Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2013
The Allen Brain Atlas (ABA) database provides comprehensive 3D atlas of gene expression in the ad... more The Allen Brain Atlas (ABA) database provides comprehensive 3D atlas of gene expression in the adult mouse brain for studying the spatial expression patterns in the mammalian central nervous system. It is computationally challenging to construct the accurate anatomical and genetic networks using the ABA 4D data. In this paper, we propose a novel sparse simplex model to accurately construct the brain anatomical and genetic networks, which are important to reveal the brain spatial expression patterns. Our new approach addresses the shift-invariant and parameter tuning problems, which are notorious in the existing network analysis methods, such that the proposed model is more suitable for solving practical biomedical problems. We validate our new model using the 4D ABA data, and the network construction results show the superior performance of the proposed sparse simplex model.
Information processing in medical imaging : proceedings of the ... conference, 2013
Neuroimaging markers have been widely used to predict the cognitive functions relevant to the pro... more Neuroimaging markers have been widely used to predict the cognitive functions relevant to the progression of Alzheimer's disease (AD). Most previous studies identify the imaging markers without considering the brain structural correlations between neuroimaging measures. However, many neuroimaging markers interrelate and work together to reveal the cognitive functions, such that these relevant markers should be selected together as the phenotypic markers. To solve this problem, in this paper, we propose a novel network constrained feature selection (NCFS) model to identify the neuroimaging markers guided by the structural brain network, which is constructed by the sparse representation method such that the interrelations between neuroimaging features are encoded into probabilities. Our new methods are evaluated by the MRI and AV45-PET data from ADNI-GO and ADNI-2 (Alzheimer's Disease Neuroimaging Initiative). In all cognitive function prediction tasks, our new NCFS method out...
To systematically evaluate whether immunochemical fecal occult blood tests (iFOBT) could improve ... more To systematically evaluate whether immunochemical fecal occult blood tests (iFOBT) could improve clinical performance and test accuracy in screening and surveillance for advanced colorectal neoplasms. Eligible articles were identified by searches of electronic databases. All randomized trials and diagnostic cohort trials directly comparing iFOBT with guaiac-based FOBT (gFOBT) were included. A statistical analysis was performed using RevMan 4.2.8. A sensitivity, specificity and summary receiver operating characteristic curve was performed using Meta Disc. We identified five randomized trials and 11 diagnostic cohort trials. In the randomized trials, the detection rates of advanced colorectal neoplasms with iFOBT or gFOBT were 2.23 percent and 1.24 percent, respectively. The pooled odds ratio (OR) was 1.50 (95% CI 0.94-2.39). In cohort trials, the advanced neoplasm detection rates of iFOBT or gFOBT were 1.44 percent and 0.50 percent (OR 1.99, 95% CI 1.24-3.19) in the average-risk screened population, and were 8.8 percent and 7.1 percent (OR 1.27, 95% CI 1.01-1.60) in diagnosed patients scheduled for colonoscopy. The sensitivity of iFOBT (0.67, 95% CI 0.61-0.73) was superior to that of gFOBT (0.54, 95% CI 0.48-0.60), as well as the specificities (0.85, 95% CI 0.83-0.87 vs 0.80, 95% CI 0.78-0.82) and positive predictive values (0.41 vs 0.29) in cohort trials of diagnosed patients. Our review suggests that iFOBT could perform better in increasing the detection rate of advanced colorectal neoplasm than gFOBT and possesses higher sensitivity and specificity in the surveillance of advanced colorectal neoplasm for patients.
... Science and Technology, Lanzhou University, Lanzhou 730020);Research progress on genetic tran... more ... Science and Technology, Lanzhou University, Lanzhou 730020);Research progress on genetic transformation and ecological adaptability in white clover[J];Acta ... 6, DONG Kuan-hu1,HAO Chun-yan2,WANG Kang1 (1.College of Animal Science and Veterinary Medicine, Shanxi ...
... 1, LI Jie-fei, LI Wei-hua, JIN Tai-yi, DING Xun-cheng ( School of Public Health, Fudan Univer... more ... 1, LI Jie-fei, LI Wei-hua, JIN Tai-yi, DING Xun-cheng ( School of Public Health, Fudan University, Shanghai, 200032; Shanghai Institute of Planned Parenthood Research, Shanghai, 200032);Zebrafish and its Application in Environmental Toxicology[J];Journal of Labour Medicine ...
A post‐chemiluminescence (PCL) was observed when loperamide hydrochloride solution was injected i... more A post‐chemiluminescence (PCL) was observed when loperamide hydrochloride solution was injected into the reaction mixture after the finish of CL reaction of alkaline N‐Chlorosuccinimide (NCS) and dichlorofluorescein. Based on this phenomenon, a simple, sensitive and fast flow injection PCL method was established for the determination of loperamide hydrochloride. The possible mechanism for the PCL reaction was discussed via the investigation
... NRF2008IDM-IDM-004-018) and NSFC (Grant No. 60835002). several works have been proposed to pe... more ... NRF2008IDM-IDM-004-018) and NSFC (Grant No. 60835002). several works have been proposed to perform K-means clus-tering and dimension reduction iteratively for high dimen-sional data [la Torre and Kanade, 2006; Ding and Li, 2007; Ye et al., 2007]. ...
A gas/liquid interface will be formed when the free volatilized methyl aldehyde gas begins to dis... more A gas/liquid interface will be formed when the free volatilized methyl aldehyde gas begins to dissolve in to solution. On the basis of the traditional silver mirror reaction, silver nanoparticle-manganese oxyhydroxide-graphene oxide (Ag-MnOOH-GO) nanocomposite was synthesized at the gas/liquid interface without any protection of inert gas at room temprature. The morphology of the nanocomposites could be controlled by adjusting the reaction temperature and time. The morphology and composition of the nanocomposites were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. The composites were then applied for electrochemical sensing. The electrochemical investigation for the sensor indicates that it has excellent property to catalyze H2O2, and could detect H2O2 with a low detection limit of 0.2μM and wide linear range of 0.5 μM to 17.8 mM. The present study provides a general platform for the controlled synthesis of nanomaterials and can be extended to other optical, electronic, and magnetic nanocompounds.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2013
The Allen Brain Atlas (ABA) database provides comprehensive 3D atlas of gene expression in the ad... more The Allen Brain Atlas (ABA) database provides comprehensive 3D atlas of gene expression in the adult mouse brain for studying the spatial expression patterns in the mammalian central nervous system. It is computationally challenging to construct the accurate anatomical and genetic networks using the ABA 4D data. In this paper, we propose a novel sparse simplex model to accurately construct the brain anatomical and genetic networks, which are important to reveal the brain spatial expression patterns. Our new approach addresses the shift-invariant and parameter tuning problems, which are notorious in the existing network analysis methods, such that the proposed model is more suitable for solving practical biomedical problems. We validate our new model using the 4D ABA data, and the network construction results show the superior performance of the proposed sparse simplex model.
Information processing in medical imaging : proceedings of the ... conference, 2013
Neuroimaging markers have been widely used to predict the cognitive functions relevant to the pro... more Neuroimaging markers have been widely used to predict the cognitive functions relevant to the progression of Alzheimer's disease (AD). Most previous studies identify the imaging markers without considering the brain structural correlations between neuroimaging measures. However, many neuroimaging markers interrelate and work together to reveal the cognitive functions, such that these relevant markers should be selected together as the phenotypic markers. To solve this problem, in this paper, we propose a novel network constrained feature selection (NCFS) model to identify the neuroimaging markers guided by the structural brain network, which is constructed by the sparse representation method such that the interrelations between neuroimaging features are encoded into probabilities. Our new methods are evaluated by the MRI and AV45-PET data from ADNI-GO and ADNI-2 (Alzheimer's Disease Neuroimaging Initiative). In all cognitive function prediction tasks, our new NCFS method out...
To systematically evaluate whether immunochemical fecal occult blood tests (iFOBT) could improve ... more To systematically evaluate whether immunochemical fecal occult blood tests (iFOBT) could improve clinical performance and test accuracy in screening and surveillance for advanced colorectal neoplasms. Eligible articles were identified by searches of electronic databases. All randomized trials and diagnostic cohort trials directly comparing iFOBT with guaiac-based FOBT (gFOBT) were included. A statistical analysis was performed using RevMan 4.2.8. A sensitivity, specificity and summary receiver operating characteristic curve was performed using Meta Disc. We identified five randomized trials and 11 diagnostic cohort trials. In the randomized trials, the detection rates of advanced colorectal neoplasms with iFOBT or gFOBT were 2.23 percent and 1.24 percent, respectively. The pooled odds ratio (OR) was 1.50 (95% CI 0.94-2.39). In cohort trials, the advanced neoplasm detection rates of iFOBT or gFOBT were 1.44 percent and 0.50 percent (OR 1.99, 95% CI 1.24-3.19) in the average-risk screened population, and were 8.8 percent and 7.1 percent (OR 1.27, 95% CI 1.01-1.60) in diagnosed patients scheduled for colonoscopy. The sensitivity of iFOBT (0.67, 95% CI 0.61-0.73) was superior to that of gFOBT (0.54, 95% CI 0.48-0.60), as well as the specificities (0.85, 95% CI 0.83-0.87 vs 0.80, 95% CI 0.78-0.82) and positive predictive values (0.41 vs 0.29) in cohort trials of diagnosed patients. Our review suggests that iFOBT could perform better in increasing the detection rate of advanced colorectal neoplasm than gFOBT and possesses higher sensitivity and specificity in the surveillance of advanced colorectal neoplasm for patients.
... Science and Technology, Lanzhou University, Lanzhou 730020);Research progress on genetic tran... more ... Science and Technology, Lanzhou University, Lanzhou 730020);Research progress on genetic transformation and ecological adaptability in white clover[J];Acta ... 6, DONG Kuan-hu1,HAO Chun-yan2,WANG Kang1 (1.College of Animal Science and Veterinary Medicine, Shanxi ...
... 1, LI Jie-fei, LI Wei-hua, JIN Tai-yi, DING Xun-cheng ( School of Public Health, Fudan Univer... more ... 1, LI Jie-fei, LI Wei-hua, JIN Tai-yi, DING Xun-cheng ( School of Public Health, Fudan University, Shanghai, 200032; Shanghai Institute of Planned Parenthood Research, Shanghai, 200032);Zebrafish and its Application in Environmental Toxicology[J];Journal of Labour Medicine ...
A post‐chemiluminescence (PCL) was observed when loperamide hydrochloride solution was injected i... more A post‐chemiluminescence (PCL) was observed when loperamide hydrochloride solution was injected into the reaction mixture after the finish of CL reaction of alkaline N‐Chlorosuccinimide (NCS) and dichlorofluorescein. Based on this phenomenon, a simple, sensitive and fast flow injection PCL method was established for the determination of loperamide hydrochloride. The possible mechanism for the PCL reaction was discussed via the investigation
... NRF2008IDM-IDM-004-018) and NSFC (Grant No. 60835002). several works have been proposed to pe... more ... NRF2008IDM-IDM-004-018) and NSFC (Grant No. 60835002). several works have been proposed to perform K-means clus-tering and dimension reduction iteratively for high dimen-sional data [la Torre and Kanade, 2006; Ding and Li, 2007; Ye et al., 2007]. ...
A gas/liquid interface will be formed when the free volatilized methyl aldehyde gas begins to dis... more A gas/liquid interface will be formed when the free volatilized methyl aldehyde gas begins to dissolve in to solution. On the basis of the traditional silver mirror reaction, silver nanoparticle-manganese oxyhydroxide-graphene oxide (Ag-MnOOH-GO) nanocomposite was synthesized at the gas/liquid interface without any protection of inert gas at room temprature. The morphology of the nanocomposites could be controlled by adjusting the reaction temperature and time. The morphology and composition of the nanocomposites were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. The composites were then applied for electrochemical sensing. The electrochemical investigation for the sensor indicates that it has excellent property to catalyze H2O2, and could detect H2O2 with a low detection limit of 0.2μM and wide linear range of 0.5 μM to 17.8 mM. The present study provides a general platform for the controlled synthesis of nanomaterials and can be extended to other optical, electronic, and magnetic nanocompounds.
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