This study aimed to determine (a) the influence of noise exposure background (NEB) on the periphe... more This study aimed to determine (a) the influence of noise exposure background (NEB) on the peripheral and central auditory system functioning and (b) the influence of NEB on speech recognition in noise abilities in student musicians. Twenty non-musician students with self-reported low NEB and 18 student musicians with self-reported high NEB completed a battery of tests that consisted of physiological measures, including auditory brainstem responses (ABRs) at three different stimulus rates (11.3 Hz, 51.3 Hz, and 81.3 Hz), and P300, and behavioral measures including conventional and extended high-frequency audiometry, consonant–vowel nucleus–consonant (CNC) word test and AzBio sentence test for assessing speech perception in noise abilities at −9, −6, −3, 0, and +3 dB signal to noise ratios (SNRs). The NEB was negatively associated with performance on the CNC test at all five SNRs. A negative association was found between NEB and performance on the AzBio test at 0 dB SNR. No effect of ...
Tinnitus, a phantom perception of sound in the absence of any external sound source, is a prevale... more Tinnitus, a phantom perception of sound in the absence of any external sound source, is a prevalent health condition often accompanied by psychiatric comorbidities. Recent genome-wide association studies (GWAS) highlighted a polygenic nature of tinnitus susceptibility. A shared genetic component between tinnitus and psychiatric conditions remains elusive. Here we present a GWAS using the UK Biobank to investigate the genetic processes linked to tinnitus and tinnitus-related distress, followed by gene-set enrichment analyses. The UK Biobank sample comprised 132,438 individuals with tinnitus and genotype data. Among the study sample, 38,525 individuals reported tinnitus, and 26,889 participants mentioned they experienced tinnitus-related distress in daily living. The genome-wide association analyses were conducted on tinnitus and tinnitus-related distress. We conducted enrichment analyses using FUMA to further understand the genetic processes linked to tinnitus and tinnitus-related di...
Background Over 1 billion young adults are at risk for developing noise-induced hearing loss (NIH... more Background Over 1 billion young adults are at risk for developing noise-induced hearing loss (NIHL) due to their habit of listening to music at loud levels. The gold standard for detecting NIHL is the audiometric notch around 3,000 to 6,000 Hz observed in pure tone audiogram. However, recent studies suggested that suprathreshold auditory measures might be more sensitive to detect early-stage NIHL in young adults. Purpose The present study compared suprathreshold measures in individuals with high and low noise exposure backgrounds (NEBs). We hypothesized that individuals with high NEB would exhibit reduced performance on suprathreshold measures than those with low NEB. Study sample An initial sample of 100 English-speaking healthy adults (18–35 years; females = 70) was obtained from five university classes. We identified 15 participants with the lowest NEB scores (10 females) and 15 participants with the highest NEB scores (10 females). We selected a sample of healthy young adults wi...
Over 1.1 billion individuals are at risk for noise induced hearing loss yet there is no accepted ... more Over 1.1 billion individuals are at risk for noise induced hearing loss yet there is no accepted therapy. A long history of research has demonstrated that excessive noise exposure will kill outer hair cells (OHCs). Such observations have fueled the notion that dead OHCs underlie hearing loss. Therefore, previous and current therapeutic approaches are based on preventing the loss of OHCs. However, the relationship between OHC loss and hearing loss is at best a modest correlation. This suggests that in addition to the death of OHCs, other mechanisms may regulate the type and degree of hearing loss. In the current study, we tested the hypothesis that permanent noise-induced-hearing loss is consequent to additional mechanisms beyond the noise dose and the death of OHCs. Hooded male rats were randomly divided into noise and control groups. Morphological and physiological assessments were conducted on both groups. The combined results suggest that beyond OHC loss, the surviving cochlear e...
Introduction. With the worldwide spread of SARS-CoV-2 infection, temporary suspension of all the ... more Introduction. With the worldwide spread of SARS-CoV-2 infection, temporary suspension of all the elective dental procedures and an urgent shift to nonaerosol producing dental treatments were observed. This study provides a detailed description of emergency treatments provided in the Department of Endodontics at a tertiary healthcare centre during the period of prelockdown, lockdown, and sequential unlocking from March 1, 2020, to October 31, 2020. Methods. Access to General and Departmental OPD data along with treatment records was obtained and was segregated based on age, sex, and treatments performed. Treatments were divided into aerosol generating procedures (AGPs) and non-AGPs and further subdivided into palliative treatment (PT), pulp capping (PC), incision and drainage (ID), temporary filling (TF), pulpectomy (PU), and pulpotomy (PO). Data was analysed and subjected to chi-square test. Results. A total of 15052 patients approached general OPD during the period of 8 months of w...
A country’s economy is dependent on several parameters among these parameters stock markets plays... more A country’s economy is dependent on several parameters among these parameters stock markets plays a very important role. There are typically two sorts of risks in regard with the security exchange which are systematic risk and unsystematic risks and this is the reason why stock market is stochastic in nature. From years, scholars are trying to find a definitive solution for better decision making in market to generate more returns and reduce risk. There are many ratios, formulas and theorems which attempts to predict the stock market but in reality these theorems are made on countless assumptions. With the new age technology and fast computing, we can now solve this problem by advanced algorithms and machine learning. We will take help of probability to solve problems generating because of stochastic nature of Stock market. Computing series of probability at different scenarios and parameters of stock market by using machine learning.
Objectives: About 15% of U.S. adults report speech perception difficulties despite showing normal... more Objectives: About 15% of U.S. adults report speech perception difficulties despite showing normal audiograms. Recent research suggests that genetic factors might influence the phenotypic spectrum of speech perception difficulties. The primary objective of the present study was to describe a conceptual framework of a deep phenotyping method, referred to as AudioChipping, for deconstructing and quantifying complex audiometric phenotypes. Design: In a sample of 70 females 18 to 35 years of age with normal audiograms (from 250 to 8000 Hz), the study measured behavioral hearing thresholds (250 to 16,000 Hz), distortion product otoacoustic emissions (1000 to 16,000 Hz), click-evoked auditory brainstem responses (ABR), complex ABR (cABR), QuickSIN, dichotic digit test score, loudness discomfort level, and noise exposure background. The speech perception difficulties were evaluated using the Speech, Spatial, and Quality of Hearing Scale–12-item version (SSQ). A multiple linear regression model was used to determine the relationship between SSQ scores and audiometric measures. Participants were categorized into three groups (i.e., high, mid, and low) using the SSQ scores before performing the clustering analysis. Audiometric measures were normalized and standardized before performing unsupervised k-means clustering to generate AudioChip. Results: The results showed that SSQ and noise exposure background exhibited a significant negative correlation. ABR wave I amplitude, cABR offset latency, cABR response morphology, and loudness discomfort level were significant predictors for SSQ scores. These predictors explained about 18% of the variance in the SSQ score. The k-means clustering was used to split the participants into three major groups; one of these clusters revealed 53% of participants with low SSQ. Conclusions: Our study highlighted the relationship between SSQ and auditory coding precision in the auditory brainstem in normal-hearing young females. AudioChip was useful in delineating and quantifying internal homogeneity and heterogeneity in audiometric measures among individuals with a range of SSQ scores. AudioChip could help identify the genotype-phenotype relationship, document longitudinal changes in auditory phenotypes, and pair individuals in case-control groups for the genetic association analysis.
In the last few decades, our population has grown at a tremendous rate. This unsustainably high r... more In the last few decades, our population has grown at a tremendous rate. This unsustainably high rate of growth becomes a major issue for healthcare centers. Not only are they already quite limited in numbers, but their own rate of growth is nowhere close to the population growth rate. Thus, due to these mentioned factors, there now exists a tremendous demand for Industrial health IoT services post COVID 19 outbreaks. These services involve a patient getting treatment within the comfort of their own home environment. To do this, an existing healthcare center can very well be transformed into an Industrial health IoT service center. This can be achieved with the help of various emerging, modern technologies such as IoT, which stands for 'Internet of Things'. This model is based upon the overall health of a patient and involves realizing symptoms with the help of mobile devices and multichannel technology. The main idea behind this project is to introduce a set of systems to su...
Entire world is facing a huge competition in the market. Companies are spending tremendously over... more Entire world is facing a huge competition in the market. Companies are spending tremendously over marketing of products and services. These costs are taking a toll on profit as well. Many industrial units are facing loses and banks are getting cash deficit. In order to revive market, it is necessary to understand new consumer approaches and behaviour to identify their buying pattern. Clearly lesser profits and increasing marketing cost are signs of down trend. There are many types of consumer behaviour theories. They have their own advantages but they also contain serious flaws. These flaws make them vulnerable. This paper proposes to discover a new consumer behaviour or perspective of millennials. This will help in increase of profits and decrease marketing costs. The framework will also help in reducing operational cost, human resource costs and distribution cost all together. Keywords— upcoming consumer behaviour trend, digital sophisticates, digital enthusiasts, marketing for mi...
Manual debugging is a common productivity drain in the machine learning (ML) lifecycle. Identifyi... more Manual debugging is a common productivity drain in the machine learning (ML) lifecycle. Identifying underperforming training jobs requires constant developer attention and deep domain expertise. As state-of-the-art models grow in size and complexity, debugging becomes increasingly difficult. Just as unit tests boost traditional software development, an automated ML debugging library can save time and money. We present Amazon SageMaker Debugger, a machine learning feature that automatically identifies and stops underperforming training jobs. Debugger is a new feature of Amazon SageMaker that automatically captures relevant data during training and evaluation and presents it for online and offline inspection. Debugger helps users define a set of conditions, in the form of built-in or custom rules, that are applied to this data, thereby enabling users to catch training issues as well as monitor and debug ML model training in real-time. These rules save time and money by alerting the de...
International Journal of Environmental Research and Public Health, 2021
Objectives: (1) To measure sound exposures of marching band and non-marching band students during... more Objectives: (1) To measure sound exposures of marching band and non-marching band students during a football game, (2) to compare these to sound level dose limits set by NIOSH, and (3) to assess the perceptions of marching band students about their hearing health risk from loud sound exposure and their use of hearing protection devices (HPDs). Methods: Personal noise dosimetry was completed on six marching band members and the band director during rehearsals and performances. Dosimetry measurements for two audience members were collected during the performances. Noise dose values were calculated using NIOSH criteria. One hundred twenty-three marching band members responded to a questionnaire analyzing perceptions of loud music exposure, the associated hearing health risks, and preventive behavior. Results: Noise dose values exceeded the NIOSH recommended limits among all six marching band members during rehearsals and performances. Higher sound levels were recorded during performanc...
Micro-Electronics and Telecommunication Engineering, 2020
This project describes, in detail, the different regression models used in the analysis of popula... more This project describes, in detail, the different regression models used in the analysis of population on various parameters like HDI, GDP, energy consumption and Internet usage. Population analysis can be useful in providing demographics of an area, help in targeted marketing and also help government to identify the areas of weakness of a country. Here, we have taken major countries and their various parameters like HDI, GDP, etc., and applied the regression models on them to find the most suitable one.
International Journal of Engineering Technology and Management Sciences, 2020
The bright capability of showing up Internet of things (IoT) advancements for wellbeing gadgets a... more The bright capability of showing up Internet of things (IoT) advancements for wellbeing gadgets and sensors assumed an essential job in the new age of Healthcare industry for secure patient care and maintaining social distancing. After Corona virus outbreak, it has been observed that there is an utter need for the automated healthcare system for the patients in need or elderly incapable or un-helped people. This paper proposed a Healthcare and quarantined install with IoT devices for the benefiting of quarantined people and Covid-19 patients.
Journal of the American Academy of Audiology, 2020
Background Noise-induced hearing loss (NIHL) is often characterized by the presence of an audiome... more Background Noise-induced hearing loss (NIHL) is often characterized by the presence of an audiometric notch at 3000-6000 Hz in a behavioral audiogram. The audiometric notch is widely used to investigate NIHL in children and young adults. However, the determinants of the audiometric notch in young adults largely remain unknown. Purpose The study aimed to investigate the determinants of the audiometric notch in young adults. Research Design A cross-sectional design was adopted for the study. Study Sample A sample of 124 adults (38 males and 86 females) aged 18-35 years with normal otoscopic and tympanometric findings was recruited. Data Collection and Analysis Hearing thresholds and real-ear sound pressure levels (RESPLs) were obtained with calibrated ER-3A (Etymotic Research, Elk Grove Village, IL) andTDH-50P receivers (Telephonics, Farmingdale, NY). Distortion-product otoacoustic emissions (DPOAEs) were used to evaluate the cochlear function. The external auditory canal (EAC) length...
Introduction: Subjective tinnitus, a perception of phantom sound, is a common otological conditio... more Introduction: Subjective tinnitus, a perception of phantom sound, is a common otological condition that affects almost 15% of the general population. It is known that noise-induced hearing loss (NIHL) and tinnitus exhibit a high level of comorbidity in individuals exposed to intense noise and music. However, the influence of genetic variants associated with NIHL on tinnitus remains elusive. We hypothesized that young musicians carrying genetic variants associated with NIHL would exhibit a higher prevalence of tinnitus than their counterparts. Methods: To test this hypothesis, we analyzed the database by Bhatt et al. (2020) (originally developed by Phillips et al., 2015) that investigated the genetic links to NIHL in young college-aged musicians. The present study identified 186 participants (average age = 20.3 yrs, range = 18–25 yrs) with normal tympanometry and otoscopic findings and with no missing data. We included 19 single nucleotide polymorphisms in 13 cochlear genes that were previously associated with NIHL. The candidate genes include: KCNE1, KCNQ1, CDH23, GJB2, GJB4, KCNJ10, CAT, HSP70, PCDH70, MYH14, GRM7, PON2, and ESRRB. Results: We find that individuals with at least one minor allele of rs163171 (C > T) in KCNQ1 exhibit significantly higher odds of reporting tinnitus compared to individuals carrying the major allele of rs163171. KCNE1 rs2070358 revealed a suggestive association (p = 0.049) with tinnitus, but the FDR corrected p-value did not achieve statistical significance (p < 0.05). A history of ear infection and sound level tolerance showed a statistically significant association with tinnitus. Music exposure showed a suggestive association trend with tinnitus. Biological sex revealed a statistically significant association with distortion product otoacoustic emissions SNR measures. Conclusions: We concluded that KCNQ1/KCNE1 voltage-gated potassium ion channel plays a critical role in the pathogenesis of NIHL and tinnitus. Further research is required to construct clinical tools for identifying genetically predisposed individuals well before they acquire NIHL and tinnitus.
This study aimed to determine (a) the influence of noise exposure background (NEB) on the periphe... more This study aimed to determine (a) the influence of noise exposure background (NEB) on the peripheral and central auditory system functioning and (b) the influence of NEB on speech recognition in noise abilities in student musicians. Twenty non-musician students with self-reported low NEB and 18 student musicians with self-reported high NEB completed a battery of tests that consisted of physiological measures, including auditory brainstem responses (ABRs) at three different stimulus rates (11.3 Hz, 51.3 Hz, and 81.3 Hz), and P300, and behavioral measures including conventional and extended high-frequency audiometry, consonant–vowel nucleus–consonant (CNC) word test and AzBio sentence test for assessing speech perception in noise abilities at −9, −6, −3, 0, and +3 dB signal to noise ratios (SNRs). The NEB was negatively associated with performance on the CNC test at all five SNRs. A negative association was found between NEB and performance on the AzBio test at 0 dB SNR. No effect of ...
Tinnitus, a phantom perception of sound in the absence of any external sound source, is a prevale... more Tinnitus, a phantom perception of sound in the absence of any external sound source, is a prevalent health condition often accompanied by psychiatric comorbidities. Recent genome-wide association studies (GWAS) highlighted a polygenic nature of tinnitus susceptibility. A shared genetic component between tinnitus and psychiatric conditions remains elusive. Here we present a GWAS using the UK Biobank to investigate the genetic processes linked to tinnitus and tinnitus-related distress, followed by gene-set enrichment analyses. The UK Biobank sample comprised 132,438 individuals with tinnitus and genotype data. Among the study sample, 38,525 individuals reported tinnitus, and 26,889 participants mentioned they experienced tinnitus-related distress in daily living. The genome-wide association analyses were conducted on tinnitus and tinnitus-related distress. We conducted enrichment analyses using FUMA to further understand the genetic processes linked to tinnitus and tinnitus-related di...
Background Over 1 billion young adults are at risk for developing noise-induced hearing loss (NIH... more Background Over 1 billion young adults are at risk for developing noise-induced hearing loss (NIHL) due to their habit of listening to music at loud levels. The gold standard for detecting NIHL is the audiometric notch around 3,000 to 6,000 Hz observed in pure tone audiogram. However, recent studies suggested that suprathreshold auditory measures might be more sensitive to detect early-stage NIHL in young adults. Purpose The present study compared suprathreshold measures in individuals with high and low noise exposure backgrounds (NEBs). We hypothesized that individuals with high NEB would exhibit reduced performance on suprathreshold measures than those with low NEB. Study sample An initial sample of 100 English-speaking healthy adults (18–35 years; females = 70) was obtained from five university classes. We identified 15 participants with the lowest NEB scores (10 females) and 15 participants with the highest NEB scores (10 females). We selected a sample of healthy young adults wi...
Over 1.1 billion individuals are at risk for noise induced hearing loss yet there is no accepted ... more Over 1.1 billion individuals are at risk for noise induced hearing loss yet there is no accepted therapy. A long history of research has demonstrated that excessive noise exposure will kill outer hair cells (OHCs). Such observations have fueled the notion that dead OHCs underlie hearing loss. Therefore, previous and current therapeutic approaches are based on preventing the loss of OHCs. However, the relationship between OHC loss and hearing loss is at best a modest correlation. This suggests that in addition to the death of OHCs, other mechanisms may regulate the type and degree of hearing loss. In the current study, we tested the hypothesis that permanent noise-induced-hearing loss is consequent to additional mechanisms beyond the noise dose and the death of OHCs. Hooded male rats were randomly divided into noise and control groups. Morphological and physiological assessments were conducted on both groups. The combined results suggest that beyond OHC loss, the surviving cochlear e...
Introduction. With the worldwide spread of SARS-CoV-2 infection, temporary suspension of all the ... more Introduction. With the worldwide spread of SARS-CoV-2 infection, temporary suspension of all the elective dental procedures and an urgent shift to nonaerosol producing dental treatments were observed. This study provides a detailed description of emergency treatments provided in the Department of Endodontics at a tertiary healthcare centre during the period of prelockdown, lockdown, and sequential unlocking from March 1, 2020, to October 31, 2020. Methods. Access to General and Departmental OPD data along with treatment records was obtained and was segregated based on age, sex, and treatments performed. Treatments were divided into aerosol generating procedures (AGPs) and non-AGPs and further subdivided into palliative treatment (PT), pulp capping (PC), incision and drainage (ID), temporary filling (TF), pulpectomy (PU), and pulpotomy (PO). Data was analysed and subjected to chi-square test. Results. A total of 15052 patients approached general OPD during the period of 8 months of w...
A country’s economy is dependent on several parameters among these parameters stock markets plays... more A country’s economy is dependent on several parameters among these parameters stock markets plays a very important role. There are typically two sorts of risks in regard with the security exchange which are systematic risk and unsystematic risks and this is the reason why stock market is stochastic in nature. From years, scholars are trying to find a definitive solution for better decision making in market to generate more returns and reduce risk. There are many ratios, formulas and theorems which attempts to predict the stock market but in reality these theorems are made on countless assumptions. With the new age technology and fast computing, we can now solve this problem by advanced algorithms and machine learning. We will take help of probability to solve problems generating because of stochastic nature of Stock market. Computing series of probability at different scenarios and parameters of stock market by using machine learning.
Objectives: About 15% of U.S. adults report speech perception difficulties despite showing normal... more Objectives: About 15% of U.S. adults report speech perception difficulties despite showing normal audiograms. Recent research suggests that genetic factors might influence the phenotypic spectrum of speech perception difficulties. The primary objective of the present study was to describe a conceptual framework of a deep phenotyping method, referred to as AudioChipping, for deconstructing and quantifying complex audiometric phenotypes. Design: In a sample of 70 females 18 to 35 years of age with normal audiograms (from 250 to 8000 Hz), the study measured behavioral hearing thresholds (250 to 16,000 Hz), distortion product otoacoustic emissions (1000 to 16,000 Hz), click-evoked auditory brainstem responses (ABR), complex ABR (cABR), QuickSIN, dichotic digit test score, loudness discomfort level, and noise exposure background. The speech perception difficulties were evaluated using the Speech, Spatial, and Quality of Hearing Scale–12-item version (SSQ). A multiple linear regression model was used to determine the relationship between SSQ scores and audiometric measures. Participants were categorized into three groups (i.e., high, mid, and low) using the SSQ scores before performing the clustering analysis. Audiometric measures were normalized and standardized before performing unsupervised k-means clustering to generate AudioChip. Results: The results showed that SSQ and noise exposure background exhibited a significant negative correlation. ABR wave I amplitude, cABR offset latency, cABR response morphology, and loudness discomfort level were significant predictors for SSQ scores. These predictors explained about 18% of the variance in the SSQ score. The k-means clustering was used to split the participants into three major groups; one of these clusters revealed 53% of participants with low SSQ. Conclusions: Our study highlighted the relationship between SSQ and auditory coding precision in the auditory brainstem in normal-hearing young females. AudioChip was useful in delineating and quantifying internal homogeneity and heterogeneity in audiometric measures among individuals with a range of SSQ scores. AudioChip could help identify the genotype-phenotype relationship, document longitudinal changes in auditory phenotypes, and pair individuals in case-control groups for the genetic association analysis.
In the last few decades, our population has grown at a tremendous rate. This unsustainably high r... more In the last few decades, our population has grown at a tremendous rate. This unsustainably high rate of growth becomes a major issue for healthcare centers. Not only are they already quite limited in numbers, but their own rate of growth is nowhere close to the population growth rate. Thus, due to these mentioned factors, there now exists a tremendous demand for Industrial health IoT services post COVID 19 outbreaks. These services involve a patient getting treatment within the comfort of their own home environment. To do this, an existing healthcare center can very well be transformed into an Industrial health IoT service center. This can be achieved with the help of various emerging, modern technologies such as IoT, which stands for 'Internet of Things'. This model is based upon the overall health of a patient and involves realizing symptoms with the help of mobile devices and multichannel technology. The main idea behind this project is to introduce a set of systems to su...
Entire world is facing a huge competition in the market. Companies are spending tremendously over... more Entire world is facing a huge competition in the market. Companies are spending tremendously over marketing of products and services. These costs are taking a toll on profit as well. Many industrial units are facing loses and banks are getting cash deficit. In order to revive market, it is necessary to understand new consumer approaches and behaviour to identify their buying pattern. Clearly lesser profits and increasing marketing cost are signs of down trend. There are many types of consumer behaviour theories. They have their own advantages but they also contain serious flaws. These flaws make them vulnerable. This paper proposes to discover a new consumer behaviour or perspective of millennials. This will help in increase of profits and decrease marketing costs. The framework will also help in reducing operational cost, human resource costs and distribution cost all together. Keywords— upcoming consumer behaviour trend, digital sophisticates, digital enthusiasts, marketing for mi...
Manual debugging is a common productivity drain in the machine learning (ML) lifecycle. Identifyi... more Manual debugging is a common productivity drain in the machine learning (ML) lifecycle. Identifying underperforming training jobs requires constant developer attention and deep domain expertise. As state-of-the-art models grow in size and complexity, debugging becomes increasingly difficult. Just as unit tests boost traditional software development, an automated ML debugging library can save time and money. We present Amazon SageMaker Debugger, a machine learning feature that automatically identifies and stops underperforming training jobs. Debugger is a new feature of Amazon SageMaker that automatically captures relevant data during training and evaluation and presents it for online and offline inspection. Debugger helps users define a set of conditions, in the form of built-in or custom rules, that are applied to this data, thereby enabling users to catch training issues as well as monitor and debug ML model training in real-time. These rules save time and money by alerting the de...
International Journal of Environmental Research and Public Health, 2021
Objectives: (1) To measure sound exposures of marching band and non-marching band students during... more Objectives: (1) To measure sound exposures of marching band and non-marching band students during a football game, (2) to compare these to sound level dose limits set by NIOSH, and (3) to assess the perceptions of marching band students about their hearing health risk from loud sound exposure and their use of hearing protection devices (HPDs). Methods: Personal noise dosimetry was completed on six marching band members and the band director during rehearsals and performances. Dosimetry measurements for two audience members were collected during the performances. Noise dose values were calculated using NIOSH criteria. One hundred twenty-three marching band members responded to a questionnaire analyzing perceptions of loud music exposure, the associated hearing health risks, and preventive behavior. Results: Noise dose values exceeded the NIOSH recommended limits among all six marching band members during rehearsals and performances. Higher sound levels were recorded during performanc...
Micro-Electronics and Telecommunication Engineering, 2020
This project describes, in detail, the different regression models used in the analysis of popula... more This project describes, in detail, the different regression models used in the analysis of population on various parameters like HDI, GDP, energy consumption and Internet usage. Population analysis can be useful in providing demographics of an area, help in targeted marketing and also help government to identify the areas of weakness of a country. Here, we have taken major countries and their various parameters like HDI, GDP, etc., and applied the regression models on them to find the most suitable one.
International Journal of Engineering Technology and Management Sciences, 2020
The bright capability of showing up Internet of things (IoT) advancements for wellbeing gadgets a... more The bright capability of showing up Internet of things (IoT) advancements for wellbeing gadgets and sensors assumed an essential job in the new age of Healthcare industry for secure patient care and maintaining social distancing. After Corona virus outbreak, it has been observed that there is an utter need for the automated healthcare system for the patients in need or elderly incapable or un-helped people. This paper proposed a Healthcare and quarantined install with IoT devices for the benefiting of quarantined people and Covid-19 patients.
Journal of the American Academy of Audiology, 2020
Background Noise-induced hearing loss (NIHL) is often characterized by the presence of an audiome... more Background Noise-induced hearing loss (NIHL) is often characterized by the presence of an audiometric notch at 3000-6000 Hz in a behavioral audiogram. The audiometric notch is widely used to investigate NIHL in children and young adults. However, the determinants of the audiometric notch in young adults largely remain unknown. Purpose The study aimed to investigate the determinants of the audiometric notch in young adults. Research Design A cross-sectional design was adopted for the study. Study Sample A sample of 124 adults (38 males and 86 females) aged 18-35 years with normal otoscopic and tympanometric findings was recruited. Data Collection and Analysis Hearing thresholds and real-ear sound pressure levels (RESPLs) were obtained with calibrated ER-3A (Etymotic Research, Elk Grove Village, IL) andTDH-50P receivers (Telephonics, Farmingdale, NY). Distortion-product otoacoustic emissions (DPOAEs) were used to evaluate the cochlear function. The external auditory canal (EAC) length...
Introduction: Subjective tinnitus, a perception of phantom sound, is a common otological conditio... more Introduction: Subjective tinnitus, a perception of phantom sound, is a common otological condition that affects almost 15% of the general population. It is known that noise-induced hearing loss (NIHL) and tinnitus exhibit a high level of comorbidity in individuals exposed to intense noise and music. However, the influence of genetic variants associated with NIHL on tinnitus remains elusive. We hypothesized that young musicians carrying genetic variants associated with NIHL would exhibit a higher prevalence of tinnitus than their counterparts. Methods: To test this hypothesis, we analyzed the database by Bhatt et al. (2020) (originally developed by Phillips et al., 2015) that investigated the genetic links to NIHL in young college-aged musicians. The present study identified 186 participants (average age = 20.3 yrs, range = 18–25 yrs) with normal tympanometry and otoscopic findings and with no missing data. We included 19 single nucleotide polymorphisms in 13 cochlear genes that were previously associated with NIHL. The candidate genes include: KCNE1, KCNQ1, CDH23, GJB2, GJB4, KCNJ10, CAT, HSP70, PCDH70, MYH14, GRM7, PON2, and ESRRB. Results: We find that individuals with at least one minor allele of rs163171 (C > T) in KCNQ1 exhibit significantly higher odds of reporting tinnitus compared to individuals carrying the major allele of rs163171. KCNE1 rs2070358 revealed a suggestive association (p = 0.049) with tinnitus, but the FDR corrected p-value did not achieve statistical significance (p < 0.05). A history of ear infection and sound level tolerance showed a statistically significant association with tinnitus. Music exposure showed a suggestive association trend with tinnitus. Biological sex revealed a statistically significant association with distortion product otoacoustic emissions SNR measures. Conclusions: We concluded that KCNQ1/KCNE1 voltage-gated potassium ion channel plays a critical role in the pathogenesis of NIHL and tinnitus. Further research is required to construct clinical tools for identifying genetically predisposed individuals well before they acquire NIHL and tinnitus.
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Papers by Ishan Bhatt