Research Interests: Pediatrics, Pain, Medicine, Prospective studies, Humans, and 14 morePlacebo, Female, Male, Anesthesia, Newborn Infant, Randomized Controlled Trial, Vaginal Delivery, Acetaminophen, Medicine and Health Sciences, Pain Measurement, Pain Scale, Hyperalgesia, Heel, and Paediatrics and reproductive medicine
data about women who failed to complete integrated test have been collected and analysed Results: 1197 (1.23%) women did not come back to perform the second blood sampling to complete the test. About these “lost” women: 261 women (0.27%)... more
data about women who failed to complete integrated test have been collected and analysed Results: 1197 (1.23%) women did not come back to perform the second blood sampling to complete the test. About these “lost” women: 261 women (0.27%) miscarried between the two blood samples (changeless percentage during all the enrolment period); 313 women (0.32%) chose to undergo an invasive diagnostic test because they were older than 35 years; 623 women (0.64%) were really lost and 255 (41%) of them were foreigners. So 99.04% enlisted women with pregnancy in evolution completed the test as they understood that the analysis of all biochemical markers gives a better sensibility to the risk evaluation. Conclusions: In our experience only 623 women on 97,510 (0.64%) don’t complete integrated test and 41% of them were stranger (probably language difficulty played a role). Integrated test was terminated by the great majority of pregnant who chose to perform it for its better sensibility and low false positive rate.
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Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication... more
Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families. Moreover, the guideline panel formulated considerations of the ethical implications that are associated with these procedures. Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the evidence and recommendations. In this clinical practice guideline, existing evidence and international expertise are combined to develop transparent recommendations that are easy to use to facilitate ongoing communication between health-care providers and patients with childhood, adolescent, and young adult cancer who might be at high risk for fertility impairment and their families.
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Research Interests: Psychology and Feeling
Many adult childhood cancer survivors (CCS) suffer from diverse and often multiple late effects. Offering these patients a comprehensive follow-up (FU) is challenging. An optimal preparation of the clinic visits is important in order to... more
Many adult childhood cancer survivors (CCS) suffer from diverse and often multiple late effects. Offering these patients a comprehensive follow-up (FU) is challenging. An optimal preparation of the clinic visits is important in order to adequately assess the current health status and to satisfy the needs of the CCS. In 2017, we developed a FU program for adult CCS, addressing the specific needs of CCS according to the Long-Term Follow-Up (LTFU) Guidelines of the Children's Oncology Group (COG). The program was implemented at the Cantonal Hospital Baselland in Liestal in 2017 and later at the Inselspital in Bern. The overall aim of this program is to offer a structured check-up covering all aspects potentially affecting the CCS's well-being in order to improve quality of life as well as long term survival of CCS.
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Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication... more
Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families. Moreover, the guideline panel formulated considerations of the ethical implications that are associated with these procedures. Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the evidence and recommendations...
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Background: Childhood cancer survivors are at high risk for late effects. Regular attendance to long-term follow-up care is crucial and helps monitoring survivors’ health. The Theory of Planned Behaviour (TPB) was developed to predict a... more
Background: Childhood cancer survivors are at high risk for late effects. Regular attendance to long-term follow-up care is crucial and helps monitoring survivors’ health. The Theory of Planned Behaviour (TPB) was developed to predict a diverse range of health behaviours. We investigated whether the TPB helps explain attendance to follow-up care in Swiss survivors. We aimed to i) identify TPB-related predictors for the intention to attend follow-up, and ii) examine associations between intention and actual attendance. Methods: We sent a questionnaire to 716 eligible Swiss childhood cancer survivors (diagnosed with cancer aged <16 years; ≥5 years since diagnosis; aged 18 - 40 years at study). We assessed TPB-related predictors (attitude, subjective norm, perceived control), intention to attend follow-up care, and actual attendance. We applied structural equation modelling to investigate predictors of intention and logistic regression models to study the association between the int...
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Taking care of children diagnosed with cancer affects parents' professional life and may place the family at risk-of-poverty. We aimed to (i) compare the household income and risk-of-poverty of parents of childhood cancer survivors... more
Taking care of children diagnosed with cancer affects parents' professional life and may place the family at risk-of-poverty. We aimed to (i) compare the household income and risk-of-poverty of parents of childhood cancer survivors (CCS) to parents of the general population, and (ii) identify sociodemographic and cancer-related factors associated with risk-of-poverty. As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire to parents of CCS aged 5-15 years, who survived ≥5 years after diagnosis. Information on parents of the general population came from the Swiss Household Panel (parents with ≥1 child aged 5-15 years). Risk-of-poverty was defined as having a monthly household income of <4,500 Swiss Francs (CHF) for single parents and <6,000 CHF for parent-couples. We used logistic regression to identify factors associated with risk-of-poverty. We included parents of 383 CCS and 769 control parent households. Parent-couples of CCS had a lower household...
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Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be... more
Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated by interleukin-13 secreted in the context of Th2-type immune responses and to induce asthma. We assessed whether chitin-containing components induced chitinases in an innate immune-dependent way and whether this results in bronchial hyperresponsiveness. Materials and Methods: Monocyte/macrophage cell lines were stimulated with chitin-containing or bacterial components in vitro. Chitinase activity in the supernatant and the expression of the chitotriosidase gene were measured by enzyme assay and quantitative PCR, respectively. Non-sensitized mice were stimulated with chitin-containing components intranasally, and a chitinase inhibitor was administered intraperitoneally. As markers for inflammation leukocytes were counted in the bronchoalveola...
Research Interests: Immunology and Medicine
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Research Interests: Pathology, Survival Analysis, Immunohistochemistry, Bladder Cancer, Humans, and 15 moreFemale, Male, Sarcoma, Follow-up studies, The, Non small cell carcinoma, Clinical Sciences, Aged, Middle Aged, Oral Squamous Cell Carcinoma (OSCC), Adult, Retrospective Studies, Prognosis, Chi Square Distribution, and Adenocarcinoma
The objective of the study was to compare the stress response and pain expression of newborns (NBs) in the early postpartum period. This was a prospective study with 280 NBs enclosed at 3 Swiss university hospitals. Stress response and... more
The objective of the study was to compare the stress response and pain expression of newborns (NBs) in the early postpartum period. This was a prospective study with 280 NBs enclosed at 3 Swiss university hospitals. Stress response and pain reaction were analyzed according to the mode of delivery: elective cesarean section (ELCS), spontaneous vaginal delivery, and assisted vaginal delivery by vacuum extraction (VE). Saliva cortisol and clinical pain expression were evaluated after delivery and before and after heel prick for metabolic screening. Significant differences were evident during the first 72 hours postpartum with highest nominations in the VE group. Meconium-stained amniotic fluid was the only intrapartum stress factor with an impact on clinical pain expression. NBs delivered vaginally show a higher incidence of stress response and pain expression than infants of the ELCS group. The long-term impact of these findings remains to be determined.