Ramsay-Hunt syndrome: Report of two cases with identification of the varicella zoster virus genom... more Ramsay-Hunt syndrome: Report of two cases with identification of the varicella zoster virus genome in cerebrospinal fluid Like other alpha-herpesviruses, the varicella-zoster virus (VZV) remains latent in the neural ganglia following the primary varicella infection. The reactivation of the VZV in the dorsal root ganglia results in herpes zoster. Herpes zoster eruption is characterized by localized cutaneous lesions and neuralgic pain mostly in older and immunocompromised persons, especially those living with the human immunodeficiency virus (HIV). The most commonly reported complications include VZV pneumonia, meningitis, encephalitis, and hepatitis. Several neurologic syndromes have been described associated with herpes zoster localized in cranial areas including peripheral nerve palsies and the Ramsay-Hunt syndrome, which has a varied clinical presentation and is the second most common cause of peripheral facial paralysis. Facial paralysis in this syndrome occurs in 60 to 90% of cases and it may precede or appear after the cutaneous lesions with a worse prognosis than idiopathic Bell paralysis. Here we present two cases of herpes zoster from the geniculate ganglia with peripheral facial paralysis that appeared simultaneously with vesicular herpetic otic lesions (multimetameric Ramsay-Hunt syndrome). In the two cases, amplifiable varicella-zoster viral DNA was found in the cerebrospinal fluid by RT-PCR Multiplex. Keywords: Herpes zoster; HIV; acquired immunodeficiency syndrome; facial paralysis, cerebrospinal fluid.
We report the case of a man from Dominican Republic who consulted for a tenosynovitis of the righ... more We report the case of a man from Dominican Republic who consulted for a tenosynovitis of the right middle finger extensor; in the immediate convalescence second febrile curve, after 48 hours of no symptoms of an acute febrile illness, with marked fatigue, itchy rash, polyarthralgia, functional impairment and general stiffness. Biochemical tests did not provide useful data for diagnosis. Dengue virus serology was negative. Detection of IgM and neutralizing antibodies (PRNT) for Chikundunya virus (CHIKV) were positive.
Como los otros alfa-herpes virus, el (VZV) establece un estado de latencia en los ganglios neural... more Como los otros alfa-herpes virus, el (VZV) establece un estado de latencia en los ganglios neurales que sigue a la infección primaria (varicela). La reactivación de una infección latente por VZV desde los ganglios de la raíz dorsal da como resultado el herpes zóster (HZ). La erupción debida a HZ se caracteriza por lesiones cutáneas metaméricas que se acompañan de dolor neurítico y comprometen con mayor frecuencia a ancianos y sujetos inmunocomprometidos, en especial aquellos infectados por el virus de la inmunodeficiencia humana (VIH). Las complicaciones que se observan en esta población de pacientes incluyen neumonía, hepatitis y compromiso del sistema nervioso central (meningitis y encefalitis). Distintos síndromes clínicos se asocian al HZ de localización craneal, incluyendo la parálisis facial periférica y el síndrome de Ramsay Hunt. El síndrome de Ramsay Hunt es la segunda causa en frecuencia de parálisis facial periférica, con una gran variedad de presentaciones clínicas. La...
Pre-exposure prophylaxis (PrEP) is an
effective measure to prevent HIV transmission.
If the adher... more Pre-exposure prophylaxis (PrEP) is an effective measure to prevent HIV transmission. If the adherence is high, transmission rates are reduced by more than 90%. In Argentina, FTC-TDF is not yet approved for PrEP by the local regulatory agency. PrEP awareness, PrEP adoption, and factors associated with adoption among argentine physicians had not been studied to date. We designed a cross-sectional online survey conducted in August 2017 among argentine physicians and valored differents items about PrEP, (knowledge, attitudes, and beliefs associated with adoption). Univariate analysis was performed; the associations between categorical variables were analyzed by means of the chi2 test. The level of significance was considered with p <0.05. A total of 238 surveys were received from 81 centers in Argentina. Clinical scenarios associated with the highest prescription were: serodiscordant couples 77%, sex workers 61%, transgender patients 32%, people who inject drugs 31%, and men who have sex with men (MSM) 23%. Factors associated with PrEP prescription between physicians were been chief of staff (p<0.05), been an infectious diseases specialist (p<0.05), assist more than 200 HIV seropositive patients per year (p<0.009) and having prescribed postexposure prophylaxis (PEP) (p<0.008). The authors concluded that in spite of not yet approved by the local regulatory agency, PrEP is been prescribed off- label by argentine physicians. Adopters were more likely to have experience providing HIV care, been chief of staff and ID specialist. These results could be used to plan future HIV prevention strategies in Argentina.
Ramsay-Hunt syndrome: Report of two cases with identification of the varicella zoster virus genom... more Ramsay-Hunt syndrome: Report of two cases with identification of the varicella zoster virus genome in cerebrospinal fluid Like other alpha-herpesviruses, the varicella-zoster virus (VZV) remains latent in the neural ganglia following the primary varicella infection. The reactivation of the VZV in the dorsal root ganglia results in herpes zoster. Herpes zoster eruption is characterized by localized cutaneous lesions and neuralgic pain mostly in older and immunocompromised persons, especially those living with the human immunodeficiency virus (HIV). The most commonly reported complications include VZV pneumonia, meningitis, encephalitis, and hepatitis. Several neurologic syndromes have been described associated with herpes zoster localized in cranial areas including peripheral nerve palsies and the Ramsay-Hunt syndrome, which has a varied clinical presentation and is the second most common cause of peripheral facial paralysis. Facial paralysis in this syndrome occurs in 60 to 90% of cases and it may precede or appear after the cutaneous lesions with a worse prognosis than idiopathic Bell paralysis. Here we present two cases of herpes zoster from the geniculate ganglia with peripheral facial paralysis that appeared simultaneously with vesicular herpetic otic lesions (multimetameric Ramsay-Hunt syndrome). In the two cases, amplifiable varicella-zoster viral DNA was found in the cerebrospinal fluid by RT-PCR Multiplex. Keywords: Herpes zoster; HIV; acquired immunodeficiency syndrome; facial paralysis, cerebrospinal fluid.
We report the case of a man from Dominican Republic who consulted for a tenosynovitis of the righ... more We report the case of a man from Dominican Republic who consulted for a tenosynovitis of the right middle finger extensor; in the immediate convalescence second febrile curve, after 48 hours of no symptoms of an acute febrile illness, with marked fatigue, itchy rash, polyarthralgia, functional impairment and general stiffness. Biochemical tests did not provide useful data for diagnosis. Dengue virus serology was negative. Detection of IgM and neutralizing antibodies (PRNT) for Chikundunya virus (CHIKV) were positive.
Como los otros alfa-herpes virus, el (VZV) establece un estado de latencia en los ganglios neural... more Como los otros alfa-herpes virus, el (VZV) establece un estado de latencia en los ganglios neurales que sigue a la infección primaria (varicela). La reactivación de una infección latente por VZV desde los ganglios de la raíz dorsal da como resultado el herpes zóster (HZ). La erupción debida a HZ se caracteriza por lesiones cutáneas metaméricas que se acompañan de dolor neurítico y comprometen con mayor frecuencia a ancianos y sujetos inmunocomprometidos, en especial aquellos infectados por el virus de la inmunodeficiencia humana (VIH). Las complicaciones que se observan en esta población de pacientes incluyen neumonía, hepatitis y compromiso del sistema nervioso central (meningitis y encefalitis). Distintos síndromes clínicos se asocian al HZ de localización craneal, incluyendo la parálisis facial periférica y el síndrome de Ramsay Hunt. El síndrome de Ramsay Hunt es la segunda causa en frecuencia de parálisis facial periférica, con una gran variedad de presentaciones clínicas. La...
Pre-exposure prophylaxis (PrEP) is an
effective measure to prevent HIV transmission.
If the adher... more Pre-exposure prophylaxis (PrEP) is an effective measure to prevent HIV transmission. If the adherence is high, transmission rates are reduced by more than 90%. In Argentina, FTC-TDF is not yet approved for PrEP by the local regulatory agency. PrEP awareness, PrEP adoption, and factors associated with adoption among argentine physicians had not been studied to date. We designed a cross-sectional online survey conducted in August 2017 among argentine physicians and valored differents items about PrEP, (knowledge, attitudes, and beliefs associated with adoption). Univariate analysis was performed; the associations between categorical variables were analyzed by means of the chi2 test. The level of significance was considered with p <0.05. A total of 238 surveys were received from 81 centers in Argentina. Clinical scenarios associated with the highest prescription were: serodiscordant couples 77%, sex workers 61%, transgender patients 32%, people who inject drugs 31%, and men who have sex with men (MSM) 23%. Factors associated with PrEP prescription between physicians were been chief of staff (p<0.05), been an infectious diseases specialist (p<0.05), assist more than 200 HIV seropositive patients per year (p<0.009) and having prescribed postexposure prophylaxis (PEP) (p<0.008). The authors concluded that in spite of not yet approved by the local regulatory agency, PrEP is been prescribed off- label by argentine physicians. Adopters were more likely to have experience providing HIV care, been chief of staff and ID specialist. These results could be used to plan future HIV prevention strategies in Argentina.
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Papers by Jorge Correa
Like other alpha-herpesviruses, the varicella-zoster virus (VZV) remains latent in the neural ganglia following the primary varicella infection. The reactivation of the VZV in the dorsal root ganglia results in herpes zoster. Herpes zoster eruption is characterized by localized cutaneous lesions and neuralgic pain mostly in older and immunocompromised persons,
especially those living with the human immunodeficiency virus (HIV).
The most commonly reported complications include VZV pneumonia, meningitis, encephalitis, and hepatitis. Several neurologic syndromes have been described associated with herpes zoster localized in cranial areas including peripheral nerve palsies and the Ramsay-Hunt syndrome, which has a varied clinical presentation and is the second most
common cause of peripheral facial paralysis. Facial paralysis in this syndrome occurs in 60 to 90% of cases and it may precede or appear after the cutaneous lesions with a worse prognosis than idiopathic Bell paralysis.
Here we present two cases of herpes zoster from the geniculate ganglia with peripheral
facial paralysis that appeared simultaneously with vesicular herpetic otic lesions (multimetameric Ramsay-Hunt syndrome). In the two cases, amplifiable varicella-zoster viral DNA was found in the cerebrospinal fluid by RT-PCR Multiplex.
Keywords: Herpes zoster; HIV; acquired immunodeficiency syndrome; facial paralysis, cerebrospinal fluid.
effective measure to prevent HIV transmission.
If the adherence is high, transmission
rates are reduced by more than
90%. In Argentina, FTC-TDF is not yet
approved for PrEP by the local regulatory
agency. PrEP awareness, PrEP adoption,
and factors associated with adoption
among argentine physicians had
not been studied to date. We designed a
cross-sectional online survey conducted
in August 2017 among argentine physicians
and valored differents items about
PrEP, (knowledge, attitudes, and beliefs
associated with adoption). Univariate
analysis was performed; the associations
between categorical variables were analyzed
by means of the chi2 test. The level of
significance was considered with p <0.05.
A total of 238 surveys were received from
81 centers in Argentina. Clinical scenarios
associated with the highest prescription
were: serodiscordant couples 77%, sex
workers 61%, transgender patients 32%,
people who inject drugs 31%, and men
who have sex with men (MSM) 23%.
Factors associated with PrEP prescription
between physicians were been chief
of staff (p<0.05), been an infectious diseases
specialist (p<0.05), assist more than
200 HIV seropositive patients per year
(p<0.009) and having prescribed postexposure
prophylaxis (PEP) (p<0.008).
The authors concluded that in spite of not
yet approved by the local regulatory agency,
PrEP is been prescribed off- label by
argentine physicians. Adopters were more
likely to have experience providing HIV
care, been chief of staff and ID specialist.
These results could be used to plan future
HIV prevention strategies in Argentina.
Like other alpha-herpesviruses, the varicella-zoster virus (VZV) remains latent in the neural ganglia following the primary varicella infection. The reactivation of the VZV in the dorsal root ganglia results in herpes zoster. Herpes zoster eruption is characterized by localized cutaneous lesions and neuralgic pain mostly in older and immunocompromised persons,
especially those living with the human immunodeficiency virus (HIV).
The most commonly reported complications include VZV pneumonia, meningitis, encephalitis, and hepatitis. Several neurologic syndromes have been described associated with herpes zoster localized in cranial areas including peripheral nerve palsies and the Ramsay-Hunt syndrome, which has a varied clinical presentation and is the second most
common cause of peripheral facial paralysis. Facial paralysis in this syndrome occurs in 60 to 90% of cases and it may precede or appear after the cutaneous lesions with a worse prognosis than idiopathic Bell paralysis.
Here we present two cases of herpes zoster from the geniculate ganglia with peripheral
facial paralysis that appeared simultaneously with vesicular herpetic otic lesions (multimetameric Ramsay-Hunt syndrome). In the two cases, amplifiable varicella-zoster viral DNA was found in the cerebrospinal fluid by RT-PCR Multiplex.
Keywords: Herpes zoster; HIV; acquired immunodeficiency syndrome; facial paralysis, cerebrospinal fluid.
effective measure to prevent HIV transmission.
If the adherence is high, transmission
rates are reduced by more than
90%. In Argentina, FTC-TDF is not yet
approved for PrEP by the local regulatory
agency. PrEP awareness, PrEP adoption,
and factors associated with adoption
among argentine physicians had
not been studied to date. We designed a
cross-sectional online survey conducted
in August 2017 among argentine physicians
and valored differents items about
PrEP, (knowledge, attitudes, and beliefs
associated with adoption). Univariate
analysis was performed; the associations
between categorical variables were analyzed
by means of the chi2 test. The level of
significance was considered with p <0.05.
A total of 238 surveys were received from
81 centers in Argentina. Clinical scenarios
associated with the highest prescription
were: serodiscordant couples 77%, sex
workers 61%, transgender patients 32%,
people who inject drugs 31%, and men
who have sex with men (MSM) 23%.
Factors associated with PrEP prescription
between physicians were been chief
of staff (p<0.05), been an infectious diseases
specialist (p<0.05), assist more than
200 HIV seropositive patients per year
(p<0.009) and having prescribed postexposure
prophylaxis (PEP) (p<0.008).
The authors concluded that in spite of not
yet approved by the local regulatory agency,
PrEP is been prescribed off- label by
argentine physicians. Adopters were more
likely to have experience providing HIV
care, been chief of staff and ID specialist.
These results could be used to plan future
HIV prevention strategies in Argentina.