Research Interests: Photosynthesis, Plant Biology, Biology, Soil moisture, Water Stress, and 12 moreAbscisic Acid, Aqueous Solution, Gibberellic Acid, Adenosine Triphosphate, Field capacity, Soil moisture content, Shoot, Indole Acetic Acid, Gossypium hirsutum L., Nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and Growth Regulator
Citronella oil is one of the essential oils obtained from Cymbopogon sp. having medicinally important aromatic chemicals (like citronellal, citronellol, hydroxy-citronellol and geraniol) exhibiting insecticidal, anti-oxidant and... more
Citronella oil is one of the essential oils obtained from Cymbopogon sp. having medicinally important aromatic chemicals (like citronellal, citronellol, hydroxy-citronellol and geraniol) exhibiting insecticidal, anti-oxidant and anti-inflammatory effects. Geraniol Dehydrogenase (GDH) is responsible for the degradation of Citronella oil. Therefore, we aimed to generate 3D structure of GDH and a potent specific GDH inhibitor by homology modelling, virtual screening of ligand database and molecular docking. Inhibitor model indicated strong binding affinity to the binding pocket of GDH and varying affinity for different ligands. Obtained structures will open the possibility of testing new inhibitor families, in addition to new substituent for the already known lead structures.
Research Interests: Biochemistry, Bioinformatics, Computer Science, Chemistry, Computational Biology, and 13 moreComputer Aided Design, Enzyme Inhibitors, Medicine, Next generation sequencing, Biological Sciences, Drug Design, Docking, Cymbopogon Citratus, MODELLER, Protein Binding, Ligands, Plant Oils, and Medical and Health Sciences
MicroRNAs (miRNAs) regulate gene expression mainly by post-transcriptional gene silencing (PTGS) and in some cases by transcriptional genes silencing (TGS). miRNAs play critical roles in developmental processes, nutrient homeostasis,... more
MicroRNAs (miRNAs) regulate gene expression mainly by post-transcriptional gene silencing (PTGS) and in some cases by transcriptional genes silencing (TGS). miRNAs play critical roles in developmental processes, nutrient homeostasis, abiotic stress and ...