The Physiome is an umbrella term that refers to human modelling with mathematics and computationa... more The Physiome is an umbrella term that refers to human modelling with mathematics and computational methods, accommodating cross-disciplinary science (chemistry, biology, physics) and a breadth of dimensional and temporal scale (sub-cellular to organs, sub-microsecond to tens-of-years). The Virtual Physiological Human is a European initiative that is intended to provide a unifying architecture for the integration and cooperation of multi-scale physiome
3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006., 2006
This paper summarises the current achievements and future developments of the virtual physiologic... more This paper summarises the current achievements and future developments of the virtual physiological human (VPH) technology. The VPH is an organised collection of computational frameworks and ICT-based tools for the multilevel modelling and simulation of the human anatomy and physiology. Once sufficiently developed, the VPH will provide an essential technological infrastructure to the Physiome Project, to pathology-specific initiatives in translational
The challenge of modelling cancer presents a major opportunity to improve our ability to reduce m... more The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adapt...
The Physiome is an umbrella term that refers to human modelling with mathematics and computationa... more The Physiome is an umbrella term that refers to human modelling with mathematics and computational methods, accommodating cross-disciplinary science (chemistry, biology, physics) and a breadth of dimensional and temporal scale (sub-cellular to organs, sub-microsecond to tens-of-years). The Virtual Physiological Human is a European initiative that is intended to provide a unifying architecture for the integration and cooperation of multi-scale physiome
3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006., 2006
This paper summarises the current achievements and future developments of the virtual physiologic... more This paper summarises the current achievements and future developments of the virtual physiological human (VPH) technology. The VPH is an organised collection of computational frameworks and ICT-based tools for the multilevel modelling and simulation of the human anatomy and physiology. Once sufficiently developed, the VPH will provide an essential technological infrastructure to the Physiome Project, to pathology-specific initiatives in translational
The challenge of modelling cancer presents a major opportunity to improve our ability to reduce m... more The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adapt...
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Papers by G. Clapworthy