Alcoholism, clinical and experimental research, 2016
Experimental studies investigating the impact of advertising with ecological stimuli on alcohol-r... more Experimental studies investigating the impact of advertising with ecological stimuli on alcohol-related cognition are scarce. This research investigated the cognitive processes involved in learning implicit attitudes toward alcohol after incidental exposure to alcohol advertisements presented in a dynamic context. We hypothesized that incidental exposure to a specific alcohol brand would lead to heightened positive implicit attitudes toward alcohol due to a mere exposure effect. In total, 108 participants were randomly exposed to dynamic sporting events excerpts with and without advertising for a specific brand of alcohol, after completing self-reported measures of alcohol-related expectancies, alcohol consumption, and attitudes toward sport. Participants then completed a lexical decision task and an affective priming task. We showed that participants were faster to detect brand name after being exposed to advertising during a sports game, and that implicit attitudes of participants...
Objective:Numerous studies have examined the impact of alcohol on violence; however, only a small... more Objective:Numerous studies have examined the impact of alcohol on violence; however, only a small number have addressed differences elicited by different doses of alcohol. Such studies are limited by mixed findings, small sample sizes, inconsistent alcohol doses and control conditions, a bias toward studying only male participants, and the predominant use of only one particular measure to assess aggression. The present laboratory investigation was designed to elucidate and advance this literature by improving on these limitations.Method:Participants were 187 (95 men and 92 women) social drinkers. Following the consumption of one of six alcohol doses (i.e., 0.0 g/kg, 0.125 g/kg, 0.25 g/kg, 0.5 g/kg, 0.75 g/kg, and 1.0 g/kg), participants were tested on a laboratory task in which electric shocks were received from and administered to a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the intensity and duration of shocks administered to one's “opponent.”Results:Analyses revealed a highly significant positive linear trend between alcohol dose and aggression for both genders.Conclusions:Our data aid in clarifying a body of literature that has been afflicted with numerous limitations and will help guide the selection of alcohol doses for researchers conducting future laboratory-based aggression studies.
Numerous studies have examined the impact of alcohol on violence; however, only a small number ha... more Numerous studies have examined the impact of alcohol on violence; however, only a small number have addressed differences elicited by different doses of alcohol. Such studies are limited by mixed findings, small sample sizes, inconsistent alcohol doses and control conditions, a bias toward studying only male participants, and the predominant use of only one particular measure to assess aggression. The present laboratory investigation was designed to elucidate and advance this literature by improving on these limitations. Participants were 187 (95 men and 92 women) social drinkers. Following the consumption of one of six alcohol doses (i.e., 0.0 g/kg, 0.125 g/kg, 0.25 g/kg, 0.5 g/kg, 0.75 g/kg, and 1.0 g/kg), participants were tested on a laboratory task in which electric shocks were received from and administered to a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the intensity and duration of shocks administered to one'...
The relative sensitivities of eight commonly used clinical chemistry end points and histopatholog... more The relative sensitivities of eight commonly used clinical chemistry end points and histopathology to detect potential toxic effects in liver and kidney were evaluated for a series of 61 13-week rat toxicity studies conducted for the National Toxicology Program. The data consisted of 1-,2- to 3-, and 13 week clinical chemistry measurements and 13-week histopathological assessments of liver and kidney. Except for serum alkaline phosphatase, treatment-related alterations of individual clinical chemistry variables occurred in 20-48% of the studies, depending on the analyte, sampling time, and sex. Liver and kidney lesions were reported for 31% and 41% of the studies respectively. There was an association between treatment-related increases in alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities and histopathological changes in the liver. SDH activity had greater positive and negative predictive values than similar changes in ALT; by week 1 in females and weeks 2-3 in both sexes. SDH predicted morphological hepatic change at study termination with 75% or better accuracy. If increases in activities of both enzymes occurred simultaneously, however, terminal histopathological changes could be predicted, in both sexes, with 75% accuracy by week 1, increasing to 100% by weeks 2-3. There also was an association between treatment-related increases in urea nitrogen (UN) and creatinine (Cre) concentrations and morphological kidney change. Cre concentration had greater positive predictive values than similar changes in UN; by weeks 2-3 in males and week 13 in both sexes. Cre predicted morphological renal change at study termination with 56% or better accuracy. UN concentration was associated and predictive of morphological kidney change only in females at week 13. Depending on time point and sex, serum alkaline phosphatase activity increased in 5-22% of the studies. Increases in total bile acid concentration occurred in 33-48% of the studies. Because both tests are used as markers of cholestasis, this marked discrepancy was unexpected. Treatment-related decreases in alkaline phosphatase activity occurred, however, in 39-56% of the studies; serum alkaline phosphatase may be more useful as an indicator of decreased food intake (decreased activity) than of cholestasis (increased activity). In summary, treatment-related alterations of clinical chemistry and histopathology occurred frequently in this series of toxicity studies in rats. Changes in the chemistry end points also occurred frequently at interim time points, indicating that clinical chemistry evaluations can be useful for detecting potential treatment effects throughout a study. This observation is important, since histopathological evaluations are limited to animal termination and not useful for detecting transient responses or the onset of treatment-related effects.
Perspectives on Psychological Science, May 1, 2010
The alcohol myopia model (AMM; Steele & Josephs, 1990) is reviewed in light of its unique ability... more The alcohol myopia model (AMM; Steele & Josephs, 1990) is reviewed in light of its unique ability to account for a variety of alcohol and nonalcohol-related disinhibited behaviors, particularly aggression. The AMM posits that alcohol has a narrowing, or a “myopic,” effect on one's ability to attend to competing instigatory and inhibitory cues. Disinhibited behavior is presumed to occur when attention is directed toward salient provocative or instigatory cues rather than inhibitory cues. AMM research is reviewed with ...
Alcoholism, clinical and experimental research, 2016
Experimental studies investigating the impact of advertising with ecological stimuli on alcohol-r... more Experimental studies investigating the impact of advertising with ecological stimuli on alcohol-related cognition are scarce. This research investigated the cognitive processes involved in learning implicit attitudes toward alcohol after incidental exposure to alcohol advertisements presented in a dynamic context. We hypothesized that incidental exposure to a specific alcohol brand would lead to heightened positive implicit attitudes toward alcohol due to a mere exposure effect. In total, 108 participants were randomly exposed to dynamic sporting events excerpts with and without advertising for a specific brand of alcohol, after completing self-reported measures of alcohol-related expectancies, alcohol consumption, and attitudes toward sport. Participants then completed a lexical decision task and an affective priming task. We showed that participants were faster to detect brand name after being exposed to advertising during a sports game, and that implicit attitudes of participants...
Objective:Numerous studies have examined the impact of alcohol on violence; however, only a small... more Objective:Numerous studies have examined the impact of alcohol on violence; however, only a small number have addressed differences elicited by different doses of alcohol. Such studies are limited by mixed findings, small sample sizes, inconsistent alcohol doses and control conditions, a bias toward studying only male participants, and the predominant use of only one particular measure to assess aggression. The present laboratory investigation was designed to elucidate and advance this literature by improving on these limitations.Method:Participants were 187 (95 men and 92 women) social drinkers. Following the consumption of one of six alcohol doses (i.e., 0.0 g/kg, 0.125 g/kg, 0.25 g/kg, 0.5 g/kg, 0.75 g/kg, and 1.0 g/kg), participants were tested on a laboratory task in which electric shocks were received from and administered to a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the intensity and duration of shocks administered to one's “opponent.”Results:Analyses revealed a highly significant positive linear trend between alcohol dose and aggression for both genders.Conclusions:Our data aid in clarifying a body of literature that has been afflicted with numerous limitations and will help guide the selection of alcohol doses for researchers conducting future laboratory-based aggression studies.
Numerous studies have examined the impact of alcohol on violence; however, only a small number ha... more Numerous studies have examined the impact of alcohol on violence; however, only a small number have addressed differences elicited by different doses of alcohol. Such studies are limited by mixed findings, small sample sizes, inconsistent alcohol doses and control conditions, a bias toward studying only male participants, and the predominant use of only one particular measure to assess aggression. The present laboratory investigation was designed to elucidate and advance this literature by improving on these limitations. Participants were 187 (95 men and 92 women) social drinkers. Following the consumption of one of six alcohol doses (i.e., 0.0 g/kg, 0.125 g/kg, 0.25 g/kg, 0.5 g/kg, 0.75 g/kg, and 1.0 g/kg), participants were tested on a laboratory task in which electric shocks were received from and administered to a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the intensity and duration of shocks administered to one'...
The relative sensitivities of eight commonly used clinical chemistry end points and histopatholog... more The relative sensitivities of eight commonly used clinical chemistry end points and histopathology to detect potential toxic effects in liver and kidney were evaluated for a series of 61 13-week rat toxicity studies conducted for the National Toxicology Program. The data consisted of 1-,2- to 3-, and 13 week clinical chemistry measurements and 13-week histopathological assessments of liver and kidney. Except for serum alkaline phosphatase, treatment-related alterations of individual clinical chemistry variables occurred in 20-48% of the studies, depending on the analyte, sampling time, and sex. Liver and kidney lesions were reported for 31% and 41% of the studies respectively. There was an association between treatment-related increases in alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities and histopathological changes in the liver. SDH activity had greater positive and negative predictive values than similar changes in ALT; by week 1 in females and weeks 2-3 in both sexes. SDH predicted morphological hepatic change at study termination with 75% or better accuracy. If increases in activities of both enzymes occurred simultaneously, however, terminal histopathological changes could be predicted, in both sexes, with 75% accuracy by week 1, increasing to 100% by weeks 2-3. There also was an association between treatment-related increases in urea nitrogen (UN) and creatinine (Cre) concentrations and morphological kidney change. Cre concentration had greater positive predictive values than similar changes in UN; by weeks 2-3 in males and week 13 in both sexes. Cre predicted morphological renal change at study termination with 56% or better accuracy. UN concentration was associated and predictive of morphological kidney change only in females at week 13. Depending on time point and sex, serum alkaline phosphatase activity increased in 5-22% of the studies. Increases in total bile acid concentration occurred in 33-48% of the studies. Because both tests are used as markers of cholestasis, this marked discrepancy was unexpected. Treatment-related decreases in alkaline phosphatase activity occurred, however, in 39-56% of the studies; serum alkaline phosphatase may be more useful as an indicator of decreased food intake (decreased activity) than of cholestasis (increased activity). In summary, treatment-related alterations of clinical chemistry and histopathology occurred frequently in this series of toxicity studies in rats. Changes in the chemistry end points also occurred frequently at interim time points, indicating that clinical chemistry evaluations can be useful for detecting potential treatment effects throughout a study. This observation is important, since histopathological evaluations are limited to animal termination and not useful for detecting transient responses or the onset of treatment-related effects.
Perspectives on Psychological Science, May 1, 2010
The alcohol myopia model (AMM; Steele & Josephs, 1990) is reviewed in light of its unique ability... more The alcohol myopia model (AMM; Steele & Josephs, 1990) is reviewed in light of its unique ability to account for a variety of alcohol and nonalcohol-related disinhibited behaviors, particularly aggression. The AMM posits that alcohol has a narrowing, or a “myopic,” effect on one's ability to attend to competing instigatory and inhibitory cues. Disinhibited behavior is presumed to occur when attention is directed toward salient provocative or instigatory cues rather than inhibitory cues. AMM research is reviewed with ...
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