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    John Spencer

    Newly qualified doctors spend much of their time with nurses, but little research has considered informal learning during that formative contact. This article reports findings from a multiple case study that explored what newly qualified... more
    Newly qualified doctors spend much of their time with nurses, but little research has considered informal learning during that formative contact. This article reports findings from a multiple case study that explored what newly qualified doctors felt they learned from nurses in the workplace. Analysis of interviews conducted with UK doctors in their first year of practice identified four overarching themes: attitudes towards working with nurses, learning about roles, professional hierarchies and learning skills. Informal learning was found to contribute to the newly qualified doctors' knowledge of their own and others' roles. A dynamic hierarchy was identified: one in which a "pragmatic hierarchy" recognising nurses' expertise was superseded by a "normative structural…
    This aim of this paper was to explore new... more
    This aim of this paper was to explore new doctors' preparedness for prescribing. This was a multiple methods study including face-to-face and telephone interviews, questionnaires and secondary data from a safe prescribing assessment (n= 284). Three medical schools with differing curricula and cohorts were included: Newcastle (systems-based, integrated curriculum); Warwick (graduate entry) and Glasgow [problem-based learning (PBL)], with graduates entering F1 in their local deanery. The primary sample consisted of final year medical students, stratified by academic quartile (n= 65) from each of the three UK medical schools. In addition an anonymous cohort questionnaire was distributed at each site (n= 480), triangulating interviews were conducted with 92 clinicians and questionnaire data were collected from 80 clinicians who had worked with F1s. Data from the primary sample and cohort data highlighted that graduates entering F1 felt under-prepared for prescribing. However there was improvement over the F1 year through practical experience and support. Triangulating data reinforced the primary sample findings. Participants reported that learning in an applied setting would be helpful and increase confidence in prescribing. No clear differences were found in preparedness to prescribe between graduates of the three medical schools. The results form part of a larger study 'Are medical graduates fully prepared for practice?'. Prescribing was found to be the weakest area of practice in all sources of data. There is a need for more applied learning to develop skill-based, applied aspects of prescribing which would help to improve preparedness for prescribing.
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    The aim was to explore the use of Light Detection and Ranging (LiDAR) data to map the micro-topography of an intertidal wetland in southeast Queensland Australia. The driver for this was the need to identify and map the habitats of the... more
    The aim was to explore the use of Light Detection and Ranging (LiDAR) data to map the micro-topography of an intertidal wetland in southeast Queensland Australia. The driver for this was the need to identify and map the habitats of the immature stages of an aedine disease vector mosquito (Aedes vigilax (Skuse)). We derived a high resolution digital elevation model (DEM) data set at a vertical resolution of 0.05 m from LiDAR data. The relative accuracy of the DEM across the site was tested by comparing water depth predictions derived from the DEM against in-situ water depth readings from pressure sensors over a 10-day tidal cycle, which included high spring tides. We found that the field observations of micro-topographic units important for mosquito management matched those delineated from the DEM. The micro-topography included a low berm or central ridge that was more or less continuous across the site, a shallow back basin and fringing mangroves. The fringing mangroves had unimpede...
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    In 2004, an aerial reconnaissance survey of Gulf of Carpentaria rivers identified alluvial gully erosion as a likely key sediment source into many rivers. The process is found to varying degrees within alluvial river types along most Gulf... more
    In 2004, an aerial reconnaissance survey of Gulf of Carpentaria rivers identified alluvial gully erosion as a likely key sediment source into many rivers. The process is found to varying degrees within alluvial river types along most Gulf rivers, and is more extensive in the larger, steeper gradient rivers. It is hypothesised that the high connectivity between alluvial gullies and trunk streams makes these features a significant sediment source to the Gulf. The process appears to differ significantly in scale and process from the well documented, largely colluvial, gullies that abound in southern Australia. New conceptual models of the processes driving these gullies, and controls on their morphology and spatial distribution, are required if this process is to be adequately parameterised into existing sediment budget models, such as SedNet, in northern Australia. It is likely that similar features exist in eastern draining tropical rivers, suggesting existing SedNet models may need ...
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    River classification schemes are now widely used by a range of government agencies, managers and researchers to help reach an understanding of river form and process among the geomorphic complexity found in river channels, as a basis for... more
    River classification schemes are now widely used by a range of government agencies, managers and researchers to help reach an understanding of river form and process among the geomorphic complexity found in river channels, as a basis for understanding ecosystem patch dynamics and connections, and as means of organising and prioritising research and management activities. With some exceptions, existing schemas are generally qualitative, relying largely on expert judgement to delineate “homogeneous geomorphic reaches” for a specific river, from field, GIS, and/or remotely sensed data. In this paper, we demonstrate that continuous data for a number of morphological metrics can be derived relatively cheaply from available remotely sensed and GIS data, as a basis for a regional to continental geomorphic river classification. This approach is intended as a “proof of concept” for further development into a classification approach that can be applied across Northern Australia. Others, have ...
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    Alluvial gully erosion is a dominant sediment source of many large rivers draining into the Gulf of Carpentaria. Recent field reconnaissance and aerial survey has highlighted that gullies have a considerable impact on the landscape. In... more
    Alluvial gully erosion is a dominant sediment source of many large rivers draining into the Gulf of Carpentaria. Recent field reconnaissance and aerial survey has highlighted that gullies have a considerable impact on the landscape. In order to understand alluvial gully erosion it is essential that a detailed survey of the nature and extent of alluvial gully erosion be undertaken. Remote sensing is the only practical approach for undertaking this assessment due to the extent and nature of gully erosion in Australia's tropical rivers. In this paper a two level method for mapping gully erosion in Australia's tropical rivers is reported that uses Aster (Advanced Spaceborne Thermal Emission and Reflection Radiometer) satellite image data as the regional level data source. The first level is a data centred remote sensing overview and the second level is a remote sensing image analysis method. Results of a pilot study looking at a 600km2 section of the Mitchell River demonstrate f...
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    This work presents an alternative approach to estimate river bank erosion at regional scale through the Self-Organizing Maps (SOM) technique. LIDAR data was used to calculate erosion values at local scale, while satellite imagery combined... more
    This work presents an alternative approach to estimate river bank erosion at regional scale through the Self-Organizing Maps (SOM) technique. LIDAR data was used to calculate erosion values at local scale, while satellite imagery combined with digital elevation model (DEM) were used as predictive variables for regional scale. The LIDAR data was collected in the Normamby River Basin, Australia in 2009 and 2011, from which elevation, canopy height and percent canopy coverage were calculated. The differences in elevation between 2009 and 2011 produced values of erosion along the rivers that were used as training points in the modeling process. Landsat TM5 (Thematic Mapper) sensor images were corrected for atmospheric attenuation and converted into reflectance values to calculate band ratios to enhance spectral features. A subset of fifteen hundred points was randomly selected in areas where erosion was detected and associated to band ratios values and DEM derived measures (elevation, s...
    This report presents a sediment and nutrient budget for the Mitchell River catchment, located on the western flanks of Cape York and draining to the Gulf of Carpentaria. A catchment sediment (or nutrient) budget accounts for the major... more
    This report presents a sediment and nutrient budget for the Mitchell River catchment, located on the western flanks of Cape York and draining to the Gulf of Carpentaria. A catchment sediment (or nutrient) budget accounts for the major sources, transport pathways and sinks of sediments and nutrients within a catchment. It is difficult to measure all of the relevant components of a catchment sediment budget across space and time. Consequently a modelling framework is useful to bring together the individual components of the budget in a coherent manner, whether derived from local empirical data or theoretical models. The SedNet and ANNEX models have been used in this study; these models have been widely applied in tropical Queensland settings and elsewhere in Australia. Each sediment budget term comprises its own sub-model and here, a combination of national-scale models (terrain, hillslope erosion, colluvial gully density and surface soil nutrient concentrations), state-wide data sets...
    ABSTRACT
    We present the first global disk-resolved maps of the distribution of Ganymede's 2600 Angstroms absorption band, due probably to O_3 (Noll et al. 1997), obtained with STIS on HST. These data complement earlier... more
    We present the first global disk-resolved maps of the distribution of Ganymede's 2600 Angstroms absorption band, due probably to O_3 (Noll et al. 1997), obtained with STIS on HST. These data complement earlier disk-integrated UV spectra by IUE (Nelson et al. 1987) and HST (Noll et al. 1996), and Galileo UVS spectra of selected regions of the surface (Hendrix et
    The recent drought in southern Australia and the increasing realisation that this may be the norm as a result of global warming has led to increased interest in developing the land and water resource of the tropical savannah in northern... more
    The recent drought in southern Australia and the increasing realisation that this may be the norm as a result of global warming has led to increased interest in developing the land and water resource of the tropical savannah in northern Australia. Intensive land and water resource development in tropical savannahs in other parts of the world has been shown to lead to significant land degradation, and there are signs this has already occurred with the comparatively moderate levels of historic grazing and agriculture in northern Australia. It is critical that we understand contemporary and historical landscape dynamics before land use is intensified in this region. As a way of beginning to quantify key sediment sources and to start to understand potential changes in relative contributions associated with land use and other drivers, we have begun to construct a sediment budget for the Mitchell River, a 71 360 km2 catchment draining into the Gulf of Carpentaria. We present some prelimin...
    Catchments in northern Australian have undergone dramatic land-use changes from traditional Aboriginal management to widespread cattle grazing post-European settlement. Quantifying the soil erosion impacts of these changes is essential to... more
    Catchments in northern Australian have undergone dramatic land-use changes from traditional Aboriginal management to widespread cattle grazing post-European settlement. Quantifying the soil erosion impacts of these changes is essential to the future sustainable management of the soils in these catchments. Rates of gully erosion in alluvial soils were measured using recent GPS surveys and historical air photographs. The results indicated that median erosion rates currently and historically are within the same order of magnitude (0.1 to 1m per year). Historic air photo analysis demonstrated rapid increases in gully area of 2 to 10 times their initial 1949 area. Extrapolation of gully area growth trends backward in time suggested that most gullies initiated between 1880 and 1950. European cattle were introduced into the lower Mitchell catchment in the 1880's, suggesting the contribution of land use intensification to either gully initiation or acceleration. It is hypothesized that ...
    To find how early experience in clinical and community settings ("early experience") affects medical education, and identify strengths and limitations of the available evidence. A systematic review rating, by consensus, the... more
    To find how early experience in clinical and community settings ("early experience") affects medical education, and identify strengths and limitations of the available evidence. A systematic review rating, by consensus, the strength and importance of outcomes reported in the decade 1992-2001. Bibliographical databases and journals were searched for publications on the topic, reviewed under the auspices of the recently formed Best Evidence Medical Education (BEME) collaboration. All empirical studies (verifiable, observational data) were included, whatever their design, method, or language of publication. Early experience was most commonly provided in community settings, aiming to recruit primary care practitioners for underserved populations. It increased the popularity of primary care residencies, albeit among self selected students. It fostered self awareness and empathic attitudes towards ill people, boosted students' confidence, motivated them, gave them satisfacti...
    Compare how different researchers performed in screening for informative evidence about medical education. Six researchers with three different levels of involvement in a systematic literature review screened articles by title and (where... more
    Compare how different researchers performed in screening for informative evidence about medical education. Six researchers with three different levels of involvement in a systematic literature review screened articles by title and (where available) abstract, and then by reading articles they had selected in full text. The reference standard was a consensus decision to include or exclude the article in the final analysis, whose results are published elsewhere. The single screener most involved in the literature search, who was also the most junior member of the topic review group, achieved a sensitivity approaching 100% and a specificity of 98-100% for informative articles. She far outperformed the other researchers, all of whom had as much or more topic knowledge and greater research experience. It was not possible to improve on the performance of the single motivated and capable primary screener and trying to do so increased the number of uninformative articles retrieved. One inter...
    Given the non-spherical shape of Enceladus, the satellite may experience gravitational torques that will cause it to physically librate as it orbits Saturn. Physical libration would produce a diurnal oscillation in the longitude of... more
    Given the non-spherical shape of Enceladus, the satellite may experience gravitational torques that will cause it to physically librate as it orbits Saturn. Physical libration would produce a diurnal oscillation in the longitude of Enceladus' tidal bulge, which could have a profound effect on the diurnal stresses experienced by the surface of the satellite. Although Cassini ISS has placed an
    ... Submitted by T. YOSHIDA* and S. OTSd'KA* Checked by DG JONES,? J. L. SPENCER,f P. BINGER,$ A. BRINKMA",* and P. WEDEMANNZ ... The phosphines and (q5-C5H5)(q3-Cfi3) Pd are malo-dorous materials with unknown physiological... more
    ... Submitted by T. YOSHIDA* and S. OTSd'KA* Checked by DG JONES,? J. L. SPENCER,f P. BINGER,$ A. BRINKMA",* and P. WEDEMANNZ ... The phosphines and (q5-C5H5)(q3-Cfi3) Pd are malo-dorous materials with unknown physiological effects. ...
    With the remarkable Cassini discovery of active water ice plumes emanating from the south pole of Enceladus, this tiny moon has become an exciting possible target for a future Flagship mission. A NASA HQ-directed study was performed by... more
    With the remarkable Cassini discovery of active water ice plumes emanating from the south pole of Enceladus, this tiny moon has become an exciting possible target for a future Flagship mission. A NASA HQ-directed study was performed by the Goddard Space Flight Center, with science input from a Science Definition Team drawn from the broad scientific community. It was recognized
    In the title compound, [Pt{Ph2P(CH2)3PPh2}2]Cl2·5CHCl3, the Pt(II) cations, located on a centre of inversion, is coordinated by two chelating diphosphane ligands in a geometry which is close to square-planar. The chelate rings adopt a... more
    In the title compound, [Pt{Ph2P(CH2)3PPh2}2]Cl2·5CHCl3, the Pt(II) cations, located on a centre of inversion, is coordinated by two chelating diphosphane ligands in a geometry which is close to square-planar. The chelate rings adopt a chair conformation. The Pt(II) cations are arranged in layers separated by Cl(-) anions as well as CHCl3 solvent mol-ecules. While this complex has been reported previously [Anderson et al. (1983 ▶). Inorg. Chim. Acta, 76, L251-L252], this is the first time a structure has been determined.
    BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a... more
    BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding; and (ii) the co-presence of the EGFR inhibitor PD153035 potentiates BC-11's cytotoxicity. Exposure of cells to a higher concentration of BC-11 corresponding to its ED75 at 72 h (250 μM) caused additional impairment of mitochondrial activity, the production of reactive oxygen species and promotion...
    Three contrasting stratigraphic assemblages characterize fault-bounded terranes in the Southern Plomosa Mtns. (1) The Six Price sequence (SPS) consists of Proterozoic coarse-grained granitoid overlain by Paleozoic and Mesozoic strata. (2)... more
    Three contrasting stratigraphic assemblages characterize fault-bounded terranes in the Southern Plomosa Mtns. (1) The Six Price sequence (SPS) consists of Proterozoic coarse-grained granitoid overlain by Paleozoic and Mesozoic strata. (2) The Apache Wash sequence consists of a basal mega-breccia and conglomerate unit overlain by sandstone in a fining-upward sequence. Paleozoic blocks in the mega-breccia include a Cambrian Muav-like lithology not
    ABSTRACT A series of complexes [Pt(η2-quinone)(C2H4){P(cyclo-C6H11)3}] has been prepared by treating [Pt(C2H4)2{P(cyclo-C6H11)3}] with benzo-1,4-quinones. Carbon-13 n.m.r. studies on the compounds containing the ligands 2,3-dimethyl-,... more
    ABSTRACT A series of complexes [Pt(η2-quinone)(C2H4){P(cyclo-C6H11)3}] has been prepared by treating [Pt(C2H4)2{P(cyclo-C6H11)3}] with benzo-1,4-quinones. Carbon-13 n.m.r. studies on the compounds containing the ligands 2,3-dimethyl-, 2,5-dimethyl-, 2,5-diphenyl-benzo-1,4-quinone, and naphtho-1,4-quinone revealed that although the C2H4 group is undergoing rapid rotation, the η2-bonded quinone is rigid on the n.m.r. time scale. In contrast, in the derivatives from 2,6-dimethyl-, 2,6-di-t-butyl-, 2,6-dimethoxy-, and 2,3,5,6-tetramethyl-benzo-1,4-quinone, the quinone ligands are also undergoing dynamic behaviour. The η2 ground-state structure was established by an X-ray diffraction study on the compound [Pt(η2-C6Me4O2)(C2H4){P(cyclo-C6H11)3}]. Crystals are triclinic, space group P, Z= 2, in a unit cell with lattice parameters a= 9.818(3), b= 10.489(3), c= 14.486(3)Å, α= 97.27(2), β= 97.93(2), and γ= 91.33(3)°. The structure has been refined to R 0.027 (R′ 0.033) for 6 467 independent reflections collected at 200 K for 2.9 2θ 55°(Mo-KαX-radiation). The results establish that the 2,3,5,6-tetramethylbenzo-1,4-quinone ligand is attached to the platinum by two carbon atoms of one C(Me)C(Me) group, and the metal is in a trigonal planar environment with the midpoint of this group, the phosphorus atom, and the midpoint of the C–C bond of the ethylene ligand, with all these co-ordinated atoms lying within 0.1 Å of the co-ordination plane.
    New Horizons obtained 400 ring images of the Jovian ring system using the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 µm. The ring was imaged at phase angles... more
    New Horizons obtained 400 ring images of the Jovian ring system using the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 µm. The ring was imaged at phase angles 7°-159°. In addition, one sequence of near-IR spectra (lambda = 1.25 to 2.5 µm) was obtained by the Linear Etalon Imaging
    Development of the New Horizons mission to Pluto and the Kuiper Belt is now fully funded by NASA (Stern and Spencer, this volume). If all goes well, New Horizons will be launched in January 2006, followed by a Jupiter gravity assist in... more
    Development of the New Horizons mission to Pluto and the Kuiper Belt is now fully funded by NASA (Stern and Spencer, this volume). If all goes well, New Horizons will be launched in January 2006, followed by a Jupiter gravity assist in 2007, with Pluto arrival expected in either 2015 or 2016, depending on the launch vehicle chosen. A backup
    Carbon-Carbon Bond Cleavages in Agostic Cations Formed by Protonation of Cobalt-Diene Complexes ... Martin A. Bennett,*a Julian C. Nicholls,b AK Fazlur Rahman,a Alan D. Redhouse,b John L. Spencer,*b and Anthony C. Willisa a Research... more
    Carbon-Carbon Bond Cleavages in Agostic Cations Formed by Protonation of Cobalt-Diene Complexes ... Martin A. Bennett,*a Julian C. Nicholls,b AK Fazlur Rahman,a Alan D. Redhouse,b John L. Spencer,*b and Anthony C. Willisa a Research School of Chemistry, ...
    1,4-Benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of... more
    1,4-Benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
    Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous... more
    Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance of chronic inflammatory processes like those observed in the leprosy granuloma involve an ongoing network of communications via cytokines. IL-10 has immunosuppressive properties and IL-10 genetic variants have been associated with leprosy development and reactions. The role of IL-10 in resistance and inflammation in leprosy was investigated using Mycobacterium leprae infection of mice deficient in IL-10 (IL-10-/-), as well as mice deficient in both inducible nitric oxide synthase (NOS2-/-) and IL-10 (10NOS2-/-). Although a lack of IL-10 did not affect M. leprae multiplication in the footpads (FP), inflammation increased from C57Bl/6 (B6)<IL-10-/-<NOS2-/-<10NOS2-/-. While IL-10-/- mice exhibit...
    New Horizons passed Jupiter on February 28, 2007, en route to its Pluto encounter in 2015. During the flyby, the spacecraft made extensive observations of Jovian system. We will discuss preliminary conclusions from the 300 ring images... more
    New Horizons passed Jupiter on February 28, 2007, en route to its Pluto encounter in 2015. During the flyby, the spacecraft made extensive observations of Jovian system. We will discuss preliminary conclusions from the 300 ring images obtained by the Long Range Reconnaissance Imager (LORRI). This camera has a broad bandpass spanning wavelengths lambda = 0.35 to 0.85 mum. The
    IAUC 5898 available at Central Bureau for Astronomical Telegrams.
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    Abstract A general microwave-assisted procedure for the synthesis of 6-amino-β-cyclodextrins is reported. Mono-tosyl-β-cyclodextrin was used as the starting material in a one-pot route employing a solvent-free microwave-assisted reaction... more
    Abstract A general microwave-assisted procedure for the synthesis of 6-amino-β-cyclodextrins is reported. Mono-tosyl-β-cyclodextrin was used as the starting material in a one-pot route employing a solvent-free microwave-assisted reaction with a liquid amine. ...
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