This work presents an alternative approach to estimate river bank erosion at regional scale through the Self-Organizing Maps (SOM) technique. LIDAR data was used to calculate erosion values at local scale, while satellite imagery combined... more
This work presents an alternative approach to estimate river bank erosion at regional scale through the Self-Organizing Maps (SOM) technique. LIDAR data was used to calculate erosion values at local scale, while satellite imagery combined with digital elevation model (DEM) were used as predictive variables for regional scale. The LIDAR data was collected in the Normamby River Basin, Australia in 2009 and 2011, from which elevation, canopy height and percent canopy coverage were calculated. The differences in elevation between 2009 and 2011 produced values of erosion along the rivers that were used as training points in the modeling process. Landsat TM5 (Thematic Mapper) sensor images were corrected for atmospheric attenuation and converted into reflectance values to calculate band ratios to enhance spectral features. A subset of fifteen hundred points was randomly selected in areas where erosion was detected and associated to band ratios values and DEM derived measures (elevation, s...
This report presents a sediment and nutrient budget for the Mitchell River catchment, located on the western flanks of Cape York and draining to the Gulf of Carpentaria. A catchment sediment (or nutrient) budget accounts for the major... more
This report presents a sediment and nutrient budget for the Mitchell River catchment, located on the western flanks of Cape York and draining to the Gulf of Carpentaria. A catchment sediment (or nutrient) budget accounts for the major sources, transport pathways and sinks of sediments and nutrients within a catchment. It is difficult to measure all of the relevant components of a catchment sediment budget across space and time. Consequently a modelling framework is useful to bring together the individual components of the budget in a coherent manner, whether derived from local empirical data or theoretical models. The SedNet and ANNEX models have been used in this study; these models have been widely applied in tropical Queensland settings and elsewhere in Australia. Each sediment budget term comprises its own sub-model and here, a combination of national-scale models (terrain, hillslope erosion, colluvial gully density and surface soil nutrient concentrations), state-wide data sets...
ABSTRACT
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We present the first global disk-resolved maps of the distribution of Ganymede's 2600 Angstroms absorption band, due probably to O_3 (Noll et al. 1997), obtained with STIS on HST. These data complement earlier... more
We present the first global disk-resolved maps of the distribution of Ganymede's 2600 Angstroms absorption band, due probably to O_3 (Noll et al. 1997), obtained with STIS on HST. These data complement earlier disk-integrated UV spectra by IUE (Nelson et al. 1987) and HST (Noll et al. 1996), and Galileo UVS spectra of selected regions of the surface (Hendrix et
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To find how early experience in clinical and community settings ("early experience") affects medical education, and identify strengths and limitations of the available evidence. A systematic review rating, by consensus, the... more
To find how early experience in clinical and community settings ("early experience") affects medical education, and identify strengths and limitations of the available evidence. A systematic review rating, by consensus, the strength and importance of outcomes reported in the decade 1992-2001. Bibliographical databases and journals were searched for publications on the topic, reviewed under the auspices of the recently formed Best Evidence Medical Education (BEME) collaboration. All empirical studies (verifiable, observational data) were included, whatever their design, method, or language of publication. Early experience was most commonly provided in community settings, aiming to recruit primary care practitioners for underserved populations. It increased the popularity of primary care residencies, albeit among self selected students. It fostered self awareness and empathic attitudes towards ill people, boosted students' confidence, motivated them, gave them satisfacti...
Research Interests: Evidence Based Medicine, Educational Measurement, Medical Education, Teaching, British medical history, and 14 moreMedical Students, Humans, Socially-responsible Investing, Clinical Medicine, Undergraduate medical education, Empirical Study, Systematic review, Career Choice, Public health systems and services research, BMJ, Socially Responsible Investing, Educational Status, Clinical Competence, and Bibliographic Database
Compare how different researchers performed in screening for informative evidence about medical education. Six researchers with three different levels of involvement in a systematic literature review screened articles by title and (where... more
Compare how different researchers performed in screening for informative evidence about medical education. Six researchers with three different levels of involvement in a systematic literature review screened articles by title and (where available) abstract, and then by reading articles they had selected in full text. The reference standard was a consensus decision to include or exclude the article in the final analysis, whose results are published elsewhere. The single screener most involved in the literature search, who was also the most junior member of the topic review group, achieved a sensitivity approaching 100% and a specificity of 98-100% for informative articles. She far outperformed the other researchers, all of whom had as much or more topic knowledge and greater research experience. It was not possible to improve on the performance of the single motivated and capable primary screener and trying to do so increased the number of uninformative articles retrieved. One inter...
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... Submitted by T. YOSHIDA* and S. OTSd'KA* Checked by DG JONES,? J. L. SPENCER,f P. BINGER,$ A. BRINKMA",* and P. WEDEMANNZ ... The phosphines and (q5-C5H5)(q3-Cfi3) Pd are malo-dorous materials with unknown physiological... more
... Submitted by T. YOSHIDA* and S. OTSd'KA* Checked by DG JONES,? J. L. SPENCER,f P. BINGER,$ A. BRINKMA",* and P. WEDEMANNZ ... The phosphines and (q5-C5H5)(q3-Cfi3) Pd are malo-dorous materials with unknown physiological effects. ...
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With the remarkable Cassini discovery of active water ice plumes emanating from the south pole of Enceladus, this tiny moon has become an exciting possible target for a future Flagship mission. A NASA HQ-directed study was performed by... more
With the remarkable Cassini discovery of active water ice plumes emanating from the south pole of Enceladus, this tiny moon has become an exciting possible target for a future Flagship mission. A NASA HQ-directed study was performed by the Goddard Space Flight Center, with science input from a Science Definition Team drawn from the broad scientific community. It was recognized
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In the title compound, [Pt{Ph2P(CH2)3PPh2}2]Cl2·5CHCl3, the Pt(II) cations, located on a centre of inversion, is coordinated by two chelating diphosphane ligands in a geometry which is close to square-planar. The chelate rings adopt a... more
In the title compound, [Pt{Ph2P(CH2)3PPh2}2]Cl2·5CHCl3, the Pt(II) cations, located on a centre of inversion, is coordinated by two chelating diphosphane ligands in a geometry which is close to square-planar. The chelate rings adopt a chair conformation. The Pt(II) cations are arranged in layers separated by Cl(-) anions as well as CHCl3 solvent mol-ecules. While this complex has been reported previously [Anderson et al. (1983 ▶). Inorg. Chim. Acta, 76, L251-L252], this is the first time a structure has been determined.
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a... more
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding; and (ii) the co-presence of the EGFR inhibitor PD153035 potentiates BC-11's cytotoxicity. Exposure of cells to a higher concentration of BC-11 corresponding to its ED75 at 72 h (250 μM) caused additional impairment of mitochondrial activity, the production of reactive oxygen species and promotion...
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ABSTRACT A series of complexes [Pt(η2-quinone)(C2H4){P(cyclo-C6H11)3}] has been prepared by treating [Pt(C2H4)2{P(cyclo-C6H11)3}] with benzo-1,4-quinones. Carbon-13 n.m.r. studies on the compounds containing the ligands 2,3-dimethyl-,... more
ABSTRACT A series of complexes [Pt(η2-quinone)(C2H4){P(cyclo-C6H11)3}] has been prepared by treating [Pt(C2H4)2{P(cyclo-C6H11)3}] with benzo-1,4-quinones. Carbon-13 n.m.r. studies on the compounds containing the ligands 2,3-dimethyl-, 2,5-dimethyl-, 2,5-diphenyl-benzo-1,4-quinone, and naphtho-1,4-quinone revealed that although the C2H4 group is undergoing rapid rotation, the η2-bonded quinone is rigid on the n.m.r. time scale. In contrast, in the derivatives from 2,6-dimethyl-, 2,6-di-t-butyl-, 2,6-dimethoxy-, and 2,3,5,6-tetramethyl-benzo-1,4-quinone, the quinone ligands are also undergoing dynamic behaviour. The η2 ground-state structure was established by an X-ray diffraction study on the compound [Pt(η2-C6Me4O2)(C2H4){P(cyclo-C6H11)3}]. Crystals are triclinic, space group P, Z= 2, in a unit cell with lattice parameters a= 9.818(3), b= 10.489(3), c= 14.486(3)Å, α= 97.27(2), β= 97.93(2), and γ= 91.33(3)°. The structure has been refined to R 0.027 (R′ 0.033) for 6 467 independent reflections collected at 200 K for 2.9 2θ 55°(Mo-KαX-radiation). The results establish that the 2,3,5,6-tetramethylbenzo-1,4-quinone ligand is attached to the platinum by two carbon atoms of one C(Me)C(Me) group, and the metal is in a trigonal planar environment with the midpoint of this group, the phosphorus atom, and the midpoint of the C–C bond of the ethylene ligand, with all these co-ordinated atoms lying within 0.1 Å of the co-ordination plane.
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Research Interests: Pharmacology, Biochemistry, Bioinformatics, Evolutionary Biology, Genetics, and 47 moreMarine Biology, Neuroscience, Environmental Science, Geophysics, Physics, Materials Science, Quantum Physics, Developmental Biology, Immunology, Climate Change, Molecular Biology, Structural Biology, Genomics, RNA, Computational Biology, Transcriptomics, Biotechnology, Systems Biology, Cancer, Biology, Metabolomics, Cell Cycle, Proteomics, Ecology, Drug Discovery, Evolution, Nanotechnology, Astrophysics, Neurobiology, Medicine, Multidisciplinary, Palaeobiology, Functional Genomics, Nature, Signal Transduction, Exobiology, Astronomy, DNA, Cell Signalling, Medical Research, Chemical Analysis, Ice, South Pole, Saturn, Earth Science, Organic Chemicals, and *Hot Temperature
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New Horizons obtained 400 ring images of the Jovian ring system using the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 µm. The ring was imaged at phase angles... more
New Horizons obtained 400 ring images of the Jovian ring system using the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 µm. The ring was imaged at phase angles 7°-159°. In addition, one sequence of near-IR spectra (lambda = 1.25 to 2.5 µm) was obtained by the Linear Etalon Imaging
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Development of the New Horizons mission to Pluto and the Kuiper Belt is now fully funded by NASA (Stern and Spencer, this volume). If all goes well, New Horizons will be launched in January 2006, followed by a Jupiter gravity assist in... more
Development of the New Horizons mission to Pluto and the Kuiper Belt is now fully funded by NASA (Stern and Spencer, this volume). If all goes well, New Horizons will be launched in January 2006, followed by a Jupiter gravity assist in 2007, with Pluto arrival expected in either 2015 or 2016, depending on the launch vehicle chosen. A backup
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Carbon-Carbon Bond Cleavages in Agostic Cations Formed by Protonation of Cobalt-Diene Complexes ... Martin A. Bennett,*a Julian C. Nicholls,b AK Fazlur Rahman,a Alan D. Redhouse,b John L. Spencer,*b and Anthony C. Willisa a Research... more
Carbon-Carbon Bond Cleavages in Agostic Cations Formed by Protonation of Cobalt-Diene Complexes ... Martin A. Bennett,*a Julian C. Nicholls,b AK Fazlur Rahman,a Alan D. Redhouse,b John L. Spencer,*b and Anthony C. Willisa a Research School of Chemistry, ...
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1,4-Benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of... more
1,4-Benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
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Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous... more
Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance of chronic inflammatory processes like those observed in the leprosy granuloma involve an ongoing network of communications via cytokines. IL-10 has immunosuppressive properties and IL-10 genetic variants have been associated with leprosy development and reactions. The role of IL-10 in resistance and inflammation in leprosy was investigated using Mycobacterium leprae infection of mice deficient in IL-10 (IL-10-/-), as well as mice deficient in both inducible nitric oxide synthase (NOS2-/-) and IL-10 (10NOS2-/-). Although a lack of IL-10 did not affect M. leprae multiplication in the footpads (FP), inflammation increased from C57Bl/6 (B6)<IL-10-/-<NOS2-/-<10NOS2-/-. While IL-10-/- mice exhibit...
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New Horizons passed Jupiter on February 28, 2007, en route to its Pluto encounter in 2015. During the flyby, the spacecraft made extensive observations of Jovian system. We will discuss preliminary conclusions from the 300 ring images... more
New Horizons passed Jupiter on February 28, 2007, en route to its Pluto encounter in 2015. During the flyby, the spacecraft made extensive observations of Jovian system. We will discuss preliminary conclusions from the 300 ring images obtained by the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 mum. The
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IAUC 5898 available at Central Bureau for Astronomical Telegrams.
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Abstract A general microwave-assisted procedure for the synthesis of 6-amino-β-cyclodextrins is reported. Mono-tosyl-β-cyclodextrin was used as the starting material in a one-pot route employing a solvent-free microwave-assisted reaction... more
Abstract A general microwave-assisted procedure for the synthesis of 6-amino-β-cyclodextrins is reported. Mono-tosyl-β-cyclodextrin was used as the starting material in a one-pot route employing a solvent-free microwave-assisted reaction with a liquid amine. ...