Journal of Exposure Science & Environmental Epidemiology
Background Disparities in adverse COVID-19 health outcomes have been associated with multiple soc... more Background Disparities in adverse COVID-19 health outcomes have been associated with multiple social and environmental stressors. However, research is needed to evaluate the consistency and efficiency of methods for studying these associations at local scales. Objective To assess socioexposomic associations with COVID-19 outcomes across New Jersey and evaluate consistency of findings from multiple modeling approaches. Methods We retrieved data for COVID-19 cases and deaths for the 565 municipalities of New Jersey up to the end of the first phase of the pandemic, and calculated mortality rates with and without long-term-care (LTC) facility deaths. We considered 84 spatially heterogeneous environmental, demographic and socioeconomic factors from publicly available databases, including air pollution, proximity to industrial sites/facilities, transportation-related noise, occupation and commuting, neighborhood and housing characteristics, age structure, racial/ethnic composition, povert...
The 4th Annual CMAS Models-3 User′ s Conference, Sep 26, 2005
past studies with air quality modeling have used very few Monte Carlo runs for studying uncertain... more past studies with air quality modeling have used very few Monte Carlo runs for studying uncertainties∗ of the order of 20-200 simulations involving 10-100 parameters• Direct Decoupled Method (DDM)–provides accurate local sensitivity information–significant memory requirements as number of parameters increase–large number of simulations for global sensitivity/uncertainty analysis–requires re-coding major portions of a model (not a black-box tool)
<p>Figures in brackets denote percentage composition in alveolar PL (data from <a href=&... more <p>Figures in brackets denote percentage composition in alveolar PL (data from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080917#pone.0080917-Notter1" target="_blank">[3]</a>).</p>*<p>Source: Avanti Polar Lipids, Co.</p
<p>Total chemicals in (a) venous blood, (b) urine, and (c) feces after ingestion of 1.23 mg... more <p>Total chemicals in (a) venous blood, (b) urine, and (c) feces after ingestion of 1.23 mg/kg body weight of <i>α</i>-ZAL by adult healthy human subjects: results from PBTK model (red line) compared with <i>in vivo</i> measurements from Migdalof <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Migdalof1" target="_blank">[16]</a>.</p
<p>Blood serum (venous blood) concentration of ZEA for 8 mg/kg BW of (a) injected dose, and... more <p>Blood serum (venous blood) concentration of ZEA for 8 mg/kg BW of (a) injected dose, and (b) oral dose over a period of 24 hours; PBTK model predictions (red line) compared with <i>in vivo</i> measurements in rats from Shin <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Shin2" target="_blank">[34]</a>.</p
<p>(a) Compounds of the zeranol family of mycotoxins and their biotransformation pathways (... more <p>(a) Compounds of the zeranol family of mycotoxins and their biotransformation pathways (adapted from Kleinova <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Kleinova1" target="_blank">[29]</a>); The stars represent the relative estrogenic potency of the compounds which is in the order: <i>α</i>-ZAL> <i>α</i>-ZOL> <i>β</i>-ZAL> ZEA> <i>β</i>-ZOL. (b) Zearalenone (ZEA) (bottom) and Zeranol (ZAL) (top) molecules with their structural representation.</p
<p>Contributions of the various major food groups towards (a) entire diet of the JGS subjec... more <p>Contributions of the various major food groups towards (a) entire diet of the JGS subjects and (b) estimated ZEA dose; major food groups were constituted by combining similar smaller food groups as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone-0113632-t004" target="_blank">Table 4</a>.</p
<p>Summary of available dietary concentrations (means and ranges) from published literature... more <p>Summary of available dietary concentrations (means and ranges) from published literature of ZEA (in blue) and <i>α</i>-ZAL (in red) in major food groups identified for the Jersey Girl Study (Food groups explained in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone-0113632-t004" target="_blank">Table 4</a>); green bars at the bottom represent the percentages of positive detects among the food samples tested (Only the food groups with any positive detects identified from the literature are shown here).</p
Motivation: In microarray experiments, missing entries arise from blemishes on the chips. In larg... more Motivation: In microarray experiments, missing entries arise from blemishes on the chips. In large-scale studies, virtually every chip contains some missing entries and more than 90 % of the genes are affected. Many analysis methods require a full set of data. Either those genes with missing entries are excluded, or the missing entries are filled with estimates prior to the analyses. This study compares methods of missing value estimation. Results: Two evaluation metrics of imputation accuracy are employed. First, the root mean squared error measures the difference between the true values and the imputed values. Second, the number of misclustered genes measures the difference between clustering with true values and that with imputed values; it examines the bias introduced by imputation to clustering. The Gaussian mixture clustering with model averaging imputation is superior to all other imputation methods, according to both evaluation metrics, on both time-series (correlated) and n...
Environmental, dietary, demographic, and activity variables associated with biomarkers of exposur... more Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead
Journal of Exposure Science & Environmental Epidemiology
Background Disparities in adverse COVID-19 health outcomes have been associated with multiple soc... more Background Disparities in adverse COVID-19 health outcomes have been associated with multiple social and environmental stressors. However, research is needed to evaluate the consistency and efficiency of methods for studying these associations at local scales. Objective To assess socioexposomic associations with COVID-19 outcomes across New Jersey and evaluate consistency of findings from multiple modeling approaches. Methods We retrieved data for COVID-19 cases and deaths for the 565 municipalities of New Jersey up to the end of the first phase of the pandemic, and calculated mortality rates with and without long-term-care (LTC) facility deaths. We considered 84 spatially heterogeneous environmental, demographic and socioeconomic factors from publicly available databases, including air pollution, proximity to industrial sites/facilities, transportation-related noise, occupation and commuting, neighborhood and housing characteristics, age structure, racial/ethnic composition, povert...
The 4th Annual CMAS Models-3 User′ s Conference, Sep 26, 2005
past studies with air quality modeling have used very few Monte Carlo runs for studying uncertain... more past studies with air quality modeling have used very few Monte Carlo runs for studying uncertainties∗ of the order of 20-200 simulations involving 10-100 parameters• Direct Decoupled Method (DDM)–provides accurate local sensitivity information–significant memory requirements as number of parameters increase–large number of simulations for global sensitivity/uncertainty analysis–requires re-coding major portions of a model (not a black-box tool)
<p>Figures in brackets denote percentage composition in alveolar PL (data from <a href=&... more <p>Figures in brackets denote percentage composition in alveolar PL (data from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080917#pone.0080917-Notter1" target="_blank">[3]</a>).</p>*<p>Source: Avanti Polar Lipids, Co.</p
<p>Total chemicals in (a) venous blood, (b) urine, and (c) feces after ingestion of 1.23 mg... more <p>Total chemicals in (a) venous blood, (b) urine, and (c) feces after ingestion of 1.23 mg/kg body weight of <i>α</i>-ZAL by adult healthy human subjects: results from PBTK model (red line) compared with <i>in vivo</i> measurements from Migdalof <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Migdalof1" target="_blank">[16]</a>.</p
<p>Blood serum (venous blood) concentration of ZEA for 8 mg/kg BW of (a) injected dose, and... more <p>Blood serum (venous blood) concentration of ZEA for 8 mg/kg BW of (a) injected dose, and (b) oral dose over a period of 24 hours; PBTK model predictions (red line) compared with <i>in vivo</i> measurements in rats from Shin <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Shin2" target="_blank">[34]</a>.</p
<p>(a) Compounds of the zeranol family of mycotoxins and their biotransformation pathways (... more <p>(a) Compounds of the zeranol family of mycotoxins and their biotransformation pathways (adapted from Kleinova <i>et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone.0113632-Kleinova1" target="_blank">[29]</a>); The stars represent the relative estrogenic potency of the compounds which is in the order: <i>α</i>-ZAL> <i>α</i>-ZOL> <i>β</i>-ZAL> ZEA> <i>β</i>-ZOL. (b) Zearalenone (ZEA) (bottom) and Zeranol (ZAL) (top) molecules with their structural representation.</p
<p>Contributions of the various major food groups towards (a) entire diet of the JGS subjec... more <p>Contributions of the various major food groups towards (a) entire diet of the JGS subjects and (b) estimated ZEA dose; major food groups were constituted by combining similar smaller food groups as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone-0113632-t004" target="_blank">Table 4</a>.</p
<p>Summary of available dietary concentrations (means and ranges) from published literature... more <p>Summary of available dietary concentrations (means and ranges) from published literature of ZEA (in blue) and <i>α</i>-ZAL (in red) in major food groups identified for the Jersey Girl Study (Food groups explained in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113632#pone-0113632-t004" target="_blank">Table 4</a>); green bars at the bottom represent the percentages of positive detects among the food samples tested (Only the food groups with any positive detects identified from the literature are shown here).</p
Motivation: In microarray experiments, missing entries arise from blemishes on the chips. In larg... more Motivation: In microarray experiments, missing entries arise from blemishes on the chips. In large-scale studies, virtually every chip contains some missing entries and more than 90 % of the genes are affected. Many analysis methods require a full set of data. Either those genes with missing entries are excluded, or the missing entries are filled with estimates prior to the analyses. This study compares methods of missing value estimation. Results: Two evaluation metrics of imputation accuracy are employed. First, the root mean squared error measures the difference between the true values and the imputed values. Second, the number of misclustered genes measures the difference between clustering with true values and that with imputed values; it examines the bias introduced by imputation to clustering. The Gaussian mixture clustering with model averaging imputation is superior to all other imputation methods, according to both evaluation metrics, on both time-series (correlated) and n...
Environmental, dietary, demographic, and activity variables associated with biomarkers of exposur... more Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead
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Papers by Panos Georgopoulos