The etiological factors in the development of comorbidity between alcohol use disorder (AUD) and ... more The etiological factors in the development of comorbidity between alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are complex. Preclinical research in animal models is necessary to understand how genetic and biological mechanisms contribute to the risk for developing comorbid AUD and PTSD. This research is critical for identifying specific and efficacious biological and behavioral treatments for these comorbid disorders. The goals of this chapter are to highlight: (1) epidemiological data on the prevalence of comorbid AUD and PTSD in humans, (2) theories that attempt to explain comorbidity, (3) current animal models of comorbid AUD and PTSD, and (4) findings from our laboratory in a unique genetic mouse model of comorbid AUD and PTSD. We will highlight the translational applicability of findings using this model to speed the identification of novel treatments for humans suffering with comorbid AUD and PTSD.
Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the cli... more Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the clinical and pre-clinical literature speak to the need for better paradigms to study this interaction. The present experiments compared animal models of the propensity to consume ethanol, the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) rat lines, in their response to yohimbine on ethanol seeking and self-administration and anxiety-like behavior. The P and HAD lines consume similar amounts of ethanol, yet differ in apparent motivation to drink ethanol, in anxiety-like behavior, and response to stress in alcohol drinking. Therefore, it was of interest to determine whether stress may differentially affect ethanol-motivated behaviors between the P and HAD lines. Acute administration of yohimbine, an α-2 adrenoreceptor antagonist that increases anxiety and activate stress systems, increased operant ethanol self-administration and reinstatement of ethanol seeking in P ...
This document has been made available through Purdue e-Pubs, a service of the Purdue University L... more This document has been made available through Purdue e-Pubs, a service of the Purdue University Libraries. Please contact epubs@purdue.edu for additional information.
The etiological factors in the development of comorbidity between alcohol use disorder (AUD) and ... more The etiological factors in the development of comorbidity between alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are complex. Preclinical research in animal models is necessary to understand how genetic and biological mechanisms contribute to the risk for developing comorbid AUD and PTSD. This research is critical for identifying specific and efficacious biological and behavioral treatments for these comorbid disorders. The goals of this chapter are to highlight: (1) epidemiological data on the prevalence of comorbid AUD and PTSD in humans, (2) theories that attempt to explain comorbidity, (3) current animal models of comorbid AUD and PTSD, and (4) findings from our laboratory in a unique genetic mouse model of comorbid AUD and PTSD. We will highlight the translational applicability of findings using this model to speed the identification of novel treatments for humans suffering with comorbid AUD and PTSD.
Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the cli... more Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the clinical and pre-clinical literature speak to the need for better paradigms to study this interaction. The present experiments compared animal models of the propensity to consume ethanol, the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) rat lines, in their response to yohimbine on ethanol seeking and self-administration and anxiety-like behavior. The P and HAD lines consume similar amounts of ethanol, yet differ in apparent motivation to drink ethanol, in anxiety-like behavior, and response to stress in alcohol drinking. Therefore, it was of interest to determine whether stress may differentially affect ethanol-motivated behaviors between the P and HAD lines. Acute administration of yohimbine, an α-2 adrenoreceptor antagonist that increases anxiety and activate stress systems, increased operant ethanol self-administration and reinstatement of ethanol seeking in P ...
This document has been made available through Purdue e-Pubs, a service of the Purdue University L... more This document has been made available through Purdue e-Pubs, a service of the Purdue University Libraries. Please contact epubs@purdue.edu for additional information.
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