Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and... more Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significan...
Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and... more Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significantly increase the activity of both AST and ALT, in the liver and caused a significant decrease in the deleterious effect induced by IBU. The present results confirm that the antioxidant activity of volatile oil of the Coriandrum sativum L., against hepatotoxicity of IBU.
Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw ... more Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw materials for various industries. It is also a type of raw material from which phenols, naphthalenes, and anthracene can be extracted. The present study was designed to investigate the possibility of coal tar creosote to induce oxidative stress and biochemical perturbations in rat liver and the role of rosemary (Rosmarinus officinalis) in ameliorating its toxic effects. Male Wister Albino rats were randomly divided into four groups of seven each, group I served as control; group II treated with rosemary (10 mL of water extract/kg BW for 21 days), group III received coal tar creosote (200 mg/4 mL olive oil/kg BW for 3 days), and group IV treated with both rosemary and coal tar creosote. The administration of coal tar creosote significantly caused elevation in lipid peroxidation (LPO) and reduction in the activities of glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). A significant decrease in reduced glutathione (GSH) content was also observed. Liver aminotransferases aspartate transaminase (AST) and alanine transaminase (ALT)] and alkaline phosphatase (AlP) were significantly decreased while lactate dehydrogenase (LDH) was increased. Rosemary pretreatment to coal tar creosote-treated rats decreased LPO level and normalized GPx, GR, SOD, CAT, and GST activities, while GSH content was increased. Also, liver AST, ALT, AlP, and LDH were maintained near normal level due to rosemary treatment. In conclusion, rosemary has beneficial effects and could be able to antagonize coal tar creosote toxicity.
The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants w... more The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants working in three different food processing plants in Egypt. Using skin swabs, 75 (38%) of the 200 tested persons were positive for the presence of S. aureus. Of the S. aureus positive persons, 28 (14%) harboured S. aureus produced staphylococcal enterotoxins. The serotypes of these enterotoxins were enterotoxin A (68%), enterotoxin B (36%), enterotoxin C (46%) and enterotoxin D (18%). Some of these isolates produced more than one type of enterotoxins namely AB, AC, BC, BD, ABC and ACD. Analysis of risk factors implicated in skin carriage of S. aureus as age, gender, marital status, education, duration in employment, frequency and method of hand wash and incidence of chronic skin infection revealed insignificant association with staphylococcal skin carriage. The obtained results put forth the risk of food contracting contamination with enterotoxigenic strains of S. aureus owing to skin colonization of S. aureus among food handlers.
Zeitschrift für Pflanzenernährung und Bodenkunde, 1990
Page 1. 33 Adsorption mechanisms of nicotine on humic acid and clay humic acid complex Ahmed H. K... more Page 1. 33 Adsorption mechanisms of nicotine on humic acid and clay humic acid complex Ahmed H. Khairy, Hoda H. Baghdadi and Elham A. Ghabbour Institute of Graduate Studies and Research, Alexandria University, PO Box 832, El-Shatby, Alexandria, Egypt ...
Journal of Environmental Science and Health, Part B- Pesticides, Food Contaminants, and Agricultural Wastes, 2004
The objective of this study was to determine the effect of either 2.5 mg/kg Body Weight or 5 mg/k... more The objective of this study was to determine the effect of either 2.5 mg/kg Body Weight or 5 mg/kg Body Weight (BW) doses of isoflavones on semen quality, testosterone levels, lipid peroxidation and semen biochemistry of male New Zealand White rabbits. Animals were given both 2.5 mg/kg BW and 5 mg/kg BW doses of isoflavones. The tested doses were given to rabbits orally every other day for 13 weeks. Treatment with isoflavones caused an increase (p < 0.05) in libido (by decreasing the reaction time), sperm concentration, sperm motility (%), total motile sperm per ejaculate (TMS), packed sperm volume (PSV), total functional sperm fraction (TFSF), total sperm output, initial fructose concentration and normal sperm, while dead sperm was reduced compared to control animals. On the other hand, ejaculate volume, initial hydrogen ion concentration (pH) and plasma testosterone levels did not change in treated animals with both doses of isoflavones as compared to control. Concentrations of thiobarbituric acid-reactive substances (TBARS), total lipids, and low density lipoprotein were significantly (p < 0.05) reduced in seminal plasma of rabbits treated with either 2.5 mg/kg BW or 5 mg/kg BW doses of isoflavones. While, the activities of glutathione S-transferase (GST), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), acid phosphatase (AcP), and alkaline phosphatase (AlP) were significantly (p < 0.05) increased in seminal plasma of treated animals. Also, total cholesterol, percentage cholesterol (out of total lipids), and high density lipoprotein were significantly (p < 0.05) increased, while triglyceride did not change in seminal plasma of treated animals. Supplementation at either level of isoflavones did not cause changes in live body weight (LBW), dry matter intake (DMI), and relative weights of testes and epididymis. The present results showed that either 2.5 mg/kg BW or 5 mg/kg BW doses of isoflavones caused an improvement of some semen characteristics and did not have negative effects on male fertility.
Journal of Environmental Science and Health, Part B, 2004
Abstract Role of α-tocopherol (vitamin E), β-carotene and/or their combination as antioxidants ag... more Abstract Role of α-tocopherol (vitamin E), β-carotene and/or their combination as antioxidants against the toxicity of fenvalerate on blood hematology, free radicals, biochemical parameters, and semen quality were studied in male rats. Fenvalerate (20 mg ...
Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved... more Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved in cadmium-related toxicity. Vitamin E and beta-carotene are effective antioxidants and free radical scavengers. Therefore, the present study was carried out to investigate the potential protective effects of vitamin E and beta-carotene alone or in combination against cadmium (Cd) toxicity. Cadmium chloride (CdCl2, 5 mg/kg BW, 1/15 LD50), vitamin E (100 mg/kg BW), beta-carotene (10 mg/kg BW), and vitamin E with beta-carotene (100 + 10 mg/kg BW, respectively) were orally administered by gavage alone or in combination. The tested doses were given to rats every other day (15 times). Results obtained showed that CdCl2 significantly (P < 0.05) induced free radicals in plasma, liver and brain. The activities of glutathione S-transferase (GST) (plasma and liver), alkaline phosphatase (AlP) (plasma and liver), aspartate aminotransferase (AST), alanine aminotransferase (ALT) (liver) and acetylcholinesterase (AChE) (plasma and brain) were significantly (P < 0.05) decreased due to CdCl2 administration, whereas, the activities of AST and ALT were increased in plasma. Treatment with CdCl2 caused a significant (P < 0.05) increase in glucose, urea, creatinine and bilirubin in plasma. On the other hand, results showed that CdCl2 significantly (P < 0.05) decreased plasma total protein (TP), albumin (A), blood hemoglobin (Hb), total erythrocytic count (TEC) and packed cell volume (PCV), while total leukocyte count (TLC) increased. Treatment with CdCl2 caused a significant (P < 0.05) decrease in sperm concentration, motility (%), weight of testes and epididymis, and increase in dead and abnormal sperm. Results demonstrated the beneficial influences of vitamin E, -carotene alone and/or in combination in reducing the harmful effects of CdCl2.
Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such a... more Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such as cancer and cardiovascular disease and the soy isoflavones have been the focus of particular. Consumption of soy isoflavones may reduce the risk of cardiovascular disease both through reduction in serum lipids and by the antioxidant properties. We have therefore investigate the effects of either 2.5 or 5 mg/kg B.W. doses of isoflavones on the levels of free radicals, lipids and lipoproteins in male New Zealand White rabbits. Animals were orally given 2.5 or 5 mg/kg B.W. doses of isoflavones. The tested doses were given to rabbits every other day for 13 weeks. Treatment with isoflavones caused significant (P < 0:05) decrease in the concentrations of free radicals in plasma by 33% and 35%, liver by 18% and 27%, brain by 12% and 33%, testes by 40% and 21%, and kidney by 38% and 20% for 2.5 or 5 mg/kg B.W. doses, respectively, as compared to the control. On the other hand, the activity of glutathione S-transferase (GST) did not change in treated animals as compared to control. Also, results showed that isoflavones caused a significant decrease (P < 0:05) in the levels of plasma total lipids (TL) by 16% and 19%, total cholesterol by 20% and 20%, triglyceride (TG) by 18% and 23%, low density lipoprotein (LDL) by 19%, 22%, very low density lipoprotein (VLDL) by 18% and 23%, and LDL:HDL ratio by 36% and 39% for 2.5 or 5 mg/kg B.W. doses, respectively, as compared to the control. While the level of high density lipoprotein (HDL) increased by 29% and 32%. The present results showed that the 5 mg/kg dose of isoflavone seemed to be related to a better plasma lipid and lipoprotein profiles and antioxidant activity.
Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and... more Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significan...
Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and... more Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significantly increase the activity of both AST and ALT, in the liver and caused a significant decrease in the deleterious effect induced by IBU. The present results confirm that the antioxidant activity of volatile oil of the Coriandrum sativum L., against hepatotoxicity of IBU.
Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw ... more Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw materials for various industries. It is also a type of raw material from which phenols, naphthalenes, and anthracene can be extracted. The present study was designed to investigate the possibility of coal tar creosote to induce oxidative stress and biochemical perturbations in rat liver and the role of rosemary (Rosmarinus officinalis) in ameliorating its toxic effects. Male Wister Albino rats were randomly divided into four groups of seven each, group I served as control; group II treated with rosemary (10 mL of water extract/kg BW for 21 days), group III received coal tar creosote (200 mg/4 mL olive oil/kg BW for 3 days), and group IV treated with both rosemary and coal tar creosote. The administration of coal tar creosote significantly caused elevation in lipid peroxidation (LPO) and reduction in the activities of glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). A significant decrease in reduced glutathione (GSH) content was also observed. Liver aminotransferases aspartate transaminase (AST) and alanine transaminase (ALT)] and alkaline phosphatase (AlP) were significantly decreased while lactate dehydrogenase (LDH) was increased. Rosemary pretreatment to coal tar creosote-treated rats decreased LPO level and normalized GPx, GR, SOD, CAT, and GST activities, while GSH content was increased. Also, liver AST, ALT, AlP, and LDH were maintained near normal level due to rosemary treatment. In conclusion, rosemary has beneficial effects and could be able to antagonize coal tar creosote toxicity.
The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants w... more The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants working in three different food processing plants in Egypt. Using skin swabs, 75 (38%) of the 200 tested persons were positive for the presence of S. aureus. Of the S. aureus positive persons, 28 (14%) harboured S. aureus produced staphylococcal enterotoxins. The serotypes of these enterotoxins were enterotoxin A (68%), enterotoxin B (36%), enterotoxin C (46%) and enterotoxin D (18%). Some of these isolates produced more than one type of enterotoxins namely AB, AC, BC, BD, ABC and ACD. Analysis of risk factors implicated in skin carriage of S. aureus as age, gender, marital status, education, duration in employment, frequency and method of hand wash and incidence of chronic skin infection revealed insignificant association with staphylococcal skin carriage. The obtained results put forth the risk of food contracting contamination with enterotoxigenic strains of S. aureus owing to skin colonization of S. aureus among food handlers.
Zeitschrift für Pflanzenernährung und Bodenkunde, 1990
Page 1. 33 Adsorption mechanisms of nicotine on humic acid and clay humic acid complex Ahmed H. K... more Page 1. 33 Adsorption mechanisms of nicotine on humic acid and clay humic acid complex Ahmed H. Khairy, Hoda H. Baghdadi and Elham A. Ghabbour Institute of Graduate Studies and Research, Alexandria University, PO Box 832, El-Shatby, Alexandria, Egypt ...
Journal of Environmental Science and Health, Part B- Pesticides, Food Contaminants, and Agricultural Wastes, 2004
The objective of this study was to determine the effect of either 2.5 mg/kg Body Weight or 5 mg/k... more The objective of this study was to determine the effect of either 2.5 mg/kg Body Weight or 5 mg/kg Body Weight (BW) doses of isoflavones on semen quality, testosterone levels, lipid peroxidation and semen biochemistry of male New Zealand White rabbits. Animals were given both 2.5 mg/kg BW and 5 mg/kg BW doses of isoflavones. The tested doses were given to rabbits orally every other day for 13 weeks. Treatment with isoflavones caused an increase (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) in libido (by decreasing the reaction time), sperm concentration, sperm motility (%), total motile sperm per ejaculate (TMS), packed sperm volume (PSV), total functional sperm fraction (TFSF), total sperm output, initial fructose concentration and normal sperm, while dead sperm was reduced compared to control animals. On the other hand, ejaculate volume, initial hydrogen ion concentration (pH) and plasma testosterone levels did not change in treated animals with both doses of isoflavones as compared to control. Concentrations of thiobarbituric acid-reactive substances (TBARS), total lipids, and low density lipoprotein were significantly (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) reduced in seminal plasma of rabbits treated with either 2.5 mg/kg BW or 5 mg/kg BW doses of isoflavones. While, the activities of glutathione S-transferase (GST), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), acid phosphatase (AcP), and alkaline phosphatase (AlP) were significantly (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) increased in seminal plasma of treated animals. Also, total cholesterol, percentage cholesterol (out of total lipids), and high density lipoprotein were significantly (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) increased, while triglyceride did not change in seminal plasma of treated animals. Supplementation at either level of isoflavones did not cause changes in live body weight (LBW), dry matter intake (DMI), and relative weights of testes and epididymis. The present results showed that either 2.5 mg/kg BW or 5 mg/kg BW doses of isoflavones caused an improvement of some semen characteristics and did not have negative effects on male fertility.
Journal of Environmental Science and Health, Part B, 2004
Abstract Role of α-tocopherol (vitamin E), β-carotene and/or their combination as antioxidants ag... more Abstract Role of α-tocopherol (vitamin E), β-carotene and/or their combination as antioxidants against the toxicity of fenvalerate on blood hematology, free radicals, biochemical parameters, and semen quality were studied in male rats. Fenvalerate (20 mg ...
Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved... more Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved in cadmium-related toxicity. Vitamin E and beta-carotene are effective antioxidants and free radical scavengers. Therefore, the present study was carried out to investigate the potential protective effects of vitamin E and beta-carotene alone or in combination against cadmium (Cd) toxicity. Cadmium chloride (CdCl2, 5 mg/kg BW, 1/15 LD50), vitamin E (100 mg/kg BW), beta-carotene (10 mg/kg BW), and vitamin E with beta-carotene (100 + 10 mg/kg BW, respectively) were orally administered by gavage alone or in combination. The tested doses were given to rats every other day (15 times). Results obtained showed that CdCl2 significantly (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) induced free radicals in plasma, liver and brain. The activities of glutathione S-transferase (GST) (plasma and liver), alkaline phosphatase (AlP) (plasma and liver), aspartate aminotransferase (AST), alanine aminotransferase (ALT) (liver) and acetylcholinesterase (AChE) (plasma and brain) were significantly (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) decreased due to CdCl2 administration, whereas, the activities of AST and ALT were increased in plasma. Treatment with CdCl2 caused a significant (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) increase in glucose, urea, creatinine and bilirubin in plasma. On the other hand, results showed that CdCl2 significantly (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) decreased plasma total protein (TP), albumin (A), blood hemoglobin (Hb), total erythrocytic count (TEC) and packed cell volume (PCV), while total leukocyte count (TLC) increased. Treatment with CdCl2 caused a significant (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) decrease in sperm concentration, motility (%), weight of testes and epididymis, and increase in dead and abnormal sperm. Results demonstrated the beneficial influences of vitamin E, -carotene alone and/or in combination in reducing the harmful effects of CdCl2.
Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such a... more Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such as cancer and cardiovascular disease and the soy isoflavones have been the focus of particular. Consumption of soy isoflavones may reduce the risk of cardiovascular disease both through reduction in serum lipids and by the antioxidant properties. We have therefore investigate the effects of either 2.5 or 5 mg/kg B.W. doses of isoflavones on the levels of free radicals, lipids and lipoproteins in male New Zealand White rabbits. Animals were orally given 2.5 or 5 mg/kg B.W. doses of isoflavones. The tested doses were given to rabbits every other day for 13 weeks. Treatment with isoflavones caused significant (P < 0:05) decrease in the concentrations of free radicals in plasma by 33% and 35%, liver by 18% and 27%, brain by 12% and 33%, testes by 40% and 21%, and kidney by 38% and 20% for 2.5 or 5 mg/kg B.W. doses, respectively, as compared to the control. On the other hand, the activity of glutathione S-transferase (GST) did not change in treated animals as compared to control. Also, results showed that isoflavones caused a significant decrease (P < 0:05) in the levels of plasma total lipids (TL) by 16% and 19%, total cholesterol by 20% and 20%, triglyceride (TG) by 18% and 23%, low density lipoprotein (LDL) by 19%, 22%, very low density lipoprotein (VLDL) by 18% and 23%, and LDL:HDL ratio by 36% and 39% for 2.5 or 5 mg/kg B.W. doses, respectively, as compared to the control. While the level of high density lipoprotein (HDL) increased by 29% and 32%. The present results showed that the 5 mg/kg dose of isoflavone seemed to be related to a better plasma lipid and lipoprotein profiles and antioxidant activity.
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Papers by Hoda Baghdadi