We report a new case of glial tissue in uterine cervix found in a 63 year-old woman with an abort... more We report a new case of glial tissue in uterine cervix found in a 63 year-old woman with an abortion 30 years ago. The lesion, measuring 0.5 cm in diameter, showed a typical feature of mature glial tissue immunoreactive for the glial fibrillary acid protein. Hypothesis concerning its histogenesis (fetal graft, tumor, metaplasia) are discussed. Fetal implantation is likely as in the majority of published cases.
The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or ... more The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or interphase on cytological preparations and frozen tissue sections, using oligonucleotide primers derived from chromosome specific subsets of repeated DNA families. PRINS technique is an alternative to fluorescence in situ hybridization, as sensitive as FISH but faster and more specific. This technique is potentially of great interest for pathologists involved in transplantation pathology or cytogenetic interphasic oncology.
We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy Univer... more We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy University Hospital from 1987 to 1997. There were 9 males and 7 females. Mean age at onset of symptoms was 9.5 years (range: 3 months to 29 years) and the mean age at surgery was 16 years. Nine patients experienced partial complex seizures, 5 patients generalized seizures, 1 patient partial seizures with secondary generalization and one patient ataxia. The diagnosis of DNT was made under consideration of clinical, radiological and neuropathological features. All patients underwent surgery. Removal of the tumor was complete for 10 patients, subtotal or partial for 6 patients. Histological examination revealed that 7 cases were specific forms of DNT due to the presence of the specific glioneuronal element. For the 9 remained cases, the diagnosis of DNT could only be made with the consideration of clinical and radiological features. Mean post-surgical follow-up was 3.5 years (range: 1-8 years). E...
We report 4 cases of central neurocytoma removed by a transfrontal approach with no recurrence af... more We report 4 cases of central neurocytoma removed by a transfrontal approach with no recurrence after a mean follow up of 3 years. This uncommon lesion of the supratentorial ventricles (150 cases reported) occurs in young adults, and often induces intracranial hypertension secondary to an obstructive hydrocephalus. The CT scan, MRI and histopathological features are related. This neuronal origin tumor is difficult to distinguish from other intraventricular processes as oligodendroglioma or ependymoma. However, the immunopositivity for the neuronal markers as synaptophysin, calcineurin and microtubul associated protein 2, and the negativity for the glial fibrillary acidic protein, allow the diagnosis of this neuropathological entity. The prognosis is favorable though some cases of recurrence (14 cases) and cerebrospinal dissemination (2 cases) has been reported in the literature.
A 21-year old woman underwent surgery in December 1996 for the removal of a presumed tuberculum s... more A 21-year old woman underwent surgery in December 1996 for the removal of a presumed tuberculum sellae meningioma. However, some radio-clinical findings were proved somewhat intriguing:the patient's age, the presence of inflammatory and febrile syndromes together with the diagnosis of aseptic meningitis associated with perilesional edema intensity (an unusual feature in such cases) made us challenge the initial neuroradiological diagnosis evoked in connection with the tumoral location and dural attachment pattern. A right sub-fronto-temporal approach allowed complete tumor resection (confirmed with a postoperative MRI) and clinical recovery of the patient. But while pathological examination suggested a chordoma, the study of immunohistochemical stains revealed a meningioma. The final diagnosis was chordoid meningioma. Our review of the literature has shown that chordoid meningiomas display several areas of physaliferous cells which give the tumor a chordoma-like aspect. However,...
Waldenström's disease is a B-cell, low grade lymphoma, secreting an immunoglobulin M, and is ... more Waldenström's disease is a B-cell, low grade lymphoma, secreting an immunoglobulin M, and is called immunocytoma. Neurological complications are frequent, but encephalopathies due to lymphoplasmocytoid infiltration are rare (Bing-Neel syndrome). Tumors, probably arising from confluence of infiltrative areas, are exceedingly rare. The authors report the case of a 70-year-old man, suffering from a Waldenström's immunoglobulinemia, who underwent surgery for a right sided rolandic tumor involving the vault, the dura-mater, and the cortex. On the CT scan, the tumor mimicked a meningioma. Histological study and immunohistologic stains confirmed the monoclonal nature of the tumor. Based on the review of the literature, clinical and neuroradiological features of these infiltrative and tumoral rare lesions, as well as their histopathogenesis and treatment, are discussed.
We report two cases of intra-auditory canal lipoma, presenting as acoustic neuroma, observed in r... more We report two cases of intra-auditory canal lipoma, presenting as acoustic neuroma, observed in respectively 45 and 53 year old patients. Cerebellopontine angle lipomas are unusual lesions, more exceptional than their intracranial counter-parts. The knowledge of these tumoral lesions and of their close relationships with cranial nerves incite to perform a frozen section when imagery is evocative, to limit functional postoperative sequelae.
Rhabdomyomas are benign tumors of striated muscle. They are distinguished by topographic data: ca... more Rhabdomyomas are benign tumors of striated muscle. They are distinguished by topographic data: cardiac or genital and by histological criteria: foetal or adult type. The foetal type is the most heterogeneous, with either a majority of immature cells or a mixture of maturing elements. This diversity has led to distinguish immature (or standard) foetal Rhabdomyomas from intermediate foetal Rhabdomyomas. One observation of this last type is reported. The authors highlight the essential characteristics of foetal Rhabdomyomas, however the exact meaning remains unclear: an anomaly in the differentiation of the striated muscle? or a true tumoral process through genetic anomaly?
We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tum... more We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tumor showed a typical histological appearance with pseudoepithelial pigmented structures immunoreactive for S100 protein and vimentin. The tumor did not recur after total surgical removal and post operative radiation. However, after a 10 year follow-up, imaging demonstrated that a second tumor occurred in the left cerebellar hemisphere, which, on histological examination, was a typical glioblastoma. Hypothesis concerning the histogenesis of the second tumor, as well as a causal association with radiation therapy and possible contribution of growth hormone therapy are discussed.
The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or ... more The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or interphase on cytological preparations and frozen tissue sections, using oligonucleotide primers derived from chromosome specific subsets of repeated DNA families. PRINS technique is an alternative to fluorescence in situ hybridization, as sensitive as FISH but faster and more specific. This technique is potentially of great interest for pathologists involved in transplantation pathology or cytogenetic interphasic oncology.
We report 2 cases of spinal epidural cavernous angiomas revealed by paraplegia, and present the m... more We report 2 cases of spinal epidural cavernous angiomas revealed by paraplegia, and present the main cases reported in the literature since 1895. The diagnosis of this uncommon affection seems to be difficult to establish only upon clinical and radiological features. In spite of recent advances in neuroradiological imaging, these kinds of angiomas still remain an operative and histopathological discovery. A laminectomy was performed revealing a vascular lesion which was totally extirpated. Functional recovery was achieved in both cases.
We present a case of orbital lipogranuloma with a supero-nasal retrobulbar localisation associate... more We present a case of orbital lipogranuloma with a supero-nasal retrobulbar localisation associated with axial proptosis and major choroidal thickening. No clinical sign of inflammation, neither orbital nor in the posterior segment, was revealed. The systemic work-up as well as paraclinical data were within normal limits. The diagnosis was made after histopathologic examination of the biopsy taken via superior orbit. Outcome was favorable following long-term systemic corticotherapy. Orbital lipogranuloma is a rare particular form of orbital pseudotumour of unknown etiology. It is characterized, histologically, by orbital fat necrosis. Pathogenesis remains controversial. The differential diagnosis includes iatrogenic lipogranulomas secondary to sinus surgery (paraffinoma), orbital granulomas in sarcoidosis and Wegener's disease and orbital lymphomas. The prognosis is usually good following treatment with steroids.
Archives d'anatomie et de cytologie pathologiques, 1993
Müllerian adenosarcoma is an uncommon disease of the female genital tract with a special place am... more Müllerian adenosarcoma is an uncommon disease of the female genital tract with a special place among mixed müllerian tumors because of its slow and more favorable clinical course. This tumor is composed of a benign epithelial contingent and a sarcomatous one. A case of Müllerian adenosarcoma clinically characterized by an atypical outset is described and the literature is reviewed.
Epithelial tumors of the lacrimal gland account for 50% of the expansive lesions of the lacrimal ... more Epithelial tumors of the lacrimal gland account for 50% of the expansive lesions of the lacrimal fossa. Pleomorphic adenomas have a good prognosis if surgery achieves en bloc removal distant from the tumoral capsule. Nevertheless, despite more severe treatment, the average survival remains limited for adenocarcinomas and cylindromas.
Orbital tumors arising from paranasal sinuses comprise mucoceles and malignant ethmoidal tumors. ... more Orbital tumors arising from paranasal sinuses comprise mucoceles and malignant ethmoidal tumors. Most often, anamnestic, clinical, and radiological data as well as endoscopic biopsy performed by an ENT surgeon provide the preoperative diagnosis. If the tumor is benign, surgery can cure the patient. It is associated with chemotherapy and radiotherapy if the tumor is malignant.
We report a new case of glial tissue in uterine cervix found in a 63 year-old woman with an abort... more We report a new case of glial tissue in uterine cervix found in a 63 year-old woman with an abortion 30 years ago. The lesion, measuring 0.5 cm in diameter, showed a typical feature of mature glial tissue immunoreactive for the glial fibrillary acid protein. Hypothesis concerning its histogenesis (fetal graft, tumor, metaplasia) are discussed. Fetal implantation is likely as in the majority of published cases.
The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or ... more The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or interphase on cytological preparations and frozen tissue sections, using oligonucleotide primers derived from chromosome specific subsets of repeated DNA families. PRINS technique is an alternative to fluorescence in situ hybridization, as sensitive as FISH but faster and more specific. This technique is potentially of great interest for pathologists involved in transplantation pathology or cytogenetic interphasic oncology.
We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy Univer... more We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy University Hospital from 1987 to 1997. There were 9 males and 7 females. Mean age at onset of symptoms was 9.5 years (range: 3 months to 29 years) and the mean age at surgery was 16 years. Nine patients experienced partial complex seizures, 5 patients generalized seizures, 1 patient partial seizures with secondary generalization and one patient ataxia. The diagnosis of DNT was made under consideration of clinical, radiological and neuropathological features. All patients underwent surgery. Removal of the tumor was complete for 10 patients, subtotal or partial for 6 patients. Histological examination revealed that 7 cases were specific forms of DNT due to the presence of the specific glioneuronal element. For the 9 remained cases, the diagnosis of DNT could only be made with the consideration of clinical and radiological features. Mean post-surgical follow-up was 3.5 years (range: 1-8 years). E...
We report 4 cases of central neurocytoma removed by a transfrontal approach with no recurrence af... more We report 4 cases of central neurocytoma removed by a transfrontal approach with no recurrence after a mean follow up of 3 years. This uncommon lesion of the supratentorial ventricles (150 cases reported) occurs in young adults, and often induces intracranial hypertension secondary to an obstructive hydrocephalus. The CT scan, MRI and histopathological features are related. This neuronal origin tumor is difficult to distinguish from other intraventricular processes as oligodendroglioma or ependymoma. However, the immunopositivity for the neuronal markers as synaptophysin, calcineurin and microtubul associated protein 2, and the negativity for the glial fibrillary acidic protein, allow the diagnosis of this neuropathological entity. The prognosis is favorable though some cases of recurrence (14 cases) and cerebrospinal dissemination (2 cases) has been reported in the literature.
A 21-year old woman underwent surgery in December 1996 for the removal of a presumed tuberculum s... more A 21-year old woman underwent surgery in December 1996 for the removal of a presumed tuberculum sellae meningioma. However, some radio-clinical findings were proved somewhat intriguing:the patient's age, the presence of inflammatory and febrile syndromes together with the diagnosis of aseptic meningitis associated with perilesional edema intensity (an unusual feature in such cases) made us challenge the initial neuroradiological diagnosis evoked in connection with the tumoral location and dural attachment pattern. A right sub-fronto-temporal approach allowed complete tumor resection (confirmed with a postoperative MRI) and clinical recovery of the patient. But while pathological examination suggested a chordoma, the study of immunohistochemical stains revealed a meningioma. The final diagnosis was chordoid meningioma. Our review of the literature has shown that chordoid meningiomas display several areas of physaliferous cells which give the tumor a chordoma-like aspect. However,...
Waldenström's disease is a B-cell, low grade lymphoma, secreting an immunoglobulin M, and is ... more Waldenström's disease is a B-cell, low grade lymphoma, secreting an immunoglobulin M, and is called immunocytoma. Neurological complications are frequent, but encephalopathies due to lymphoplasmocytoid infiltration are rare (Bing-Neel syndrome). Tumors, probably arising from confluence of infiltrative areas, are exceedingly rare. The authors report the case of a 70-year-old man, suffering from a Waldenström's immunoglobulinemia, who underwent surgery for a right sided rolandic tumor involving the vault, the dura-mater, and the cortex. On the CT scan, the tumor mimicked a meningioma. Histological study and immunohistologic stains confirmed the monoclonal nature of the tumor. Based on the review of the literature, clinical and neuroradiological features of these infiltrative and tumoral rare lesions, as well as their histopathogenesis and treatment, are discussed.
We report two cases of intra-auditory canal lipoma, presenting as acoustic neuroma, observed in r... more We report two cases of intra-auditory canal lipoma, presenting as acoustic neuroma, observed in respectively 45 and 53 year old patients. Cerebellopontine angle lipomas are unusual lesions, more exceptional than their intracranial counter-parts. The knowledge of these tumoral lesions and of their close relationships with cranial nerves incite to perform a frozen section when imagery is evocative, to limit functional postoperative sequelae.
Rhabdomyomas are benign tumors of striated muscle. They are distinguished by topographic data: ca... more Rhabdomyomas are benign tumors of striated muscle. They are distinguished by topographic data: cardiac or genital and by histological criteria: foetal or adult type. The foetal type is the most heterogeneous, with either a majority of immature cells or a mixture of maturing elements. This diversity has led to distinguish immature (or standard) foetal Rhabdomyomas from intermediate foetal Rhabdomyomas. One observation of this last type is reported. The authors highlight the essential characteristics of foetal Rhabdomyomas, however the exact meaning remains unclear: an anomaly in the differentiation of the striated muscle? or a true tumoral process through genetic anomaly?
We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tum... more We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tumor showed a typical histological appearance with pseudoepithelial pigmented structures immunoreactive for S100 protein and vimentin. The tumor did not recur after total surgical removal and post operative radiation. However, after a 10 year follow-up, imaging demonstrated that a second tumor occurred in the left cerebellar hemisphere, which, on histological examination, was a typical glioblastoma. Hypothesis concerning the histogenesis of the second tumor, as well as a causal association with radiation therapy and possible contribution of growth hormone therapy are discussed.
The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or ... more The PRimed IN Situ synthesis is a method for rapid identification of chromosomes in metaphase or interphase on cytological preparations and frozen tissue sections, using oligonucleotide primers derived from chromosome specific subsets of repeated DNA families. PRINS technique is an alternative to fluorescence in situ hybridization, as sensitive as FISH but faster and more specific. This technique is potentially of great interest for pathologists involved in transplantation pathology or cytogenetic interphasic oncology.
We report 2 cases of spinal epidural cavernous angiomas revealed by paraplegia, and present the m... more We report 2 cases of spinal epidural cavernous angiomas revealed by paraplegia, and present the main cases reported in the literature since 1895. The diagnosis of this uncommon affection seems to be difficult to establish only upon clinical and radiological features. In spite of recent advances in neuroradiological imaging, these kinds of angiomas still remain an operative and histopathological discovery. A laminectomy was performed revealing a vascular lesion which was totally extirpated. Functional recovery was achieved in both cases.
We present a case of orbital lipogranuloma with a supero-nasal retrobulbar localisation associate... more We present a case of orbital lipogranuloma with a supero-nasal retrobulbar localisation associated with axial proptosis and major choroidal thickening. No clinical sign of inflammation, neither orbital nor in the posterior segment, was revealed. The systemic work-up as well as paraclinical data were within normal limits. The diagnosis was made after histopathologic examination of the biopsy taken via superior orbit. Outcome was favorable following long-term systemic corticotherapy. Orbital lipogranuloma is a rare particular form of orbital pseudotumour of unknown etiology. It is characterized, histologically, by orbital fat necrosis. Pathogenesis remains controversial. The differential diagnosis includes iatrogenic lipogranulomas secondary to sinus surgery (paraffinoma), orbital granulomas in sarcoidosis and Wegener's disease and orbital lymphomas. The prognosis is usually good following treatment with steroids.
Archives d'anatomie et de cytologie pathologiques, 1993
Müllerian adenosarcoma is an uncommon disease of the female genital tract with a special place am... more Müllerian adenosarcoma is an uncommon disease of the female genital tract with a special place among mixed müllerian tumors because of its slow and more favorable clinical course. This tumor is composed of a benign epithelial contingent and a sarcomatous one. A case of Müllerian adenosarcoma clinically characterized by an atypical outset is described and the literature is reviewed.
Epithelial tumors of the lacrimal gland account for 50% of the expansive lesions of the lacrimal ... more Epithelial tumors of the lacrimal gland account for 50% of the expansive lesions of the lacrimal fossa. Pleomorphic adenomas have a good prognosis if surgery achieves en bloc removal distant from the tumoral capsule. Nevertheless, despite more severe treatment, the average survival remains limited for adenocarcinomas and cylindromas.
Orbital tumors arising from paranasal sinuses comprise mucoceles and malignant ethmoidal tumors. ... more Orbital tumors arising from paranasal sinuses comprise mucoceles and malignant ethmoidal tumors. Most often, anamnestic, clinical, and radiological data as well as endoscopic biopsy performed by an ENT surgeon provide the preoperative diagnosis. If the tumor is benign, surgery can cure the patient. It is associated with chemotherapy and radiotherapy if the tumor is malignant.
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Papers by F. Baylac