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Selective breeding of house mice for increased voluntary wheel running has resulted in multiple physiological and behavioral changes. Characterizing these differences may lead to experimental models that can elucidate factors involved in... more
Selective breeding of house mice for increased voluntary wheel running has resulted in multiple physiological and behavioral changes. Characterizing these differences may lead to experimental models that can elucidate factors involved in human diseases and disorders associated with physical inactivity, or potentially treated by physical activity, such as diabetes, obesity, and depression. Herein, we present ethological data for adult males from a line of mice that has been selectively bred for high levels of voluntary wheel running and from a non-selected control line, housed with or without wheels. Additionally, we present concentrations of central monoamines in limbic, striatal, and midbrain regions. We monitored wheel running for 8 weeks, and observed home cage behavior during the last five weeks of the study. Mice from the selected line accumulated more revolutions per day than controls due to increased speed and duration of running. Selected mice exhibited more active behaviors...
Publication Name: Brain research
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Publication Date: 2012
Publication Name: Journal of Experimental Biology
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Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel runningmore
by J. Malisch and Theodore Garland
Publication Date: 2009
Publication Name: Journal of Experimental Biology
Research Interests: Skeletal muscle biology, Phenotypic Plasticity, Biological Sciences, Experimental evolution, Blood Glucose, and 15 moreMice, Female, Animals, The, Phenotype, Glucose Transport, Skeletal Muscle, Time Factors, Group, Selective Breeding, Artificial Selection, *Physical Exertion, Glycogen, Experimental Biology, and Muscle mass
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Publication Date: 2011
Publication Name: Proceedings of the Royal Society B: Biological Sciences
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Proximity to a high traffic road: Glucocorticoid and life history consequences for nestling white-crowned sparrowsmore
by J. Malisch
Publication Date: 2011
Publication Name: General and Comparative Endocrinology
Research Interests: Physiology, Zoology, Life history, Stress, Predation, and 15 moreFemale, Animals, Corticosterone, Anthropogenic Disturbance, Male, Nest Predation, Reproductive Success, Body Size, Food Availability, Nesting Behavior, Veterinary Sciences, Sparrows, Paternal Care, Glucocorticoids, and Motor vehicles act
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Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel runningmore
by J. Malisch and Theodore Garland
Publication Date: 2014
Publication Name: Experimental Physiology
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by J. Malisch and Theodore Garland
Selective-breeding of house mice for increased voluntary wheel-running has resulted in multiple physiological and behavioral changes. Characterizing these differences may lead to experimental models that can elucidate factors involved in... more
Selective-breeding of house mice for increased voluntary wheel-running has resulted in multiple physiological and behavioral changes. Characterizing these differences may lead to experimental models that can elucidate factors involved in human diseases and disorders associated with physical inactivity, or potentially treated by physical activity, such as diabetes, obesity, and depression. Herein, we present ethological data for adult males from a line of mice that has been selectively bred for high levels of voluntary wheel-running and from a non-selected control line, housed with or without wheels. Additionally, we present concentrations of central monoamines in limbic, striatal, and midbrain regions. We monitored wheel-running for 8 weeks, and observed home-cage behavior during the last 5 weeks of the study. Mice from the selected line accumulated more revolutions per day than controls due to increased speed and duration of running. Selected mice exhibited more active behaviors than controls, regardless of wheel access, and exhibited less inactivity and grooming than controls. Selective-breeding also influenced the longitudinal patterns of behavior. We found statistically significant differences in monoamine concentrations and associated metabolites in brain regions that influence exercise and motivational state. These results suggest underlying neurochemical differences between selected and control lines that may influence the observed differences in behavior. Our results bolster the argument that selected mice can provide a useful model of human psychological and physiological diseases and disorders.
Publication Date: 2013
Publication Name: Brain Research
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Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)more
by Helga Guderley and J. Malisch
An animal model was developed to study effects on components of exercise physiology of both "nature" (10 generations of genetic selection for high voluntary activity on running wheels) and "nurture" (7-8 wk of access... more
An animal model was developed to study effects on components of exercise physiology of both "nature" (10 generations of genetic selection for high voluntary activity on running wheels) and "nurture" (7-8 wk of access or no access to running wheels, beginning at weaning). At the end of the experiment, mice from both wheel-access groups were significantly lighter in body mass than mice from sedentary groups. Within the wheel-access group, a statistically significant, negative relationship existed between activity and final body mass. In measurements of maximum oxygen consumption during forced treadmill exercise (VO2max), mice with wheel access were significantly more cooperative than sedentary mice; however, trial quality was not a significant predictor of individual variation in VO2max. Nested two-way analysis of covariance demonstrated that both genetic selection history and access to wheels had significant positive effects on VO2max. A 12% difference in VO2max e...