Cyanosis refers to a blue tone visible in the skin and mucous membranes, caused by desaturated or... more Cyanosis refers to a blue tone visible in the skin and mucous membranes, caused by desaturated or abnormal hemoglobin. Jaundice in the first 24 hours of life of a term newborn is pathologic. Cardiac disease presenting in the neonatal period are often congenital but can be acquired. Age at presentation of CHD varies with the underlying lesion, its impact on cardiac performance, and its dependence upon the ductus arteriosus. Neonatal sepsis can be categorized into early onset (occurring in newborns who are less than 72 hours of life) or late onset (occurring between 3 and 7 days of life). Keywords: Neonate; emergency; notes.
Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cell... more Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca 2+ pathways have been identified as potential pathways regulating insulin synthesis by preserving pancreatic β-cell functioning. The current study aimed to evaluate the therapeutic effect of aged garlic extract (AGE) against DM in a streptozotocin (STZ)-induced rat model with particular emphasis on pancreatic β-cell functioning. Methods AGE was characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) to evaluate its physio-chemical characteristics followed by in-vitro anti-diabetic and antioxidant potential. This was followed by the induction of DM in laboratory animals for investigating the therapeutic action of AGE by evaluating the role of NF-κβ/TLR-4 and the SERCA/Ca 2+ pathway. The parameters assessed in the present experimental setup encompassed antioxidant parameters, metabolic indicators, insulin concentration, intracellular calcium levels, apoptotic markers (CCK-8 and Caspase Glo-8), and protein expression (P-62 and APACHE-II). Results AGE characterization by SEM, GC-MS, and X-ray diffraction (XRD) revealed the presence of phenylalanine, alliin, S-allylmercaptocysteine (SAMC), tryptophan, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid as major bioactive constituents of AGE. Metabolic studies, including intraperitoneal glucose tolerance test (IPGTT), revealed significantly lower blood glucose levels in the AGE group compared to the disease control group. In contrast, the intraperitoneal insulin tolerance test (ITT) exhibited no significant difference in insulin sensitivity between the AGE
Background: In the world, Neonatal Sepsis firmly to their morbidity and mortality; it constitutes... more Background: In the world, Neonatal Sepsis firmly to their morbidity and mortality; it constitutes a significant public health challenge. Infections were the most common causes of neonatal deaths, followed by prematurity, intrapartum complications, and asphyxia. The diagnosis is based on anamnestic, clinical and laboratory findings. Although the defined diagnosis is based on the isolation of the causative organism by culture on a fluid sample (blood, cerebrospinal fluid, urine, etc.), low sensitivity of the culture leads to the use of inflammatory markers such as C-reactive protein, procalcitonin and interleukins. Many studies worldwide have commenced to evaluate a new nontraditional value of red cell distribution width as a diagnostic and prognostic biomarker in neonatal sepsis. Objective: To assess the value of Red Cell Distribution Width (RDW) in predicting neonatal outcome in neonatal sepsis. Method: In a retrospective, observational study, we enrolled 100 term neonates who were diagnosed with neonatal sepsis who were admitted at a Soba University hospital during the period January 2021-January 2022. Results: Of 100 neonates, 57% were males and 43% were females. Increased RDW was seen in 86.8% of neonates who had systemic involvement during illness, 100% of deceased patients had high RDW at their deaths, and 90% of survived neonates had normal RDW (p=0.000). The association between the RDW value and the duration of admission was found to be of statistical significance, as the p-value was 0.012. Conclusion: RDW can be used for evaluating neonates with suspected sepsis, especially in low-resource countries. Increased RDW can be a prognostic marker in neonates with sepsis.
Journal of Ophthalmic Research and Discoveries , 2024
Malaria is one of the most lethal diseases worldwide, and cerebral malaria
is the most severe fo... more Malaria is one of the most lethal diseases worldwide, and cerebral malaria is the most severe form of the disease. Plasmodium falciparum is the leading cause of cerebral malaria. The retina combines the window to the central nervous system with the direct ability to visualise neurodegenerative processes in the central nervous system. Retinal whitening, retinal vessel discolouration to pinkorange or white, retinal haemorrhage, and papilledema are characteristic findings of cerebral malaria. Ophthalmological examination of children with neurological emergencies is unavailable in most African countries, and cerebral malaria is frequently not diagnosed. In addition, few studies describe the neurological or ophthalmological complications related to cerebral malaria retinopathy. The terms "malaria in children", "cerebral malaria", and "malaria retinopathy" were searched in the PubMed and Google Scholar databases, and the most representative of several articles on the same topic was selected. The search was not restricted to specific years. The aim of the study to determine whether retinopathy is pathognomonic for cerebral malaria, as this will allow early treatment and prevent complications of the disease. In conclusion ophthalmological examination in children suspected of cerebral malaria is mandatory for all patients in countries where malaria is endemic, and this form of the disease has a pathological picture that differentiates it from other neurological conditions.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Urine analysis and measuring blood pressure are part of clinical examination of children fitness ... more Urine analysis and measuring blood pressure are part of clinical examination of children fitness and are useful in detection of renal diseases. Through a systematic randomised procedure I studied 213 children, aged 2 to 18 years old. Proteinuria was in 11.7% among them 72% were 10 years old or more (p.value=0.001). Haematuria was found in 11.7%. Those who had proteinuria and are prehypertensive were 2.9% (p.value. value =0.001). Prehypertension was found in 4.8% of underweight and in 8.8% of normal weight children with insignificant p.value. Urine examination and blood pressure measurement in developing countries is essential and should be routine for early detection of a symptomatic children. This study was done to help pediatricians and nephrologists to look behind the aetiology of end stage renal diseases.
Cyanosis refers to a blue tone visible in the skin and mucous membranes, caused by desaturated or... more Cyanosis refers to a blue tone visible in the skin and mucous membranes, caused by desaturated or abnormal hemoglobin. Jaundice in the first 24 hours of life of a term newborn is pathologic. Cardiac disease presenting in the neonatal period are often congenital but can be acquired. Age at presentation of CHD varies with the underlying lesion, its impact on cardiac performance, and its dependence upon the ductus arteriosus. Neonatal sepsis can be categorized into early onset (occurring in newborns who are less than 72 hours of life) or late onset (occurring between 3 and 7 days of life). Keywords: Neonate; emergency; notes.
Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cell... more Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca 2+ pathways have been identified as potential pathways regulating insulin synthesis by preserving pancreatic β-cell functioning. The current study aimed to evaluate the therapeutic effect of aged garlic extract (AGE) against DM in a streptozotocin (STZ)-induced rat model with particular emphasis on pancreatic β-cell functioning. Methods AGE was characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) to evaluate its physio-chemical characteristics followed by in-vitro anti-diabetic and antioxidant potential. This was followed by the induction of DM in laboratory animals for investigating the therapeutic action of AGE by evaluating the role of NF-κβ/TLR-4 and the SERCA/Ca 2+ pathway. The parameters assessed in the present experimental setup encompassed antioxidant parameters, metabolic indicators, insulin concentration, intracellular calcium levels, apoptotic markers (CCK-8 and Caspase Glo-8), and protein expression (P-62 and APACHE-II). Results AGE characterization by SEM, GC-MS, and X-ray diffraction (XRD) revealed the presence of phenylalanine, alliin, S-allylmercaptocysteine (SAMC), tryptophan, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid as major bioactive constituents of AGE. Metabolic studies, including intraperitoneal glucose tolerance test (IPGTT), revealed significantly lower blood glucose levels in the AGE group compared to the disease control group. In contrast, the intraperitoneal insulin tolerance test (ITT) exhibited no significant difference in insulin sensitivity between the AGE
Background: In the world, Neonatal Sepsis firmly to their morbidity and mortality; it constitutes... more Background: In the world, Neonatal Sepsis firmly to their morbidity and mortality; it constitutes a significant public health challenge. Infections were the most common causes of neonatal deaths, followed by prematurity, intrapartum complications, and asphyxia. The diagnosis is based on anamnestic, clinical and laboratory findings. Although the defined diagnosis is based on the isolation of the causative organism by culture on a fluid sample (blood, cerebrospinal fluid, urine, etc.), low sensitivity of the culture leads to the use of inflammatory markers such as C-reactive protein, procalcitonin and interleukins. Many studies worldwide have commenced to evaluate a new nontraditional value of red cell distribution width as a diagnostic and prognostic biomarker in neonatal sepsis. Objective: To assess the value of Red Cell Distribution Width (RDW) in predicting neonatal outcome in neonatal sepsis. Method: In a retrospective, observational study, we enrolled 100 term neonates who were diagnosed with neonatal sepsis who were admitted at a Soba University hospital during the period January 2021-January 2022. Results: Of 100 neonates, 57% were males and 43% were females. Increased RDW was seen in 86.8% of neonates who had systemic involvement during illness, 100% of deceased patients had high RDW at their deaths, and 90% of survived neonates had normal RDW (p=0.000). The association between the RDW value and the duration of admission was found to be of statistical significance, as the p-value was 0.012. Conclusion: RDW can be used for evaluating neonates with suspected sepsis, especially in low-resource countries. Increased RDW can be a prognostic marker in neonates with sepsis.
Journal of Ophthalmic Research and Discoveries , 2024
Malaria is one of the most lethal diseases worldwide, and cerebral malaria
is the most severe fo... more Malaria is one of the most lethal diseases worldwide, and cerebral malaria is the most severe form of the disease. Plasmodium falciparum is the leading cause of cerebral malaria. The retina combines the window to the central nervous system with the direct ability to visualise neurodegenerative processes in the central nervous system. Retinal whitening, retinal vessel discolouration to pinkorange or white, retinal haemorrhage, and papilledema are characteristic findings of cerebral malaria. Ophthalmological examination of children with neurological emergencies is unavailable in most African countries, and cerebral malaria is frequently not diagnosed. In addition, few studies describe the neurological or ophthalmological complications related to cerebral malaria retinopathy. The terms "malaria in children", "cerebral malaria", and "malaria retinopathy" were searched in the PubMed and Google Scholar databases, and the most representative of several articles on the same topic was selected. The search was not restricted to specific years. The aim of the study to determine whether retinopathy is pathognomonic for cerebral malaria, as this will allow early treatment and prevent complications of the disease. In conclusion ophthalmological examination in children suspected of cerebral malaria is mandatory for all patients in countries where malaria is endemic, and this form of the disease has a pathological picture that differentiates it from other neurological conditions.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Urine analysis and measuring blood pressure are part of clinical examination of children fitness ... more Urine analysis and measuring blood pressure are part of clinical examination of children fitness and are useful in detection of renal diseases. Through a systematic randomised procedure I studied 213 children, aged 2 to 18 years old. Proteinuria was in 11.7% among them 72% were 10 years old or more (p.value=0.001). Haematuria was found in 11.7%. Those who had proteinuria and are prehypertensive were 2.9% (p.value. value =0.001). Prehypertension was found in 4.8% of underweight and in 8.8% of normal weight children with insignificant p.value. Urine examination and blood pressure measurement in developing countries is essential and should be routine for early detection of a symptomatic children. This study was done to help pediatricians and nephrologists to look behind the aetiology of end stage renal diseases.
Cyanosis refers to a blue tone visible in the skin and mucous membranes,
caused by desaturated o... more Cyanosis refers to a blue tone visible in the skin and mucous membranes, caused by desaturated or abnormal hemoglobin. Jaundice in the first 24 hours of life of a term newborn is pathologic. Cardiac disease presenting in the neonatal period are often congenital but can be acquired. Age at presentation of CHD varies with the underlying lesion, its impact on cardiac performance, and its dependence upon the ductus arteriosus. Neonatal sepsis can be categorized into early onset (occurring in newborns who are less than 72 hours of life) or late onset (occurring between 3 and 7 days of life). Keywords: Neonate; emergency; notes.
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Papers by Elsharif Bazie
is the most severe form of the disease. Plasmodium falciparum is the
leading cause of cerebral malaria.
The retina combines the window to the central nervous system with the
direct ability to visualise neurodegenerative processes in the central
nervous system. Retinal whitening, retinal vessel discolouration to pinkorange or white, retinal haemorrhage, and papilledema are characteristic
findings of cerebral malaria. Ophthalmological examination of children
with neurological emergencies is unavailable in most African countries,
and cerebral malaria is frequently not diagnosed. In addition, few studies
describe the neurological or ophthalmological complications related to
cerebral malaria retinopathy.
The terms "malaria in children", "cerebral malaria", and "malaria
retinopathy" were searched in the PubMed and Google Scholar
databases, and the most representative of several articles on the same
topic was selected. The search was not restricted to specific years.
The aim of the study to determine whether retinopathy is
pathognomonic for cerebral malaria, as this will allow early treatment and
prevent complications of the disease.
In conclusion ophthalmological examination in children suspected of
cerebral malaria is mandatory for all patients in countries where malaria is
endemic, and this form of the disease has a pathological picture that
differentiates it from other neurological conditions.
is the most severe form of the disease. Plasmodium falciparum is the
leading cause of cerebral malaria.
The retina combines the window to the central nervous system with the
direct ability to visualise neurodegenerative processes in the central
nervous system. Retinal whitening, retinal vessel discolouration to pinkorange or white, retinal haemorrhage, and papilledema are characteristic
findings of cerebral malaria. Ophthalmological examination of children
with neurological emergencies is unavailable in most African countries,
and cerebral malaria is frequently not diagnosed. In addition, few studies
describe the neurological or ophthalmological complications related to
cerebral malaria retinopathy.
The terms "malaria in children", "cerebral malaria", and "malaria
retinopathy" were searched in the PubMed and Google Scholar
databases, and the most representative of several articles on the same
topic was selected. The search was not restricted to specific years.
The aim of the study to determine whether retinopathy is
pathognomonic for cerebral malaria, as this will allow early treatment and
prevent complications of the disease.
In conclusion ophthalmological examination in children suspected of
cerebral malaria is mandatory for all patients in countries where malaria is
endemic, and this form of the disease has a pathological picture that
differentiates it from other neurological conditions.
caused by desaturated or abnormal hemoglobin.
Jaundice in the first 24 hours of life of a term newborn is pathologic.
Cardiac disease presenting in the neonatal period are often congenital but can
be acquired. Age at presentation of CHD varies with the underlying lesion, its
impact on cardiac performance, and its dependence upon the ductus arteriosus.
Neonatal sepsis can be categorized into early onset (occurring in newborns who
are less than 72 hours of life) or late onset (occurring between 3 and 7 days of
life).
Keywords: Neonate; emergency; notes.