Thrombosis in the portal system causes a wide spectrum of clinical pictures. There are few publis... more Thrombosis in the portal system causes a wide spectrum of clinical pictures. There are few published studies describing the clinical features and consequences of portal venous system thrombosis. We aimed to document presentations and outcomes in patients with thrombosis in the portal and/or splenic veins. The study included 95 patients who were diagnosed with portal venous system thrombosis in the period September 2001 to April 2006. Demographics, clinical presentation, diagnostic investigation, management, morbidity, and mortality were recorded in their follow-up. Of the 95 patients with portal vein thrombosis (PVT), 35 had isolated PVT (IPVT), 27 had isolated splenic vein thrombosis (ISVT), and 33 had thrombosis in both the portal and splenic veins (PSVT). The mean follow-up periods after diagnosis of IPVT, ISVT, and PSVT were 36, 31, and 32 months, respectively. Abdominal pain and gastrointestinal bleeding were the most common symptoms at presentation in the IPVT and PSVT groups, whereas abdominal pain was the dominant symptom in the ISVT group. During the follow-up period, no bleeding was seen in 26 of the 35 (74%) patients with IPVT, in 23 of the 33 (70%) patients with PSVT, and in 24 of the 27 (89%) patients with ISVT. Biliopathy developed during follow-up in 11 of 35 patients with IPVT, in 1 of 27 with ISVT, and in 5 of 33 with PSVT. In the ISVT group, there were 11 deaths, and one each in the IPVT and PSVT groups. The etiology of PVT varies in portal and splenic veins. IPVT has a higher morbidity (bleeding and portal biliopathy), whereas ISVT that is not associated with an underlying malignancy has a favorable prognosis.
Aim. To present follow-up results of our chronic hepatitis patients infected with HDV treated wit... more Aim. To present follow-up results of our chronic hepatitis patients infected with HDV treated with subcutaneous interferon (IFN). Method. A total of 24 patients, 21 males and 3 females with HBsAg (+), AntiHBc IgM (-), antibody against hepatitis D virus (anti HDV) and/or HDV RNA (+) and with above normal values for serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), who had no contraindications for treatment and had suitable histological activity index (HAI) and fibrosis scores in their liver biopsies were enrolled. Patients treated with three doses of 9-10 MU subcutaneous IFN per week. Serum aminotransferases, HBsAg, antibody against HbsAg (anti HBs), hepatitis B e antigen (HBeAg), antibody against HBeAg (anti HBe), HBV DNA, anti HDV and/or HDV RNA levels were determined before, during and after treatment. Results. Nine patients (37.5%) stopped treatment in an early phase. In 3 patients (12.5%), treatment was discontinued due to severe side effects. In the pos...
papil agzindan kontrast maddenin kacmasi kitle- nin kolanjiogramdaki goruntusunun kaybolma- sina ... more papil agzindan kontrast maddenin kacmasi kitle- nin kolanjiogramdaki goruntusunun kaybolma- sina neden oluyordu. Calisma kanali 4.2 mm olan duodenoskopta forsepsin yanindan kateter ile de girip lezyonunun proksimalinden kontrast madde verilerek forseps ve kitlenin skopi altinda goruntulenmesi saglanarak biyopsi basari ile alindi
Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In ... more Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In this study, we aimed to investigate the association between thrombopoietin (TPO) levels and the stage of liver fibrosis in patients with chronic hepatitis B (CHB). Seventy-seven patients (64 active and 13 inactive) with CHB were included in this cross-sectional study. Patients were divided into three groups: In group 1, patients with mild or no fibrosis (F0, F1); in group 2, patients with significant fibrosis (F2-F4); and in group 3, inactive CHB carriers. Digital patient records were used to access pre-treatment laboratory findings including HBV DNA, HBeAg, ALT, AST, total bilirubin, PLT, albumin, INR. Liver biopsies were examined by experienced pathologists in our hospital who were blinded to the data of the patients. Serum TPO levels were measured using commercial ELISA kit. Serum TPO levels were sig- nificantly lower in patients with active CHB compared with the inactive carriers (52...
Buna gore stent, stent cikartici forsepsle duodenu- ma tamamen cikartilir ve yukarda kalan ucun- ... more Buna gore stent, stent cikartici forsepsle duodenu- ma tamamen cikartilir ve yukarda kalan ucun- dan snare ile tutularak endoskopun calisma ka- nalindan disariya alinir . Stentin bu sirada gastrointestinal traktta ulasilamayacak kadar distale gitmesi endisesi, gozlemlerimize go- re duodenum aksini kisa surede donmediginden, yersiz gibi gorunmektedir
Bu calismanin amaci inflamatuar barsak hastal??? (?BH) hastalik aktivitesi ile ortalama trombosit... more Bu calismanin amaci inflamatuar barsak hastal??? (?BH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) ili?kisini ortaya koymak ve hastalik aktivitesi icin kullanilan di?er parametrelerle korelasyonunu incelemektir. 145 ulseratif kolit (UK), 73 Crohn hastasi (CH) ve 92 saglikli birey calismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lokosit, trombosit, MPV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaci?er ve renal fonksiyon testlerinin sonuclari kaydedildi. Hastalik aktiviteleri; UK icin klinik aktivite indeksi ve CH icin Crohn hastal??? aktivite indeksine (CDAI) gore hesapland?; aktif ve inaktif gruplar olu?turuldu. UK ve CH grubunda MPV kontrol grubuna gore anlamli derecede du?uktu (p0.05). Hem aktif, hem de inaktif UK grupta MPV duzeyi kontrol gruptan anlamli derecede du?uktu (p
ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama tromb... more ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) iliskisini ortaya koymak ve hastalik aktivitesi için kullanilan diger parametrelerle korelasyonunu incelemektir. 145 ülseratif kolit (ÜK), 73 Crohn hastasi (CH) ve 92 saglikli birey çalismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lökosit, trombosit, M PV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaciger ve renal fonksiyon testlerinin sonuçlari kaydedildi. Hastalik aktiviteleri; ÜK için klinik aktivite indeksi ve CH için Crohn hastaligi aktivite indeksine (CDAI) göre hesaplandi; aktif ve inaktif gruplar olusturuldu. ÜK ve CH grubunda MPV kontrol grubuna göre anlamli derecede düsüktü (p<0.05), CH ve ÜK'li gruplar arasinda ise anlamli farklilik yoktu (p>0.05). Hem aktif, hem de inaktif ÜK grupta MPV düzeyi kontrol gruptan anlamli derecede düsüktü (p<0.05). Aktif ÜK'li g...
International journal of clinical and experimental medicine, 2014
Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In ... more Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In this study, we aimed to investigate the association between thrombopoietin (TPO) levels and the stage of liver fibrosis in patients with chronic hepatitis B (CHB). Seventy-seven patients (64 active and 13 inactive) with CHB were included in this cross-sectional study. Patients were divided into three groups: In group 1, patients with mild or no fibrosis (F0, F1); in group 2, patients with significant fibrosis (F2-F4); and in group 3, inactive CHB carriers. Digital patient records were used to access pre-treatment laboratory findings including HBV DNA, HBeAg, ALT, AST, total bilirubin, PLT, albumin, INR. Liver biopsies were examined by experienced pathologists in our hospital who were blinded to the data of the patients. Serum TPO levels were measured using commercial ELISA kit. Serum TPO levels were significantly lower in patients with active CHB compared with the inactive carriers (528 ...
Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths w... more Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. The early diagnosis of gastric cancer is fundamental in decreasing the mortality rates. It has been shown that MPV level is a sign of inflammation in hepatocellular carcinoma and pancreatic adenocarcinoma. The aim of this study is to examine whether MPV would be a useful inflammatory marker for differentiating gastric cancer patients from healthy controls. Thirty-one gastric cancer patients and 31 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.31 fL vs. 7.85; p: 0.007). ROC analysis suggested 8.25 fL as the cut-off value for MPV (AUC: 0.717, sensitivity: 61%, specificity: 81%). Surgical tumor resection resulted in a significant decrease in MPV level (8.31 fL vs. 7.55 fL; p: 0.001). No significant difference was found in MPV level between the post-operative group and control subjects. We did not find statistically significant difference between MPV and TNM stages. In conclusion, changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients for GC risk and may prompt physicians to make an early diagnosis of GC.
Autosomal-dominant polycystic kidney disease is an inherited disorder characterized by multiple c... more Autosomal-dominant polycystic kidney disease is an inherited disorder characterized by multiple cysts in kidneys and other organs. A 63-year-old man was evaluated for the etiology of recurrent pancreatitis and chronic renal failure. Multiple cysts of kidneys, liver, and pancreas and pancreas divisum was diagnosed. Pancreatitis should be included in the differential diagnosis of abdominal pain in patients with ADPKD. Pancreas divisum may be a predisposing factor for acute pancreatitis in these patients.
Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the path... more Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the pathogenesis of ulcerative colitis. Apoptotic cells increase as a result of injured mucosa in ulcerative colitis and serum M 30 levels increase in epithelial cell apoptosis. In this study, we aimed to evaluate the relation between M 30 serum levels and ulcerative colitis activity. Eighty patients with ulcerative colitis and 40 healthy controls were enrolled into the study. The patient group consisted of 31 extensive colitis, 30 left-sided colitis, and 19 proctitis. The activity of ulcerative colitis was determined with clinical and endoscopic findings. Serum M 30 levels, acute phase reactants, and biochemical tests were analyzed in all subjects. Serum M 30 levels in patients with active ulcerative colitis were significantly higher when compared with the healthy controls (165.6 ± 60.6 and 129.6 ± 37.4; P = 0.003). Serum M 30 levels in active left-sided colitis patients was significantly higher when compared with patients in remission phase (180.6 ± 58.5, 141.5 ± 35.4; P = 0.044). When we exclude patients with ulcerative proctitis, M 30 levels in active ulcerative colitis patients were significantly higher than that the patients in remission phase (174.0 ± 63.5, 135.0 ± 29.9; P = 0.017). We found that M 30 levels increase in patients with active ulcerative colitis. Our findings support the role of apoptosis demonstrated by serum M 30 levels in the pathogenesis of active ulcerative colitis.
ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama tromb... more ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) iliskisini ortaya koymak ve hastalik aktivitesi için kullanilan diger parametrelerle korelasyonunu incelemektir. 145 ülseratif kolit (ÜK), 73 Crohn hastasi (CH) ve 92 saglikli birey çalismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lökosit, trombosit, M PV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaciger ve renal fonksiyon testlerinin sonuçlari kaydedildi. Hastalik aktiviteleri; ÜK için klinik aktivite indeksi ve CH için Crohn hastaligi aktivite indeksine (CDAI) göre hesaplandi; aktif ve inaktif gruplar olusturuldu. ÜK ve CH grubunda MPV kontrol grubuna göre anlamli derecede düsüktü (p<0.05), CH ve ÜK'li gruplar arasinda ise anlamli farklilik yoktu (p>0.05). Hem aktif, hem de inaktif ÜK grupta MPV düzeyi kontrol gruptan anlamli derecede düsüktü (p<0.05). Aktif ÜK'li g...
Thrombosis in the portal system causes a wide spectrum of clinical pictures. There are few publis... more Thrombosis in the portal system causes a wide spectrum of clinical pictures. There are few published studies describing the clinical features and consequences of portal venous system thrombosis. We aimed to document presentations and outcomes in patients with thrombosis in the portal and/or splenic veins. The study included 95 patients who were diagnosed with portal venous system thrombosis in the period September 2001 to April 2006. Demographics, clinical presentation, diagnostic investigation, management, morbidity, and mortality were recorded in their follow-up. Of the 95 patients with portal vein thrombosis (PVT), 35 had isolated PVT (IPVT), 27 had isolated splenic vein thrombosis (ISVT), and 33 had thrombosis in both the portal and splenic veins (PSVT). The mean follow-up periods after diagnosis of IPVT, ISVT, and PSVT were 36, 31, and 32 months, respectively. Abdominal pain and gastrointestinal bleeding were the most common symptoms at presentation in the IPVT and PSVT groups, whereas abdominal pain was the dominant symptom in the ISVT group. During the follow-up period, no bleeding was seen in 26 of the 35 (74%) patients with IPVT, in 23 of the 33 (70%) patients with PSVT, and in 24 of the 27 (89%) patients with ISVT. Biliopathy developed during follow-up in 11 of 35 patients with IPVT, in 1 of 27 with ISVT, and in 5 of 33 with PSVT. In the ISVT group, there were 11 deaths, and one each in the IPVT and PSVT groups. The etiology of PVT varies in portal and splenic veins. IPVT has a higher morbidity (bleeding and portal biliopathy), whereas ISVT that is not associated with an underlying malignancy has a favorable prognosis.
Aim. To present follow-up results of our chronic hepatitis patients infected with HDV treated wit... more Aim. To present follow-up results of our chronic hepatitis patients infected with HDV treated with subcutaneous interferon (IFN). Method. A total of 24 patients, 21 males and 3 females with HBsAg (+), AntiHBc IgM (-), antibody against hepatitis D virus (anti HDV) and/or HDV RNA (+) and with above normal values for serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), who had no contraindications for treatment and had suitable histological activity index (HAI) and fibrosis scores in their liver biopsies were enrolled. Patients treated with three doses of 9-10 MU subcutaneous IFN per week. Serum aminotransferases, HBsAg, antibody against HbsAg (anti HBs), hepatitis B e antigen (HBeAg), antibody against HBeAg (anti HBe), HBV DNA, anti HDV and/or HDV RNA levels were determined before, during and after treatment. Results. Nine patients (37.5%) stopped treatment in an early phase. In 3 patients (12.5%), treatment was discontinued due to severe side effects. In the pos...
papil agzindan kontrast maddenin kacmasi kitle- nin kolanjiogramdaki goruntusunun kaybolma- sina ... more papil agzindan kontrast maddenin kacmasi kitle- nin kolanjiogramdaki goruntusunun kaybolma- sina neden oluyordu. Calisma kanali 4.2 mm olan duodenoskopta forsepsin yanindan kateter ile de girip lezyonunun proksimalinden kontrast madde verilerek forseps ve kitlenin skopi altinda goruntulenmesi saglanarak biyopsi basari ile alindi
Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In ... more Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In this study, we aimed to investigate the association between thrombopoietin (TPO) levels and the stage of liver fibrosis in patients with chronic hepatitis B (CHB). Seventy-seven patients (64 active and 13 inactive) with CHB were included in this cross-sectional study. Patients were divided into three groups: In group 1, patients with mild or no fibrosis (F0, F1); in group 2, patients with significant fibrosis (F2-F4); and in group 3, inactive CHB carriers. Digital patient records were used to access pre-treatment laboratory findings including HBV DNA, HBeAg, ALT, AST, total bilirubin, PLT, albumin, INR. Liver biopsies were examined by experienced pathologists in our hospital who were blinded to the data of the patients. Serum TPO levels were measured using commercial ELISA kit. Serum TPO levels were sig- nificantly lower in patients with active CHB compared with the inactive carriers (52...
Buna gore stent, stent cikartici forsepsle duodenu- ma tamamen cikartilir ve yukarda kalan ucun- ... more Buna gore stent, stent cikartici forsepsle duodenu- ma tamamen cikartilir ve yukarda kalan ucun- dan snare ile tutularak endoskopun calisma ka- nalindan disariya alinir . Stentin bu sirada gastrointestinal traktta ulasilamayacak kadar distale gitmesi endisesi, gozlemlerimize go- re duodenum aksini kisa surede donmediginden, yersiz gibi gorunmektedir
Bu calismanin amaci inflamatuar barsak hastal??? (?BH) hastalik aktivitesi ile ortalama trombosit... more Bu calismanin amaci inflamatuar barsak hastal??? (?BH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) ili?kisini ortaya koymak ve hastalik aktivitesi icin kullanilan di?er parametrelerle korelasyonunu incelemektir. 145 ulseratif kolit (UK), 73 Crohn hastasi (CH) ve 92 saglikli birey calismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lokosit, trombosit, MPV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaci?er ve renal fonksiyon testlerinin sonuclari kaydedildi. Hastalik aktiviteleri; UK icin klinik aktivite indeksi ve CH icin Crohn hastal??? aktivite indeksine (CDAI) gore hesapland?; aktif ve inaktif gruplar olu?turuldu. UK ve CH grubunda MPV kontrol grubuna gore anlamli derecede du?uktu (p0.05). Hem aktif, hem de inaktif UK grupta MPV duzeyi kontrol gruptan anlamli derecede du?uktu (p
ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama tromb... more ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) iliskisini ortaya koymak ve hastalik aktivitesi için kullanilan diger parametrelerle korelasyonunu incelemektir. 145 ülseratif kolit (ÜK), 73 Crohn hastasi (CH) ve 92 saglikli birey çalismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lökosit, trombosit, M PV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaciger ve renal fonksiyon testlerinin sonuçlari kaydedildi. Hastalik aktiviteleri; ÜK için klinik aktivite indeksi ve CH için Crohn hastaligi aktivite indeksine (CDAI) göre hesaplandi; aktif ve inaktif gruplar olusturuldu. ÜK ve CH grubunda MPV kontrol grubuna göre anlamli derecede düsüktü (p<0.05), CH ve ÜK'li gruplar arasinda ise anlamli farklilik yoktu (p>0.05). Hem aktif, hem de inaktif ÜK grupta MPV düzeyi kontrol gruptan anlamli derecede düsüktü (p<0.05). Aktif ÜK'li g...
International journal of clinical and experimental medicine, 2014
Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In ... more Many noninvasive serum markers have been studied to determine the liver fibrosis score (LFS). In this study, we aimed to investigate the association between thrombopoietin (TPO) levels and the stage of liver fibrosis in patients with chronic hepatitis B (CHB). Seventy-seven patients (64 active and 13 inactive) with CHB were included in this cross-sectional study. Patients were divided into three groups: In group 1, patients with mild or no fibrosis (F0, F1); in group 2, patients with significant fibrosis (F2-F4); and in group 3, inactive CHB carriers. Digital patient records were used to access pre-treatment laboratory findings including HBV DNA, HBeAg, ALT, AST, total bilirubin, PLT, albumin, INR. Liver biopsies were examined by experienced pathologists in our hospital who were blinded to the data of the patients. Serum TPO levels were measured using commercial ELISA kit. Serum TPO levels were significantly lower in patients with active CHB compared with the inactive carriers (528 ...
Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths w... more Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. The early diagnosis of gastric cancer is fundamental in decreasing the mortality rates. It has been shown that MPV level is a sign of inflammation in hepatocellular carcinoma and pancreatic adenocarcinoma. The aim of this study is to examine whether MPV would be a useful inflammatory marker for differentiating gastric cancer patients from healthy controls. Thirty-one gastric cancer patients and 31 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.31 fL vs. 7.85; p: 0.007). ROC analysis suggested 8.25 fL as the cut-off value for MPV (AUC: 0.717, sensitivity: 61%, specificity: 81%). Surgical tumor resection resulted in a significant decrease in MPV level (8.31 fL vs. 7.55 fL; p: 0.001). No significant difference was found in MPV level between the post-operative group and control subjects. We did not find statistically significant difference between MPV and TNM stages. In conclusion, changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients for GC risk and may prompt physicians to make an early diagnosis of GC.
Autosomal-dominant polycystic kidney disease is an inherited disorder characterized by multiple c... more Autosomal-dominant polycystic kidney disease is an inherited disorder characterized by multiple cysts in kidneys and other organs. A 63-year-old man was evaluated for the etiology of recurrent pancreatitis and chronic renal failure. Multiple cysts of kidneys, liver, and pancreas and pancreas divisum was diagnosed. Pancreatitis should be included in the differential diagnosis of abdominal pain in patients with ADPKD. Pancreas divisum may be a predisposing factor for acute pancreatitis in these patients.
Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the path... more Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the pathogenesis of ulcerative colitis. Apoptotic cells increase as a result of injured mucosa in ulcerative colitis and serum M 30 levels increase in epithelial cell apoptosis. In this study, we aimed to evaluate the relation between M 30 serum levels and ulcerative colitis activity. Eighty patients with ulcerative colitis and 40 healthy controls were enrolled into the study. The patient group consisted of 31 extensive colitis, 30 left-sided colitis, and 19 proctitis. The activity of ulcerative colitis was determined with clinical and endoscopic findings. Serum M 30 levels, acute phase reactants, and biochemical tests were analyzed in all subjects. Serum M 30 levels in patients with active ulcerative colitis were significantly higher when compared with the healthy controls (165.6 ± 60.6 and 129.6 ± 37.4; P = 0.003). Serum M 30 levels in active left-sided colitis patients was significantly higher when compared with patients in remission phase (180.6 ± 58.5, 141.5 ± 35.4; P = 0.044). When we exclude patients with ulcerative proctitis, M 30 levels in active ulcerative colitis patients were significantly higher than that the patients in remission phase (174.0 ± 63.5, 135.0 ± 29.9; P = 0.017). We found that M 30 levels increase in patients with active ulcerative colitis. Our findings support the role of apoptosis demonstrated by serum M 30 levels in the pathogenesis of active ulcerative colitis.
ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama tromb... more ZET Bu çalismanin amaci inflamatuar barsak hastaligi (IBH) hastalik aktivitesi ile ortalama trombosit hacminin (mean platelet volume, MPV) iliskisini ortaya koymak ve hastalik aktivitesi için kullanilan diger parametrelerle korelasyonunu incelemektir. 145 ülseratif kolit (ÜK), 73 Crohn hastasi (CH) ve 92 saglikli birey çalismaya dahil edildi. Hastalarin klinik ve endoskopik aktivite indeksleri, hemoglobin, lökosit, trombosit, M PV, eritrosit sedimantasyon hizi (ESH), fibrinojen, CRP, albumin, karaciger ve renal fonksiyon testlerinin sonuçlari kaydedildi. Hastalik aktiviteleri; ÜK için klinik aktivite indeksi ve CH için Crohn hastaligi aktivite indeksine (CDAI) göre hesaplandi; aktif ve inaktif gruplar olusturuldu. ÜK ve CH grubunda MPV kontrol grubuna göre anlamli derecede düsüktü (p<0.05), CH ve ÜK'li gruplar arasinda ise anlamli farklilik yoktu (p>0.05). Hem aktif, hem de inaktif ÜK grupta MPV düzeyi kontrol gruptan anlamli derecede düsüktü (p<0.05). Aktif ÜK'li g...
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