Sea surface topography from TOPEX/Poseidon and ERS satellites, SST images derived from advanced v... more Sea surface topography from TOPEX/Poseidon and ERS satellites, SST images derived from advanced very high resolution radiometer (AVHRR) sensors, and conductivity-temperature-depth (CTD) data collected during an oceanographic survey are examined to investigate an intense mesoscale anticyclonic eddy observed at the northern boundary of the Balearic Sea (western Mediterranean). This eddy, which constitutes the strongest signal detected in the Balearic basin since altimetric data are available, appeared in September 1998 to the northwest of Menorca Island and remained almost in the same location until its disappearance in March 1999. The paper focuses mainly on identifying the conditions that led to the eddy formation and on the description of its evolution and sudden disappearance. Derived variables such as geostrophic velocity or vorticity are computed to complement the hydrographic and dynamical information provided by observed variables. Also, meteorological data are examined related to the main hypothesis made for the origin of the eddy.
The efficacy of surgery in the postendoscopic management of low-risk malignant polyps is unclear.... more The efficacy of surgery in the postendoscopic management of low-risk malignant polyps is unclear. Although interobserver variability in the histological diagnosis was shown, its importance is unknown. The purpose of this study was to guide future research on the optimal strategy for low-risk polyps with the use of value-of-information analysis. A decision-analysis model was constructed comparing the strategies of referring or not referring (waiting) to surgery patients with low-risk polyps. Probabilistic sensitivity analysis was performed to explore the effect of uncertainty about the input parameters. Value-of-information analysis was used to estimate the expected benefit of future research that would eliminate the decision uncertainty. The number of postendoscopic surgeries to prevent 1 cancer-related death was 208. The incremental cost-effectiveness ratio of surgery vs waiting strategy was $215,291/life-year gained, surgery being a suboptimal choice in the reference case analysis. Probabilistic sensitivity analysis demonstrated that surgery was the optimal choice in 61% of the simulated scenarios. Most of the decision uncertainty was related with the combination of histological inaccuracy, prevalence of residual disease, and surgical mortality. The expected societal monetary benefit of further research from the perspective of the United States was estimated to be $1 billion. The small benefit and the relatively high costs associated with surgery argue against surgical referral for low-risk malignant polyps; however, when a suboptimal histopathological accuracy was simulated, surgery appeared to be the most cost-effective option, prompting the need for further research.
Open Waters Optical Remote Sensing of the Mediterranean Sea Rosalia Santoleri1, Gianluca Volpe1, ... more Open Waters Optical Remote Sensing of the Mediterranean Sea Rosalia Santoleri1, Gianluca Volpe1, Salvatore Marullo2, and 1 Bruno Buongiorno Nardelli 1 Istituto di Scienze dell'Atmosfera e del Clima (ISAC) 2Ente per le Nuove tecnologie l'Energia el ... 1998; Crispi et al. ...
Sea surface topography from TOPEX/Poseidon and ERS satellites, SST images derived from advanced v... more Sea surface topography from TOPEX/Poseidon and ERS satellites, SST images derived from advanced very high resolution radiometer (AVHRR) sensors, and conductivity-temperature-depth (CTD) data collected during an oceanographic survey are examined to investigate an intense mesoscale anticyclonic eddy observed at the northern boundary of the Balearic Sea (western Mediterranean). This eddy, which constitutes the strongest signal detected in the Balearic basin since altimetric data are available, appeared in September 1998 to the northwest of Menorca Island and remained almost in the same location until its disappearance in March 1999. The paper focuses mainly on identifying the conditions that led to the eddy formation and on the description of its evolution and sudden disappearance. Derived variables such as geostrophic velocity or vorticity are computed to complement the hydrographic and dynamical information provided by observed variables. Also, meteorological data are examined related to the main hypothesis made for the origin of the eddy.
The efficacy of surgery in the postendoscopic management of low-risk malignant polyps is unclear.... more The efficacy of surgery in the postendoscopic management of low-risk malignant polyps is unclear. Although interobserver variability in the histological diagnosis was shown, its importance is unknown. The purpose of this study was to guide future research on the optimal strategy for low-risk polyps with the use of value-of-information analysis. A decision-analysis model was constructed comparing the strategies of referring or not referring (waiting) to surgery patients with low-risk polyps. Probabilistic sensitivity analysis was performed to explore the effect of uncertainty about the input parameters. Value-of-information analysis was used to estimate the expected benefit of future research that would eliminate the decision uncertainty. The number of postendoscopic surgeries to prevent 1 cancer-related death was 208. The incremental cost-effectiveness ratio of surgery vs waiting strategy was $215,291/life-year gained, surgery being a suboptimal choice in the reference case analysis. Probabilistic sensitivity analysis demonstrated that surgery was the optimal choice in 61% of the simulated scenarios. Most of the decision uncertainty was related with the combination of histological inaccuracy, prevalence of residual disease, and surgical mortality. The expected societal monetary benefit of further research from the perspective of the United States was estimated to be $1 billion. The small benefit and the relatively high costs associated with surgery argue against surgical referral for low-risk malignant polyps; however, when a suboptimal histopathological accuracy was simulated, surgery appeared to be the most cost-effective option, prompting the need for further research.
Open Waters Optical Remote Sensing of the Mediterranean Sea Rosalia Santoleri1, Gianluca Volpe1, ... more Open Waters Optical Remote Sensing of the Mediterranean Sea Rosalia Santoleri1, Gianluca Volpe1, Salvatore Marullo2, and 1 Bruno Buongiorno Nardelli 1 Istituto di Scienze dell'Atmosfera e del Clima (ISAC) 2Ente per le Nuove tecnologie l'Energia el ... 1998; Crispi et al. ...
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