Multiple sclerosis (MS) is one of the most frequent diseases of the central nervous system in young adults. MS believed to be autoimmune and manifests itself mostly as white matter demyelination and associated damage of axons. Various... more
Multiple sclerosis (MS) is one of the most frequent diseases of the central nervous system in young adults. MS believed to be autoimmune and manifests itself mostly as white matter demyelination and associated damage of axons. Various symptoms occur in MS. Cognitive dysfunction is a common symptom occurring in 30-70% of patients at all stages of the disease. The purpose of this study was to investigate the pattern of cognitive dysfunction in different MS subtypes and clinically isolated syndromes suggestive of MS relative to control participants in the Greek population. We suppose that distinct patterns of cognitive dysfunction might occur. We suggest a cognitive science approach of cognitive dysfunction in MS based on impairments on working memory and executive functions. Relapsing remitting patients (RR N=130), secondary progressive patients (SP N=30), primary progressive patients (PP N=30), patients with clinically isolated syndrome (CIS N=42) and healthy control participants (N=...
Purpose The COVID-19 outbreak escalated into a global pandemic, forcing governments around the world to impose measures affecting all aspects of life. Like other countries, Greece adopted social restriction, lockdowns, and quarantines to... more
Purpose The COVID-19 outbreak escalated into a global pandemic, forcing governments around the world to impose measures affecting all aspects of life. Like other countries, Greece adopted social restriction, lockdowns, and quarantines to reduce transmission from person-to-person. This cross-sectional study investigated the impact of social restriction measures on mental health in a Greek adult sample. Method An online questionnaire collected data during the second national lockdown (February to May 2021). A total of 650 participants (M age: 33.13, 71.5% female) comprised the final sample. Results 21.3% of respondents reported moderate-to-extremely severe anxiety, 33% moderate-to-extremely severe depression, 31.8% moderate-to-severe stress, and 38% clinically significant trauma-related distress. Hierarchical linear regression analyses revealed that the strongest contributors to adverse mental health outcomes were being female, younger age, experiencing increases in verbal arguments a...
ABSTRACT To investigate the effect of APOE epsilon4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS). A total of 125 patients with MS and 43 controls were included in this study and underwent... more
ABSTRACT To investigate the effect of APOE epsilon4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS). A total of 125 patients with MS and 43 controls were included in this study and underwent neuropsychological assessment with Rao's Brief Repeatable Battery. All patients with MS were genotyped for APOE. The effect of APOE epsilon4 on different cognitive domains was investigated. Fifty-one percent of patients with MS were cognitively impaired. E4 carriers had a sixfold increase in the relative risk of impairment in verbal learning vs noncarriers (OR 6.28, 95% CI 1.74 to 22.69). This effect was domain-specific and was not observed in other cognitive domains assessed by the battery. We found an association of APOE epsilon4 with impaired verbal learning in patients with multiple sclerosis.
ABSTRACT To investigate the effect of APOE epsilon4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS). A total of 125 patients with MS and 43 controls were included in this study and underwent... more
ABSTRACT To investigate the effect of APOE epsilon4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS). A total of 125 patients with MS and 43 controls were included in this study and underwent neuropsychological assessment with Rao's Brief Repeatable Battery. All patients with MS were genotyped for APOE. The effect of APOE epsilon4 on different cognitive domains was investigated. Fifty-one percent of patients with MS were cognitively impaired. E4 carriers had a sixfold increase in the relative risk of impairment in verbal learning vs noncarriers (OR 6.28, 95% CI 1.74 to 22.69). This effect was domain-specific and was not observed in other cognitive domains assessed by the battery. We found an association of APOE epsilon4 with impaired verbal learning in patients with multiple sclerosis.
Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 -75G/A promoter polymorphism has been associated with elevated ApoA1 levels. We sought to investigate the effect of the APOA1 -75G/A... more
Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 -75G/A promoter polymorphism has been associated with elevated ApoA1 levels. We sought to investigate the effect of the APOA1 -75G/A promoter polymorphism on cognitive performance in patients with multiple sclerosis (MS). A total of 138 patients with MS and 43 controls were studied and underwent neuropsychological assessment with Rao's Brief Repeatable Battery and the Stroop test. All patients were genotyped for APOA1. APOA1 A-allele carriers displayed superior overall cognitive performance compared with non-carriers (P 0.008) and had a three-fold decrease in the relative risk of overall cognitive impairment (OR 0.29, 95% CI 0.11-0.74). Regarding performance on individual cognitive domains, although APOA1 A-allele carriers performed better than non-carriers on all tests, this was significant only for semantic verbal fluency and the Stroop interference task (P 0.036 and 0.018, respectively). We found an association of the APOA1 -75G/A promoter polymorphism with cognitive performance in MS. This effect was most prominent on semantic verbal fluency and the Stroop interference task.
