Research Interests:
Recent field studies indicated that insecticide-treated bednets (ITNs) maintain their efficacy despite a high frequency of the knock-down resistance (kdr) gene in Anopheles gambiae populations. It was essential to evaluate ITNs efficacy... more
Recent field studies indicated that insecticide-treated bednets (ITNs) maintain their efficacy despite a high frequency of the knock-down resistance (kdr) gene in Anopheles gambiae populations. It was essential to evaluate ITNs efficacy in areas with metabolic-based resistance. Bifenthrin was used in this experiment because it is considered a promising candidate for bednets impregnation. Nets were treated at 50 mg/m2, a dose that has high insecticidal activity on kdr mosquitoes and at 5 mg/m2, a dose that kills 95% of susceptible mosquitoes under laboratory conditions with 3 minutes exposure. Bednets were holed to mimic physical damage. The trial was conducted in three experimental huts from Pitoa, North-Cameroon where Anopheles gambiae displays metabolic resistance and cohabits with An. funestus. Bifenthrin at 50 mg/m2 significantly reduced anophelines' entry rate (>80%). This was not observed at 5 mg/m2. Both treatments increased exophily in An. gambiae, and to a lesser ext...
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Pyrethroid resistant mosquitoes are becoming increasingly common in parts of Africa. It is important to identify alternative insecticides which, if necessary, could be used to replace or supplement the pyrethroids for use on treated nets.... more
Pyrethroid resistant mosquitoes are becoming increasingly common in parts of Africa. It is important to identify alternative insecticides which, if necessary, could be used to replace or supplement the pyrethroids for use on treated nets. Certain compounds of an earlier generation of insecticides, the organophosphates may have potential as net treatments. Comparative studies of chlorpyrifos-methyl (CM), an organophosphate with low mammalian toxicity, and lambdacyhalothrin (L), a pyrethroid, were conducted in experimental huts in Côte d'Ivoire, West Africa. Anopheles gambiae and Culex quinquefasciatus mosquitoes from the area are resistant to pyrethroids and organophosphates (kdr and insensitive acetylcholinesterase Ace.1R). Several treatments and application rates on intact or holed nets were evaluated, including single treatments, mixtures, and differential wall/ceiling treatments. All of the treatments were effective in reducing blood feeding from sleepers under the nets and i...
Research Interests: West Africa, Medical Microbiology, Malaria, Treatment Outcome, High Frequency, and 15 moreInsecticides, Insecticide Resistance, Humans, Low Dose, Nitriles, Female, Animals, Acetylcholinesterase, Culex, Anopheles gambiae, Mosquito Control, Culex quinquefasciatus, Genotype, Chlorpyrifos, and Insect Vectors
Although pyrethroid-treated materials are a promising tool for the prevention and the control of dengue in the tropics, the development of pyrethroid resistance in the main mosquito vector (Aedes aegypti) may negate their use for personal... more
Although pyrethroid-treated materials are a promising tool for the prevention and the control of dengue in the tropics, the development of pyrethroid resistance in the main mosquito vector (Aedes aegypti) may negate their use for personal and/or community protection. In that context, the efficacy of a mixture of a repellent (N,N-diethyl toluamide (DEET)) and a non-pyrethroid insecticide (propoxur) was investigated
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Research Interests: Medical Microbiology, Malaria, Survival Analysis, Insecticides, Female, and 18 moreAnimals, Drug Resistance, Male, Population Density, Culex, Anopheles gambiae, Vector control, Mosquito Control, Paint, Culex quinquefasciatus, Time Factors, Pyridines, Porous Material, Chlorpyrifos, Diazinon, Larval Development, New Products, and Mortality rate
Research Interests: West Africa, Medical Microbiology, Malaria, Survival Analysis, Insecticides, and 17 moreBenin, Female, Animals, Drug Resistance, Culex, Anopheles gambiae, Vector control, Mosquito Control, Paint, Field Trial, Culex quinquefasciatus, Time Factors, Pyridines, Chlorpyrifos, Diazinon, New Products, and Mortality rate
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Research Interests:
Research Interests:
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Research Interests: Neurotoxicology, Insecticides, Animals, Negative Feedback, Male, and 17 moreFeedback, Central Nervous System, Detoxification, Acetylcholine, Synaptic Transmission, Cockroaches, Enzyme, Culex quinquefasciatus, Time Factors, Larva, Periplaneta Americana, Lethal Dose, Muscarinic Receptor, Propoxur, Neurosciences, Synergistic effect, and Excitatory Postsynaptic Potentials
Research Interests: West Africa, Medical Microbiology, Malaria, Temporal dynamics, Insecticides, and 16 moreInsecticide Resistance, Seasonality, Humans, Burkina Faso, Animals, Polymerase Chain Reaction, Acetylcholinesterase, Anopheles gambiae, Enzyme, Vector control, Sodium channel, Plasmodium falciparum, Voltage-Gated Sodium Channels, Protozoan Proteins, Resistance Genes Mechanism), and Enzyme Linked Immunosorbent Assay
Research Interests: Medical Microbiology, Malaria, Insecticides, Insecticide Resistance, Humans, and 17 moreBenin, Nitriles, Animals, Plastics, Polypropylene, Culex, Anopheles gambiae, Field Study, Vector control, Mosquito Control, Culex quinquefasciatus, Sub Saharan Africa, Management Strategy, Resistance Genes Mechanism), Laundering, Carbamates, and Parameter Selection
Research Interests:
Research Interests:
Research Interests: Medical Entomology, Biological Sciences, Insecticides, Anopheles, Animals, and 5 moreCulex, Larva, Culicidae, Sunlight, and Aedes
Pyrethroid-treated nets are an efficient tool for reducing malaria transmission and morbidity. The recent evolution of pyrethroid resistance in several Anopheles species represents a major threat for the future success of roll back... more
Pyrethroid-treated nets are an efficient tool for reducing malaria transmission and morbidity. The recent evolution of pyrethroid resistance in several Anopheles species represents a major threat for the future success of roll back malaria in Africa. The possible use of nonpyrethroid insecticides, such as carbamates, on nets is a promising alternative solution because these insecticides are effective against susceptible and pyrethroid-resistant populations of Anopheles and Culex mosquitoes. Unfortunately, carbamate resistance as a result of insensitive acetylcholinesterase has recently been detected in Anopheles gambiae s.s. populations from Côte d'Ivoire. Using biochemical assays on surviving Anopheles mosquitoes from an experimental hut trial, we showed evidence for selection for an insensitive acetylcholinesterase mechanism by carbamate impregnated bednets. However, no such selection has been found with nets treated with pyrethroid alone or pyrethroid/carbamate "two-in-one" -treated nets. Because pyrethroid-impregnated nets were suspected to select for the Kdr mutation in An. gambiae, we propose that use of two-in-one nets could be a promising alternative strategy for the management of insecticide resistance in malaria vectors.