... International Journal of Pharmaceutics 1(151), 7580 (1997) 2. Informa: PAT - Quality by desi... more ... International Journal of Pharmaceutics 1(151), 7580 (1997) 2. Informa: PAT - Quality by design and process improvement, Amsterdam (2007) 3. Juran, J ... 4(4) (2003) 8. Belic, A., Zupancic, D., krjanc, I., Vrecer, F., Karba, R.: Artificial neural networks for optimisation of tablet ...
The effect of dry granulation (roller compaction and slugging) on compactibility and tablet cappi... more The effect of dry granulation (roller compaction and slugging) on compactibility and tablet capping tendency in a formulation with macrolide antibiotic and microcrystalline cellulose (MCC) was investigated. Direct tableting of this formulation revealed a pronounced capping tendency. Both dry granulated systems exhibit better compactibility and significant reductions in capping tendency compared to direct tableting. The capping tendency was also reduced through the use of precompression during direct tableting. The main volume reduction mechanism for macrolide antibiotic is fragmentation; this was confirmed by Heckel analysis, the lubricant sensitivity test, and SEM images. The yield pressure (Py) of the direct tableting system is lower than the Py of dry granulated systems, which indicates the lower plasticity of dry granulated systems. These findings do not explain the lower capping tendency of dry granulated systems compared to direct tableting. The main differentiating bonding mechanism is attributed to long distance intermolecular bonds due to the intense amorphization of macrolide antibiotic that occurs during dry granulation. Amorphization leads to a significant increase in surface free energy and consequently stronger long distance bonding between particles, which can withstand elastic relaxation and therefore reduce the capping problem. Solid bridges probably do not make a notable contribution to the mechanical strength of tablets, due to the brittle nature of the particles and the complex molecular structure of macrolide antibiotic.
The effect of dry granulation (roller compaction and slugging) on compactibility and tablet cappi... more The effect of dry granulation (roller compaction and slugging) on compactibility and tablet capping tendency in a formulation with macrolide antibiotic and microcrystalline cellulose (MCC) was investigated. Direct tableting of this formulation revealed a pronounced capping tendency. Both dry granulated systems exhibit better compactibility and significant reductions in capping tendency compared to direct tableting. The capping tendency was also reduced through the use of precompression during direct tableting. The main volume reduction mechanism for macrolide antibiotic is fragmentation; this was confirmed by Heckel analysis, the lubricant sensitivity test, and SEM images. The yield pressure (Py) of the direct tableting system is lower than the Py of dry granulated systems, which indicates the lower plasticity of dry granulated systems. These findings do not explain the lower capping tendency of dry granulated systems compared to direct tableting. The main differentiating bonding mechanism is attributed to long distance intermolecular bonds due to the intense amorphization of macrolide antibiotic that occurs during dry granulation. Amorphization leads to a significant increase in surface free energy and consequently stronger long distance bonding between particles, which can withstand elastic relaxation and therefore reduce the capping problem. Solid bridges probably do not make a notable contribution to the mechanical strength of tablets, due to the brittle nature of the particles and the complex molecular structure of macrolide antibiotic.
... a KRKA dd, Novo mesto, Pharmaceutical Production Division, Smarjeska cesta 6, 8501 Novo mesto... more ... a KRKA dd, Novo mesto, Pharmaceutical Production Division, Smarjeska cesta 6, 8501 Novo mesto, Slovenia. b KRKA dd, Novo mesto, R and D Division, Smarjeska cesta 6, 8501 Novo mesto, Slovenia. c University in Ljubljana ...
... International Journal of Pharmaceutics 1(151), 7580 (1997) 2. Informa: PAT - Quality by desi... more ... International Journal of Pharmaceutics 1(151), 7580 (1997) 2. Informa: PAT - Quality by design and process improvement, Amsterdam (2007) 3. Juran, J ... 4(4) (2003) 8. Belic, A., Zupancic, D., krjanc, I., Vrecer, F., Karba, R.: Artificial neural networks for optimisation of tablet ...
The effect of dry granulation (roller compaction and slugging) on compactibility and tablet cappi... more The effect of dry granulation (roller compaction and slugging) on compactibility and tablet capping tendency in a formulation with macrolide antibiotic and microcrystalline cellulose (MCC) was investigated. Direct tableting of this formulation revealed a pronounced capping tendency. Both dry granulated systems exhibit better compactibility and significant reductions in capping tendency compared to direct tableting. The capping tendency was also reduced through the use of precompression during direct tableting. The main volume reduction mechanism for macrolide antibiotic is fragmentation; this was confirmed by Heckel analysis, the lubricant sensitivity test, and SEM images. The yield pressure (Py) of the direct tableting system is lower than the Py of dry granulated systems, which indicates the lower plasticity of dry granulated systems. These findings do not explain the lower capping tendency of dry granulated systems compared to direct tableting. The main differentiating bonding mechanism is attributed to long distance intermolecular bonds due to the intense amorphization of macrolide antibiotic that occurs during dry granulation. Amorphization leads to a significant increase in surface free energy and consequently stronger long distance bonding between particles, which can withstand elastic relaxation and therefore reduce the capping problem. Solid bridges probably do not make a notable contribution to the mechanical strength of tablets, due to the brittle nature of the particles and the complex molecular structure of macrolide antibiotic.
The effect of dry granulation (roller compaction and slugging) on compactibility and tablet cappi... more The effect of dry granulation (roller compaction and slugging) on compactibility and tablet capping tendency in a formulation with macrolide antibiotic and microcrystalline cellulose (MCC) was investigated. Direct tableting of this formulation revealed a pronounced capping tendency. Both dry granulated systems exhibit better compactibility and significant reductions in capping tendency compared to direct tableting. The capping tendency was also reduced through the use of precompression during direct tableting. The main volume reduction mechanism for macrolide antibiotic is fragmentation; this was confirmed by Heckel analysis, the lubricant sensitivity test, and SEM images. The yield pressure (Py) of the direct tableting system is lower than the Py of dry granulated systems, which indicates the lower plasticity of dry granulated systems. These findings do not explain the lower capping tendency of dry granulated systems compared to direct tableting. The main differentiating bonding mechanism is attributed to long distance intermolecular bonds due to the intense amorphization of macrolide antibiotic that occurs during dry granulation. Amorphization leads to a significant increase in surface free energy and consequently stronger long distance bonding between particles, which can withstand elastic relaxation and therefore reduce the capping problem. Solid bridges probably do not make a notable contribution to the mechanical strength of tablets, due to the brittle nature of the particles and the complex molecular structure of macrolide antibiotic.
... a KRKA dd, Novo mesto, Pharmaceutical Production Division, Smarjeska cesta 6, 8501 Novo mesto... more ... a KRKA dd, Novo mesto, Pharmaceutical Production Division, Smarjeska cesta 6, 8501 Novo mesto, Slovenia. b KRKA dd, Novo mesto, R and D Division, Smarjeska cesta 6, 8501 Novo mesto, Slovenia. c University in Ljubljana ...
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