•
J. theor. Biol. (1981) 93, 53-62A New Approach to Microtubule DepolymerizationDANIEL RIPOLL, EZIO MARCHI AND JULIO BENEGASFacultad de Ciencias Fisico-Matemdticas y Naturales, Universidad Nacional de San Luis 5700 San Luis,... more
J. theor. Biol. (1981) 93, 53-62A New Approach to Microtubule DepolymerizationDANIEL RIPOLL, EZIO MARCHI AND JULIO BENEGASFacultad de Ciencias Fisico-Matemdticas y Naturales, Universidad Nacional de San Luis 5700 San Luis, Argentina(Received 29 ...
Publisher: Elsevier BV
Publication Date: 1981
Publication Name: Journal of Theoretical Biology
Research Interests:
•
by D. Ripoll
Publisher: Wiley-Blackwell
Publication Date: 1996
Publication Name: FEBS Letters
Research Interests: Molecular Dynamics, Computer Simulation, Kidney, Mutation, Animals, and 15 moreAcetylcholinesterase, Acetylcholine, Enzyme, Active site, Protein Conformation, Base Sequence, MPT, Recombinant Proteins, Molecular Dynamic Simulation, Binding Site, Catalytic Activity, Biochemistry and cell biology, ACH, Molecular Sequence Data, and binding sites
•
Publication Date: 2011
Publication Name: Infection, Genetics and Evolution
Research Interests:
•
by Sidhartha Chaudhury and D. Ripoll
Glycans attached to the cell surface via proteins or lipids or exposed in the extracellular matrix affect many cellular processes, including neuritogenesis, cell survival and migration, as well as synaptic activity and plasticity. These... more
Glycans attached to the cell surface via proteins or lipids or exposed in the extracellular matrix affect many cellular processes, including neuritogenesis, cell survival and migration, as well as synaptic activity and plasticity. These functions make glycans attractive molecules for stimulating repair of the injured nervous system. Yet, glycans are often difficult to synthesize or isolate and have the disadvantage to be unstable in a complex tissue environment. To circumvent these issues, we have screened a library of small organic compounds to search for structural and functional mimetics of the neurostimulatory glycan polysialic acid (PSA) and identified the 5-HT4 receptor agonist tegaserod as a PSA mimetic. The PSA mimicking activity of tegaserod was shown in cultures of central and peripheral nervous system cells of the mouse and found to be independent of its described function as a serotonin (5-HT4) receptor agonist. In an in vivo model for peripheral nerve regeneration, mice receiving tegaserod at the site of injury showed enhanced recovery compared to control mice receiving vehicle control as evidenced by functional measurements and histology. These data indicate that tegaserod could be repurposed for treatment of nervous system injuries and underscores the potential of using small molecules as mimetics of neurostimulatory glycans.
Publication Date: 2014
Publication Name: Neuropharmacology
Research Interests:
•
Tracing the Origin of the Fungal α1 Domain Places Its Ancestor in the HMG-Box Superfamily: Implication for Fungal Mating-Type Evolutionmore
by Christina Dixelius and D. Ripoll