THC-2010-0586 IOS Press Biomaterials and Tissue Engineering Cellular and molecular biomechanics Veronica A. Campbell a,b,∗ and Brian O&#x27;Connell a,c ... [20] RJ Hendrickson, C. Cappadona, EN Yankah, JV ...
The Trp gene product has been proposed as a candidate protein for the store-operated Ca2+ channel... more The Trp gene product has been proposed as a candidate protein for the store-operated Ca2+ channel, but the Trp protein(s) has not been identified in any nonexcitable cell. We report here the cloning of a rat brain Trp1beta cDNA and detection and immunolocalization of the endogenous and expressed Trp1 protein. A 400-bp product, with >95% homology to mouse Trp1, was amplified from rat submandibular gland RNA. Rat-specific primers were used for cloning of a full-length rat brain Trp1beta cDNA (rTrp1), encoding a protein of 759 amino acids. Northern blot analysis demonstrated the transcript in several rat and mouse tissues. The peptide (amino acids 523-536) was used to generate a polyclonal antiserum. The affinity-purified antibody 1) immunoprecipitated human Trp1 (hTrp1) from transfected HEK-293 cells, 2) reacted with a protein of approximately 92 kDa, but not with hTrp3, in membranes of hTrp3-expressing HEK-293 cells, and 3) reacted with proteins of 92 and 56 kDa in human and rat b...
The internalization of DNA can be facilitated by adenovirus infection. Using the replication-defi... more The internalization of DNA can be facilitated by adenovirus infection. Using the replication-deficient adenovirus, Ad-dl312, and a plasmid-based firefly luciferase gene as a reporter, we have optimized the uptake and expression of DNA in rat submandibular glands in vivo. Luciferase expression is transient and peaked at approximately 18 h after infection. Luciferase activity increased with plasmid concentration and was greatest at 10(9) to 10(10) plaque-forming units of Ad-dl312 per gland. We next examined the expression in vivo of plasmids containing deletions of the glutamine/glutamic acid-rich protein (GRP-Ca isoform) gene upstream region linked to a chloramphenicol acetyltransferase (CAT) reporter. Constructs with 9.4, 6.3, and 2.7 kb and 17 base pairs of upstream sequence gave relative CAT activities of 100, 30, 7.6, and 38.5, respectively. With the 9.4-kb GRP-Ca construct, CAT was preferentially expressed in acinar cells, which is characteristic of GRP. This gene transfer appro...
This study was carried out to determine the prevalence, severity and pattern of hypodontia in Iri... more This study was carried out to determine the prevalence, severity and pattern of hypodontia in Irish patients referred to a tertiary care clinic for developmental dental disorders. Details of 168 patients with hypodontia referred during the period 2002-2006 were entered in a database designed as a national record. Tooth charting was completed using clinical and radiographic examinations. The age of patients ranged from 7-50 years, with a median age of 20 years (Mean: 21.79; SD: 8.005). Hypodontia referrals constituted 65.5% of the total referrals. Females were more commonly affected than males with a ratio of 1.3:1. The number of referrals reflected the population density in this area; the majority were referrals from the public dental service. Mandibular second premolars were the most commonly missing teeth, followed by maxillary second premolars and maxillary lateral incisors; maxillary central incisors were the least affected. Symmetry of tooth agenesis between the right and left ...
The International journal of oral & maxillofacial implants
To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in pat... more To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in patients treated with implant-supported overdentures and complete implant fixed prostheses. From a database of patients who had undergone implant treatment over a 6-year period, a study population of 62 patients was identified; every patient had at least four implants placed in one edentulous arch and was restored with either an overdenture or a fixed prosthesis. Patients were examined and a self-administered, structured multiple-response questionnaire, including the Oral Health Impact Profile-14 measurement tool and a patient satisfaction survey, was used to evaluate patient-centered treatment outcomes. Generally, patient satisfaction was very high in both the implant overdenture and fixed prosthesis groups, although the subjects in the overdenture group, who had mostly maxillary prostheses, reported significantly lower overall satisfaction and lower satisfaction with chewing capacity and ...
The International journal of oral & maxillofacial implants
The objective of this study was to assess the accuracy of the model-based NobelGuide method in tr... more The objective of this study was to assess the accuracy of the model-based NobelGuide method in transferring preoperative planning and estimation of bone volume to the surgical situation. Thirteen implant replicas were placed in bounded edentulous spaces in nine human cadavers. Highly restrictive guides were fabricated using preoperative bone mapping data. A stone cast was modified to represent the bone contours at the implant site. Postoperative impressions were taken for comparison with the planning cast that had been used to generate the guides. Mucoperiosteal flaps were raised over each implant site, and the areas were inspected for fenestrations, thread exposures, or dehiscences. A coordinate measuring device was used to obtain positional and angular information from each implant placed in the planned and postsurgical casts. These were compared and analyzed for clinical and statistical significance. The median value for linear accuracy in three dimensions for the model-based Nob...
Gene transfer to the salivary glands holds the potential for the therapy of salivary gland disord... more Gene transfer to the salivary glands holds the potential for the therapy of salivary gland disorders and for delivery of therapeutic proteins to the mouth and upper gastrointestinal tract. Administration of the recombinant adenovirus vectors Ad.RSV beta gal [coding for the intracellular protein beta-galactosidase (beta-Gal)] and Ad alpha 1AT [coding for human alpha 1-antitrypsin (alpha 1-AT), a secreted protein] to salivary gland cell lines in vitro demonstrated exogenous gene expression. Retrograde ductal injection of the Ad.RSV beta gal vector to rat salivary glands in vivo resulted in beta-Gal expression in acinar and ductal cells. Exposure of submandibular glands in vivo to Ad alpha 1AT resulted in expression of alpha 1-AT mRNA transcripts, de novo synthesis of alpha 1-AT, and secretion in the saliva. To evaluate the feasibility of adenovirus-mediated gene transfer to human glands, human minor salivary glands were infected ex vivo with Ad.RSV beta gal, and implanted into severe combined immunodeficient mice. Evaluation of the human tissue demonstrated beta-Gal activity. These observations demonstrate that adenovirus vectors are capable of direct delivery of genes to the salivary glands, suggesting a variety of possible gene therapy applications.
The International journal of oral & maxillofacial implants
The objective of this study was to assess the accuracy of the model-based NobelGuide method in tr... more The objective of this study was to assess the accuracy of the model-based NobelGuide method in transferring preoperative planning and estimation of bone volume to the surgical situation. Thirteen implant replicas were placed in bounded edentulous spaces in nine human cadavers. Highly restrictive guides were fabricated using preoperative bone mapping data. A stone cast was modified to represent the bone contours at the implant site. Postoperative impressions were taken for comparison with the planning cast that had been used to generate the guides. Mucoperiosteal flaps were raised over each implant site, and the areas were inspected for fenestrations, thread exposures, or dehiscences. A coordinate measuring device was used to obtain positional and angular information from each implant placed in the planned and postsurgical casts. These were compared and analyzed for clinical and statistical significance. The median value for linear accuracy in three dimensions for the model-based NobelGuide was 0.48 mm and the median angular deviation was 2.88 degrees. The greatest measured errors were still within clinically acceptable limits. The bone mapping was of sufficient diagnostic value for implant placement in sites with sufficient bone volume (greater than 5 mm buccolingually). In sites with insufficient bone volume, dehiscences were seen, but the accuracy was independent of bone volume. The use of the model-based NobelGuide encourages adherence to the restorative-driven approach. The accuracy of the method is within acceptable limits for guided surgery described in the literature, and the use of the bone mapping is satisfactory in cases with adequate bone volume. The technique can also be used in sites with insufficient bone volume, but a mucoperiosteal flap procedure is recommended. Int J Oral Maxillofac Implants 2010;25:999-1006.
toxigenic Clostridium difficile is responsible for a spectrum of disease severity ranging from mi... more toxigenic Clostridium difficile is responsible for a spectrum of disease severity ranging from mild diarrhoea to fulminant colitis. This study attempts to determine the proportion of patients in each category of severity and evaluate the risk factors for a more prolonged and complicated course. prospective cohort study. university teaching hospital. all patients with symptomatic C. difficile infection during 4 months of an outbreak (January-April 1995); n=73; median age 74 years (range 17-91). incidence of C. difficile-associated disease (CDAD); severity of disease; percentage of patients in each category of severity; risk factors for severe disease/prolonged symptoms (univariate and multivariable analyses). the incidence of CDAD was 0.93%. Of the cases identified, 18 (24.7%) had mild, self-limiting disease; 26 (35.6%) had moderately severe disease; 23 (31.5%) had prolonged symptoms and six (8.2%) had a complicated course. Although CDAD was more common in older patients (P < 0.00...
The International journal of oral & maxillofacial implants
To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in pat... more To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in patients treated with implant-supported overdentures and complete implant fixed prostheses. From a database of patients who had undergone implant treatment over a 6-year period, a study population of 62 patients was identified; every patient had at least four implants placed in one edentulous arch and was restored with either an overdenture or a fixed prosthesis. Patients were examined and a self-administered, structured multiple-response questionnaire, including the Oral Health Impact Profile-14 measurement tool and a patient satisfaction survey, was used to evaluate patient-centered treatment outcomes. Generally, patient satisfaction was very high in both the implant overdenture and fixed prosthesis groups, although the subjects in the overdenture group, who had mostly maxillary prostheses, reported significantly lower overall satisfaction and lower satisfaction with chewing capacity and ...
Objectives: To determine if the severity of the oral condition in edentulous patients was a predi... more Objectives: To determine if the severity of the oral condition in edentulous patients was a predictor of oral health related quality of life, denture satisfaction and nutritional status. Second, whether response to treatment was related to the severity of the edentulous state. Methods: 46 edentulous patients, seeking new dentures, were recruited (14 men and 32 women), aged 49-91 years (mean 71±10). Patients were classified according to the degree that their oral condition was compromised using an objective measure, the Prosthodontic Diagnostic Index (PDI). Group 1 consisted of patients in PDI class I&II (less compromised, n=20) ;Group 2 were patients in PDI class III&IV (more compromised, n=26). Subjects completed the OHIP-Edent, Denture Satisfaction Questionnaire (DSQ) and Mini-Nutritional Analysis Short Form (MNA-SF). 22 patients were re-tested following complete denture treatment. Results: There were no significant differences in OHIP-Edent, total denture satisfaction and nutriti...
During extensive prosthodontic treatment, the use of an accurately adjusted articulator is recomm... more During extensive prosthodontic treatment, the use of an accurately adjusted articulator is recommended to simulate mandibular movements. This clinical study was undertaken to assess any possible effect of the underlying skeletal pattern on programming articulator settings. Subjects (n = 73, mean age: 22.8 ± 6.8 years) were recruited from a dental school and two regional specialist orthodontic units. Subjects were allocated into groups based on their underlying sagittal (I, II, or III) and vertical (reduced, average, or increased) skeletal patterns by three orthodontists and three prosthodontists who examined their profile photographs. Electronic pantographic recordings were made of each subject using the Cadiax Compact system to record the sagittal condylar inclination (SCI), progressive mandibular lateral translation (PMLT), and immediate mandibular lateral translation (IMLT). Agreement between assessors for sagittal skeletal pattern classification was excellent (97% for total or g...
Little has been reported about the demographics of implant placement in the Irish population and ... more Little has been reported about the demographics of implant placement in the Irish population and the complications that occur. This is important in terms of service planning and providing patient information. The purpose of this study was to construct a database of patients who had implants placed in the Dublin Dental School et Hospital from 2000 to 2006. Also, we wanted to compare the complications that occurred in patients who had overdentures to those with a fixed prosthesis. Hospital records were searched for all patients who had implants placed over a seven-year period and we recorded demographic information, as well as details of the implant site, implant type and restoration. Patients who had four or more implants placed for an implant-supported overdenture or fixed prosthesis were invited to attend for a clinical examination. A total of 1,111 implants were placed in 452 patients over the study period--half of the implants supported single crowns, while the other half support...
The International journal of oral & maxillofacial implants
Radiographs are commonly used to assess the fit of implant components, but there is no clear agre... more Radiographs are commonly used to assess the fit of implant components, but there is no clear agreement on the amount of misfit that can be detected by this method. This study investigated the effect of gap size and the relative angle at which a radiograph was taken on the detection of component misfit. Different types of implant connections (internal or external) and radiographic modalities (film or digital) were assessed. Twelve internal-connection and 12 external-connection implant analogs with impression copings were assembled, with radiolucent washers interposed, to produce vertical misfits of 0, 12.7, 25, 38, 51, 63, 76, 88, 102, 114, 127, and 190 μm. A custom-made positioning apparatus was used to obtain radiographs of the components at angulations between 0 and 35 degrees. The images were randomized, and three experienced examiners assessed whether a gap was visible at the interface. Their responses were compared to the actual status of the samples, and a probability model wa...
Technology and health care : official journal of the European Society for Engineering and Medicine, 2010
Technology and Health Care 18 (2010) 233243 233 DOI 10.3233/THC-2010-0586 IOS Press Biomaterials... more Technology and Health Care 18 (2010) 233243 233 DOI 10.3233/THC-2010-0586 IOS Press Biomaterials and Tissue Engineering Cellular and molecular biomechanics Veronica A. Campbell a,b,∗ and Brian O&#x27;Connell a,c ... [20] RJ Hendrickson, C. Cappadona, EN Yankah, JV ...
The Trp gene product has been proposed as a candidate protein for the store-operated Ca2+ channel... more The Trp gene product has been proposed as a candidate protein for the store-operated Ca2+ channel, but the Trp protein(s) has not been identified in any nonexcitable cell. We report here the cloning of a rat brain Trp1beta cDNA and detection and immunolocalization of the endogenous and expressed Trp1 protein. A 400-bp product, with >95% homology to mouse Trp1, was amplified from rat submandibular gland RNA. Rat-specific primers were used for cloning of a full-length rat brain Trp1beta cDNA (rTrp1), encoding a protein of 759 amino acids. Northern blot analysis demonstrated the transcript in several rat and mouse tissues. The peptide (amino acids 523-536) was used to generate a polyclonal antiserum. The affinity-purified antibody 1) immunoprecipitated human Trp1 (hTrp1) from transfected HEK-293 cells, 2) reacted with a protein of approximately 92 kDa, but not with hTrp3, in membranes of hTrp3-expressing HEK-293 cells, and 3) reacted with proteins of 92 and 56 kDa in human and rat b...
The internalization of DNA can be facilitated by adenovirus infection. Using the replication-defi... more The internalization of DNA can be facilitated by adenovirus infection. Using the replication-deficient adenovirus, Ad-dl312, and a plasmid-based firefly luciferase gene as a reporter, we have optimized the uptake and expression of DNA in rat submandibular glands in vivo. Luciferase expression is transient and peaked at approximately 18 h after infection. Luciferase activity increased with plasmid concentration and was greatest at 10(9) to 10(10) plaque-forming units of Ad-dl312 per gland. We next examined the expression in vivo of plasmids containing deletions of the glutamine/glutamic acid-rich protein (GRP-Ca isoform) gene upstream region linked to a chloramphenicol acetyltransferase (CAT) reporter. Constructs with 9.4, 6.3, and 2.7 kb and 17 base pairs of upstream sequence gave relative CAT activities of 100, 30, 7.6, and 38.5, respectively. With the 9.4-kb GRP-Ca construct, CAT was preferentially expressed in acinar cells, which is characteristic of GRP. This gene transfer appro...
This study was carried out to determine the prevalence, severity and pattern of hypodontia in Iri... more This study was carried out to determine the prevalence, severity and pattern of hypodontia in Irish patients referred to a tertiary care clinic for developmental dental disorders. Details of 168 patients with hypodontia referred during the period 2002-2006 were entered in a database designed as a national record. Tooth charting was completed using clinical and radiographic examinations. The age of patients ranged from 7-50 years, with a median age of 20 years (Mean: 21.79; SD: 8.005). Hypodontia referrals constituted 65.5% of the total referrals. Females were more commonly affected than males with a ratio of 1.3:1. The number of referrals reflected the population density in this area; the majority were referrals from the public dental service. Mandibular second premolars were the most commonly missing teeth, followed by maxillary second premolars and maxillary lateral incisors; maxillary central incisors were the least affected. Symmetry of tooth agenesis between the right and left ...
The International journal of oral & maxillofacial implants
To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in pat... more To assess and compare patient satisfaction and oral health-related quality of life (OHQOL) in patients treated with implant-supported overdentures and complete implant fixed prostheses. From a database of patients who had undergone implant treatment over a 6-year period, a study population of 62 patients was identified; every patient had at least four implants placed in one edentulous arch and was restored with either an overdenture or a fixed prosthesis. Patients were examined and a self-administered, structured multiple-response questionnaire, including the Oral Health Impact Profile-14 measurement tool and a patient satisfaction survey, was used to evaluate patient-centered treatment outcomes. Generally, patient satisfaction was very high in both the implant overdenture and fixed prosthesis groups, although the subjects in the overdenture group, who had mostly maxillary prostheses, reported significantly lower overall satisfaction and lower satisfaction with chewing capacity and ...
The International journal of oral & maxillofacial implants
The objective of this study was to assess the accuracy of the model-based NobelGuide method in tr... more The objective of this study was to assess the accuracy of the model-based NobelGuide method in transferring preoperative planning and estimation of bone volume to the surgical situation. Thirteen implant replicas were placed in bounded edentulous spaces in nine human cadavers. Highly restrictive guides were fabricated using preoperative bone mapping data. A stone cast was modified to represent the bone contours at the implant site. Postoperative impressions were taken for comparison with the planning cast that had been used to generate the guides. Mucoperiosteal flaps were raised over each implant site, and the areas were inspected for fenestrations, thread exposures, or dehiscences. A coordinate measuring device was used to obtain positional and angular information from each implant placed in the planned and postsurgical casts. These were compared and analyzed for clinical and statistical significance. The median value for linear accuracy in three dimensions for the model-based Nob...
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Papers by Brian O'Connell