- Egresado de la Facultad de Medicina, Universidad Autónoma de Guadalajara (UAG). Estudios de posgrado en el Hospital U... moreEgresado de la Facultad de Medicina, Universidad Autónoma de Guadalajara (UAG). Estudios de posgrado en el Hospital Universitario Dr. Ángel Leaño, UAG, Instituto Nacional de la Nutrición .Hospital General de Centro médico Nacional, IMSS. Instituto Nacional de Cancerología de México (INCan), Cirugía oncológica. Labora en el INCan y práctica privada en el Hospital Ángeles del Pedregal, Ciudad de México. Expresidente de la Sociedad Mexicana de Oncología(SMeO), Consejo Mexicano de Oncología (CMOncol), Academia Mexicana de Cirugía (AMC), International College of Surgeons (ICS) y Presidente de la Asociación Mexicana de la Lucha Contra el Cáncer(AMLCC). Profesor de la Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM).Miembro del Sistema Nacional de Investigadores (SNI)edit
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Research Interests: Medicine and Gynecology
IntroductionIn patients with unresectable Differentiated thyroid cancer (DTC), the use of external beam radiation therapy (EBRT), leads mostly to palliation. Our aim is to define the role of upfront EBRT, followed or not by salvage... more
IntroductionIn patients with unresectable Differentiated thyroid cancer (DTC), the use of external beam radiation therapy (EBRT), leads mostly to palliation. Our aim is to define the role of upfront EBRT, followed or not by salvage surgery, on Progression-free survival (PFS) or Overall survival (OS) in patients with DTC.MethodsThis is a cohort study of patients with initially unresectable DTC who received EBRT. Cohort A received EBRT followed by rescue surgery and cohort B, EBRT only. The Kaplan-Meier method and Cox model were employed for survival analysis.ResultsThirty-three patients were included; 69.6% females and 30.3% males. Mean age was 60.6 and mean tumor diameter was 10.4 cm; 17 and 16 patients were included in cohorts A and B, respectively. Belonging to cohort A (Hazard ratio [HR] 0.177, 95% CI 0.05–0.7) and use of intensity modulated radiotherapy (HR 0.177, 95% CI 0.03–1.08) were associated to better PFS, while high-risk histopathology (HR 6.6, 95% CI 0.9–50) and EBRT dos...
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Research Interests: Humanities and Medicine
Of women between 15 and 29 years of age, 13.6% will die from breast cancer. For women between 30 and 64 years of age, 19% will die from breast cancer. We studied 1728 oncological patients and 295 patients were included, 293 with breast... more
Of women between 15 and 29 years of age, 13.6% will die from breast cancer. For women between 30 and 64 years of age, 19% will die from breast cancer. We studied 1728 oncological patients and 295 patients were included, 293 with breast cancer (17%) and two patients with primary breast lymphoma (0.1%). There were 98% females and 2% males. SUVmax for the primary tumor was 4.2 +/- 2.6 SD. Mean SUVmax for patients with primary breast lymphoma were 3.2 and 1.4. Sites of metastases were lymph nodes in the neck (4.4% SUVmax 2.7), internal mammary lymph nodes (5% SUVmax 5.3), mediastinum (8.3% SUVmax 5.0), retroperitoneal (6 % SUVmax 5.4), ipsilateral axilla (94% SUVmax 4.5), contralateral axilla (4.4% SUVmax 2.8), pectoral muscle (10.2% SUVmax 2.6), pleura (4.4% SUVmax 3.9), lung (32.3% SUVmax 2.9), liver (19.1% SUVmax 4.5), bone (36.7%), adrenal gland (4.4% SUVmax 2.4), brain (4.4%), spleen and contralateral breast, one case each. One patient presented thymic hyperplasia after chemotherap...
Research Interests: Breast Cancer, Positron Emission Tomography, Medicine, Humans, Female, and 14 morePubmed, Male, Hyperplasia, Mammography, Carcinoma, Adult, Cost Benefit Analysis, Retrospective Studies, Radiopharmaceuticals, Sensitivity and Specificity, X ray Computed Tomography, Brain Neoplasms, Breast Neoplasms, and Thymus Gland
LA ADICCION AL TABACO PRODUCE CANCER, YA SEA EN LA CAVIDAD ORAL, LA LARINGE, EL ESOFAGO, PANCREAS O VEJIGA, Y AL MISMO TIEMPO OCASIONA PROBLEMAS CARDIACOS O DE PRESION ARTERIAL, AFIRMO EL DOCTOR FRANCISCO OCHOA CARRILLO, JEFE DE LA... more
LA ADICCION AL TABACO PRODUCE CANCER, YA SEA EN LA CAVIDAD ORAL, LA LARINGE, EL ESOFAGO, PANCREAS O VEJIGA, Y AL MISMO TIEMPO OCASIONA PROBLEMAS CARDIACOS O DE PRESION ARTERIAL, AFIRMO EL DOCTOR FRANCISCO OCHOA CARRILLO, JEFE DE LA DIVISION DE CIRUGIA DEL INSTITUTO NACIONAL DE CANCEROLOGIA, EN EL AUDITORIO JOSE J. ROJO DE LA FACULTAD DE ODONTOLOGIA (FO) AL OFRECER LA CONFERENCIA "TABAQUISMO, SALUD Y EL CANCER EN LA CAVIDAD ORAL". ENTRE OTROS PERJUICIOS, AGREGO QUE EL TABAQUISMO OCASIONA ALITOSIS, PERDIDA TEMPRANA DE DIENTES Y NECROSISIS DE LA CAVIDAD ORAL.
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AL INTERVENIR EN EL VI CONGRESO ESTUDIANTIL, ORGANIZADO POR LA FACULTAD DE ODONTOLOGIA (FO), EL DOCTOR FRANCISCO OCHOA CARRILLO, JEFE DE CIRUGIA DEL INSTITUTO NACIONAL DE CANCEROLOGIA, SENALO QUE MAS DEL 35 POR CIENTO DE TODOS LOS TIPOS... more
AL INTERVENIR EN EL VI CONGRESO ESTUDIANTIL, ORGANIZADO POR LA FACULTAD DE ODONTOLOGIA (FO), EL DOCTOR FRANCISCO OCHOA CARRILLO, JEFE DE CIRUGIA DEL INSTITUTO NACIONAL DE CANCEROLOGIA, SENALO QUE MAS DEL 35 POR CIENTO DE TODOS LOS TIPOS DE CANCER ESTA ASOCIADO CON EL USO Y ABUSO DEL HABITO DEL TABACO. EL TABAQUISMO, ASEVERO, ES UN PROBLEMA SOCIAL PERMISIBLE, ACEPTABLE Y TOLERABLE, Y PROMOVIDO POR CAMPANAS DE PUBLICIDAD. ESTE NOCIVO HABITO PRODUCE CANCER, PADECIMIENTOS CRONICOS, ENVEJECIMIENTO PREMATURO Y ALTERACIONES CARDIOVASCULARES, ASI COMO UNA MUERTE TEMPRANA, SENALO. EL DIRECTOR DE LA FO, DOCTOR JAVIER PORTILLA ROBERTSON, AL INAUGURAR LOS TRABAJOS DEL CONGRESO, DESTACO QUE FORMAR CIRUJANOS DENTISTAS CON CONVICCIONES Y PRINCIPIOS BIEN DEFINIDOS ES UNO DE LOS GRANDES RETOS QUE HA ASUMIDO ESTA DEPENDENCIA. SE ANOTAN DATOS SOBRE LOS ANTECEDENTES DEL CONGRESO ESTUDIANTIL ORGANIZADO EN LA FO.
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Two ferrite-martensite stainless steels(FMSSs)were developed by Baosteel based on the T4003 composition,through optimizing the manganese and nickel contents,reducing silicon,carbon and nitrogen contents,controlling remnant niobium and... more
Two ferrite-martensite stainless steels(FMSSs)were developed by Baosteel based on the T4003 composition,through optimizing the manganese and nickel contents,reducing silicon,carbon and nitrogen contents,controlling remnant niobium and molybdenum,adding sufficient titanium and controlling the processing.In this study,the physical metallurgy of such FMSSs was investigated with the emphasis on the alloying effect on the phase balance during processing and the transformation behavior during welding for different microstructures.In addition,the mechanical behavior and the weldability were investigated.The results indicate that such steels have a good combination of strength and toughness and better weldability compared with the traditional 1.4003 steel.Such high strength steels are highly suitable for railway cargo transportation where the wall thickness of the wagons can be reduced,resulting in weight savings.
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We describe an 18-year-old woman with a mass in the region of the right ovary. The mass, which had a central cavity lined by endometrium and surrounded by smooth muscle, extraordinarily resembled a uterus. Review of the literature... more
We describe an 18-year-old woman with a mass in the region of the right ovary. The mass, which had a central cavity lined by endometrium and surrounded by smooth muscle, extraordinarily resembled a uterus. Review of the literature disclosed only one such case in which this change was considered to arise from endomyometriosis of the ovary, a phenomenon characterized by smooth-muscle metaplasia in a focus of endometriosis. Although this possibility is interesting and plausible, we believe that a congenital malformation, possibly caused by a defect in fusion of müllerian ducts, should strongly be considered in explaining the pathogenesis of this kind of lesion.
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Angiocentric lymphomas (AL) involving the mid-face are infrequent lesions. Their incidence seems to be higher in certain Asian and Latin American countries, where most of the reported series reveal a predominance of T-cell lineage and a... more
Angiocentric lymphomas (AL) involving the mid-face are infrequent lesions. Their incidence seems to be higher in certain Asian and Latin American countries, where most of the reported series reveal a predominance of T-cell lineage and a high frequency of EBV-positive cells. The clinical and pathological features of 12 AL that affected the palate are presented. Immunophenotypic studies were performed in nine of these cases. Seven (77%) demonstrated T-cell lineage, one was of B-cell origin and one could not be classified. The high incidence of T-cell lesions in this and other studies supports the existence of geographical and possibly of etiological differences in these neoplasms.
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Research Interests: Pathology, Medicine, Prospective studies, Humans, Thyroid gland, and 15 moreMexico City, Accuracy, Clinical Sciences, Middle Aged, Adult, Size, Precision, Diagnostic Accuracy, Sensitivity and Specificity, Prospective Study, Thyroiditis, Thyroid nodule, False Negative, thyroid carcinoma, and Thyroid Neoplasms
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Although various sources of vascularized bone/composite tissue have been used for mandibular reconstruction, the vascularized fibular flap has been reported to have many advantages over the others and to be the most suitable for bridging... more
Although various sources of vascularized bone/composite tissue have been used for mandibular reconstruction, the vascularized fibular flap has been reported to have many advantages over the others and to be the most suitable for bridging a long-span mandibular defect. In this paper, positive experience of 14 consecutive cases in which a free vascularized fibular graft with or without a skin paddle has been used to reconstruct a long mandibular defect is reported. Half of the cases were primarily reconstructed, the rest secondarily. The average length of the fibula graft harvested was 16.7 cm, with a range of 12 to 22 cm. The number of wedge osteotomies ranged from 0 to 4, with an average of 1.67. In ten flaps, a peroneal skin paddle was included. The donor wound was typically closed directly, except in three cases, where a skin graft was used. Vein grafts were performed in five cases to lengthen the pedicle. In two cases, the skin partially necrosed. All scintigrams except one showed good bone viability. But there was no total flap failure. Postoperative facial appearances were fair to excellent, with mouth opening ranging from 21 to 50 mm. Although unusual serious donor wound rupture was experienced in one case, in general the donor site complications were minimal.
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Current research indicates that prostate-specific membrane antigen (PSMA) is related to angiogenesis of many solid tumors including breast cancer (BC), our objective is evaluating PSMA expression in primary tumor and metastatic BC by... more
Current research indicates that prostate-specific membrane antigen (PSMA) is related to angiogenesis of many solid tumors including breast cancer (BC), our objective is evaluating PSMA expression in primary tumor and metastatic BC by Positron emission tomography/computed tomography (PET/CT). In this retrospective study twenty-one patients with BC included all molecular subtypes, was evaluated with 18F-FDG-PET/CT imaging as stratification and 68Ga-PSMA-PET/CT. Primary sites of BC was identifying in all patients with 18F-FDG-PET/CT. We identified lymph node metastases in 17 patients (81%) and metastatic disease in 15 patients (71%). A total 127 lesions were detected by 18F-FDG-PET/CT, 30 of which were in the breast, 31 axillary lymph-node metastases, 25 mediastinal lymph-node metastases, 15 distant non-bone metastases and 26 bone metastases. 68Ga-PSMA-11-PET/CT showed lower detection-rate (DRs) than did 18F-FDG-PET/CT in all patients with LUM-A and LUM-B HER2. All 18F-FDG PET/CT posit...
Los individuos con cancer tienen mayor riesgo de desarrollar enfermedad tromboembolica venosa. La prevalencia depende de factores relacionados con la neoplasia, como el tipo histologico, el estadio, el empleo de cateteres venosos... more
Los individuos con cancer tienen mayor riesgo de desarrollar enfermedad tromboembolica venosa. La prevalencia depende de factores relacionados con la neoplasia, como el tipo histologico, el estadio, el empleo de cateteres venosos centrales, el tratamiento con quimioterapia o radioterapia, el tipo de cirugia, asi como factores protromboticos generales que incluyen edad, inmovilizacion, obesidad, trombofilias hereditarias y comorbilidades. El tratamiento de individuos con trombosis venosa debe ser personalizado e integral y depende tanto del riesgo de trombosis como de hemorragia. En esta revision se actualizan conceptos que han cambiado sustancialmente en los ultimos anos, como la indicacion de reposo absoluto en pacientes con trombosis reciente o de dietas libres en alimentos verdes. Se proponen estrategias terapeuticas basadas en evidencia sobre los problemas clinicos encontrados con mayor frecuencia en pacientes con cancer y trombosis
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BACKGROUND Fluordeoxyglucose ((18)FDG) is the most common radiotracer used for PET/CT studies. It enters the cell because of the glucose transporter proteins (GLUTs): 1) erythrocytic membrane, skeletal muscle, lymphocytes, ovaries,... more
BACKGROUND Fluordeoxyglucose ((18)FDG) is the most common radiotracer used for PET/CT studies. It enters the cell because of the glucose transporter proteins (GLUTs): 1) erythrocytic membrane, skeletal muscle, lymphocytes, ovaries, breast; 2) pancreas, retina, erythrocytes; 3) adipocytes, ovaries, testis; 4) skeletal muscle, adipocytes, ovaries, myocardium; 5) breast, small intestine, testis, kidney, erythrocytes; 6) spleen, leucocytes, brain; 7) liver; 8) testis, brain; 9) liver, kidney; 10) liver, pancreas; 11) heart, muscle; 12) heart, prostate; 13) brain. We undertook this study to expand the knowledge about physiological uptake. Physiological uptake of (18)FDG was in brain, Waldeyer ring (adenoids, palatine tonsils, lingual tonsils), salivary glands (parotids, submandibular), tongue, vocal cords, cricoarythenoid muscle, thyroid, brown fat (supraclavicular, mediastinal, neck, pericardial fat, around kidney, around great vessels in the thorax, subdiaphragmatic, intercostals, para...
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One of the greatest achievements of medicine is the understanding of the infection from human papillomavirus (HPV) and its causal relation to some types of cancer. Most people with HIV infections have no symptoms, so it may go unnoticed... more
One of the greatest achievements of medicine is the understanding of the infection from human papillomavirus (HPV) and its causal relation to some types of cancer. Most people with HIV infections have no symptoms, so it may go unnoticed and the infection is limited by the host. It is important to note that less than 10% of patients have a persistent infection, which can lead to the development of malignancy. HPV requires a small tissue damage placed in a transitional area of epithelia, such as the existent in the cervix, anus or tonsils, to infect cells. The KEYWORDS
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In the last decade, minimal invasion surgery (MIS) has been used in a great variety of diseases and clinical situations. In gastric carcinoma (GC), specific indications in various circumstances have been described. MIS is used to make a... more
In the last decade, minimal invasion surgery (MIS) has been used in a great variety of diseases and clinical situations. In gastric carcinoma (GC), specific indications in various circumstances have been described. MIS is used to make a diagnosis, for clinical stage classification, and for respectability evaluation, allowing to design a suitable therapy for each patient, because effective neoadjuvant treatments (chemotherapy and radiochemotherapy) are available. MIS has also been used for surgical resection of gastric neoplasia, including endoscopic mucosal resection, wedge resection of gastric wall, subtotal gastrectomy, total gastrectomy or even lymphadenectomy. MIS is used for perform palliative gastrojejunostomy in patients with distal GC, as well as for gastrostomy or jejunostomy for enteral nutrition in specific situations. MIS is still in experimental phase in GC, except in the case of preoperative staging laparoscopy.
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Resumen Introducción: La Tomografía por emisión de Positrones y Tomografía computarizada, es la innovación más moderna de la Medicina Nuclear y de la Radiología, que es capaz de proporcionar imágenes de procesos biológicos in vivo, previa... more
Resumen Introducción: La Tomografía por emisión de Positrones y Tomografía computarizada, es la innovación más moderna de la Medicina Nuclear y de la Radiología, que es capaz de proporcionar imágenes de procesos biológicos in vivo, previa ...
aServicio de Cirugía Cardiovascular. Instituto Nacional de Pediatría, México D.F., México. bSociedad Mexicana de Ortopedia, México DF., México. cSociedad Mexicana de Oncología, AC, México DF., México. Academia Mexicana de Cirugía, México... more
aServicio de Cirugía Cardiovascular. Instituto Nacional de Pediatría, México D.F., México. bSociedad Mexicana de Ortopedia, México DF., México. cSociedad Mexicana de Oncología, AC, México DF., México. Academia Mexicana de Cirugía, México DF., México. dComité de Programación, Asociación Mexicana de Cirugía Endoscópica Servicio de Apoyo Metabólico Nutricio. Centro Médico Nacional 20 de Noviembre, ISSSTE, México DF., México.
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Resumen. El cáncer de pulmón es una de las principales causas de mortalidad alrededor del mundo. Su historia natural, con la manifestación de síntomas en etapas avanzadas y el retraso en su diagnóstico hacen que una gran proporción de... more
Resumen. El cáncer de pulmón es una de las principales causas de mortalidad alrededor del mundo. Su historia natural, con la manifestación de síntomas en etapas avanzadas y el retraso en su diagnóstico hacen que una gran proporción de pacientes se diagnostiquen en estadios tardíos de la enfermedad, lo que hace muy complicado el tratamiento exitoso de la misma. De esto deriva la importancia de dar origen a recomendaciones basadas en evidencia para soportar la toma de decisiones clínicas por parte de los grupos interdisicplinarios que se encargan del manejo de este padecimiento. Objetivos. Esta Guía de Práctica Clínica (GPC) contiene recomendaciones clínicas desarrolladas de forma sistematizada para asistir la toma de decisiones de médicos especialistas, pacientes, cuidadores de pacientes y elaboradores de políticas públicas involucrados en el manejo de pacientes con cáncer de pulmón en estadios tempranos, localmente avanzados y metastásicos. Material y métodos. Este documento se des...