Isobutene oligomerization was carried out at room temperature over sulfated-titania sol–gel catal... more Isobutene oligomerization was carried out at room temperature over sulfated-titania sol–gel catalysts prepared by three methods; (i) “in situ” sulfation using sulfuric acid, (ii) gelling with nitric acid and sulfation (a), and (iii) gelling with ammonium hydroxide and sulfation (b). XRD spectra identified anatase as the crystalline phase in all the sulfated samples. The specific surface areas were 126, 115
Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degrad... more Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degradation and an antagonist of both N-methyl-D-aspartate (NMDA) and alpha-7 nicotinic acetylcholine (α7nACh) receptors. KYNA has also been shown to scavenge hydroxyl radicals (OH) under controlled conditions of free radical production. In this work we evaluated the ability of KYNA to scavenge superoxide anion (O(2)(-)) and peroxynitrite (ONOO(-)). The scavenging ability of KYNA (expressed as IC(50) values) was as follows: OH=O(2)(-)>ONOO(-). In parallel, the antiperoxidative and scavenging capacities of KYNA (0-150 μM) were tested in cerebellum and forebrain homogenates exposed to 5 μM FeSO(4) and 2.5 mM 3-nitropropionic acid (3-NPA). Both FeSO(4) and 3-NPA increased lipid peroxidation (LP) and ROS formation in a significant manner in these preparations, whereas KYNA significantly reduced these markers. Reactive oxygen species (ROS) formation were determined in the presence of FeSO(4) and...
Isobutene oligomerization was carried out at room temperature over sulfated-titania sol–gel catal... more Isobutene oligomerization was carried out at room temperature over sulfated-titania sol–gel catalysts prepared by three methods; (i) “in situ” sulfation using sulfuric acid, (ii) gelling with nitric acid and sulfation (a), and (iii) gelling with ammonium hydroxide and sulfation (b). XRD spectra identified anatase as the crystalline phase in all the sulfated samples. The specific surface areas were 126, 115
Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degrad... more Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degradation and an antagonist of both N-methyl-D-aspartate (NMDA) and alpha-7 nicotinic acetylcholine (α7nACh) receptors. KYNA has also been shown to scavenge hydroxyl radicals (OH) under controlled conditions of free radical production. In this work we evaluated the ability of KYNA to scavenge superoxide anion (O(2)(-)) and peroxynitrite (ONOO(-)). The scavenging ability of KYNA (expressed as IC(50) values) was as follows: OH=O(2)(-)>ONOO(-). In parallel, the antiperoxidative and scavenging capacities of KYNA (0-150 μM) were tested in cerebellum and forebrain homogenates exposed to 5 μM FeSO(4) and 2.5 mM 3-nitropropionic acid (3-NPA). Both FeSO(4) and 3-NPA increased lipid peroxidation (LP) and ROS formation in a significant manner in these preparations, whereas KYNA significantly reduced these markers. Reactive oxygen species (ROS) formation were determined in the presence of FeSO(4) and...
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Papers by E. Ortiz-Islas