3rd International Conference on Semantic Technologies (i-semantics 2007), Graz, Austria, Sep 1, 2007
Abstract: The desideratum of semantic interoperability has been intensively discussed in medical ... more Abstract: The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally it was assumed by many that this issue could be addressed simply by insisting on the application of shared clinical terminologies. More recently however the use of the term 'ontology'has been steadily growing. We here address the issue of the degree to which the use of ontologies represents any real advance on the road to semantic interoperability. Keywords: Clinical Ontologies, Knowledge ...
In any realworld application scenario, natural language gen-eration (NLG) systems have to employ... more In any realworld application scenario, natural language gen-eration (NLG) systems have to employ grammars consisting of tremendous amounts of rules. Detecting and fixing errors in such grammars is therefore a highly tedious task. In this work we present a data mining ...
Quality assurance and audit issues play a major role in maintening large biomedical terminology, ... more Quality assurance and audit issues play a major role in maintening large biomedical terminology, such as SNOMED CT. Several automatized techniques have been proposed to facilitate the identification of weak spots and suggest adequate improvements.In this study, we address a well-known issue within SNOMED CT: Albeit the wording of many free-text concept descriptions suggests a connection to other concepts, they are often not referred to in the logical concept definition.To detect such inconsistencies, we use a semantic indexing approach which maps free text onto a sequence of semantic identifiers. Applied to SNOMED CT concepts without attributes, our technique spots refinable concepts and suggests appropriate attributes, i.e., connections to other concepts. Based on a manual analysis of random samples, we estimate that approximately 18,000 refinable concepts can be found.
Introduction The pharmaceutical industry has historically focused on the development of novel blo... more Introduction The pharmaceutical industry has historically focused on the development of novel blockbuster drugs. There is now an increasing focus on personalized medicines, requiring the right patients to receive the right drug at the right dose. In order to develop a tailored drug, ...
ICBO: International Conference on Biomedical Ontology July 24-26, 2009▪ Buffalo, New York, USA To... more ICBO: International Conference on Biomedical Ontology July 24-26, 2009▪ Buffalo, New York, USA Towards an Ontology of Biomedical Educational Objectives Martin Boeker, Holger Stenzhorn, Felix Balzer, Stefan Schulz Freiburg University Medical Center, Freiburg i. Br., ...
Studies in health technology and informatics, 2011
The challenges regarding seamless integration of distributed, heterogeneous and multilevel data a... more The challenges regarding seamless integration of distributed, heterogeneous and multilevel data arising in the context of contemporary, post-genomic clinical trials cannot be effectively addressed with current methodologies. An urgent need exists to access data in a uniform manner, to share information among different clinical and research centers, and to store data in secure repositories assuring the privacy of patients. Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the -omics era. The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic scenarios. This paper describes the main experiences using the ACGT platform and its tools within one such scenario and highlights the very promising results obt...
Zusammenfassung: In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehr... more Zusammenfassung: In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehrt enorme Mengen an neuen Daten produziert und diese in Folge verstärkt per Internet veröffentlicht. Viele Experten sehen in dieser Vorge-hensweise die Chance zur ...
3rd International Conference on Semantic Technologies (i-semantics 2007), Graz, Austria, Sep 1, 2007
Abstract: The desideratum of semantic interoperability has been intensively discussed in medical ... more Abstract: The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally it was assumed by many that this issue could be addressed simply by insisting on the application of shared clinical terminologies. More recently however the use of the term 'ontology'has been steadily growing. We here address the issue of the degree to which the use of ontologies represents any real advance on the road to semantic interoperability. Keywords: Clinical Ontologies, Knowledge ...
In any realworld application scenario, natural language gen-eration (NLG) systems have to employ... more In any realworld application scenario, natural language gen-eration (NLG) systems have to employ grammars consisting of tremendous amounts of rules. Detecting and fixing errors in such grammars is therefore a highly tedious task. In this work we present a data mining ...
Quality assurance and audit issues play a major role in maintening large biomedical terminology, ... more Quality assurance and audit issues play a major role in maintening large biomedical terminology, such as SNOMED CT. Several automatized techniques have been proposed to facilitate the identification of weak spots and suggest adequate improvements.In this study, we address a well-known issue within SNOMED CT: Albeit the wording of many free-text concept descriptions suggests a connection to other concepts, they are often not referred to in the logical concept definition.To detect such inconsistencies, we use a semantic indexing approach which maps free text onto a sequence of semantic identifiers. Applied to SNOMED CT concepts without attributes, our technique spots refinable concepts and suggests appropriate attributes, i.e., connections to other concepts. Based on a manual analysis of random samples, we estimate that approximately 18,000 refinable concepts can be found.
Introduction The pharmaceutical industry has historically focused on the development of novel blo... more Introduction The pharmaceutical industry has historically focused on the development of novel blockbuster drugs. There is now an increasing focus on personalized medicines, requiring the right patients to receive the right drug at the right dose. In order to develop a tailored drug, ...
ICBO: International Conference on Biomedical Ontology July 24-26, 2009▪ Buffalo, New York, USA To... more ICBO: International Conference on Biomedical Ontology July 24-26, 2009▪ Buffalo, New York, USA Towards an Ontology of Biomedical Educational Objectives Martin Boeker, Holger Stenzhorn, Felix Balzer, Stefan Schulz Freiburg University Medical Center, Freiburg i. Br., ...
Studies in health technology and informatics, 2011
The challenges regarding seamless integration of distributed, heterogeneous and multilevel data a... more The challenges regarding seamless integration of distributed, heterogeneous and multilevel data arising in the context of contemporary, post-genomic clinical trials cannot be effectively addressed with current methodologies. An urgent need exists to access data in a uniform manner, to share information among different clinical and research centers, and to store data in secure repositories assuring the privacy of patients. Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the -omics era. The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic scenarios. This paper describes the main experiences using the ACGT platform and its tools within one such scenario and highlights the very promising results obt...
Zusammenfassung: In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehr... more Zusammenfassung: In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehrt enorme Mengen an neuen Daten produziert und diese in Folge verstärkt per Internet veröffentlicht. Viele Experten sehen in dieser Vorge-hensweise die Chance zur ...
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Papers by Holger Stenzhorn